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Protein

Histone H4

Gene

HHF1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 245

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Name:HHF1
Ordered Locus Names:ECU09_0440
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU09_0440.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Histone H4PRO_0000158314Add
BLAST

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

STRINGi284813.XP_955597.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SQP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOGENOMiHOG000234654.
InParanoidiQ8SQP4.
KOiK11254.
OMAiCIYATHA.
OrthoDBiEOG092C5WME.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR001951. Histone_H4.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTQSIGAKG KSKAAKGIAK RHRKQSSLSD SISKPAIRRI ARRAGVRRVG
60 70 80 90 100
GGCFKEINNA AREYIRDTLS IACIYATHAK RKTITCSDIL HSLKRMGIKY

IGY
Length:103
Mass (Da):11,377
Last modified:June 1, 2002 - v1
Checksum:i99157B2D0327AF67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590451 Genomic DNA. Translation: CAD27016.1.
RefSeqiXP_955597.1. XM_950504.1.

Genome annotation databases

EnsemblFungiiCAD27016; CAD27016; CAD27016.
GeneIDi860382.
KEGGiecu:ECU09_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590451 Genomic DNA. Translation: CAD27016.1.
RefSeqiXP_955597.1. XM_950504.1.

3D structure databases

ProteinModelPortaliQ8SQP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.XP_955597.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD27016; CAD27016; CAD27016.
GeneIDi860382.
KEGGiecu:ECU09_0440.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU09_0440.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOGENOMiHOG000234654.
InParanoidiQ8SQP4.
KOiK11254.
OMAiCIYATHA.
OrthoDBiEOG092C5WME.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR001951. Histone_H4.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH4_ENCCU
AccessioniPrimary (citable) accession number: Q8SQP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.