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Q8SQP0

- KPYK_ENCCU

UniProt

Q8SQP0 - KPYK_ENCCU

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Protein

Pyruvate kinase

Gene
PYK1, ECU09_0640
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341Substrate By similarity
Metal bindingi36 – 361Potassium By similarity
Metal bindingi38 – 381Potassium By similarity
Metal bindingi68 – 681Potassium By similarity
Metal bindingi69 – 691Potassium; via carbonyl oxygen By similarity
Sitei212 – 2121Transition state stabilizer By similarity
Metal bindingi214 – 2141Magnesium Reviewed prediction
Binding sitei237 – 2371Substrate; via amide nitrogen By similarity
Metal bindingi238 – 2381Magnesium By similarity
Binding sitei238 – 2381Substrate; via amide nitrogen By similarity
Binding sitei270 – 2701Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK1
Ordered Locus Names:ECU09_0640
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome IX

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU09_0640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Pyruvate kinasePRO_0000379473Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi6035.ECU09_0640.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SQP0-1 [UniParc]FASTAAdd to Basket

« Hide

MRMVLTKIVC TIGPRTSSRE KIKELIDAGM SIARLNFSHG SREAHLEVIR    50
NIRDSRSGAG RHVSIALDTR GPEVRLRTPE MKDIKVEGGE VLRFSLLSSE 100
KDIWIPGVDL KSLGVDNRVF IDDGAIELRV VNVEEDGFEC EVLNSGMIKS 150
NKSMNFPGTD IGDRALGDED KNDIAFGLEN GIDMVFASFV SCRADVEEIR 200
RLVGSKVPVV SKIESCLGMR NLKEIALCSD GVMIARGDLG VEIGLENMFS 250
AQKRILYEVK REGRPVICAT QMMESMTLKN APNRSEISDV GNAVLDGCDC 300
VMLSAESAVG MFPVETVKFM RSICADAERY DMESRKGAGA CGVSSYVDGV 350
VICSGTESQI EKIYLSKPET PIIVISESLW ILRRFSIYRG IIPVYGKGSE 400
DAEATLRRLG LRGRFLAVGR EDVRMVSV 428
Length:428
Mass (Da):47,063
Last modified:May 29, 2013 - v2
Checksum:i7594602E9E920AC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590451 Genomic DNA. Translation: CAD27037.2.
RefSeqiXP_955618.1. XM_950525.1.

Genome annotation databases

GeneIDi860403.
KEGGiecu:ECU09_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590451 Genomic DNA. Translation: CAD27037.2 .
RefSeqi XP_955618.1. XM_950525.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU09_0640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860403.
KEGGi ecu:ECU09_0640.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU09_0640.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
    Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
    BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GB-M1.
  3. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiKPYK_ENCCU
AccessioniPrimary (citable) accession number: Q8SQP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 29, 2013
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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