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Q8SQG8 (HYAL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-2

Short name=Hyal-2
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-2
Gene names
Name:HYAL2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R By similarity.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subunit structure

Interacts with MST1R By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainEGF-like domain
Signal
   Molecular functionGlycosidase
Hydrolase
Receptor
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

cartilage development

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to UV-B

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to fibroblast growth factor stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to interleukin-1

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to transforming growth factor beta stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: Ensembl

fusion of virus membrane with host plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

glycosaminoglycan catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

hematopoietic progenitor cell differentiation

Inferred from electronic annotation. Source: Ensembl

hyaluronan catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

monocyte activation

Inferred from sequence or structural similarity. Source: UniProtKB

multicellular organismal aging

Inferred from electronic annotation. Source: Ensembl

multicellular organismal iron ion homeostasis

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAP kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of fibroblast migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein kinase B signaling

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein tyrosine kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-6 secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of interleukin-8 secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of urine volume

Inferred from sequence or structural similarity. Source: UniProtKB

renal water absorption

Inferred from sequence or structural similarity. Source: UniProtKB

response to antibiotic

Inferred from electronic annotation. Source: Ensembl

response to reactive oxygen species

Inferred from sequence or structural similarity. Source: UniProtKB

response to virus

Inferred from sequence or structural similarity. Source: UniProtKB

skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

transformation of host cell by virus

Inferred from sequence or structural similarity. Source: UniProtKB

viral entry into host cell

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentanchored component of external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

anchored component of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

apical plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic membrane-bounded vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

endocytic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

lysosome

Inferred from sequence or structural similarity. Source: UniProtKB

membrane raft

Inferred from sequence or structural similarity. Source: UniProtKB

microvillus

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionhyaluronic acid binding

Inferred from sequence or structural similarity. Source: UniProtKB

hyaluronoglucuronidase activity

Inferred from sequence or structural similarity. Source: UniProtKB

hyalurononglucosaminidase activity

Inferred from sequence or structural similarity. Source: UniProtKB

receptor signaling protein tyrosine kinase inhibitor activity

Inferred from sequence or structural similarity. Source: UniProtKB

virus receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 451431Hyaluronidase-2
PRO_0000296276
Propeptide452 – 47322Removed in mature form Potential
PRO_0000296277

Regions

Domain364 – 44279EGF-like

Sites

Active site1381Proton donor By similarity

Amino acid modifications

Lipidation4511GPI-anchor amidated glycine Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 343 By similarity
Disulfide bond214 ↔ 230 By similarity
Disulfide bond368 ↔ 379 By similarity
Disulfide bond373 ↔ 430 By similarity
Disulfide bond432 ↔ 441 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SQG8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: BC3D1E5DD120622E

FASTA47353,881
        10         20         30         40         50         60 
MWTGLGPAVT LALVLVVAWA TELKPTAPPI FTGRPFVVAW DVPTQDCGPR HKMPLDPKDM 

        70         80         90        100        110        120 
KAFDVQASPN EGFVNQNITI FYRDRLGMYP HFNSVGRSVH GGVPQNGSLW VHLEMLKGHV 

       130        140        150        160        170        180 
EHYIRTQEPA GLAVIDWEDW RPVWVRNWQD KDVYRRLSRH LVAIRHPDWP PERVAKEAQY 

       190        200        210        220        230        240 
EFEFAARQFM LETLRFVKAF RPRHLWGFYL FPDCYNHDYV QNWETYTGRC PDVEVSRNDQ 

       250        260        270        280        290        300 
LAWLWAESTA LFPSVYLEET LASSTHGRNF VSFRVQEALR VADVHHANHA LPVYVFTRPT 

       310        320        330        340        350        360 
YSRGLTGLSE MDLISTIGES AALGAAGVIL WGDAGFTTSN ETCRRLKDYL TRSLVPYVVN 

       370        380        390        400        410        420 
VSWAAQYCSW AQCHGHGRCV RRDPNAHTFL HLSASSFRLV PSHAPDEPRL RPEGELSWAD 

       430        440        450        460        470 
RNHLQMHFRC QCYLGWGGEQ CQWDRRRAAG GASGAWAGSH LTGLLAVAVL AFT 

« Hide

References

« Hide 'large scale' references
[1]"Mechanism of cell entry and transformation by enzootic nasal tumor virus."
Dirks C., Duh F.-M., Rai S.K., Lerman M.I., Miller A.D.
J. Virol. 76:2141-2149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411973 mRNA. Translation: AAL78385.1.
BT021810 mRNA. Translation: AAX46657.1.
BT026155 mRNA. Translation: ABG66994.1.
BC102042 mRNA. Translation: AAI02043.1.
RefSeqNP_776772.1. NM_174347.2.
UniGeneBt.29683.

3D structure databases

ProteinModelPortalQ8SQG8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEQ8SQG8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000612; ENSBTAP00000000612; ENSBTAG00000000484.
ENSBTAT00000052079; ENSBTAP00000051198; ENSBTAG00000000484.
GeneID281838.
KEGGbta:281838.

Organism-specific databases

CTD8692.

Phylogenomic databases

eggNOGNOG77606.
GeneTreeENSGT00550000074476.
HOGENOMHOG000015133.
HOVERGENHBG052053.
InParanoidQ8SQG8.
KOK01197.
OMAGWGGEQC.
OrthoDBEOG74J97S.
TreeFamTF321598.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805744.

Entry information

Entry nameHYAL2_BOVIN
AccessionPrimary (citable) accession number: Q8SQG8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries