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Q8SQG8

- HYAL2_BOVIN

UniProt

Q8SQG8 - HYAL2_BOVIN

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Protein
Hyaluronidase-2
Gene
HYAL2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381Proton donor By similarity

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB
  2. hyaluronoglucuronidase activity Source: UniProtKB
  3. hyalurononglucosaminidase activity Source: UniProtKB
  4. receptor signaling protein tyrosine kinase inhibitor activity Source: UniProtKB
  5. virus receptor activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cellular response to UV-B Source: UniProtKB
  4. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  5. cellular response to interleukin-1 Source: UniProtKB
  6. cellular response to transforming growth factor beta stimulus Source: UniProtKB
  7. cellular response to tumor necrosis factor Source: Ensembl
  8. defense response to virus Source: Ensembl
  9. fusion of virus membrane with host plasma membrane Source: UniProtKB
  10. glycosaminoglycan catabolic process Source: UniProtKB
  11. hematopoietic progenitor cell differentiation Source: Ensembl
  12. hyaluronan catabolic process Source: UniProtKB
  13. monocyte activation Source: UniProtKB
  14. multicellular organismal aging Source: Ensembl
  15. multicellular organismal iron ion homeostasis Source: Ensembl
  16. negative regulation of MAP kinase activity Source: UniProtKB
  17. negative regulation of cell growth Source: UniProtKB
  18. negative regulation of fibroblast migration Source: UniProtKB
  19. negative regulation of protein kinase B signaling Source: UniProtKB
  20. negative regulation of protein tyrosine kinase activity Source: UniProtKB
  21. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  22. positive regulation of inflammatory response Source: UniProtKB
  23. positive regulation of interleukin-6 secretion Source: UniProtKB
  24. positive regulation of interleukin-8 secretion Source: UniProtKB
  25. positive regulation of protein import into nucleus Source: Ensembl
  26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. positive regulation of urine volume Source: UniProtKB
  28. renal water absorption Source: UniProtKB
  29. response to antibiotic Source: Ensembl
  30. response to reactive oxygen species Source: UniProtKB
  31. response to virus Source: UniProtKB
  32. skeletal system morphogenesis Source: Ensembl
  33. transformation of host cell by virus Source: UniProtKB
  34. viral entry into host cell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Receptor

Enzyme and pathway databases

ReactomeiREACT_224746. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-2 (EC:3.2.1.35)
Short name:
Hyal-2
Alternative name(s):
Hyaluronoglucosaminidase-2
Gene namesi
Name:HYAL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: Ensembl
  2. anchored component of plasma membrane Source: UniProtKB
  3. apical plasma membrane Source: UniProtKB
  4. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  5. cytoplasmic vesicle Source: UniProtKB
  6. cytosol Source: UniProtKB
  7. endocytic vesicle Source: UniProtKB
  8. lysosome Source: UniProtKB
  9. membrane raft Source: UniProtKB
  10. microvillus Source: UniProtKB
  11. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 451431Hyaluronidase-2
PRO_0000296276Add
BLAST
Propeptidei452 – 47322Removed in mature form Reviewed prediction
PRO_0000296277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 343 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi214 ↔ 230 By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi368 ↔ 379 By similarity
Disulfide bondi373 ↔ 430 By similarity
Disulfide bondi432 ↔ 441 By similarity
Lipidationi451 – 4511GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ8SQG8.

Interactioni

Subunit structurei

Interacts with MST1R By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8SQG8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini364 – 44279EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
GeneTreeiENSGT00550000074476.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ8SQG8.
KOiK01197.
OMAiGWGGEQC.
OrthoDBiEOG74J97S.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQG8-1 [UniParc]FASTAAdd to Basket

« Hide

MWTGLGPAVT LALVLVVAWA TELKPTAPPI FTGRPFVVAW DVPTQDCGPR    50
HKMPLDPKDM KAFDVQASPN EGFVNQNITI FYRDRLGMYP HFNSVGRSVH 100
GGVPQNGSLW VHLEMLKGHV EHYIRTQEPA GLAVIDWEDW RPVWVRNWQD 150
KDVYRRLSRH LVAIRHPDWP PERVAKEAQY EFEFAARQFM LETLRFVKAF 200
RPRHLWGFYL FPDCYNHDYV QNWETYTGRC PDVEVSRNDQ LAWLWAESTA 250
LFPSVYLEET LASSTHGRNF VSFRVQEALR VADVHHANHA LPVYVFTRPT 300
YSRGLTGLSE MDLISTIGES AALGAAGVIL WGDAGFTTSN ETCRRLKDYL 350
TRSLVPYVVN VSWAAQYCSW AQCHGHGRCV RRDPNAHTFL HLSASSFRLV 400
PSHAPDEPRL RPEGELSWAD RNHLQMHFRC QCYLGWGGEQ CQWDRRRAAG 450
GASGAWAGSH LTGLLAVAVL AFT 473
Length:473
Mass (Da):53,881
Last modified:June 1, 2002 - v1
Checksum:iBC3D1E5DD120622E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411973 mRNA. Translation: AAL78385.1.
BT021810 mRNA. Translation: AAX46657.1.
BT026155 mRNA. Translation: ABG66994.1.
BC102042 mRNA. Translation: AAI02043.1.
RefSeqiNP_776772.1. NM_174347.2.
UniGeneiBt.29683.

Genome annotation databases

EnsembliENSBTAT00000000612; ENSBTAP00000000612; ENSBTAG00000000484.
ENSBTAT00000052079; ENSBTAP00000051198; ENSBTAG00000000484.
GeneIDi281838.
KEGGibta:281838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411973 mRNA. Translation: AAL78385.1 .
BT021810 mRNA. Translation: AAX46657.1 .
BT026155 mRNA. Translation: ABG66994.1 .
BC102042 mRNA. Translation: AAI02043.1 .
RefSeqi NP_776772.1. NM_174347.2.
UniGenei Bt.29683.

3D structure databases

ProteinModelPortali Q8SQG8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PRIDEi Q8SQG8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000612 ; ENSBTAP00000000612 ; ENSBTAG00000000484 .
ENSBTAT00000052079 ; ENSBTAP00000051198 ; ENSBTAG00000000484 .
GeneIDi 281838.
KEGGi bta:281838.

Organism-specific databases

CTDi 8692.

Phylogenomic databases

eggNOGi NOG77606.
GeneTreei ENSGT00550000074476.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q8SQG8.
KOi K01197.
OMAi GWGGEQC.
OrthoDBi EOG74J97S.
TreeFami TF321598.

Enzyme and pathway databases

Reactomei REACT_224746. Hyaluronan uptake and degradation.

Miscellaneous databases

NextBioi 20805744.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mechanism of cell entry and transformation by enzootic nasal tumor virus."
    Dirks C., Duh F.-M., Rai S.K., Lerman M.I., Miller A.D.
    J. Virol. 76:2141-2149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiHYAL2_BOVIN
AccessioniPrimary (citable) accession number: Q8SQG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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