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Protein

Hyaluronidase-2

Gene

HYAL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity).By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei138Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Receptor

Enzyme and pathway databases

ReactomeiR-BTA-2160916. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-2 (EC:3.2.1.35)
Short name:
Hyal-2
Alternative name(s):
Hyaluronoglucosaminidase-2
Gene namesi
Name:HYAL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029627621 – 451Hyaluronidase-2Add BLAST431
PropeptideiPRO_0000296277452 – 473Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 343By similarity
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi214 ↔ 230By similarity
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi360N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi368 ↔ 379By similarity
Disulfide bondi373 ↔ 430By similarity
Disulfide bondi432 ↔ 441By similarity
Lipidationi451GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8SQG8.
PRIDEiQ8SQG8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000484.

Interactioni

Subunit structurei

Interacts with MST1R.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000612.

Structurei

3D structure databases

ProteinModelPortaliQ8SQG8.
SMRiQ8SQG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 442EGF-likeAdd BLAST79

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IECJ. Eukaryota.
ENOG410XPZT. LUCA.
GeneTreeiENSGT00550000074476.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ8SQG8.
KOiK01197.
OMAiWGGEQCQ.
OrthoDBiEOG091G064G.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTGLGPAVT LALVLVVAWA TELKPTAPPI FTGRPFVVAW DVPTQDCGPR
60 70 80 90 100
HKMPLDPKDM KAFDVQASPN EGFVNQNITI FYRDRLGMYP HFNSVGRSVH
110 120 130 140 150
GGVPQNGSLW VHLEMLKGHV EHYIRTQEPA GLAVIDWEDW RPVWVRNWQD
160 170 180 190 200
KDVYRRLSRH LVAIRHPDWP PERVAKEAQY EFEFAARQFM LETLRFVKAF
210 220 230 240 250
RPRHLWGFYL FPDCYNHDYV QNWETYTGRC PDVEVSRNDQ LAWLWAESTA
260 270 280 290 300
LFPSVYLEET LASSTHGRNF VSFRVQEALR VADVHHANHA LPVYVFTRPT
310 320 330 340 350
YSRGLTGLSE MDLISTIGES AALGAAGVIL WGDAGFTTSN ETCRRLKDYL
360 370 380 390 400
TRSLVPYVVN VSWAAQYCSW AQCHGHGRCV RRDPNAHTFL HLSASSFRLV
410 420 430 440 450
PSHAPDEPRL RPEGELSWAD RNHLQMHFRC QCYLGWGGEQ CQWDRRRAAG
460 470
GASGAWAGSH LTGLLAVAVL AFT
Length:473
Mass (Da):53,881
Last modified:June 1, 2002 - v1
Checksum:iBC3D1E5DD120622E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411973 mRNA. Translation: AAL78385.1.
BT021810 mRNA. Translation: AAX46657.1.
BT026155 mRNA. Translation: ABG66994.1.
BC102042 mRNA. Translation: AAI02043.1.
RefSeqiNP_776772.1. NM_174347.2.
XP_010815967.1. XM_010817665.2.
XP_010815968.1. XM_010817666.2.
UniGeneiBt.29683.

Genome annotation databases

EnsembliENSBTAT00000000612; ENSBTAP00000000612; ENSBTAG00000000484.
ENSBTAT00000052079; ENSBTAP00000051198; ENSBTAG00000000484.
GeneIDi281838.
KEGGibta:281838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411973 mRNA. Translation: AAL78385.1.
BT021810 mRNA. Translation: AAX46657.1.
BT026155 mRNA. Translation: ABG66994.1.
BC102042 mRNA. Translation: AAI02043.1.
RefSeqiNP_776772.1. NM_174347.2.
XP_010815967.1. XM_010817665.2.
XP_010815968.1. XM_010817666.2.
UniGeneiBt.29683.

3D structure databases

ProteinModelPortaliQ8SQG8.
SMRiQ8SQG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000612.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Proteomic databases

PaxDbiQ8SQG8.
PRIDEiQ8SQG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000612; ENSBTAP00000000612; ENSBTAG00000000484.
ENSBTAT00000052079; ENSBTAP00000051198; ENSBTAG00000000484.
GeneIDi281838.
KEGGibta:281838.

Organism-specific databases

CTDi8692.

Phylogenomic databases

eggNOGiENOG410IECJ. Eukaryota.
ENOG410XPZT. LUCA.
GeneTreeiENSGT00550000074476.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ8SQG8.
KOiK01197.
OMAiWGGEQCQ.
OrthoDBiEOG091G064G.
TreeFamiTF321598.

Enzyme and pathway databases

ReactomeiR-BTA-2160916. Hyaluronan uptake and degradation.

Gene expression databases

BgeeiENSBTAG00000000484.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYAL2_BOVIN
AccessioniPrimary (citable) accession number: Q8SQG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.