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Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. positive regulation of T cell migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_321435. Chemokine receptors bind chemokines.
REACT_338486. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:CCL20
Synonyms:MIP3A, SCYA20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 2

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 9670C-C motif chemokine 20PRO_0000005216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 58By similarity
Disulfide bondi33 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8SQB1.

Interactioni

Subunit structurei

Binds to and activate CCR6.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028430.

Structurei

3D structure databases

ProteinModelPortaliQ8SQB1.
SMRiQ8SQB1. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8SQB1.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCSSKNLLL AALMSVLLLH FCSKSEASNF DCCLRYTERI LHPSILVGFT
60 70 80 90
QQLANEACDI NAVVFYTRKK LAVCADPKKK WVKQVVHMLS QRVKRM
Length:96
Mass (Da):10,964
Last modified:June 1, 2002 - v1
Checksum:iE8BF286B8F6C1D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061959 mRNA. Translation: AAL38662.1.
RefSeqiNP_776688.1. NM_174263.2.
UniGeneiBt.9560.

Genome annotation databases

EnsembliENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326.
GeneIDi281666.
KEGGibta:281666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061959 mRNA. Translation: AAL38662.1.
RefSeqiNP_776688.1. NM_174263.2.
UniGeneiBt.9560.

3D structure databases

ProteinModelPortaliQ8SQB1.
SMRiQ8SQB1. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028430.

Proteomic databases

PRIDEiQ8SQB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326.
GeneIDi281666.
KEGGibta:281666.

Organism-specific databases

CTDi6364.

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8SQB1.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_321435. Chemokine receptors bind chemokines.
REACT_338486. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20805597.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The role of chemokines in bovine respiratory syncytial virus infection."
    Neuenschwander S., Werling D.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL20_BOVIN
AccessioniPrimary (citable) accession number: Q8SQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.