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Q8SQB1

- CCL20_BOVIN

UniProt

Q8SQB1 - CCL20_BOVIN

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Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
  4. positive regulation of T cell migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:CCL20
Synonyms:MIP3A, SCYA20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 9670C-C motif chemokine 20PRO_0000005216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 58By similarity
Disulfide bondi33 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8SQB1.

Interactioni

Subunit structurei

Binds to and activate CCR6.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028430.

Structurei

3D structure databases

ProteinModelPortaliQ8SQB1.
SMRiQ8SQB1. Positions 27-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8SQB1.
KOiK14625.
OMAiACDINAV.
OrthoDBiEOG7B31QP.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMCSSKNLLL AALMSVLLLH FCSKSEASNF DCCLRYTERI LHPSILVGFT
60 70 80 90
QQLANEACDI NAVVFYTRKK LAVCADPKKK WVKQVVHMLS QRVKRM
Length:96
Mass (Da):10,964
Last modified:June 1, 2002 - v1
Checksum:iE8BF286B8F6C1D97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY061959 mRNA. Translation: AAL38662.1.
RefSeqiNP_776688.1. NM_174263.2.
UniGeneiBt.9560.

Genome annotation databases

EnsembliENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326.
GeneIDi281666.
KEGGibta:281666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY061959 mRNA. Translation: AAL38662.1 .
RefSeqi NP_776688.1. NM_174263.2.
UniGenei Bt.9560.

3D structure databases

ProteinModelPortali Q8SQB1.
SMRi Q8SQB1. Positions 27-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000028430.

Proteomic databases

PRIDEi Q8SQB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000028430 ; ENSBTAP00000028430 ; ENSBTAG00000021326 .
GeneIDi 281666.
KEGGi bta:281666.

Organism-specific databases

CTDi 6364.

Phylogenomic databases

eggNOGi NOG44269.
GeneTreei ENSGT00530000064223.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8SQB1.
KOi K14625.
OMAi ACDINAV.
OrthoDBi EOG7B31QP.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_212617. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 20805597.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The role of chemokines in bovine respiratory syncytial virus infection."
    Neuenschwander S., Werling D.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL20_BOVIN
AccessioniPrimary (citable) accession number: Q8SQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3