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Q8SQB1

- CCL20_BOVIN

UniProt

Q8SQB1 - CCL20_BOVIN

Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_210568. G alpha (i) signalling events.
    REACT_212617. Chemokine receptors bind chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 20
    Alternative name(s):
    Macrophage inflammatory protein 3 alpha
    Short name:
    MIP-3-alpha
    Small-inducible cytokine A20
    Gene namesi
    Name:CCL20
    Synonyms:MIP3A, SCYA20
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 9670C-C motif chemokine 20PRO_0000005216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 58By similarity
    Disulfide bondi33 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8SQB1.

    Interactioni

    Subunit structurei

    Binds to and activate CCR6.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000028430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SQB1.
    SMRiQ8SQB1. Positions 27-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44269.
    GeneTreeiENSGT00530000064223.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8SQB1.
    KOiK14625.
    OMAiACDINAV.
    OrthoDBiEOG7B31QP.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8SQB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMCSSKNLLL AALMSVLLLH FCSKSEASNF DCCLRYTERI LHPSILVGFT   50
    QQLANEACDI NAVVFYTRKK LAVCADPKKK WVKQVVHMLS QRVKRM 96
    Length:96
    Mass (Da):10,964
    Last modified:June 1, 2002 - v1
    Checksum:iE8BF286B8F6C1D97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY061959 mRNA. Translation: AAL38662.1.
    RefSeqiNP_776688.1. NM_174263.2.
    UniGeneiBt.9560.

    Genome annotation databases

    EnsembliENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326.
    GeneIDi281666.
    KEGGibta:281666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY061959 mRNA. Translation: AAL38662.1 .
    RefSeqi NP_776688.1. NM_174263.2.
    UniGenei Bt.9560.

    3D structure databases

    ProteinModelPortali Q8SQB1.
    SMRi Q8SQB1. Positions 27-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000028430.

    Proteomic databases

    PRIDEi Q8SQB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000028430 ; ENSBTAP00000028430 ; ENSBTAG00000021326 .
    GeneIDi 281666.
    KEGGi bta:281666.

    Organism-specific databases

    CTDi 6364.

    Phylogenomic databases

    eggNOGi NOG44269.
    GeneTreei ENSGT00530000064223.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8SQB1.
    KOi K14625.
    OMAi ACDINAV.
    OrthoDBi EOG7B31QP.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_210568. G alpha (i) signalling events.
    REACT_212617. Chemokine receptors bind chemokines.

    Miscellaneous databases

    NextBioi 20805597.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of chemokines in bovine respiratory syncytial virus infection."
      Neuenschwander S., Werling D.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL20_BOVIN
    AccessioniPrimary (citable) accession number: Q8SQB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3