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Q8SQB1 (CCL20_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 20
Alternative name(s):
Macrophage inflammatory protein 3 alpha
Short name=MIP-3-alpha
Small-inducible cytokine A20
Gene names
Name:CCL20
Synonyms:MIP3A, SCYA20
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells By similarity.

Subunit structure

Binds to and activate CCR6 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 9670C-C motif chemokine 20
PRO_0000005216

Amino acid modifications

Disulfide bond32 ↔ 58 By similarity
Disulfide bond33 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SQB1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E8BF286B8F6C1D97

FASTA9610,964
        10         20         30         40         50         60 
MMCSSKNLLL AALMSVLLLH FCSKSEASNF DCCLRYTERI LHPSILVGFT QQLANEACDI 

        70         80         90 
NAVVFYTRKK LAVCADPKKK WVKQVVHMLS QRVKRM 

« Hide

References

[1]"The role of chemokines in bovine respiratory syncytial virus infection."
Neuenschwander S., Werling D.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY061959 mRNA. Translation: AAL38662.1.
RefSeqNP_776688.1. NM_174263.2.
UniGeneBt.9560.

3D structure databases

ProteinModelPortalQ8SQB1.
SMRQ8SQB1. Positions 27-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000028430.

Proteomic databases

PRIDEQ8SQB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326.
GeneID281666.
KEGGbta:281666.

Organism-specific databases

CTD6364.

Phylogenomic databases

eggNOGNOG44269.
GeneTreeENSGT00530000064223.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ8SQB1.
KOK14625.
OMAACDINAV.
OrthoDBEOG7B31QP.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805597.

Entry information

Entry nameCCL20_BOVIN
AccessionPrimary (citable) accession number: Q8SQB1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families