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Protein

C-C motif chemokine 20

Gene

CCL20

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-380108 Chemokine receptors bind chemokines
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:CCL20
Synonyms:MIP3A, SCYA20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:26947 CCL20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000000521627 – 96C-C motif chemokine 20Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 58By similarity
Disulfide bondi33 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8SQB1
PRIDEiQ8SQB1

Expressioni

Gene expression databases

BgeeiENSBTAG00000021326

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028430

Structurei

3D structure databases

ProteinModelPortaliQ8SQB1
SMRiQ8SQB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2BK Eukaryota
ENOG410ZGME LUCA
GeneTreeiENSGT00530000064223
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ8SQB1
KOiK14625
OMAiCCLRYTE
OrthoDBiEOG091G168B
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCSSKNLLL AALMSVLLLH FCSKSEASNF DCCLRYTERI LHPSILVGFT
60 70 80 90
QQLANEACDI NAVVFYTRKK LAVCADPKKK WVKQVVHMLS QRVKRM
Length:96
Mass (Da):10,964
Last modified:June 1, 2002 - v1
Checksum:iE8BF286B8F6C1D97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061959 mRNA Translation: AAL38662.1
RefSeqiNP_776688.1, NM_174263.2
UniGeneiBt.9560

Genome annotation databases

EnsembliENSBTAT00000028430; ENSBTAP00000028430; ENSBTAG00000021326
GeneIDi281666
KEGGibta:281666

Similar proteinsi

Entry informationi

Entry nameiCCL20_BOVIN
AccessioniPrimary (citable) accession number: Q8SQB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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