ID CCL3_BOVIN Reviewed; 93 AA. AC Q8SQA6; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 08-NOV-2023, entry version 97. DE RecName: Full=C-C motif chemokine 3; DE AltName: Full=Macrophage inflammatory protein 1-alpha; DE Short=MIP-1-alpha; DE AltName: Full=Small-inducible cytokine A3; DE Flags: Precursor; GN Name=CCL3; Synonyms=SCYA3; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Werling D.; RT "Role of chemokines in RSV infection."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds CC to CCR1, CCR4 and CCR5 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY077840; AAL78060.1; -; mRNA. DR RefSeq; NP_776936.1; NM_174511.2. DR AlphaFoldDB; Q8SQA6; -. DR SMR; Q8SQA6; -. DR STRING; 9913.ENSBTAP00000035305; -. DR PaxDb; 9913-ENSBTAP00000035305; -. DR GeneID; 282170; -. DR KEGG; bta:282170; -. DR CTD; 6348; -. DR eggNOG; ENOG502SAF0; Eukaryota. DR InParanoid; Q8SQA6; -. DR OrthoDB; 4265193at2759; -. DR Proteomes; UP000009136; Unplaced. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005829; C:cytosol; ISS:UniProtKB. DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB. DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB. DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB. DR GO; GO:0016301; F:kinase activity; ISS:UniProtKB. DR GO; GO:0016004; F:phospholipase activator activity; ISS:UniProtKB. DR GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB. DR GO; GO:0043615; P:astrocyte cell migration; ISS:UniProtKB. DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB. DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB. DR GO; GO:0001775; P:cell activation; ISS:UniProtKB. DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB. DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central. DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB. DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. DR GO; GO:0048245; P:eosinophil chemotaxis; ISS:UniProtKB. DR GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB. DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0071621; P:granulocyte chemotaxis; ISS:UniProtKB. DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; ISS:UniProtKB. DR GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB. DR GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB. DR GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB. DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB. DR GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB. DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB. DR GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB. DR GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB. DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB. DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISS:UniProtKB. DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB. DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB. DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB. DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISS:UniProtKB. DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB. DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB. DR GO; GO:0050795; P:regulation of behavior; ISS:UniProtKB. DR GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB. DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB. DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB. DR GO; GO:0070723; P:response to cholesterol; ISS:UniProtKB. DR GO; GO:0009636; P:response to toxic substance; ISS:UniProtKB. DR GO; GO:0023052; P:signaling; ISS:UniProtKB. DR GO; GO:0010818; P:T cell chemotaxis; ISS:UniProtKB. DR CDD; cd00272; Chemokine_CC; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR000827; Chemokine_CC_CS. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF183; C-C MOTIF CHEMOKINE 3; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1. PE 3: Inferred from homology; KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..24 FT /evidence="ECO:0000250|UniProtKB:P10147" FT CHAIN 25..93 FT /note="C-C motif chemokine 3" FT /id="PRO_0000005154" FT DISULFID 34..58 FT /evidence="ECO:0000250|UniProtKB:P10147" FT DISULFID 35..74 FT /evidence="ECO:0000250|UniProtKB:P10147" SQ SEQUENCE 93 AA; 10118 MW; 1266BFBFCEE5E8E9 CRC64; MKVAVAALAV LLCAMALCSQ VFSAPFGADT PTACCFSYVA RQLSRKIVAD YFETSSQCSK PGVIFQTKKG RQVCANPTED WVQEYITDLE LNA //