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Q8SQA6

- CCL3_BOVIN

UniProt

Q8SQA6 - CCL3_BOVIN

Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 By similarity.By similarity

    GO - Molecular functioni

    1. calcium-dependent protein kinase C activity Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. chemokine activity Source: UniProtKB
    4. kinase activity Source: UniProtKB
    5. phospholipase activator activity Source: UniProtKB
    6. protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. astrocyte cell migration Source: UniProtKB
    2. behavior Source: UniProtKB
    3. calcium ion transport Source: UniProtKB
    4. calcium-mediated signaling Source: UniProtKB
    5. cell activation Source: UniProtKB
    6. cell-cell signaling Source: UniProtKB
    7. cellular calcium ion homeostasis Source: UniProtKB
    8. cellular response to organic cyclic compound Source: UniProtKB
    9. chemotaxis Source: UniProtKB
    10. cytoskeleton organization Source: UniProtKB
    11. eosinophil chemotaxis Source: UniProtKB
    12. eosinophil degranulation Source: UniProtKB
    13. exocytosis Source: UniProtKB
    14. granulocyte chemotaxis Source: UniProtKB
    15. inflammatory response Source: UniProtKB
    16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    17. lymphocyte chemotaxis Source: UniProtKB
    18. macrophage chemotaxis Source: UniProtKB
    19. MAPK cascade Source: UniProtKB
    20. monocyte chemotaxis Source: UniProtKB
    21. negative regulation by host of viral transcription Source: UniProtKB
    22. negative regulation of gene expression Source: UniProtKB
    23. negative regulation of osteoclast differentiation Source: UniProtKB
    24. neutrophil chemotaxis Source: UniProtKB
    25. osteoblast differentiation Source: UniProtKB
    26. positive chemotaxis Source: GOC
    27. positive regulation of calcium ion transport Source: UniProtKB
    28. positive regulation of calcium-mediated signaling Source: UniProtKB
    29. positive regulation of catalytic activity Source: GOC
    30. positive regulation of cell migration Source: UniProtKB
    31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    32. positive regulation of gene expression Source: UniProtKB
    33. positive regulation of inflammatory response Source: UniProtKB
    34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
    35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
    36. positive regulation of neuron apoptotic process Source: UniProtKB
    37. positive regulation of tumor necrosis factor production Source: UniProtKB
    38. protein kinase B signaling Source: UniProtKB
    39. protein phosphorylation Source: UniProtKB
    40. regulation of cell shape Source: UniProtKB
    41. regulation of sensory perception of pain Source: UniProtKB
    42. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
    43. response to cholesterol Source: UniProtKB
    44. response to toxic substance Source: UniProtKB
    45. signaling Source: UniProtKB
    46. T cell chemotaxis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 3
    Alternative name(s):
    Macrophage inflammatory protein 1-alpha
    Short name:
    MIP-1-alpha
    Small-inducible cytokine A3
    Gene namesi
    Name:CCL3
    Synonyms:SCYA3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. intracellular Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 9369C-C motif chemokine 3PRO_0000005154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8SQA6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000035305.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SQA6.
    SMRiQ8SQA6. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42742.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ8SQA6.
    KOiK05408.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8SQA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVAVAALAV LLCAMALCSQ VFSAPFGADT PTACCFSYVA RQLSRKIVAD   50
    YFETSSQCSK PGVIFQTKKG RQVCANPTED WVQEYITDLE LNA 93
    Length:93
    Mass (Da):10,118
    Last modified:June 1, 2002 - v1
    Checksum:i1266BFBFCEE5E8E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY077840 mRNA. Translation: AAL78060.1.
    RefSeqiNP_776936.1. NM_174511.2.
    UniGeneiBt.9974.

    Genome annotation databases

    GeneIDi282170.
    KEGGibta:282170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY077840 mRNA. Translation: AAL78060.1 .
    RefSeqi NP_776936.1. NM_174511.2.
    UniGenei Bt.9974.

    3D structure databases

    ProteinModelPortali Q8SQA6.
    SMRi Q8SQA6. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000035305.

    Proteomic databases

    PRIDEi Q8SQA6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282170.
    KEGGi bta:282170.

    Organism-specific databases

    CTDi 6348.

    Phylogenomic databases

    eggNOGi NOG42742.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q8SQA6.
    KOi K05408.

    Miscellaneous databases

    NextBioi 20806001.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of chemokines in RSV infection."
      Werling D.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL3_BOVIN
    AccessioniPrimary (citable) accession number: Q8SQA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3