Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8SQA6

- CCL3_BOVIN

UniProt

Q8SQA6 - CCL3_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-C motif chemokine 3

Gene

CCL3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity).By similarity

GO - Molecular functioni

  1. calcium-dependent protein kinase C activity Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. chemokine activity Source: UniProtKB
  4. kinase activity Source: UniProtKB
  5. phospholipase activator activity Source: UniProtKB
  6. protein kinase activity Source: UniProtKB

GO - Biological processi

  1. astrocyte cell migration Source: UniProtKB
  2. behavior Source: UniProtKB
  3. calcium ion transport Source: UniProtKB
  4. calcium-mediated signaling Source: UniProtKB
  5. cell activation Source: UniProtKB
  6. cell-cell signaling Source: UniProtKB
  7. cellular calcium ion homeostasis Source: UniProtKB
  8. cellular response to organic cyclic compound Source: UniProtKB
  9. chemotaxis Source: UniProtKB
  10. cytoskeleton organization Source: UniProtKB
  11. eosinophil chemotaxis Source: UniProtKB
  12. eosinophil degranulation Source: UniProtKB
  13. exocytosis Source: UniProtKB
  14. granulocyte chemotaxis Source: UniProtKB
  15. inflammatory response Source: UniProtKB
  16. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  17. lymphocyte chemotaxis Source: UniProtKB
  18. macrophage chemotaxis Source: UniProtKB
  19. MAPK cascade Source: UniProtKB
  20. monocyte chemotaxis Source: UniProtKB
  21. negative regulation by host of viral transcription Source: UniProtKB
  22. negative regulation of gene expression Source: UniProtKB
  23. negative regulation of osteoclast differentiation Source: UniProtKB
  24. neutrophil chemotaxis Source: UniProtKB
  25. osteoblast differentiation Source: UniProtKB
  26. positive chemotaxis Source: GOC
  27. positive regulation of calcium ion transport Source: UniProtKB
  28. positive regulation of calcium-mediated signaling Source: UniProtKB
  29. positive regulation of catalytic activity Source: GOC
  30. positive regulation of cell migration Source: UniProtKB
  31. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  32. positive regulation of gene expression Source: UniProtKB
  33. positive regulation of inflammatory response Source: UniProtKB
  34. positive regulation of interleukin-1 beta secretion Source: UniProtKB
  35. positive regulation of natural killer cell chemotaxis Source: UniProtKB
  36. positive regulation of neuron apoptotic process Source: UniProtKB
  37. positive regulation of tumor necrosis factor production Source: UniProtKB
  38. protein kinase B signaling Source: UniProtKB
  39. protein phosphorylation Source: UniProtKB
  40. regulation of cell shape Source: UniProtKB
  41. regulation of sensory perception of pain Source: UniProtKB
  42. release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
  43. response to cholesterol Source: UniProtKB
  44. response to toxic substance Source: UniProtKB
  45. signaling Source: UniProtKB
  46. T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
Small-inducible cytokine A3
Gene namesi
Name:CCL3
Synonyms:SCYA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 9369C-C motif chemokine 3PRO_0000005154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8SQA6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035305.

Structurei

3D structure databases

ProteinModelPortaliQ8SQA6.
SMRiQ8SQA6. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42742.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ8SQA6.
KOiK05408.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVAVAALAV LLCAMALCSQ VFSAPFGADT PTACCFSYVA RQLSRKIVAD
60 70 80 90
YFETSSQCSK PGVIFQTKKG RQVCANPTED WVQEYITDLE LNA
Length:93
Mass (Da):10,118
Last modified:June 1, 2002 - v1
Checksum:i1266BFBFCEE5E8E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY077840 mRNA. Translation: AAL78060.1.
RefSeqiNP_776936.1. NM_174511.2.
UniGeneiBt.9974.

Genome annotation databases

GeneIDi282170.
KEGGibta:282170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY077840 mRNA. Translation: AAL78060.1 .
RefSeqi NP_776936.1. NM_174511.2.
UniGenei Bt.9974.

3D structure databases

ProteinModelPortali Q8SQA6.
SMRi Q8SQA6. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000035305.

Proteomic databases

PRIDEi Q8SQA6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282170.
KEGGi bta:282170.

Organism-specific databases

CTDi 6348.

Phylogenomic databases

eggNOGi NOG42742.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q8SQA6.
KOi K05408.

Miscellaneous databases

NextBioi 20806001.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of chemokines in RSV infection."
    Werling D.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL3_BOVIN
AccessioniPrimary (citable) accession number: Q8SQA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3