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Protein

CD97 antigen

Gene

CD97

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiP02.002.

Names & Taxonomyi

Protein namesi
Recommended name:
CD97 antigen
Alternative name(s):
CD_antigen: CD97
Gene namesi
Name:CD97
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 449423ExtracellularSequence analysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini471 – 4788CytoplasmicSequence analysis
Transmembranei479 – 49921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini500 – 51920ExtracellularSequence analysisAdd
BLAST
Transmembranei520 – 54021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini541 – 55010CytoplasmicSequence analysis
Transmembranei551 – 57121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini572 – 59322ExtracellularSequence analysisAdd
BLAST
Transmembranei594 – 61421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini615 – 63723CytoplasmicSequence analysisAdd
BLAST
Transmembranei638 – 65821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini659 – 6624ExtracellularSequence analysis
Transmembranei663 – 68321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini684 – 73451CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 734708CD97 antigenPRO_0000012867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 42PROSITE-ProRule annotation
Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi50 ↔ 69PROSITE-ProRule annotation
Disulfide bondi75 ↔ 89PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi100 ↔ 121PROSITE-ProRule annotation
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 140PROSITE-ProRule annotation
Disulfide bondi134 ↔ 149PROSITE-ProRule annotation
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi151 ↔ 170PROSITE-ProRule annotation
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Modified residuei730 – 7301PhosphoserineBy similarity
Modified residuei732 – 7321PhosphoserineBy similarity

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei428 – 4292CleavageBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF) and with chondroitin sulfate (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8SQA4.
SMRiQ8SQA4. Positions 31-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 7043EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini71 – 12252EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini123 – 17149EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini390 – 44051GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi300 – 3056Poly-Ala

Domaini

The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region (By similarity).By similarity
Binding to chondroitin sulfate is mediated by the fourth EGF domain.By similarity

Sequence similaritiesi

Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ8SQA4.
KOiK08446.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 2 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGPHGGPFL LFHVLCFLLT LSEVGSQNSK ACALPCPPNS SCVNGTACRC
60 70 80 90 100
APGFISFSGE IFTDPLESCD DINECGPPSP VDCGSSADCQ NTEGGYYCTC
110 120 130 140 150
SPGYEPVSGA MIFRNESENT CRDVDECSSG QHQCHNSTVC FNTVGSYTCH
160 170 180 190 200
CREGWEPKHG LKNKQKDTIC KEISFPAWTA PPGIKSRSLS AFFERVQKMS
210 220 230 240 250
RDFKPAMAKK SMQDLVGSVD DLLKNSGDLE SLDQSSKHVT VTHLLSGLEQ
260 270 280 290 300
ILRTLAKAMP KGSFTYRSLD NTELSLVVQE QGKGNVTVGQ SHARMLLDWA
310 320 330 340 350
VAAAAEESGP TVVGILSSQN MKKLLANASL KLDSEKLKET YKSPVRGAKV
360 370 380 390 400
TLLSAVSSVF LSNTNTEKLD SNVSFAFALH EQPELKPRQE LICAFWKKDS
410 420 430 440 450
NGNGSWATTG CWKMGRGNGS ITCQCSHLSS FAILMAHYDV EDPKLALITK
460 470 480 490 500
VGLALSLACL LLCILTFLLV RPIQGSRTTV HLHLCICLFV GSAIFLAGIE
510 520 530 540 550
NEGGEVGTRC RLVAVLLHYC FLAAFCWMSL EGVELYFLVV RVFQGQGMRK
560 570 580 590 600
LWLCLIGYGV PLIIVGISAG AYSKGYGREK FCWLNFEGGF LWSFVGPVTF
610 620 630 640 650
IVLGNAIIFV ITVWKLTQKF SEINPDIKKL KKARVLTITA IAQLFVLGCT
660 670 680 690 700
WVFGLLLFNP ESWVLSYIFS ILNCLQGFFL FVLYCLLNKK VREEYRKWAC
710 720 730
MVAGNKYSEF ATTTSGSGSS HNQTQALRPS ESGM
Length:734
Mass (Da):80,322
Last modified:June 1, 2002 - v1
Checksum:i4EE8AF4A63502998
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416058 mRNA. Translation: CAC94754.1.
RefSeqiNP_788834.1. NM_176661.1.
UniGeneiBt.11088.

Genome annotation databases

GeneIDi338066.
KEGGibta:338066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ416058 mRNA. Translation: CAC94754.1.
RefSeqiNP_788834.1. NM_176661.1.
UniGeneiBt.11088.

3D structure databases

ProteinModelPortaliQ8SQA4.
SMRiQ8SQA4. Positions 31-171.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiP02.002.
GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi338066.
KEGGibta:338066.

Organism-specific databases

CTDi976.

Phylogenomic databases

HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ8SQA4.
KOiK08446.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 2 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of cDNA encoding the bovine homologue of CD97."
    Eichler W., Haenel C., Vogel B., Stieler J.S.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCD97_BOVIN
AccessioniPrimary (citable) accession number: Q8SQA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.