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Protein

Cytochrome c oxidase subunit 8A, mitochondrial

Gene

COX8A

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-liver
Cytochrome c oxidase subunit 8-2
Gene namesi
Name:COX8A
Synonyms:COX8, COX8L
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 36Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei37 – 60HelicalBy similarityAdd BLAST24
Topological domaini61 – 69Mitochondrial intermembraneBy similarity9

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000618526 – 69Cytochrome c oxidase subunit 8A, mitochondrialAdd BLAST44

Expressioni

Gene expression databases

BgeeiENSGGOG00000006870.

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000006718.

Structurei

3D structure databases

ProteinModelPortaliQ8SQ79.
SMRiQ8SQ79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006255.
InParanoidiQ8SQ79.
KOiK02273.
OMAiIGLTSCF.
OrthoDBiEOG091G11UL.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiView protein in InterPro
IPR003205. Cyt_c_oxidase_su8.
IPR036548. Cyt_c_oxidase_su8_sf.
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiView protein in Pfam
PF02285. COX8. 1 hit.
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PDEKLGIMEL AVGLTSCFVT
60
FLLPAGWILS HLETYRRPE
Length:69
Mass (Da):7,637
Last modified:June 1, 2002 - v1
Checksum:i14736E52AE58E898
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072327 Genomic DNA. Translation: BAB86878.1.
AY254810, AY254809 Genomic DNA. Translation: AAP32244.1.
RefSeqiXP_004051465.1. XM_004051417.2.

Genome annotation databases

EnsembliENSGGOT00000006891; ENSGGOP00000006718; ENSGGOG00000006870.
GeneIDi101144277.
KEGGiggo:101144277.

Similar proteinsi

Entry informationi

Entry nameiCOX8A_GORGO
AccessioniPrimary (citable) accession number: Q8SQ79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families