Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 57Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini58 – 69CytoplasmicSequence analysisAdd BLAST12
Transmembranei70 – 92Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini93 – 106ExtracellularSequence analysisAdd BLAST14
Transmembranei107 – 129Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 198ExtracellularSequence analysisAdd BLAST26
Transmembranei199 – 221Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini222 – 252CytoplasmicSequence analysisAdd BLAST31
Transmembranei253 – 272Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini273 – 286ExtracellularSequence analysisAdd BLAST14
Transmembranei287 – 309Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini310 – 340CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697411 – 340Melanin-concentrating hormone receptor 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8SQ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098164.
KOiK05054.

Family and domain databases

CDDicd15339. 7tmA_MCHR2. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFHSSCWN TSAELSNKSW NKEFAYQTAS AVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTSWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWI YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVAVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRVTDKEIK NMGNTLKSHF
Length:340
Mass (Da):38,770
Last modified:June 1, 2002 - v1
Checksum:iBD22CF1972332439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058850 mRNA. Translation: BAB87843.1.
RefSeqiNP_001306455.1. NM_001319526.1.
UniGeneiMfa.6133.

Genome annotation databases

GeneIDi102142845.
KEGGimcf:102142845.

Similar proteinsi

Entry informationi

Entry nameiMCHR2_MACFA
AccessioniPrimary (citable) accession number: Q8SQ54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families