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Protein

Melanin-concentrating hormone receptor 2

Gene

MCHR2

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 2
Short name:
MCH receptor 2
Short name:
MCH-R2
Short name:
MCHR-2
Alternative name(s):
G-protein coupled receptor 145
GPRv17
MCH-2R
Short name:
MCH2
Short name:
MCH2R
Gene namesi
Name:MCHR2
Synonyms:GPR145
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 57Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini58 – 69CytoplasmicSequence analysisAdd BLAST12
Transmembranei70 – 92Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini93 – 106ExtracellularSequence analysisAdd BLAST14
Transmembranei107 – 129Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 198ExtracellularSequence analysisAdd BLAST26
Transmembranei199 – 221Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini222 – 252CytoplasmicSequence analysisAdd BLAST31
Transmembranei253 – 272Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini273 – 286ExtracellularSequence analysisAdd BLAST14
Transmembranei287 – 309Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini310 – 340CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697411 – 340Melanin-concentrating hormone receptor 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8SQ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG098164.
KOiK05054.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFHSSCWN TSAELSNKSW NKEFAYQTAS AVDTVILPSM IGIICSTGLV
60 70 80 90 100
GNILIVFTII RSRKKTVPDI YICNLAVADL VHIIGMPFLI HQWARGGEWV
110 120 130 140 150
FGGPLCTIIT SLDTCNQFAC SAIMTVMSVD RYFALVQPFR LTSWRTRYKT
160 170 180 190 200
IRINLGLWAA SFILALPVWI YSKVIKFKDG VESCAFDLTS PDDVLWYTLY
210 220 230 240 250
LTITTFFFPL PLILVCYILI LCYTWEMYQQ NKDARCCNPS VPKQRVMKLT
260 270 280 290 300
KMVLVLVAVF ILSAAPYHVI QLVNLQMEQP TLAFYVGYYL SICLSYASSS
310 320 330 340
INPFLYILLS GNFQKRLPQI QRRVTDKEIK NMGNTLKSHF
Length:340
Mass (Da):38,770
Last modified:June 1, 2002 - v1
Checksum:iBD22CF1972332439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058850 mRNA. Translation: BAB87843.1.
RefSeqiNP_001306455.1. NM_001319526.1.
UniGeneiMfa.6133.

Genome annotation databases

GeneIDi102142845.
KEGGimcf:102142845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058850 mRNA. Translation: BAB87843.1.
RefSeqiNP_001306455.1. NM_001319526.1.
UniGeneiMfa.6133.

3D structure databases

ProteinModelPortaliQ8SQ54.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102142845.
KEGGimcf:102142845.

Organism-specific databases

CTDi84539.

Phylogenomic databases

HOVERGENiHBG098164.
KOiK05054.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008362. MCH2_receptor.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01784. MCH2RECEPTOR.
PR01783. MCHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCHR2_MACFA
AccessioniPrimary (citable) accession number: Q8SQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2002
Last modified: October 5, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.