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Q8SQ43

- Q8SQ43_FELCA

UniProt

Q8SQ43 - Q8SQ43_FELCA

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Protein
Submitted name:

Bax-protein

Gene
bax
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BH3 domain binding Source: UniProtKB
  2. channel activity Source: UniProtKB
  3. lipid binding Source: UniProtKB
  4. protein homodimerization activity Source: HGNC

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  2. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
  3. apoptotic mitochondrial changes Source: UniProtKB
  4. apoptotic signaling pathway Source: UniProtKB
  5. B cell apoptotic process Source: UniProtKB
  6. establishment or maintenance of transmembrane electrochemical gradient Source: UniProtKB
  7. intrinsic apoptotic signaling pathway Source: UniProtKB
  8. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  9. mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
  10. mitochondrial fusion Source: UniProtKB
  11. negative regulation of protein binding Source: UniProtKB
  12. positive regulation of apoptotic process Source: UniProtKB
  13. positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
  14. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  15. positive regulation of neuron apoptotic process Source: UniProtKB
  16. positive regulation of protein oligomerization Source: UniProtKB
  17. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
  18. protein homooligomerization Source: HGNC
  19. regulation of mitochondrial membrane potential Source: UniProtKB
  20. regulation of protein homodimerization activity Source: UniProtKB
  21. release of cytochrome c from mitochondria Source: UniProtKB
  22. release of matrix enzymes from mitochondria Source: UniProtKB
  23. response to toxic substance Source: UniProtKB
  24. retinal cell apoptotic process Source: UniProtKB
  25. transformed cell apoptotic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bax-proteinImported
Gene namesi
Name:baxImported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Subcellular locationi

GO - Cellular componenti

  1. BAX complex Source: UniProtKB
  2. Bcl-2 family protein complex Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. endoplasmic reticulum Source: HGNC
  5. endoplasmic reticulum membrane Source: UniProtKB
  6. mitochondrial permeability transition pore complex Source: UniProtKB
  7. mitochondrion Source: UniProtKB
  8. nucleus Source: UniProtKB
  9. pore complex Source: UniProtKB
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ8SQ43.
SMRiQ8SQ43. Positions 1-192.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000095178.
HOVERGENiHBG003606.
KOiK02159.

Family and domain databases

InterProiIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQ43-1 [UniParc]FASTAAdd to Basket

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MDGSGEQPRG GGHTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELALEQV    50
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAAEMF 100
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 150
WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLAIWKK MG 192
Length:192
Mass (Da):21,284
Last modified:June 1, 2002 - v1
Checksum:i852D271AE86923FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080724 mRNA. Translation: BAB85810.1.
RefSeqiNP_001009282.1. NM_001009282.1.

Genome annotation databases

GeneIDi493837.
KEGGifca:493837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB080724 mRNA. Translation: BAB85810.1 .
RefSeqi NP_001009282.1. NM_001009282.1.

3D structure databases

ProteinModelPortali Q8SQ43.
SMRi Q8SQ43. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493837.
KEGGi fca:493837.

Organism-specific databases

CTDi 581.

Phylogenomic databases

HOGENOMi HOG000095178.
HOVERGENi HBG003606.
KOi K02159.

Family and domain databases

InterProi IPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PRINTSi PR01862. BCL2FAMILY.
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "molecular cloning of feline bcl-2 family."
    Yamazaki J., Oguma K., Kano R., Hasegawa A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8SQ43_FELCA
AccessioniPrimary (citable) accession number: Q8SQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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