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Q8SQ43

- Q8SQ43_FELCA

UniProt

Q8SQ43 - Q8SQ43_FELCA

Protein
Submitted name:

Bax-protein

Gene

bax

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. BH3 domain binding Source: UniProtKB
    2. channel activity Source: UniProtKB
    3. lipid binding Source: UniProtKB
    4. protein homodimerization activity Source: HGNC

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    2. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
    3. apoptotic mitochondrial changes Source: UniProtKB
    4. apoptotic signaling pathway Source: UniProtKB
    5. B cell apoptotic process Source: UniProtKB
    6. establishment or maintenance of transmembrane electrochemical gradient Source: UniProtKB
    7. intrinsic apoptotic signaling pathway Source: UniProtKB
    8. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    9. mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
    10. mitochondrial fusion Source: UniProtKB
    11. negative regulation of protein binding Source: UniProtKB
    12. positive regulation of apoptotic process Source: UniProtKB
    13. positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
    14. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    15. positive regulation of neuron apoptotic process Source: UniProtKB
    16. positive regulation of protein oligomerization Source: UniProtKB
    17. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
    18. protein homooligomerization Source: HGNC
    19. regulation of mitochondrial membrane potential Source: UniProtKB
    20. regulation of protein homodimerization activity Source: UniProtKB
    21. release of cytochrome c from mitochondria Source: UniProtKB
    22. release of matrix enzymes from mitochondria Source: UniProtKB
    23. response to toxic substance Source: UniProtKB
    24. retinal cell apoptotic process Source: UniProtKB
    25. transformed cell apoptotic process Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Bax-proteinImported
    Gene namesi
    Name:baxImported
    OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

    Subcellular locationi

    GO - Cellular componenti

    1. BAX complex Source: UniProtKB
    2. Bcl-2 family protein complex Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. endoplasmic reticulum Source: HGNC
    5. endoplasmic reticulum membrane Source: UniProtKB
    6. mitochondrial permeability transition pore complex Source: UniProtKB
    7. mitochondrion Source: UniProtKB
    8. nucleus Source: UniProtKB
    9. pore complex Source: UniProtKB

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SQ43.
    SMRiQ8SQ43. Positions 1-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000095178.
    HOVERGENiHBG003606.
    KOiK02159.

    Family and domain databases

    InterProiIPR026304. BAX.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF8. PTHR11256:SF8. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PRINTSiPR01862. BCL2FAMILY.
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SQ43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGSGEQPRG GGHTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELALEQV    50
    PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAAEMF 100
    SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG 150
    WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLAIWKK MG 192
    Length:192
    Mass (Da):21,284
    Last modified:June 1, 2002 - v1
    Checksum:i852D271AE86923FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080724 mRNA. Translation: BAB85810.1.
    RefSeqiNP_001009282.1. NM_001009282.1.

    Genome annotation databases

    GeneIDi493837.
    KEGGifca:493837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080724 mRNA. Translation: BAB85810.1 .
    RefSeqi NP_001009282.1. NM_001009282.1.

    3D structure databases

    ProteinModelPortali Q8SQ43.
    SMRi Q8SQ43. Positions 1-192.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493837.
    KEGGi fca:493837.

    Organism-specific databases

    CTDi 581.

    Phylogenomic databases

    HOGENOMi HOG000095178.
    HOVERGENi HBG003606.
    KOi K02159.

    Family and domain databases

    InterProi IPR026304. BAX.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF8. PTHR11256:SF8. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01862. BCL2FAMILY.
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "molecular cloning of feline bcl-2 family."
      Yamazaki J., Oguma K., Kano R., Hasegawa A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8SQ43_FELCA
    AccessioniPrimary (citable) accession number: Q8SQ43
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)