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Q8SQ43

- Q8SQ43_FELCA

UniProt

Q8SQ43 - Q8SQ43_FELCA

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Protein
Submitted name:

Bax-protein

Gene

bax

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BH3 domain binding Source: UniProtKB
  2. channel activity Source: UniProtKB
  3. lipid binding Source: UniProtKB
  4. protein homodimerization activity Source: HGNC

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  2. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
  3. apoptotic mitochondrial changes Source: UniProtKB
  4. apoptotic signaling pathway Source: UniProtKB
  5. B cell apoptotic process Source: UniProtKB
  6. establishment or maintenance of transmembrane electrochemical gradient Source: UniProtKB
  7. intrinsic apoptotic signaling pathway Source: UniProtKB
  8. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
  9. mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
  10. mitochondrial fusion Source: UniProtKB
  11. negative regulation of protein binding Source: UniProtKB
  12. positive regulation of apoptotic process Source: UniProtKB
  13. positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
  14. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  15. positive regulation of neuron apoptotic process Source: UniProtKB
  16. positive regulation of protein oligomerization Source: UniProtKB
  17. positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
  18. protein homooligomerization Source: HGNC
  19. regulation of mitochondrial membrane potential Source: UniProtKB
  20. regulation of protein homodimerization activity Source: UniProtKB
  21. release of cytochrome c from mitochondria Source: UniProtKB
  22. release of matrix enzymes from mitochondria Source: UniProtKB
  23. response to toxic substance Source: UniProtKB
  24. retinal cell apoptotic process Source: UniProtKB
  25. transformed cell apoptotic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bax-proteinImported
Gene namesi
Name:baxImported
OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Subcellular locationi

GO - Cellular componenti

  1. BAX complex Source: UniProtKB
  2. Bcl-2 family protein complex Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. endoplasmic reticulum Source: HGNC
  5. endoplasmic reticulum membrane Source: UniProtKB
  6. mitochondrial permeability transition pore complex Source: UniProtKB
  7. mitochondrion Source: UniProtKB
  8. nucleus Source: UniProtKB
  9. pore complex Source: UniProtKB
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ8SQ43.
SMRiQ8SQ43. Positions 1-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000095178.
HOVERGENiHBG003606.
KOiK02159.

Family and domain databases

InterProiIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQ43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGSGEQPRG GGHTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELALEQV
60 70 80 90 100
PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAAEMF
110 120 130 140 150
SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG
160 170 180 190
WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLAIWKK MG
Length:192
Mass (Da):21,284
Last modified:June 1, 2002 - v1
Checksum:i852D271AE86923FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080724 mRNA. Translation: BAB85810.1.
RefSeqiNP_001009282.1. NM_001009282.1.

Genome annotation databases

GeneIDi493837.
KEGGifca:493837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080724 mRNA. Translation: BAB85810.1 .
RefSeqi NP_001009282.1. NM_001009282.1.

3D structure databases

ProteinModelPortali Q8SQ43.
SMRi Q8SQ43. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493837.
KEGGi fca:493837.

Organism-specific databases

CTDi 581.

Phylogenomic databases

HOGENOMi HOG000095178.
HOVERGENi HBG003606.
KOi K02159.

Family and domain databases

InterProi IPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PRINTSi PR01862. BCL2FAMILY.
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "molecular cloning of feline bcl-2 family."
    Yamazaki J., Oguma K., Kano R., Hasegawa A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8SQ43_FELCA
AccessioniPrimary (citable) accession number: Q8SQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)