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Q8SQ43 (Q8SQ43_FELCA) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processB cell apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

Inferred from sequence or structural similarity. Source: UniProtKB

apoptotic mitochondrial changes

Inferred from sequence or structural similarity. Source: UniProtKB

apoptotic signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

establishment or maintenance of transmembrane electrochemical gradient

Inferred from sequence or structural similarity. Source: UniProtKB

intrinsic apoptotic signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial fragmentation involved in apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial fusion

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of protein binding

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endoplasmic reticulum unfolded protein response

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of intrinsic apoptotic signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein oligomerization

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of release of cytochrome c from mitochondria

Inferred from sequence or structural similarity. Source: UniProtKB

protein homooligomerization

Inferred from sequence or structural similarity. Source: HGNC

regulation of mitochondrial membrane potential

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

release of cytochrome c from mitochondria

Inferred from sequence or structural similarity. Source: UniProtKB

release of matrix enzymes from mitochondria

Inferred from sequence or structural similarity. Source: UniProtKB

response to toxic substance

Inferred from sequence or structural similarity. Source: UniProtKB

retinal cell apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

transformed cell apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentBAX complex

Inferred from sequence or structural similarity. Source: UniProtKB

Bcl-2 family protein complex

Inferred from sequence or structural similarity. Source: UniProtKB

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: HGNC

endoplasmic reticulum membrane

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial permeability transition pore complex

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrion

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

pore complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionBH3 domain binding

Inferred from sequence or structural similarity. Source: UniProtKB

channel activity

Inferred from sequence or structural similarity. Source: UniProtKB

lipid binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein homodimerization activity

Inferred from sequence or structural similarity. Source: HGNC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8SQ43 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 852D271AE86923FB

FASTA19221,284
        10         20         30         40         50         60 
MDGSGEQPRG GGHTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELALEQV PQDASTKKLS 

        70         80         90        100        110        120 
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAAEMF SDGNFNWGRV VALFYFASKL 

       130        140        150        160        170        180 
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV 

       190 
LTASLAIWKK MG 

« Hide

References

[1]"molecular cloning of feline bcl-2 family."
Yamazaki J., Oguma K., Kano R., Hasegawa A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB080724 mRNA. Translation: BAB85810.1.
RefSeqNP_001009282.1. NM_001009282.1.

3D structure databases

ProteinModelPortalQ8SQ43.
SMRQ8SQ43. Positions 1-192.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493837.
KEGGfca:493837.

Organism-specific databases

CTD581.

Phylogenomic databases

HOGENOMHOG000095178.
HOVERGENHBG003606.
KOK02159.

Family and domain databases

InterProIPR026304. BAX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF8. PTHR11256:SF8. 1 hit.
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSPR01862. BCL2FAMILY.
PROSITEPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8SQ43_FELCA
AccessionPrimary (citable) accession number: Q8SQ43
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)