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Protein

Pepsin B

Gene

PGB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds.

Catalytic activityi

Degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than that of pepsin A; does not cleave 1-Phe-|-Val-2, 4-Gln-|-His-5 or 23-Gly-|-Phe-24.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921PROSITE-ProRule annotation
Active sitei278 – 2781PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiA01.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Pepsin B (EC:3.4.23.2)
Gene namesi
Name:PGB
Synonyms:PGNB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 5943Activation peptidePRO_0000026048Add
BLAST
Chaini60 – 390331Pepsin BPRO_0000026049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 110By similarity
Disulfide bondi269 ↔ 273By similarity
Disulfide bondi312 ↔ 345By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ8SQ41.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029216.

Structurei

3D structure databases

ProteinModelPortaliQ8SQ41.
SMRiQ8SQ41. Positions 60-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 387314Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ8SQ41.
KOiK01377.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIQVLVLVC LHLSEGVERI ILKKGKSIRQ VMEERGVLET FLRNHPKVDP
60 70 80 90 100
AAKYLFNNDA VAYEPFTNYL DSYYFGEISI GTPPQNFLIL FDTGSSNLWV
110 120 130 140 150
PSTYCQSQAC SNHNRFNPSR SSTYQSSEQT YTLAYGFGSL TVLLGYDTVT
160 170 180 190 200
VQNIVIHNQL FGMSENEPNY PFYYSYFDGI LGMAYSNLAV DNGPTVLQNM
210 220 230 240 250
MQQGQLTQPI FSFYFSPQPT YEYGGELILG GVDTQFYSGE IVWAPVTREM
260 270 280 290 300
YWQVAIDEFL IGNQATGLCS QGCQGIVDTG TFPLTVPQQY LDSFVKATGA
310 320 330 340 350
QQDQSGNFVV NCNSIQSMPT ITFVISGSPL PLPPSTYVLN NNGYCTLGIE
360 370 380 390
VTYLPSPNGQ PLWILGDVFL REYYTVFDMA ANRVGFALSS
Length:390
Mass (Da):43,497
Last modified:June 1, 2002 - v1
Checksum:i0AE3F4C05A7FC662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082936 mRNA. Translation: BAB86888.1.
RefSeqiNP_001003028.1. NM_001003028.1.
UniGeneiCfa.69.

Genome annotation databases

GeneIDi403552.
KEGGicfa:403552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082936 mRNA. Translation: BAB86888.1.
RefSeqiNP_001003028.1. NM_001003028.1.
UniGeneiCfa.69.

3D structure databases

ProteinModelPortaliQ8SQ41.
SMRiQ8SQ41. Positions 60-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029216.

Protein family/group databases

MEROPSiA01.002.

Proteomic databases

PaxDbiQ8SQ41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403552.
KEGGicfa:403552.

Organism-specific databases

CTDi403552.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ8SQ41.
KOiK01377.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPB_CANLF
AccessioniPrimary (citable) accession number: Q8SQ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.