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Q8SQ40 (CCL5_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 5
Alternative name(s):
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene names
Name:CCL5
Synonyms:SCYA5
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9269C-C motif chemokine 5
PRO_0000005173

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SQ40 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2E6F087140BA3CE8

FASTA9210,167
        10         20         30         40         50         60 
MKVSTAAFAV LLTAAAFCTP ASASPYASDT TPCCFAYLSH PLPLTHLQEY FYTSSKCSMP 

        70         80         90 
AVVFVTRRKR QVCANPQKKW VRDKGINSLE MN 

« Hide

References

[1]"Molecular cloning of feline RANTES gene."
Kimura T., Kano R., Hasegawa A.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB083479 mRNA. Translation: BAB88940.1.
RefSeqNP_001009827.1. NM_001009827.1.

3D structure databases

ProteinModelPortalQ8SQ40.
SMRQ8SQ40. Positions 24-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000001170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493689.
KEGGfca:493689.

Organism-specific databases

CTD6352.

Phylogenomic databases

eggNOGNOG38896.
HOGENOMHOG000036685.
HOVERGENHBG017871.
KOK12499.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL5_FELCA
AccessionPrimary (citable) accession number: Q8SQ40
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families