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Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-SSC-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-SSC-5668541 TNFR2 non-canonical NF-kB pathway
R-SSC-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 194ExtracellularSequence analysisAdd BLAST174
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 278CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025269621 – 278Tumor necrosis factor receptor superfamily member 5Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 119PROSITE-ProRule annotation
Disulfide bondi111 ↔ 116PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8SQ34
PeptideAtlasiQ8SQ34
PRIDEiQ8SQ34

Expressioni

Gene expression databases

BgeeiENSSSCG00000007440
GenevisibleiQ8SQ34 SS

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007928

Structurei

3D structure databases

ProteinModelPortaliQ8SQ34
SMRiQ8SQ34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 60TNFR-Cys 1Add BLAST36
Repeati61 – 103TNFR-Cys 2Add BLAST43
Repeati104 – 144TNFR-Cys 3Add BLAST41
Repeati145 – 187TNFR-Cys 4Add BLAST43

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY0H Eukaryota
ENOG4112DB5 LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000136317
HOVERGENiHBG005117
InParanoidiQ8SQ34
KOiK03160
OMAiCHPWTSC
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd13407 TNFRSF5, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020435 TNFR_5
IPR034021 TNFRSF5_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01922 TNFACTORR5
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLPLKCLL WGCFLTAVHP EPPTSCKENQ YPTNSRCCNL CPPGQKLVNH
60 70 80 90 100
CTEVTETECL PCSSSEFLAT WNREKHCHQH KYCDPNLGLQ VQREGTSKTD
110 120 130 140 150
TTCVCSEGHH CTNSACESCT LHSLCFPGLG VKQMATEVSD TICEPCPVGF
160 170 180 190 200
FSNVSSASEK CQPWTSCESK GLVEQRAGTN KTDVVCGFQS RMRALVVIPI
210 220 230 240 250
TLGILFAVLL VFLCIRKVTK EQETKALHPK TERQDPVETI DLEDFPDSTA
260 270
PVQETLHWCQ PVTQEDGKES RISVQERE
Length:278
Mass (Da):30,951
Last modified:June 1, 2002 - v1
Checksum:i20D446E44AF93DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248545 mRNA Translation: AAL92924.1
RefSeqiNP_999359.1, NM_214194.1
UniGeneiSsc.26880

Genome annotation databases

EnsembliENSSSCT00000066346; ENSSSCP00000052319; ENSSSCG00000035078
GeneIDi397395
KEGGissc:397395

Similar proteinsi

Entry informationi

Entry nameiTNR5_PIG
AccessioniPrimary (citable) accession number: Q8SQ34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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