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Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-SSC-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-SSC-5668541. TNFR2 non-canonical NF-kB pathway.
R-SSC-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 194174ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 27863CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 278258Tumor necrosis factor receptor superfamily member 5PRO_0000252696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 119PROSITE-ProRule annotation
Disulfide bondi111 ↔ 116PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8SQ34.

Expressioni

Gene expression databases

GenevisibleiQ8SQ34. SS.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007928.

Structurei

3D structure databases

ProteinModelPortaliQ8SQ34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 6036TNFR-Cys 1Add
BLAST
Repeati61 – 10343TNFR-Cys 2Add
BLAST
Repeati104 – 14441TNFR-Cys 3Add
BLAST
Repeati145 – 18743TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ8SQ34.
KOiK03160.
OMAiEKCHPWT.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLPLKCLL WGCFLTAVHP EPPTSCKENQ YPTNSRCCNL CPPGQKLVNH
60 70 80 90 100
CTEVTETECL PCSSSEFLAT WNREKHCHQH KYCDPNLGLQ VQREGTSKTD
110 120 130 140 150
TTCVCSEGHH CTNSACESCT LHSLCFPGLG VKQMATEVSD TICEPCPVGF
160 170 180 190 200
FSNVSSASEK CQPWTSCESK GLVEQRAGTN KTDVVCGFQS RMRALVVIPI
210 220 230 240 250
TLGILFAVLL VFLCIRKVTK EQETKALHPK TERQDPVETI DLEDFPDSTA
260 270
PVQETLHWCQ PVTQEDGKES RISVQERE
Length:278
Mass (Da):30,951
Last modified:June 1, 2002 - v1
Checksum:i20D446E44AF93DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248545 mRNA. Translation: AAL92924.1.
RefSeqiNP_999359.1. NM_214194.1.
UniGeneiSsc.26880.

Genome annotation databases

EnsembliENSSSCT00000008144; ENSSSCP00000007928; ENSSSCG00000007440.
GeneIDi397395.
KEGGissc:397395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248545 mRNA. Translation: AAL92924.1.
RefSeqiNP_999359.1. NM_214194.1.
UniGeneiSsc.26880.

3D structure databases

ProteinModelPortaliQ8SQ34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007928.

Proteomic databases

PaxDbiQ8SQ34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008144; ENSSSCP00000007928; ENSSSCG00000007440.
GeneIDi397395.
KEGGissc:397395.

Organism-specific databases

CTDi958.

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ8SQ34.
KOiK03160.
OMAiEKCHPWT.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-SSC-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-SSC-5668541. TNFR2 non-canonical NF-kB pathway.
R-SSC-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Gene expression databases

GenevisibleiQ8SQ34. SS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the porcine CD40 molecule."
    West K.A., Li A.W., Rowden G.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTNR5_PIG
AccessioniPrimary (citable) accession number: Q8SQ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.