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Protein

Histidine triad nucleotide-binding protein 2, mitochondrial

Gene

HINT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Purine nucleotide phosphoramidateBy similarity1
Active sitei149Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 81Purine nucleotide phosphoramidateBy similarity2
Nucleotide bindingi142 – 144Purine nucleotide phosphoramidateBy similarity3
Nucleotide bindingi149 – 151Purine nucleotide phosphoramidateBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Apoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine triad nucleotide-binding protein 2, mitochondrial (EC:3.-.-.-)
Short name:
HINT-2
Alternative name(s):
HINT-3
Gene namesi
Name:HINT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000010978518 – 163Histidine triad nucleotide-binding protein 2, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119N6-acetyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8SQ21.
PeptideAtlasiQ8SQ21.
PRIDEiQ8SQ21.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011444.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015208.

Structurei

3D structure databases

ProteinModelPortaliQ8SQ21.
SMRiQ8SQ21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 163HITPROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 151Histidine triad motif5

Sequence similaritiesi

Belongs to the HINT family.Curated
Contains 1 HIT domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3275. Eukaryota.
COG0537. LUCA.
GeneTreeiENSGT00510000046448.
HOGENOMiHOG000061064.
HOVERGENiHBG051906.
InParanoidiQ8SQ21.
OMAiNVAKQES.
OrthoDBiEOG091G1001.
TreeFamiTF314862.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR23089. PTHR23089. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
PRINTSiPR00332. HISTRIAD.
SUPFAMiSSF54197. SSF54197. 1 hit.
PROSITEiPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVVLAAG LCVARRAVAV AGPRGVQVRG AAGVTDGDEV AKAQQAAPGG
60 70 80 90 100
AAPTIFSRIL DRSLPADILY EDQQCLAFRD VAPQAPVHFL VIPKKPIPRI
110 120 130 140 150
SQAEEEDQQL LGHLLLVAKE TAKAEGLGDG YRLVINDGKL GAQSVYHLHI
160
HVLGGRQLQW PPG
Length:163
Mass (Da):17,147
Last modified:June 1, 2002 - v1
Checksum:i2A7BFC6B1CB4D400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366940 mRNA. Translation: AAM00370.1.
BC114199 mRNA. Translation: AAI14200.1.
RefSeqiNP_776765.1. NM_174340.2.
UniGeneiBt.11196.

Genome annotation databases

EnsembliENSBTAT00000015208; ENSBTAP00000015208; ENSBTAG00000011444.
GeneIDi281816.
KEGGibta:281816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366940 mRNA. Translation: AAM00370.1.
BC114199 mRNA. Translation: AAI14200.1.
RefSeqiNP_776765.1. NM_174340.2.
UniGeneiBt.11196.

3D structure databases

ProteinModelPortaliQ8SQ21.
SMRiQ8SQ21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015208.

Proteomic databases

PaxDbiQ8SQ21.
PeptideAtlasiQ8SQ21.
PRIDEiQ8SQ21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015208; ENSBTAP00000015208; ENSBTAG00000011444.
GeneIDi281816.
KEGGibta:281816.

Organism-specific databases

CTDi84681.

Phylogenomic databases

eggNOGiKOG3275. Eukaryota.
COG0537. LUCA.
GeneTreeiENSGT00510000046448.
HOGENOMiHOG000061064.
HOVERGENiHBG051906.
InParanoidiQ8SQ21.
OMAiNVAKQES.
OrthoDBiEOG091G1001.
TreeFamiTF314862.

Gene expression databases

BgeeiENSBTAG00000011444.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR23089. PTHR23089. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
PRINTSiPR00332. HISTRIAD.
SUPFAMiSSF54197. SSF54197. 1 hit.
PROSITEiPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHINT2_BOVIN
AccessioniPrimary (citable) accession number: Q8SQ21
Secondary accession number(s): Q24JY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.