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Protein

Histidine triad nucleotide-binding protein 2, mitochondrial

Gene

HINT2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Purine nucleotide phosphoramidateBy similarity1
Binding sitei80Purine nucleotide phosphoramidateBy similarity1
Binding sitei136Purine nucleotide phosphoramidateBy similarity1
Active sitei149Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 145Purine nucleotide phosphoramidateBy similarity4
Nucleotide bindingi149 – 151Purine nucleotide phosphoramidateBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processApoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine triad nucleotide-binding protein 2, mitochondrialBy similarity (EC:3.-.-.-)
Short name:
HINT-2By similarity
Alternative name(s):
HINT-3By similarity
Gene namesi
Name:HINT2By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:29855 HINT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000010978518 – 163Histidine triad nucleotide-binding protein 2, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119N6-acetyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8SQ21
PeptideAtlasiQ8SQ21
PRIDEiQ8SQ21

Expressioni

Gene expression databases

BgeeiENSBTAG00000011444

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015208

Structurei

3D structure databases

ProteinModelPortaliQ8SQ21
SMRiQ8SQ21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 163HITPROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 151Histidine triad motif5

Sequence similaritiesi

Belongs to the HINT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3275 Eukaryota
COG0537 LUCA
GeneTreeiENSGT00510000046448
HOGENOMiHOG000061064
HOVERGENiHBG051906
InParanoidiQ8SQ21
OMAiNVAKQES
OrthoDBiEOG091G1001
TreeFamiTF314862

Family and domain databases

Gene3Di3.30.428.10, 1 hit
InterProiView protein in InterPro
IPR019808 Histidine_triad_CS
IPR001310 Histidine_triad_HIT
IPR011146 HIT-like
IPR036265 HIT-like_sf
PANTHERiPTHR23089 PTHR23089, 1 hit
PfamiView protein in Pfam
PF01230 HIT, 1 hit
PRINTSiPR00332 HISTRIAD
SUPFAMiSSF54197 SSF54197, 1 hit
PROSITEiView protein in PROSITE
PS00892 HIT_1, 1 hit
PS51084 HIT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVVLAAG LCVARRAVAV AGPRGVQVRG AAGVTDGDEV AKAQQAAPGG
60 70 80 90 100
AAPTIFSRIL DRSLPADILY EDQQCLAFRD VAPQAPVHFL VIPKKPIPRI
110 120 130 140 150
SQAEEEDQQL LGHLLLVAKE TAKAEGLGDG YRLVINDGKL GAQSVYHLHI
160
HVLGGRQLQW PPG
Length:163
Mass (Da):17,147
Last modified:June 1, 2002 - v1
Checksum:i2A7BFC6B1CB4D400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366940 mRNA Translation: AAM00370.1
BC114199 mRNA Translation: AAI14200.1
RefSeqiNP_776765.1, NM_174340.2
UniGeneiBt.11196

Genome annotation databases

EnsembliENSBTAT00000015208; ENSBTAP00000015208; ENSBTAG00000011444
GeneIDi281816
KEGGibta:281816

Similar proteinsi

Entry informationi

Entry nameiHINT2_BOVIN
AccessioniPrimary (citable) accession number: Q8SQ21
Secondary accession number(s): Q24JY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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