Reviewed, UniProtKB/Swiss-Prot Q8SQ05 (RNAS1_LAGLA)

Names and origin

Protein names

Recommended name:
    Ribonuclease pancreatic
    EC=3.1.27.5
Alternative name(s):
    RNase 1
    RNase A

Gene names

Name:	RNASE1
Synonyms:	RNS1

Organism

Lagothrix lagotricha (Common woolly monkey)

Taxonomic identifier

9519 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Atelidae › Atelinae › Lagothrix

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.
Catalytic activity	Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Endonuclease Hydrolase Nuclease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	By similarity
	Chain	29 – 156	128	Ribonuclease pancreatic		PRO_0000030923
Regions
	Region	69 – 73	5	Substrate binding By similarity
Sites
	Active site	40	1	Proton acceptor By similarity
	Active site	147	1	Proton donor By similarity
	Binding site	35	1	Substrate By similarity
	Binding site	38	1	Substrate By similarity
	Binding site	94	1	Substrate By similarity
	Binding site	113	1	Substrate By similarity
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Disulfide bond	54 ↔ 112		By similarity
	Disulfide bond	68 ↔ 123		By similarity
	Disulfide bond	86 ↔ 138		By similarity
	Disulfide bond	93 ↔ 100		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SQ05-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A2C9B4EFA12909A3	FASTA	156	17,559
	10 20 30 40 50 60 MALEKSLALL PLLVLVLLVL GWVQPSLGKE SRAKKFQRQH MDSDGSLSSN PTYCNNMMRR 70 80 90 100 110 120 RNMTQGWCKP VNTFVHEPLV DVQDVCFQEN VTCKNGQANC YKSSSSMHIT DCRLTSGSRY 130 140 150 PNCAYQTSQK ERHIIVACEG NPYVPVHFDA SVEDST

References

[1]	"Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey." Zhang J., Zhang Y.-P., Rosenberg H.F. Nat. Genet. 30:411-415(2002) [PubMed: 11925567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF449640 Genomic DNA. Translation: AAL87061.1.
3D structure databases
HSSP	HSSP built from PDB template 1SRN based on UniProtKB P00656.
SMR	Q8SQ05. Positions 30-155.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q8SQ05.
Enzyme and pathway databases
BRENDA	3.1.27.5. 317500.
Family and domain databases
InterPro	IPR001427. RNaseA. [Graphical view]
Gene3D	G3DSA:3.10.130.10. RNaseA. 1 hit.
PANTHER	PTHR11437. RNaseA. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00092. RNAse_Pc. 1 hit. [Graphical view]
PROSITE	PS00127. RNASE_PANCREATIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNAS1_LAGLA

Accession

Primary (citable) accession number: Q8SQ05

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)