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Protein

Nuclear receptor subfamily 1 group I member 2

Gene

NR1I2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471AgonistBy similarity
Binding sitei285 – 2851AgonistBy similarity
Binding sitei288 – 2881AgonistBy similarity
Binding sitei299 – 2991AgonistBy similarity
Binding sitei407 – 4071AgonistBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 10770Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri41 – 6121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri77 – 10226NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 2
Alternative name(s):
Orphan nuclear receptor PXR
Pregnane X receptor
Gene namesi
Name:NR1I2
Synonyms:PXR
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nuclear receptor subfamily 1 group I member 2PRO_0000053548Add
BLAST

Interactioni

Subunit structurei

Heterodimer with RXRA. Interacts with NCOA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000002638.

Structurei

3D structure databases

ProteinModelPortaliQ8SQ01.
SMRiQ8SQ01. Positions 39-124, 142-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni108 – 20497HingeBy similarityAdd
BLAST
Regioni205 – 434230Ligand-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 9227Bipartite nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri41 – 6121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri77 – 10226NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ8SQ01.
KOiK08540.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVRPKEGWN HADFVYCEDT EFAPGKPTVN ADEEVGGPQI CRVCGDKATG
60 70 80 90 100
YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR
110 120 130 140 150
KCLESGMKKE MIMSDAAVEE RRALIKRKKR ERIGTQPPGV QGLTEEQRMM
160 170 180 190 200
IRELMDAQMK TFDTTFSHFK NFRLPGVLSS GCEMPESLQA PSREEAAKWN
210 220 230 240 250
QVRKDLWSVK VSVQLRGEDG SVWNYKPPAD NGGKEIFSLL PHMADMSTYM
260 270 280 290 300
FKGIINFAKV ISYFRDLPIE DQISLLKGAT FELCQLRFNT VFNAETGTWE
310 320 330 340 350
CGRLSYCLED PAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS
360 370 380 390 400
PDRPGVVQHR VVDQLQEQYA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL
410 420 430
RSINAQHTQR LLRIQDIHPF ATPLMQELFG ITGS
Length:434
Mass (Da):49,993
Last modified:June 1, 2002 - v1
Checksum:iF3BE3017815F3A59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454671 mRNA. Translation: AAM10633.1.
RefSeqiNP_001028054.3. NM_001032882.3.
UniGeneiMmu.3678.

Genome annotation databases

GeneIDi574226.
KEGGimcc:574226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454671 mRNA. Translation: AAM10633.1.
RefSeqiNP_001028054.3. NM_001032882.3.
UniGeneiMmu.3678.

3D structure databases

ProteinModelPortaliQ8SQ01.
SMRiQ8SQ01. Positions 39-124, 142-433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000002638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574226.
KEGGimcc:574226.

Organism-specific databases

CTDi8856.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ8SQ01.
KOiK08540.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors."
    Moore L.B., Maglich J.M., McKee D.D., Wisely B., Willson T.M., Kliewer S.A., Lambert M.H., Moore J.T.
    Mol. Endocrinol. 16:977-986(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNR1I2_MACMU
AccessioniPrimary (citable) accession number: Q8SQ01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.