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Protein

Lambda-crystallin homolog

Gene

CRYL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADBy similarity1
Binding sitei100NADBy similarity1
Binding sitei105NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 20NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-BTA-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:CRYL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:27744 CRYL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325051 – 321Lambda-crystallin homologAdd BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8SPX7
PRIDEiQ8SPX7

Expressioni

Gene expression databases

BgeeiENSBTAG00000011726

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015575

Structurei

3D structure databases

ProteinModelPortaliQ8SPX7
SMRiQ8SPX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305 Eukaryota
COG1250 LUCA
GeneTreeiENSGT00390000007182
HOGENOMiHOG000141499
HOVERGENiHBG051126
InParanoidiQ8SPX7
KOiK13247
OMAiSWAMVFA
OrthoDBiEOG091G0IP3
TreeFamiTF313501

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR022694 3-OHacyl-CoA_DH
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PIRSFiPIRSF000105 HCDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SPX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGSSAPG GVAVVGSGLI GRSWAMLFAS AGFRVKLFDI EPRQVTDALV
60 70 80 90 100
SLRKEMKMLE LSGYLKGELG AEEQLSLISG CSDLREAVEG ALHVQECVPE
110 120 130 140 150
NLELKRKLFA QLDKIADDHV ILSSSSSCLL PSKLFAGLAH VKQCLVAHPV
160 170 180 190 200
NPPYYVPLVE LVPHPETAPA TVDRTYALMR RVGQSPVRLL REIDGFALNR
210 220 230 240 250
LQYAVIAEAW RLVEEGVVSP GDLDLVMSDG LGLRYAFIGP LETMHLNAEG
260 270 280 290 300
MLSYCDRYGE GMKRVLKTFG PVPEFSGATA EKVHQAMCVK VPDDAEHLAA
310 320
RRAWRDGCLM RLAQLKHQLP Q
Length:321
Mass (Da):35,072
Last modified:January 23, 2007 - v3
Checksum:i0BA232C7130F028C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480862 mRNA Translation: AAL88550.1
RefSeqiNP_776718.1, NM_174293.2
UniGeneiBt.3220

Genome annotation databases

EnsembliENSBTAT00000015575; ENSBTAP00000015575; ENSBTAG00000011726
GeneIDi281725
KEGGibta:281725

Similar proteinsi

Entry informationi

Entry nameiCRYL1_BOVIN
AccessioniPrimary (citable) accession number: Q8SPX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health