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Protein

Lambda-crystallin homolog

Gene

CRYL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADBy similarity
Binding sitei100 – 1001NADBy similarity
Binding sitei105 – 1051NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-BTA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Lambda-crystallin homolog (EC:1.1.1.45)
Alternative name(s):
L-gulonate 3-dehydrogenase
Short name:
Gul3DH
Gene namesi
Name:CRYL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Lambda-crystallin homologPRO_0000232505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8SPX7.
PRIDEiQ8SPX7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015575.

Structurei

3D structure databases

ProteinModelPortaliQ8SPX7.
SMRiQ8SPX7. Positions 10-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ8SPX7.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG7XPZ65.
TreeFamiTF313501.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGSSAPG GVAVVGSGLI GRSWAMLFAS AGFRVKLFDI EPRQVTDALV
60 70 80 90 100
SLRKEMKMLE LSGYLKGELG AEEQLSLISG CSDLREAVEG ALHVQECVPE
110 120 130 140 150
NLELKRKLFA QLDKIADDHV ILSSSSSCLL PSKLFAGLAH VKQCLVAHPV
160 170 180 190 200
NPPYYVPLVE LVPHPETAPA TVDRTYALMR RVGQSPVRLL REIDGFALNR
210 220 230 240 250
LQYAVIAEAW RLVEEGVVSP GDLDLVMSDG LGLRYAFIGP LETMHLNAEG
260 270 280 290 300
MLSYCDRYGE GMKRVLKTFG PVPEFSGATA EKVHQAMCVK VPDDAEHLAA
310 320
RRAWRDGCLM RLAQLKHQLP Q
Length:321
Mass (Da):35,072
Last modified:January 23, 2007 - v3
Checksum:i0BA232C7130F028C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480862 mRNA. Translation: AAL88550.1.
RefSeqiNP_776718.1. NM_174293.2.
UniGeneiBt.3220.

Genome annotation databases

EnsembliENSBTAT00000015575; ENSBTAP00000015575; ENSBTAG00000011726.
GeneIDi281725.
KEGGibta:281725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480862 mRNA. Translation: AAL88550.1.
RefSeqiNP_776718.1. NM_174293.2.
UniGeneiBt.3220.

3D structure databases

ProteinModelPortaliQ8SPX7.
SMRiQ8SPX7. Positions 10-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015575.

Proteomic databases

PaxDbiQ8SPX7.
PRIDEiQ8SPX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015575; ENSBTAP00000015575; ENSBTAG00000011726.
GeneIDi281725.
KEGGibta:281725.

Organism-specific databases

CTDi51084.

Phylogenomic databases

eggNOGiKOG2305. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00390000007182.
HOGENOMiHOG000141499.
HOVERGENiHBG051126.
InParanoidiQ8SPX7.
KOiK13247.
OMAiSWAMVFA.
OrthoDBiEOG7XPZ65.
TreeFamiTF313501.

Enzyme and pathway databases

ReactomeiR-BTA-5661270. Catabolism of glucuronate to xylulose-5-phosphate.

Miscellaneous databases

NextBioi20805646.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians."
    Chen J., Yu L., Li D., Gao Q., Wang J., Huang X., Bi G., Wu H., Zhao S.
    Gene 302:103-113(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCRYL1_BOVIN
AccessioniPrimary (citable) accession number: Q8SPX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.