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Protein

Dehydrogenase/reductase SDR family member 4

Gene

DHRS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).By similarity

Catalytic activityi

R-CHOH-R' + NADP+ = R-CO-R' + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateBy similarity1
Active sitei183Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 61NADPBy similarityAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4 (EC:1.1.1.184)
Alternative name(s):
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Short name:
CR
Short name:
PHCR
NADPH-dependent retinol dehydrogenase/reductase
Short name:
NDRD
Peroxisomal short-chain alcohol dehydrogenase
Short name:
PSCD
Gene namesi
Name:DHRS4
Synonyms:NDRD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546461 – 279Dehydrogenase/reductase SDR family member 4Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93N6-acetyllysine; alternateBy similarity1
Modified residuei93N6-succinyllysine; alternateBy similarity1
Modified residuei106N6-acetyllysineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei235N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8SPU8.
PeptideAtlasiQ8SPU8.
PRIDEiQ8SPU8.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ8SPU8. 1 interactor.
STRINGi9913.ENSBTAP00000023493.

Structurei

3D structure databases

ProteinModelPortaliQ8SPU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 279Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG105779.
InParanoidiQ8SPU8.
KOiK11147.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVGLPLGA CARSWKSVRM ASCGMARRNP LDNKVALVTA STDGIGFAIA
60 70 80 90 100
RRLAQDGAHV VVSSRKQQNV DRAVATLKGE GLSVTGTVCH VGKAEDRERL
110 120 130 140 150
VATAVKLHGG VDILISNAAV SPFFGSLMDV PEEVWDKILD VNVKATALLT
160 170 180 190 200
KAVVPEMAKR GGGSIVIVSS IAAYSPFPSL GPYNVSKTAL LGLTKNLALE
210 220 230 240 250
LAESNVRVNC LAPGLIRTSF SRVLWEDPAR QESIKATFQI KRIGKPEECA
260 270
GIVSFLCSED ASYITGETVV VAGGSLSHL
Length:279
Mass (Da):29,440
Last modified:October 5, 2010 - v2
Checksum:iC0A92C9F0DC8DEF9
GO

Sequence cautioni

The sequence AAL93248 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79G → A in AAI12879 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112878 mRNA. Translation: AAI12879.1.
AF487454 mRNA. Translation: AAL93248.1. Different initiation.
RefSeqiNP_777247.2. NM_174822.3.
UniGeneiBt.11194.

Genome annotation databases

GeneIDi281360.
KEGGibta:281360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112878 mRNA. Translation: AAI12879.1.
AF487454 mRNA. Translation: AAL93248.1. Different initiation.
RefSeqiNP_777247.2. NM_174822.3.
UniGeneiBt.11194.

3D structure databases

ProteinModelPortaliQ8SPU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8SPU8. 1 interactor.
STRINGi9913.ENSBTAP00000023493.

Proteomic databases

PaxDbiQ8SPU8.
PeptideAtlasiQ8SPU8.
PRIDEiQ8SPU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281360.
KEGGibta:281360.

Organism-specific databases

CTDi10901.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG105779.
InParanoidiQ8SPU8.
KOiK11147.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS4_BOVIN
AccessioniPrimary (citable) accession number: Q8SPU8
Secondary accession number(s): Q2KHU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by kaempferol, quercetin, genistein and myristic acid.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.