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Q8SPR3

- Q8SPR3_PIG

UniProt

Q8SPR3 - Q8SPR3_PIG

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Protein
Submitted name:

Prostaglandin G/H synthase-2

Gene

PGHS-2

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cyclooxygenase pathway Source: InterPro
  2. inflammatory response Source: InterPro
  3. regulation of blood pressure Source: InterPro
  4. response to oxidative stress Source: InterPro
Complete GO annotation...

Protein family/group databases

PeroxiBasei3328. SscPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase-2Imported
Gene namesi
Name:PGHS-2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016518.

Structurei

3D structure databases

ProteinModelPortaliQ8SPR3.
SMRiQ8SPR3. Positions 20-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARALLLCA AVSLCTAAKP CCSNPCQNRG ICMSVGFDHY KCDCTRTGFY
60 70 80 90 100
GENCTTPEFL TRIKLFLKPT PNTVHYILTH FKGVWNIVNN IPFLRNAIMK
110 120 130 140 150
YVLISRSHLI DSPPTYNMHY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG
160 170 180 190 200
VKGRKELPDS KEVVEKLLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDQ
210 220 230 240 250
KRGPAFTKGQ GHGVDLSHVY GESLERQHKL RLFKDGKMKY QIIDGEMYPP
260 270 280 290 300
TAKDTQVEMI YPPHTPEHLR FAVGHEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDA FQIDGHEYNY QQFLYNNSIL
410 420 430 440 450
LEHGITQFVE SFSRQIAGRV AGGRNLPAAV QKVSKASIDQ SREMRYQSFN
460 470 480 490 500
EYRKRFLLKP YRSFEELTGE KEMAAELEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE AGAPFSLKGL MGNPICSPEY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTSFSVQD PQLAKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):69,145
Last modified:June 1, 2002 - v1
Checksum:iDA951E35205F9A90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028583 mRNA. Translation: AAK27263.1.
RefSeqiNP_999486.1. NM_214321.1.
UniGeneiSsc.23994.
Ssc.55110.

Genome annotation databases

GeneIDi397590.
KEGGissc:397590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028583 mRNA. Translation: AAK27263.1 .
RefSeqi NP_999486.1. NM_214321.1.
UniGenei Ssc.23994.
Ssc.55110.

3D structure databases

ProteinModelPortali Q8SPR3.
SMRi Q8SPR3. Positions 20-569.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000016518.

Protein family/group databases

PeroxiBasei 3328. SscPGHS02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397590.
KEGGi ssc:397590.

Organism-specific databases

CTDi 5743.

Phylogenomic databases

HOGENOMi HOG000013149.
HOVERGENi HBG000366.
KOi K11987.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of Cyclooxygenase-2 in Naturally-Occurring Porcine Gastric Ulcers."
    Lajoie S., Sirois J., Dore M.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8SPR3_PIG
AccessioniPrimary (citable) accession number: Q8SPR3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)