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Q8SPQ9

- Q8SPQ9_CANFA

UniProt

Q8SPQ9 - Q8SPQ9_CANFA

Protein
Submitted name:

Cyclooxygenase 2

Gene

PTGS2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heme binding Source: Ensembl
    2. peroxidase activity Source: InterPro
    3. prostaglandin-endoperoxide synthase activity Source: Ensembl

    GO - Biological processi

    1. anagen Source: Ensembl
    2. brown fat cell differentiation Source: Ensembl
    3. cellular response to hypoxia Source: Ensembl
    4. cyclooxygenase pathway Source: Ensembl
    5. positive regulation of brown fat cell differentiation Source: Ensembl
    6. positive regulation of fever generation Source: Ensembl
    7. regulation of blood pressure Source: Ensembl
    8. regulation of cell proliferation Source: Ensembl
    9. response to oxidative stress Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
    REACT_222701. Synthesis of 15-eicosatetraenoic acid derivatives.

    Protein family/group databases

    PeroxiBasei3335. CfaPGHS02.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cyclooxygenase 2Imported
    Submitted name:
    Prostaglandin G/H synthase-2Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:PTGS2Imported
    Synonyms:COX-2Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. neuron projection Source: Ensembl

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000020288.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG39991.
    GeneTreeiENSGT00390000010743.
    HOGENOMiHOG000013149.
    HOVERGENiHBG000366.
    InParanoidiQ8SPQ9.
    KOiK11987.
    OMAiICNNVKG.
    OrthoDBiEOG7RFTHC.
    TreeFamiTF329675.

    Family and domain databases

    Gene3Di1.10.640.10. 1 hit.
    InterProiIPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view]
    PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
    PfamiPF03098. An_peroxidase. 2 hits.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SPQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY    50
    GENCSTPEFL TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK 100
    YVLTSRSHLI ESPPTYNVNY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG 150
    VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH 200
    KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY QVIDGEVYPP 250
    TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD 300
    VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE 350
    LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL 400
    LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN 450
    EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP 500
    DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI 550
    QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER 600
    STEL 604
    Length:604
    Mass (Da):68,975
    Last modified:June 1, 2002 - v1
    Checksum:i42C9FEE30D2B3928
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03005167 Genomic DNA. No translation available.
    AY044905 mRNA. Translation: AAK97783.1.
    HQ110882 Genomic DNA. Translation: ADO27661.1.
    RefSeqiNP_001003354.1. NM_001003354.1.
    XP_005622284.1. XM_005622227.1.
    UniGeneiCfa.3449.

    Genome annotation databases

    EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
    ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
    GeneIDi442942.
    KEGGicfa:442942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03005167 Genomic DNA. No translation available.
    AY044905 mRNA. Translation: AAK97783.1 .
    HQ110882 Genomic DNA. Translation: ADO27661.1 .
    RefSeqi NP_001003354.1. NM_001003354.1.
    XP_005622284.1. XM_005622227.1.
    UniGenei Cfa.3449.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000020288.

    Chemistry

    ChEMBLi CHEMBL4033.

    Protein family/group databases

    PeroxiBasei 3335. CfaPGHS02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000021841 ; ENSCAFP00000020288 ; ENSCAFG00000013762 .
    ENSCAFT00000044614 ; ENSCAFP00000038440 ; ENSCAFG00000013762 .
    GeneIDi 442942.
    KEGGi cfa:442942.

    Organism-specific databases

    CTDi 5743.

    Phylogenomic databases

    eggNOGi NOG39991.
    GeneTreei ENSGT00390000010743.
    HOGENOMi HOG000013149.
    HOVERGENi HBG000366.
    InParanoidi Q8SPQ9.
    KOi K11987.
    OMAi ICNNVKG.
    OrthoDBi EOG7RFTHC.
    TreeFami TF329675.

    Enzyme and pathway databases

    Reactomei REACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
    REACT_222701. Synthesis of 15-eicosatetraenoic acid derivatives.

    Miscellaneous databases

    NextBioi 20831612.

    Family and domain databases

    Gene3Di 1.10.640.10. 1 hit.
    InterProi IPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view ]
    PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
    Pfami PF03098. An_peroxidase. 2 hits.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro."
      Boutemmine D., Bouchard N., Boerboom D., Jones H.E., Goff A.K., Dore M., Sirois J.
      Endocrinology 143:1134-1143(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    3. "Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs."
      Whiteley M.H., Bell J.S., Rothman D.A.
      PLoS ONE 6:E16684-E16684(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.
    5. Ensembl
      Submitted (SEP-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiQ8SPQ9_CANFA
    AccessioniPrimary (citable) accession number: Q8SPQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3