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Protein
Submitted name:

Cyclooxygenase 2

Gene

PTGS2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-197264. Nicotinamide salvaging.
R-CFA-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-CFA-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Protein family/group databases

PeroxiBasei3335. CfaPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 2Imported
Submitted name:
Prostaglandin G/H synthase-2Imported
Submitted name:
Prostaglandin-endoperoxide synthase 2Imported
Gene namesi
Name:PTGS2Imported
Synonyms:COX-2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501084731218 – 604Sequence analysisAdd BLAST587

Expressioni

Gene expression databases

BgeeiENSCAFG00000013762.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038440.

Structurei

3D structure databases

SMRiQ8SPQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 55EGF-likeInterPro annotationAdd BLAST39

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiCNNVKGC.
OrthoDBiEOG091G03CD.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiView protein in InterPro
IPR029576. COX-2.
IPR000742. EGF-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR037120. Haem_peroxidase_sf.
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiView protein in Pfam
PF03098. An_peroxidase. 1 hit.
PF00008. EGF. 1 hit.
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiView protein in PROSITE
PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SPQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK
110 120 130 140 150
YVLTSRSHLI ESPPTYNVNY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG
160 170 180 190 200
VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY QVIDGEVYPP
260 270 280 290 300
TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL
410 420 430 440 450
LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN
460 470 480 490 500
EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,975
Last modified:June 1, 2002 - v1
Checksum:i42C9FEE30D2B3928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1.
HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeqiNP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.2.
UniGeneiCfa.3449.

Genome annotation databases

EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneIDi442942.
KEGGicfa:442942.

Similar proteinsi

Entry informationi

Entry nameiQ8SPQ9_CANLF
AccessioniPrimary (citable) accession number: Q8SPQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported