Q8SPQ9 (Q8SPQ9_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cyclooxygenase 2 EMBL ADO27661.1

Submitted name:
Prostaglandin G/H synthase-2 EMBL AAK97783.1
Submitted name:
Uncharacterized protein Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288

Gene names

Name:	PTGS2 Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288
Synonyms:	COX-2 EMBL ADO27661.1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anagen Inferred from electronic annotation. Source: Compara brown fat cell differentiation Inferred from electronic annotation. Source: Compara cellular response to hypoxia Inferred from electronic annotation. Source: Compara cyclooxygenase pathway Inferred from electronic annotation. Source: Compara positive regulation of brown fat cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of fever generation Inferred from electronic annotation. Source: Compara regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of cell proliferation Inferred from electronic annotation. Source: Compara response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara neuron projection Inferred from electronic annotation. Source: Compara
Molecular_function	heme binding Inferred from electronic annotation. Source: Compara peroxidase activity Inferred from electronic annotation. Source: InterPro prostaglandin-endoperoxide synthase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8SPQ9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 42C9FEE30D2B3928	FASTA	604	68,975
	10 20 30 40 50 60 MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY GENCSTPEFL 70 80 90 100 110 120 TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK YVLTSRSHLI ESPPTYNVNY 130 140 150 160 170 180 GYKSWEAFSN LSYYTRALPP VPDDCPTPMG VKGKKELPDS KEIVEKFLLR RKFIPDPQGT 190 200 210 220 230 240 NMMFAFFAQH FTHQFFKTDH KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY 250 260 270 280 290 300 QVIDGEVYPP TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD 310 320 330 340 350 360 VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNQQFQYQ 370 380 390 400 410 420 NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL LEHGLTQFVE SFSRQIAGRV 430 440 450 460 470 480 AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN EYRKRFRLKP YTSFEELTGE KEMAAGLEAL 490 500 510 520 530 540 YGDIDAMELY PALLVEKPRP DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV 550 560 570 580 590 600 GFKIINTASI QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER STEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro." Boutemmine D., Bouchard N., Boerboom D., Jones H.E., Goff A.K., Dore M., Sirois J. Endocrinology 143:1134-1143(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Genome sequence, comparative analysis and haplotype structure of the domestic dog." Broad Sequencing Platform Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S. Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Boxer Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288.
[3]	"Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs." Whiteley M.H., Bell J.S., Rothman D.A. PLoS ONE 6:E16684-E16684(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Boxer Ensembl ENSCAFP00000020288.
[5]	Ensembl Submitted (SEP-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Boxer Ensembl ENSCAFP00000038440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEX03005167 Genomic DNA. No translation available. AY044905 mRNA. Translation: AAK97783.1. HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeq	NP_001003354.1. NM_001003354.1.
UniGene	Cfa.3449.
3D structure databases
HSSP	HSSP built from PDB template 1CVU based on UniProtKB Q05769.
SMR	Q8SPQ9. Positions 18-569.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000020288.
Protein family/group databases
PeroxiBase	3335. CfaPGHS02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762. ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneID	442942.
KEGG	cfa:442942.
Organism-specific databases
CTD	5743.
Phylogenomic databases
eggNOG	NOG39991.
GeneTree	ENSGT00390000010743.
HOGENOM	HOG000013149.
HOVERGEN	HBG000366.
InParanoid	Q8SPQ9.
KO	K11987.
OMA	THFKGVW.
OrthoDB	EOG4H19VF.
Family and domain databases
Gene3D	1.10.640.10. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR010255. Haem_peroxidase. IPR002007. Haem_peroxidase_animal. IPR019791. Haem_peroxidase_animal_subgr. [Graphical view]
Pfam	PF03098. An_peroxidase. 2 hits. [Graphical view]
PRINTS	PR00457. ANPEROXIDASE.
SMART	SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS50026. EGF_3. 1 hit. PS50292. PEROXIDASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL4033.
NextBio	20831612.

Entry information

Entry name

Q8SPQ9_CANFA

Accession

Primary (citable) accession number: Q8SPQ9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)