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Protein
Submitted name:

Cyclooxygenase 2

Gene

PTGS2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-197264 Nicotinamide salvaging
R-CFA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-CFA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-CFA-9018677 Biosynthesis of DHA-derived SPMs
R-CFA-9018679 Biosynthesis of EPA-derived SPMs
R-CFA-9025094 Biosynthesis of DPAn-3 SPMs
R-CFA-9027604 Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives

Protein family/group databases

PeroxiBasei3335 CfaPGHS02

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 2Imported
Submitted name:
Prostaglandin G/H synthase-2Imported
Submitted name:
Prostaglandin-endoperoxide synthase 2Imported
Gene namesi
Name:PTGS2Imported
Synonyms:COX-2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:45152 PTGS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4033

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501410757018 – 604Sequence analysisAdd BLAST587

Expressioni

Gene expression databases

BgeeiENSCAFG00000013762

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038440

Structurei

3D structure databases

SMRiQ8SPQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 55EGF-likeInterPro annotationAdd BLAST39

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
HOGENOMiHOG000013149
HOVERGENiHBG000366
KOiK11987
OMAiCNNVKGC
OrthoDBiEOG091G03CD
TreeFamiTF329675

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR029576 COX-2
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF8 PTHR11903:SF8, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00008 EGF, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SPQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK
110 120 130 140 150
YVLTSRSHLI ESPPTYNVNY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG
160 170 180 190 200
VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY QVIDGEVYPP
260 270 280 290 300
TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL
410 420 430 440 450
LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN
460 470 480 490 500
EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,975
Last modified:June 1, 2002 - v1
Checksum:i42C9FEE30D2B3928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA No translation available.
AY044905 mRNA Translation: AAK97783.1
HQ110882 Genomic DNA Translation: ADO27661.1
RefSeqiNP_001003354.1, NM_001003354.1
XP_005622284.1, XM_005622227.2
UniGeneiCfa.3449

Genome annotation databases

EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762
GeneIDi442942
KEGGicfa:442942

Similar proteinsi

Entry informationi

Entry nameiQ8SPQ9_CANLF
AccessioniPrimary (citable) accession number: Q8SPQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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