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Q8SPQ9

- Q8SPQ9_CANFA

UniProt

Q8SPQ9 - Q8SPQ9_CANFA

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Protein
Submitted name:

Cyclooxygenase 2

Gene

PTGS2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: Ensembl
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: Ensembl

GO - Biological processi

  1. brown fat cell differentiation Source: Ensembl
  2. cellular response to hypoxia Source: Ensembl
  3. cyclooxygenase pathway Source: Ensembl
  4. inflammatory response Source: InterPro
  5. positive regulation of brown fat cell differentiation Source: Ensembl
  6. positive regulation of fever generation Source: Ensembl
  7. regulation of blood pressure Source: Ensembl
  8. regulation of cell proliferation Source: Ensembl
  9. response to oxidative stress Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_222701. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_253837. Nicotinamide salvaging.

Protein family/group databases

PeroxiBasei3335. CfaPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 2Imported
Submitted name:
Prostaglandin G/H synthase-2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PTGS2Imported
Synonyms:COX-2Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. neuron projection Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020288.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
KOiK11987.
OMAiICNNVKG.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK
110 120 130 140 150
YVLTSRSHLI ESPPTYNVNY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG
160 170 180 190 200
VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY QVIDGEVYPP
260 270 280 290 300
TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL
410 420 430 440 450
LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN
460 470 480 490 500
EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,975
Last modified:June 1, 2002 - v1
Checksum:i42C9FEE30D2B3928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1.
HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeqiNP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.1.
UniGeneiCfa.3449.

Genome annotation databases

EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneIDi442942.
KEGGicfa:442942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1 .
HQ110882 Genomic DNA. Translation: ADO27661.1 .
RefSeqi NP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.1.
UniGenei Cfa.3449.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000020288.

Chemistry

ChEMBLi CHEMBL4033.

Protein family/group databases

PeroxiBasei 3335. CfaPGHS02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000021841 ; ENSCAFP00000020288 ; ENSCAFG00000013762 .
ENSCAFT00000044614 ; ENSCAFP00000038440 ; ENSCAFG00000013762 .
GeneIDi 442942.
KEGGi cfa:442942.

Organism-specific databases

CTDi 5743.

Phylogenomic databases

eggNOGi NOG39991.
GeneTreei ENSGT00390000010743.
HOGENOMi HOG000013149.
HOVERGENi HBG000366.
KOi K11987.
OMAi ICNNVKG.
OrthoDBi EOG7RFTHC.
TreeFami TF329675.

Enzyme and pathway databases

Reactomei REACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_222701. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_253837. Nicotinamide salvaging.

Miscellaneous databases

NextBioi 20831612.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 2 hits.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro."
    Boutemmine D., Bouchard N., Boerboom D., Jones H.E., Goff A.K., Dore M., Sirois J.
    Endocrinology 143:1134-1143(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  3. "Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs."
    Whiteley M.H., Bell J.S., Rothman D.A.
    PLoS ONE 6:E16684-E16684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.
  5. Ensembl
    Submitted (SEP-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiQ8SPQ9_CANFA
AccessioniPrimary (citable) accession number: Q8SPQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3