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Q8SPQ9 (Q8SPQ9_CANFA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Prostaglandin G/H synthase-2 EMBL AAK97783.1

Uncharacterized protein Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288
Gene names
Name:COX-2 EMBL ADO27661.1
Synonyms:PTGS2 Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Sequences

Sequence LengthMass (Da)Tools
Q8SPQ9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 42C9FEE30D2B3928

FASTA60468,975
        10         20         30         40         50         60 
MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY GENCSTPEFL 

        70         80         90        100        110        120 
TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK YVLTSRSHLI ESPPTYNVNY 

       130        140        150        160        170        180 
GYKSWEAFSN LSYYTRALPP VPDDCPTPMG VKGKKELPDS KEIVEKFLLR RKFIPDPQGT 

       190        200        210        220        230        240 
NMMFAFFAQH FTHQFFKTDH KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY 

       250        260        270        280        290        300 
QVIDGEVYPP TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD 

       310        320        330        340        350        360 
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNQQFQYQ 

       370        380        390        400        410        420 
NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL LEHGLTQFVE SFSRQIAGRV 

       430        440        450        460        470        480 
AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN EYRKRFRLKP YTSFEELTGE KEMAAGLEAL 

       490        500        510        520        530        540 
YGDIDAMELY PALLVEKPRP DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV 

       550        560        570        580        590        600 
GFKIINTASI QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER 


STEL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro."
Boutemmine D., Bouchard N., Boerboom D., Jones H.E., Goff A.K., Dore M., Sirois J.
Endocrinology 143:1134-1143(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Genome sequence, comparative analysis and haplotype structure of the domestic dog."
Broad Sequencing Platform
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. expand/collapse author list , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Boxer Ensembl ENSCAFP00000038440 Ensembl ENSCAFP00000020288.
[3]"Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs."
Whiteley M.H., Bell J.S., Rothman D.A.
PLoS ONE 6:E16684-E16684(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Boxer Ensembl ENSCAFP00000020288.
[5]Ensembl
Submitted (SEP-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Boxer Ensembl ENSCAFP00000038440.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1.
HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeqNP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.1.
UniGeneCfa.3449.

3D structure databases

ProteinModelPortalQ8SPQ9.
SMRQ8SPQ9. Positions 18-569.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000020288.

Chemistry

ChEMBLCHEMBL4033.

Protein family/group databases

PeroxiBase3335. CfaPGHS02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneID442942.
KEGGcfa:442942.

Organism-specific databases

CTD5743.

Phylogenomic databases

eggNOGNOG39991.
GeneTreeENSGT00390000010743.
HOGENOMHOG000013149.
HOVERGENHBG000366.
InParanoidQ8SPQ9.
KOK11987.
OMAICNNVKG.
OrthoDBEOG7RFTHC.
TreeFamTF329675.

Family and domain databases

Gene3D1.10.640.10. 1 hit.
InterProIPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR002007. Haem_peroxidase_animal.
IPR019791. Haem_peroxidase_animal_subgr.
[Graphical view]
PfamPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSPR00457. ANPEROXIDASE.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF48113. SSF48113. 1 hit.
PROSITEPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831612.

Entry information

Entry nameQ8SPQ9_CANFA
AccessionPrimary (citable) accession number: Q8SPQ9
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)