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Protein
Submitted name:

Cyclooxygenase 2

Gene

COX-2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_291951. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_348096. Nicotinamide salvaging.
REACT_353486. Synthesis of 15-eicosatetraenoic acid derivatives.

Protein family/group databases

PeroxiBasei3335. CfaPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclooxygenase 2Imported
Submitted name:
Prostaglandin G/H synthase-2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:COX-2Imported
Synonyms:PTGS2Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038440.

Structurei

3D structure databases

ProteinModelPortaliQ8SPQ9.
SMRiQ8SPQ9. Positions 18-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
InParanoidiQ8SPQ9.
KOiK11987.
OMAiCNNVKGC.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARALVLCA ALAVVRAANP CCSHPCQNQG ICMSTGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLYLKPT PNTVHYILTH FKGVWNIVNN IPFLRNTIMK
110 120 130 140 150
YVLTSRSHLI ESPPTYNVNY GYKSWEAFSN LSYYTRALPP VPDDCPTPMG
160 170 180 190 200
VKGKKELPDS KEIVEKFLLR RKFIPDPQGT NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTKGL GHGVDLNHVY GETLDRQHKL RLFKDGKMKY QVIDGEVYPP
260 270 280 290 300
TVKDTQVEMI YPPHVPEHLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNQQFQYQ NRIAAEFNTL YHWHPLLPDT LQIDDQEYNF QQFIYNNSIL
410 420 430 440 450
LEHGLTQFVE SFSRQIAGRV AGGRNVPAAV QQVAKASIDQ SRQMKYQSLN
460 470 480 490 500
EYRKRFRLKP YTSFEELTGE KEMAAGLEAL YGDIDAMELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE MGAPFSLKGL MGNPICSPDY WKPSTFGGEV GFKIINTASI
560 570 580 590 600
QSLICNNVKG CPFTAFSVQD GQLTKTVTIN ASSSHSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,975
Last modified:June 1, 2002 - v1
Checksum:i42C9FEE30D2B3928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1.
HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeqiNP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.1.
UniGeneiCfa.3449.

Genome annotation databases

EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneIDi442942.
KEGGicfa:442942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005167 Genomic DNA. No translation available.
AY044905 mRNA. Translation: AAK97783.1.
HQ110882 Genomic DNA. Translation: ADO27661.1.
RefSeqiNP_001003354.1. NM_001003354.1.
XP_005622284.1. XM_005622227.1.
UniGeneiCfa.3449.

3D structure databases

ProteinModelPortaliQ8SPQ9.
SMRiQ8SPQ9. Positions 18-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000038440.

Chemistry

BindingDBiQ8SPQ9.
ChEMBLiCHEMBL4033.

Protein family/group databases

PeroxiBasei3335. CfaPGHS02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000021841; ENSCAFP00000020288; ENSCAFG00000013762.
ENSCAFT00000044614; ENSCAFP00000038440; ENSCAFG00000013762.
GeneIDi442942.
KEGGicfa:442942.

Organism-specific databases

CTDi5743.

Phylogenomic databases

eggNOGiNOG39991.
GeneTreeiENSGT00390000010743.
HOGENOMiHOG000013149.
HOVERGENiHBG000366.
InParanoidiQ8SPQ9.
KOiK11987.
OMAiCNNVKGC.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Enzyme and pathway databases

ReactomeiREACT_291951. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
REACT_348096. Nicotinamide salvaging.
REACT_353486. Synthesis of 15-eicosatetraenoic acid derivatives.

Miscellaneous databases

NextBioi20831612.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro."
    Boutemmine D., Bouchard N., Boerboom D., Jones H.E., Goff A.K., Dore M., Sirois J.
    Endocrinology 143:1134-1143(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  3. "Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs."
    Whiteley M.H., Bell J.S., Rothman D.A.
    PLoS ONE 6:E16684-E16684(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.
  5. Ensembl
    Submitted (SEP-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiQ8SPQ9_CANFA
AccessioniPrimary (citable) accession number: Q8SPQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.