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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 3

Gene

FMO3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
N,N,N-trimethylamine + NADPH + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O.

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14FADSequence analysis6
Nucleotide bindingi191 – 196NADPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 3
Hepatic flavin-containing monooxygenase 3
Short name:
FMO 3
Trimethylamine monooxygenase (EC:1.14.13.148)
Gene namesi
Name:FMO3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476551 – 532Dimethylaniline monooxygenase [N-oxide-forming] 3Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Liver.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000010434.

Structurei

3D structure databases

ProteinModelPortaliQ8SPQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiQ8SPQ7.
KOiK00485.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002255. Flavin_mOase_3.
PfamiView protein in Pfam
PF00743. FMO-like. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01123. FMOXYGENASE3.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8SPQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG
60 70 80 90 100
RASIYKSVFT NSSKEMMCFP DFPYPDDFPN FMHNSKIQEY LTAFAKEKSL
110 120 130 140 150
LKYIQFKTFV SSVNKRPDFA TTGQWDVTTE RDGKRESAVF DAVMVCSGHH
160 170 180 190 200
VYPNLPKESF PGLNHFKGKC FHSRDYKEPG VFKGKRVLVV GLGNSGCDIA
210 220 230 240 250
TELSHTAEQV VISSRSGSWV MSRVWDNGYP WDMVLITRFG TFLKNNLPTA
260 270 280 290 300
ISDWLYMKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA CILCGIVSVK
310 320 330 340 350
PNVKKFTETS AIFEDGTTFE GIDCVIFATG YSYTYTFLDE SIIKNRNNEI
360 370 380 390 400
ILFKGVFPPL LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA RVIKGTCTLP
410 420 430 440 450
SMEDMMNDIN EKMERKHKWY GKSETLQTDY IVYMDELSSF IGVKPNIPWL
460 470 480 490 500
FLTDPKLAME VYFGPCSPYQ FRLVGPGKWP GARNAILTQW DRSLKPLQTR
510 520 530
VVGRLQKPCF FFHWLKPFAI PILLIAVFLG LT
Length:532
Mass (Da):60,152
Last modified:January 23, 2007 - v3
Checksum:i73A4D13EE2A24A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY063498 mRNA. Translation: AAL86612.1.
RefSeqiNP_001028065.1. NM_001032893.1.
UniGeneiMmu.3639.

Genome annotation databases

GeneIDi574244.
KEGGimcc:574244.

Similar proteinsi

Entry informationi

Entry nameiFMO3_MACMU
AccessioniPrimary (citable) accession number: Q8SPQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families