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Reviewed, UniProtKB/Swiss-Prot Q8SPP7 (PGRP_BOVIN)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Peptidoglycan recognition protein
Alternative name(s):
    Peptidoglycan recognition protein short
      Short name=PGRP-S
    Oligosaccharide-binding protein
      Short name=OBP
Gene names
Name: PGLYRP1
Synonyms: PGLYRP, PGRP
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. Ref.1

Subcellular location

Secreted. Cytoplasmic granule.

Tissue specificity

Synthesized only in bone marrow. The mature protein is stored in the cytoplasmic granules of eosinophils and neutrophils but is absent from monocytes, lymphocytes, or platelets. Ref.1

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 190169Peptidoglycan recognition protein
PRO_0000023899

Amino acid modifications

Modified residue221Pyrrolidone carboxylic acid
Disulfide bond24 ↔ 148
Disulfide bond40 ↔ 85
Disulfide bond61 ↔ 67

Natural variations

Natural variant1841W → G in strain: Isolate JEW38.

Sequences

Sequence LengthMass (Da)Tools
Q8SPP7-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2BA7D659438F4ED7

FASTA19021,063
        10         20         30         40         50         60 
MSRRYTPLAW VLLALLGLGA AQDCGSIVSR GKWGALASKC SQRLRQPVRY VVVSHTAGSV 

        70         80         90        100        110        120 
CNTPASCQRQ AQNVQYYHVR ERGWCDVGYN FLIGEDGLVY EGRGWNTLGA HSGPTWNPIA 

       130        140        150        160        170        180 
IGISFMGNYM HRVPPASALR AAQSLLACGA ARGYLTPNYE VKGHRDVQQT LSPGDELYKI 

       190 
IQQWPHYRRV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils."
Tydell C.C., Yount N., Tran D., Yuan J., Selsted M.E.
J. Biol. Chem. 277:19658-19664(2002) [PubMed: 11880375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-43; 50-55; 83-88; 127-145; 141-146 AND 178-190, TISSUE SPECIFICITY, FUNCTION, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-22.
[2]"Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6."
Seabury C.M., Womack J.E.
Genomics 92:235-245(2008) [PubMed: 18639626] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Mammary gland.

Cross-references

Sequence databases

AY083309 mRNA. Translation: AAL87002.1.
EU746450 Genomic DNA. Translation: ACH92779.1.
EU746451 Genomic DNA. Translation: ACH92780.1.
EU746452 Genomic DNA. Translation: ACH92781.1.
EU746455 Genomic DNA. Translation: ACH92784.1.
BC142042 mRNA. Translation: AAI42043.1.
IPIIPI00701640.
RefSeqNP_776998.1.
UniGeneBt.9980

3D structure databases

SMRQ8SPP7. Positions 24-188.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000002635. Bos taurus. [Contig view]
GeneID282305.
KEGGbta:282305.

Phylogenomic databases

HOVERGENQ8SPP7.

Family and domain databases

InterProIPR002502. Amidase_2.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_met/bac.
[Graphical view]
Gene3DG3DSA:3.40.80.10. Amidase_2. 1 hit.
PANTHERPTHR11022. PGRPs. 1 hit.
PfamPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFPIRSF037945. PGRPs. 1 hit.
SMARTSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGRP_BOVIN
AccessionPrimary (citable) accession number: Q8SPP7
Secondary accession number(s): A5PJC0, B5T256, B5T261
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2002
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents