Peptidoglycan recognition protein 1 precursor

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Q8SPP7 (PGRP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Peptidoglycan recognition protein 1

Alternative name(s):
Oligosaccharide-binding protein
Short name=OBP
Peptidoglycan recognition protein short
Short name=PGRP-S

Gene names

Name:	PGLYRP1
Synonyms:	PGLYRP, PGRP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. Ref.1 Ref.4
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted. Cytoplasmic granule Ref.4.
Tissue specificity	Synthesized only in bone marrow. The mature protein is stored in the cytoplasmic granules of eosinophils and neutrophils but is absent from monocytes, lymphocytes, or platelets. Ref.1
Sequence similarities	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Fungicide
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of other organism Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: InterPro peptidoglycan binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Chain

22 – 190

169

Peptidoglycan recognition protein 1

PRO_0000023899

Amino acid modifications

Modified residue

Pyrrolidone carboxylic acid

Disulfide bond

24 ↔ 148

Disulfide bond

40 ↔ 85

Disulfide bond

61 ↔ 67

Natural variations

Natural variant

184

W → G in strain: Isolate JEW38.

Sequences

Sequence

Length

Mass (Da)

Tools

Q8SPP7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2BA7D659438F4ED7
Show »

FASTA

190

21,063

        10         20         30         40         50         60 
MSRRYTPLAW VLLALLGLGA AQDCGSIVSR GKWGALASKC SQRLRQPVRY VVVSHTAGSV 

        70         80         90        100        110        120 
CNTPASCQRQ AQNVQYYHVR ERGWCDVGYN FLIGEDGLVY EGRGWNTLGA HSGPTWNPIA 

       130        140        150        160        170        180 
IGISFMGNYM HRVPPASALR AAQSLLACGA ARGYLTPNYE VKGHRDVQQT LSPGDELYKI 

       190 
IQQWPHYRRV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils." Tydell C.C., Yount N., Tran D., Yuan J., Selsted M.E. J. Biol. Chem. 277:19658-19664(2002) [PubMed: 11880375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-43; 50-55; 83-88; 127-145; 141-146 AND 178-190, TISSUE SPECIFICITY, FUNCTION, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-22.
[2]	"Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6." Seabury C.M., Womack J.E. Genomics 92:235-245(2008) [PubMed: 18639626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Mammary gland.
[4]	"Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties." Tydell C.C., Yuan J., Tran P., Selsted M.E. J. Immunol. 176:1154-1162(2006) [PubMed: 16394004] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY083309 mRNA. Translation: AAL87002.1. EU746450 Genomic DNA. Translation: ACH92779.1. EU746451 Genomic DNA. Translation: ACH92780.1. EU746452 Genomic DNA. Translation: ACH92781.1. EU746455 Genomic DNA. Translation: ACH92784.1. BC142042 mRNA. Translation: AAI42043.1.
IPI	IPI00701640.
RefSeq	NP_776998.1. NM_174573.2.
UniGene	Bt.9980.
3D structure databases
ProteinModelPortal	Q8SPP7.
SMR	Q8SPP7. Positions 24-188.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8SPP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003414; ENSBTAP00000003414; ENSBTAG00000002635.
GeneID	282305.
KEGG	bta:282305.
Organism-specific databases
CTD	8993.
Phylogenomic databases
eggNOG	maNOG19643.
GeneTree	ENSGT00390000016833.
HOVERGEN	HBG007406.
InParanoid	Q8SPP7.
OrthoDB	EOG4DFPPK.
PhylomeDB	Q8SPP7.
Family and domain databases
InterPro	IPR002502. Amidase_domain. IPR017331. Peptidoglycan_recognition. IPR015510. PGRP. IPR006619. PGRP_domain_met/bac. [Graphical view]
Gene3D	G3DSA:3.40.80.10. Amidase_2. 1 hit.
KO	K01446.
PANTHER	PTHR11022. PGRPs. 1 hit.
Pfam	PF01510. Amidase_2. 1 hit. [Graphical view]
PIRSF	PIRSF037945. PGRPs. 1 hit.
SMART	SM00644. Ami_2. 1 hit. SM00701. PGRP. 1 hit. [Graphical view]
SUPFAM	SSF55846. Amidase_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGRP1_BOVIN

Accession

Primary (citable) accession number: Q8SPP7
Secondary accession number(s): A5PJC0, B5T256, B5T261

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents