Reviewed, UniProtKB/Swiss-Prot Q8SPP7 (PGRP_BOVIN)

Names and origin

Protein names

Recommended name:
    Peptidoglycan recognition protein
Alternative name(s):
    Peptidoglycan recognition protein short
      Short name=PGRP-S
    Oligosaccharide-binding protein
      Short name=OBP

Gene names

Name:	PGLYRP1
Synonyms:	PGLYRP, PGRP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. Ref.1
Subcellular location	Secreted. Cytoplasmic granule.
Tissue specificity	Synthesized only in bone marrow. The mature protein is stored in the cytoplasmic granules of eosinophils and neutrophils but is absent from monocytes, lymphocytes, or platelets. Ref.1
Sequence similarities	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Fungicide
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro xenobiotic metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 190	169	Peptidoglycan recognition protein		PRO_0000023899
Amino acid modifications
	Modified residue	22	1	Pyrrolidone carboxylic acid
	Disulfide bond	24 ↔ 148
	Disulfide bond	40 ↔ 85
	Disulfide bond	61 ↔ 67
Natural variations
	Natural variant	184	1	W → G in strain: Isolate JEW38.

Sequences

	Sequence		Length	Mass (Da)
	Q8SPP7-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 2BA7D659438F4ED7	FASTA	190	21,063
	10 20 30 40 50 60 MSRRYTPLAW VLLALLGLGA AQDCGSIVSR GKWGALASKC SQRLRQPVRY VVVSHTAGSV 70 80 90 100 110 120 CNTPASCQRQ AQNVQYYHVR ERGWCDVGYN FLIGEDGLVY EGRGWNTLGA HSGPTWNPIA 130 140 150 160 170 180 IGISFMGNYM HRVPPASALR AAQSLLACGA ARGYLTPNYE VKGHRDVQQT LSPGDELYKI 190 IQQWPHYRRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils." Tydell C.C., Yount N., Tran D., Yuan J., Selsted M.E. J. Biol. Chem. 277:19658-19664(2002) [PubMed: 11880375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-43; 50-55; 83-88; 127-145; 141-146 AND 178-190, TISSUE SPECIFICITY, FUNCTION, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-22.
[2]	"Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6." Seabury C.M., Womack J.E. Genomics 92:235-245(2008) [PubMed: 18639626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Mammary gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY083309 mRNA. Translation: AAL87002.1. EU746450 Genomic DNA. Translation: ACH92779.1. EU746451 Genomic DNA. Translation: ACH92780.1. EU746452 Genomic DNA. Translation: ACH92781.1. EU746455 Genomic DNA. Translation: ACH92784.1. BC142042 mRNA. Translation: AAI42043.1.
IPI	IPI00701640.
RefSeq	NP_776998.1.
UniGene	Bt.9980
3D structure databases
SMR	Q8SPP7. Positions 24-188.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000002635. Bos taurus. [Contig view]
GeneID	282305.
KEGG	bta:282305.
Phylogenomic databases
HOVERGEN	Q8SPP7.
Family and domain databases
InterPro	IPR002502. Amidase_2. IPR017331. Peptidoglycan_recognition. IPR015510. PGRP. IPR006619. PGRP_met/bac. [Graphical view]
Gene3D	G3DSA:3.40.80.10. Amidase_2. 1 hit.
PANTHER	PTHR11022. PGRPs. 1 hit.
Pfam	PF01510. Amidase_2. 1 hit. [Graphical view]
PIRSF	PIRSF037945. PGRPs. 1 hit.
SMART	SM00644. Ami_2. 1 hit. SM00701. PGRP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGRP_BOVIN

Accession

Primary (citable) accession number: Q8SPP7
Secondary accession number(s): A5PJC0, B5T256, B5T261

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)