Q8SPP7 (PGRP1_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 73.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peptidoglycan recognition protein 1 Alternative name(s): Oligosaccharide-binding protein Short name=OBP Peptidoglycan recognition protein short Short name=PGRP-S | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 190 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. Ref.1 Ref.4 |
| Subunit structure | Homodimer; disulfide-linked. |
| Subcellular location | |
| Tissue specificity | Synthesized only in bone marrow. The mature protein is stored in the cytoplasmic granules of eosinophils and neutrophils but is absent from monocytes, lymphocytes, or platelets. Ref.1 |
| Sequence similarities | Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | |||||||||
| Chain | 22 – 190 | 169 | Peptidoglycan recognition protein 1 | PRO_0000023899 | |||||||
Amino acid modifications | |||||||||||
| Modified residue | 22 | 1 | Pyrrolidone carboxylic acid | ||||||||
| Disulfide bond | 24 ↔ 148 | ||||||||||
| Disulfide bond | 40 ↔ 85 | ||||||||||
| Disulfide bond | 61 ↔ 67 | ||||||||||
Natural variations | |||||||||||
| Natural variant | 184 | 1 | W → G in strain: Isolate JEW38. | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils." Tydell C.C., Yount N., Tran D., Yuan J., Selsted M.E. J. Biol. Chem. 277:19658-19664(2002) [PubMed: 11880375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-43; 50-55; 83-88; 127-145; 141-146 AND 178-190, TISSUE SPECIFICITY, FUNCTION, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-22. |
| [2] | "Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6." Seabury C.M., Womack J.E. Genomics 92:235-245(2008) [PubMed: 18639626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate 44, Isolate 74, Isolate 80 and Isolate JEW38. |
| [3] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Mammary gland. |
| [4] | "Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties." Tydell C.C., Yuan J., Tran P., Selsted M.E. J. Immunol. 176:1154-1162(2006) [PubMed: 16394004] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY083309 mRNA. Translation: AAL87002.1. EU746450 Genomic DNA. Translation: ACH92779.1. EU746451 Genomic DNA. Translation: ACH92780.1. EU746452 Genomic DNA. Translation: ACH92781.1. EU746455 Genomic DNA. Translation: ACH92784.1. BC142042 mRNA. Translation: AAI42043.1. |
| IPI | IPI00701640. |
| RefSeq | NP_776998.1. NM_174573.2. |
| UniGene | Bt.9980. |
3D structure databases | |
| ProteinModelPortal | Q8SPP7. |
| SMR | Q8SPP7. Positions 24-188. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8SPP7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000003414; ENSBTAP00000003414; ENSBTAG00000002635. |
| GeneID | 282305. |
| KEGG | bta:282305. |
Organism-specific databases | |
| CTD | 8993. |
Phylogenomic databases | |
| eggNOG | maNOG19643. |
| GeneTree | ENSGT00390000016833. |
| HOVERGEN | HBG007406. |
| InParanoid | Q8SPP7. |
| OrthoDB | EOG4DFPPK. |
| PhylomeDB | Q8SPP7. |
Family and domain databases | |
| InterPro | IPR002502. Amidase_domain. IPR017331. Peptidoglycan_recognition. IPR015510. PGRP. IPR006619. PGRP_domain_met/bac. [Graphical view] |
| Gene3D | G3DSA:3.40.80.10. Amidase_2. 1 hit. |
| KO | K01446. |
| PANTHER | PTHR11022. PGRPs. 1 hit. |
| Pfam | PF01510. Amidase_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF037945. PGRPs. 1 hit. |
| SMART | SM00644. Ami_2. 1 hit. SM00701. PGRP. 1 hit. [Graphical view] |
| SUPFAM | SSF55846. Amidase_2. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PGRP1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q8SPP7 Secondary accession number(s): A5PJC0, B5T256, B5T261 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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