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Reviewed, UniProtKB/Swiss-Prot Q8SPK1 (CP4AO_PIG)

Last modified May 26, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 4A24
Alternative name(s):
    CYPIVA24
    Fatty acid omega-hydroxylase
    EC=1.14.15.3
Gene names
Name: CYP4A24
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

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Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid.

Catalytic activity

Octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome P450 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 4A24
PRO_0000280743

Regions

Transmembrane6 – 2621 Potential
Transmembrane112 – 13221 Potential

Sites

Metal binding4511Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict2021A → V in CAE52533. Ref.2
Sequence conflict2241I → T in CAE52533. Ref.2
Sequence conflict2461N → S in CAE52533. Ref.2
Sequence conflict2931R → Q in CAE52533. Ref.2
Sequence conflict382 – 3843GVS → SVG in CAE52533. Ref.2
Sequence conflict4041T → I in CAE52533. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q8SPK1-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: DB7F815966DA7D7B

FASTA50457,199
        10         20         30         40         50         60 
MTVPALASAS GLLQVASLLG LLLLLLKAAQ LYLHRQWLLK ALQQFPSPPS HWLYGHSREF 

        70         80         90        100        110        120 
QEESELPPLL KRVEKYPSAC ALWRWGTRAM VLVYDPDYMK VVLARSDPKN SVVYRLLIPW 

       130        140        150        160        170        180 
IGCGLLLLNG QTWFQRRRML TPAFHYDILK PYVGLMAKSV QVMLDKWEQL VAQDPRLEIV 

       190        200        210        220        230        240 
GPVSLMTLDT IMKCAFSHQG SAQTDGDSHS YIQAIWDLKN LFSIRTKSAF LQNDIIYRLS 

       250        260        270        280        290        300 
PEGRKNHRAA RIAHQHTDRV IQLRKAQLQK QGEMENVRKK RHLDFLDILL LARMEKGNSL 

       310        320        330        340        350        360 
SDTDLRAEVD TFMFEGHDTT ASGISWILYA LASHPEHQQR CREEIQGLLG DGTSITWDHL 

       370        380        390        400        410        420 
DQMPYTTMCI KEALRLYPPV PGVSRELSKP ITFPDGRSLP AGITLSLSIY GLHHNPQVWP 

       430        440        450        460        470        480 
NPEEFDPSRF APGSARHSHA FMPFSGGSRN CIGKQFAMNE MKVAVALTLL RFELAPDPSR 

       490        500 
KPIATPEVVL NSKNGIHLKL RKLP

« Hide

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References

[1]"Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]."
Lundell K.
Biochem. J. 363:297-303(2002) [PubMed: 11931657] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The porcine taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21) gene: evolution by gene duplication and gene conversion."
Lundell K.
Biochem. J. 378:1053-1058(2004) [PubMed: 14641109] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 83-448.

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Cross-references

Sequence databases

AJ318096 mRNA. Translation: CAC85662.1.
AJ586860 Genomic DNA. Translation: CAE52547.1.
AJ586619 Genomic DNA. Translation: CAE52533.1.
UniGeneSsc.49966

3D structure databases

HSSPHSSP built from PDB template 1JPZ based on UniProtKB P14779.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ8SPK1.

Enzyme and pathway databases

BRENDA1.14.15.3. 249.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCP4AO_PIG
AccessionPrimary (citable) accession number: Q8SPK1
Secondary accession number(s): Q70BW1, Q70BZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2002
Last modified: May 26, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents