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Q8SPJ1

- PLAK_BOVIN

UniProt

Q8SPJ1 - PLAK_BOVIN

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Protein
Junction plakoglobin
Gene
JUP
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: RefGenome
  2. cadherin binding Source: RefGenome
  3. protein binding Source: BHF-UCL
  4. protein homodimerization activity Source: BHF-UCL
  5. protein kinase binding Source: RefGenome
  6. structural molecule activity Source: RefGenome

GO - Biological processi

  1. atrioventricular valve morphogenesis Source: RefGenome
  2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  3. cell migration Source: Ensembl
  4. cell morphogenesis Source: RefGenome
  5. cellular response to indole-3-methanol Source: Ensembl
  6. cytoskeletal anchoring at plasma membrane Source: RefGenome
  7. desmosome assembly Source: Ensembl
  8. detection of mechanical stimulus Source: Ensembl
  9. ectoderm development Source: RefGenome
  10. endothelial cell-cell adhesion Source: BHF-UCL
  11. gastrulation Source: RefGenome
  12. morphogenesis of embryonic epithelium Source: RefGenome
  13. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
  14. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  15. nervous system development Source: RefGenome
  16. oocyte development Source: RefGenome
  17. positive regulation of protein import into nucleus Source: Ensembl
  18. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  19. regulation of cell proliferation Source: Ensembl
  20. regulation of heart rate by cardiac conduction Source: Ensembl
  21. skin development Source: RefGenome
  22. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_212282. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:JUP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Cell junctionadherens junction By similarity. Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity. Membrane; Peripheral membrane protein By similarity
Note: Cytoplasmic in a soluble and membrane-associated form By similarity.

GO - Cellular componenti

  1. Z disc Source: RefGenome
  2. actin cytoskeleton Source: RefGenome
  3. catenin complex Source: RefGenome
  4. cell-cell adherens junction Source: AgBase
  5. cytoplasmic side of plasma membrane Source: BHF-UCL
  6. cytoskeleton Source: BHF-UCL
  7. cytosol Source: BHF-UCL
  8. desmosome Source: BHF-UCL
  9. fascia adherens Source: RefGenome
  10. gamma-catenin-TCF7L2 complex Source: Ensembl
  11. intermediate filament Source: Ensembl
  12. protein-DNA complex Source: Ensembl
  13. zonula adherens Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Junction plakoglobin
PRO_0000064277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Glycosylationi14 – 141O-linked (GlcNAc) By similarity
Modified residuei182 – 1821Phosphoserine By similarity
Modified residuei665 – 6651Phosphoserine By similarity

Post-translational modificationi

May be phosphorylated by FER By similarity.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8SPJ1.
PRIDEiQ8SPJ1.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8SPJ1.
SMRiQ8SPJ1. Positions 118-672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17140ARM 1
Add
BLAST
Repeati172 – 21544ARM 2
Add
BLAST
Repeati216 – 25540ARM 3
Add
BLAST
Repeati258 – 29740ARM 4
Add
BLAST
Repeati298 – 34144ARM 5
Add
BLAST
Repeati342 – 38140ARM 6
Add
BLAST
Repeati383 – 42038ARM 7
Add
BLAST
Repeati423 – 46442ARM 8
Add
BLAST
Repeati470 – 51041ARM 9
Add
BLAST
Repeati512 – 55140ARM 10
Add
BLAST
Repeati574 – 61340ARM 11
Add
BLAST
Repeati615 – 66147ARM 12
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 297166Interaction with DSC1 and DSG1 By similarity
Add
BLAST
Regioni574 – 66188Interaction with DSC1 By similarity
Add
BLAST

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region By similarity.

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 12 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ8SPJ1.
KOiK10056.
OMAiMNLIEQP.
OrthoDBiEOG7X9G6B.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SPJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MEVMNLIEQP IKVTEWQQTY TYDSGIHSGA NTCVPSLSSK GLIEEDEACG    50
RQYTLKKTTT YTQSVPPGQG DLEYQMSTTA RAKRVREAMC PGVTGEDSSL 100
LLTTQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 150
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 200
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 250
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 300
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 350
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL 400
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 450
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 500
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 550
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 600
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 650
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPMN EPYADDMDAT 700
YRPMYSSDVP MDPLEMHMDM DGDYPIDTYS DGLRPPYATA DHMLA 745
Length:745
Mass (Da):81,821
Last modified:June 1, 2002 - v1
Checksum:iCCF44BAC1FEA469C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921G → S in AAI18115. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF497524
, AF497518, AF497519, AF497520, AF497521, AF497522, AF497523 Genomic DNA. Translation: AAM19329.1.
BC118114 mRNA. Translation: AAI18115.1.
PIRiB32905.
RefSeqiNP_001004024.1. NM_001004024.2.
XP_005220741.1. XM_005220684.1.
UniGeneiBt.20230.

Genome annotation databases

EnsembliENSBTAT00000023522; ENSBTAP00000023522; ENSBTAG00000017685.
GeneIDi445543.
KEGGibta:445543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF497524
, AF497518 , AF497519 , AF497520 , AF497521 , AF497522 , AF497523 Genomic DNA. Translation: AAM19329.1 .
BC118114 mRNA. Translation: AAI18115.1 .
PIRi B32905.
RefSeqi NP_001004024.1. NM_001004024.2.
XP_005220741.1. XM_005220684.1.
UniGenei Bt.20230.

3D structure databases

ProteinModelPortali Q8SPJ1.
SMRi Q8SPJ1. Positions 118-672.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8SPJ1.
PRIDEi Q8SPJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000023522 ; ENSBTAP00000023522 ; ENSBTAG00000017685 .
GeneIDi 445543.
KEGGi bta:445543.

Organism-specific databases

CTDi 3728.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000230958.
HOVERGENi HBG000919.
InParanoidi Q8SPJ1.
KOi K10056.
OMAi MNLIEQP.
OrthoDBi EOG7X9G6B.
TreeFami TF317997.

Enzyme and pathway databases

Reactomei REACT_212282. Adherens junctions interactions.

Miscellaneous databases

NextBioi 20832184.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of plakoglobin in bovine cardiomyopathy with woolly haircoat syndrome."
    Simpson M.A., Crosby A.H.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Uterus.

Entry informationi

Entry nameiPLAK_BOVIN
AccessioniPrimary (citable) accession number: Q8SPJ1
Secondary accession number(s): Q17QY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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