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Q8SEM9

- COX2_CAERE

UniProt

Q8SEM9 - COX2_CAERE

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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi163 – 1631Copper ACurated
Metal bindingi198 – 1981Copper ACurated
Metal bindingi202 – 2021Copper ACurated
Metal bindingi206 – 2061Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrionImported
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)Imported
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 29›29Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Topological domaini51 – 6313Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 230146Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 230›230Cytochrome c oxidase subunit 2PRO_0000183527Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8SEM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8SEM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF
60 70 80 90 100
YFKSKKIEYQ FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK
110 120 130 140 150
VTGHQWYWSY EYSDIPGLEF DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT
160 170 180 190 200
NIRFCITSAD VIHAWALNSL SVKLDAMSGI LSTFSYSFPM VGVFYGQCSE
210 220 230
ICGANHSFMP IALEVTLLDN FKSWCFGTME
Length:230
Mass (Da):26,459
Last modified:June 1, 2002 - v1
Checksum:i4086C53A06107DEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791V → I in strain: SB146. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1.
AF491509 Genomic DNA. Translation: AAM09711.1.
AF491510 Genomic DNA. Translation: AAM09712.1.
AF491511 Genomic DNA. Translation: AAM09713.1.
AF491512 Genomic DNA. Translation: AAM09714.1.
AF491513 Genomic DNA. Translation: AAM09715.1.
AF491514 Genomic DNA. Translation: AAM09716.1.
AF491515 Genomic DNA. Translation: AAM09717.1.
AF491516 Genomic DNA. Translation: AAM09718.1.
AF491517 Genomic DNA. Translation: AAM09719.1.
AF491518 Genomic DNA. Translation: AAM09720.1.
AF491519 Genomic DNA. Translation: AAM09721.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1 .
AF491509 Genomic DNA. Translation: AAM09711.1 .
AF491510 Genomic DNA. Translation: AAM09712.1 .
AF491511 Genomic DNA. Translation: AAM09713.1 .
AF491512 Genomic DNA. Translation: AAM09714.1 .
AF491513 Genomic DNA. Translation: AAM09715.1 .
AF491514 Genomic DNA. Translation: AAM09716.1 .
AF491515 Genomic DNA. Translation: AAM09717.1 .
AF491516 Genomic DNA. Translation: AAM09718.1 .
AF491517 Genomic DNA. Translation: AAM09719.1 .
AF491518 Genomic DNA. Translation: AAM09720.1 .
AF491519 Genomic DNA. Translation: AAM09721.1 .

3D structure databases

ProteinModelPortali Q8SEM9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
    Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
    Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-79.
    Strain: CR1014, CR1415, CR2124, EM464, PB205, PB206, PB212, PB219, PB228, PB229, SB146 and VT733.

Entry informationi

Entry nameiCOX2_CAERE
AccessioniPrimary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3