Q8SEM9 (COX2_CAERE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	cox-2
Synonyms:	coII

Encoded on

Mitochondrion

Organism

Caenorhabditis remanei (Caenorhabditis vulgaris)

Taxonomic identifier

31234 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	230 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. UniProtKB P24894
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A. UniProtKB P24894
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 230	›230	Cytochrome c oxidase subunit 2		PRO_0000183527
Regions
	Topological domain	‹1 – 29	›29	Mitochondrial intermembrane Potential
	Transmembrane	30 – 50	21	Helical; Potential
	Topological domain	51 – 63	13	Mitochondrial matrix Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 230	146	Mitochondrial intermembrane Potential
Sites
	Metal binding	163	1	Copper A Probable UniProtKB P24894
	Metal binding	198	1	Copper A Probable UniProtKB P24894
	Metal binding	202	1	Copper A Probable UniProtKB P24894
	Metal binding	206	1	Copper A Probable UniProtKB P24894
Natural variations
	Natural variant	79	1	V → I in strain: SB146. Ref.1
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q8SEM9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4086C53A06107DEA	FASTA	230	26,459
	10 20 30 40 50 60 NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF YFKSKKIEYQ 70 80 90 100 110 120 FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK VTGHQWYWSY EYSDIPGLEF 130 140 150 160 170 180 DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT NIRFCITSAD VIHAWALNSL SVKLDAMSGI 190 200 210 220 230 LSTFSYSFPM VGVFYGQCSE ICGANHSFMP IALEVTLLDN FKSWCFGTME

References

[1]

"Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis." Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F. Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-79. Strain: CR1014, CR1415, CR2124, EM464, PB205, PB206, PB212, PB219, PB228, PB229, SB146 and VT733.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF491508 Genomic DNA. Translation: AAM09710.1. AF491509 Genomic DNA. Translation: AAM09711.1. AF491510 Genomic DNA. Translation: AAM09712.1. AF491511 Genomic DNA. Translation: AAM09713.1. AF491512 Genomic DNA. Translation: AAM09714.1. AF491513 Genomic DNA. Translation: AAM09715.1. AF491514 Genomic DNA. Translation: AAM09716.1. AF491515 Genomic DNA. Translation: AAM09717.1. AF491516 Genomic DNA. Translation: AAM09718.1. AF491517 Genomic DNA. Translation: AAM09719.1. AF491518 Genomic DNA. Translation: AAM09720.1. AF491519 Genomic DNA. Translation: AAM09721.1.
3D structure databases
ProteinModelPortal	Q8SEM9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_CAERE

Accession

Primary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project