Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi163Copper ACurated1
Metal bindingi198Copper ACurated1
Metal bindingi202Copper ACurated1
Metal bindingi206Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrionImported
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)Imported
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 29Mitochondrial intermembraneSequence analysisAdd BLAST›29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 63Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 230Mitochondrial intermembraneSequence analysisAdd BLAST146

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183527‹1 – 230Cytochrome c oxidase subunit 2Add BLAST›230

Structurei

3D structure databases

ProteinModelPortaliQ8SEM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8SEM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF
60 70 80 90 100
YFKSKKIEYQ FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK
110 120 130 140 150
VTGHQWYWSY EYSDIPGLEF DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT
160 170 180 190 200
NIRFCITSAD VIHAWALNSL SVKLDAMSGI LSTFSYSFPM VGVFYGQCSE
210 220 230
ICGANHSFMP IALEVTLLDN FKSWCFGTME
Length:230
Mass (Da):26,459
Last modified:June 1, 2002 - v1
Checksum:i4086C53A06107DEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti79V → I in strain: SB146. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491508 Genomic DNA Translation: AAM09710.1
AF491509 Genomic DNA Translation: AAM09711.1
AF491510 Genomic DNA Translation: AAM09712.1
AF491511 Genomic DNA Translation: AAM09713.1
AF491512 Genomic DNA Translation: AAM09714.1
AF491513 Genomic DNA Translation: AAM09715.1
AF491514 Genomic DNA Translation: AAM09716.1
AF491515 Genomic DNA Translation: AAM09717.1
AF491516 Genomic DNA Translation: AAM09718.1
AF491517 Genomic DNA Translation: AAM09719.1
AF491518 Genomic DNA Translation: AAM09720.1
AF491519 Genomic DNA Translation: AAM09721.1

Similar proteinsi

Entry informationi

Entry nameiCOX2_CAERE
AccessioniPrimary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health