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Q8SEM9

- COX2_CAERE

UniProt

Q8SEM9 - COX2_CAERE

Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi163 – 1631Copper ACurated
    Metal bindingi198 – 1981Copper ACurated
    Metal bindingi202 – 2021Copper ACurated
    Metal bindingi206 – 2061Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:cox-2
    Synonyms:coII
    Encoded oniMitochondrionImported
    OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)Imported
    Taxonomic identifieri31234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 230›230Cytochrome c oxidase subunit 2PRO_0000183527Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SEM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 29›29Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6313Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini85 – 230146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8SEM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF    50
    YFKSKKIEYQ FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK 100
    VTGHQWYWSY EYSDIPGLEF DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT 150
    NIRFCITSAD VIHAWALNSL SVKLDAMSGI LSTFSYSFPM VGVFYGQCSE 200
    ICGANHSFMP IALEVTLLDN FKSWCFGTME 230
    Length:230
    Mass (Da):26,459
    Last modified:June 1, 2002 - v1
    Checksum:i4086C53A06107DEA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 791V → I in strain: SB146. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF491508 Genomic DNA. Translation: AAM09710.1.
    AF491509 Genomic DNA. Translation: AAM09711.1.
    AF491510 Genomic DNA. Translation: AAM09712.1.
    AF491511 Genomic DNA. Translation: AAM09713.1.
    AF491512 Genomic DNA. Translation: AAM09714.1.
    AF491513 Genomic DNA. Translation: AAM09715.1.
    AF491514 Genomic DNA. Translation: AAM09716.1.
    AF491515 Genomic DNA. Translation: AAM09717.1.
    AF491516 Genomic DNA. Translation: AAM09718.1.
    AF491517 Genomic DNA. Translation: AAM09719.1.
    AF491518 Genomic DNA. Translation: AAM09720.1.
    AF491519 Genomic DNA. Translation: AAM09721.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF491508 Genomic DNA. Translation: AAM09710.1 .
    AF491509 Genomic DNA. Translation: AAM09711.1 .
    AF491510 Genomic DNA. Translation: AAM09712.1 .
    AF491511 Genomic DNA. Translation: AAM09713.1 .
    AF491512 Genomic DNA. Translation: AAM09714.1 .
    AF491513 Genomic DNA. Translation: AAM09715.1 .
    AF491514 Genomic DNA. Translation: AAM09716.1 .
    AF491515 Genomic DNA. Translation: AAM09717.1 .
    AF491516 Genomic DNA. Translation: AAM09718.1 .
    AF491517 Genomic DNA. Translation: AAM09719.1 .
    AF491518 Genomic DNA. Translation: AAM09720.1 .
    AF491519 Genomic DNA. Translation: AAM09721.1 .

    3D structure databases

    ProteinModelPortali Q8SEM9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
      Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
      Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-79.
      Strain: CR1014, CR1415, CR2124, EM464, PB205, PB206, PB212, PB219, PB228, PB229, SB146 and VT733.

    Entry informationi

    Entry nameiCOX2_CAERE
    AccessioniPrimary (citable) accession number: Q8SEM9
    Secondary accession number(s): Q8SEN9, Q8SFX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3