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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi163Copper ACurated1
Metal bindingi198Copper ACurated1
Metal bindingi202Copper ACurated1
Metal bindingi206Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrionImported
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)Imported
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 29Mitochondrial intermembraneSequence analysisAdd BLAST›29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 63Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 230Mitochondrial intermembraneSequence analysisAdd BLAST146

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183527‹1 – 230Cytochrome c oxidase subunit 2Add BLAST›230

Structurei

3D structure databases

ProteinModelPortaliQ8SEM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8SEM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF
60 70 80 90 100
YFKSKKIEYQ FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK
110 120 130 140 150
VTGHQWYWSY EYSDIPGLEF DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT
160 170 180 190 200
NIRFCITSAD VIHAWALNSL SVKLDAMSGI LSTFSYSFPM VGVFYGQCSE
210 220 230
ICGANHSFMP IALEVTLLDN FKSWCFGTME
Length:230
Mass (Da):26,459
Last modified:June 1, 2002 - v1
Checksum:i4086C53A06107DEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti79V → I in strain: SB146. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1.
AF491509 Genomic DNA. Translation: AAM09711.1.
AF491510 Genomic DNA. Translation: AAM09712.1.
AF491511 Genomic DNA. Translation: AAM09713.1.
AF491512 Genomic DNA. Translation: AAM09714.1.
AF491513 Genomic DNA. Translation: AAM09715.1.
AF491514 Genomic DNA. Translation: AAM09716.1.
AF491515 Genomic DNA. Translation: AAM09717.1.
AF491516 Genomic DNA. Translation: AAM09718.1.
AF491517 Genomic DNA. Translation: AAM09719.1.
AF491518 Genomic DNA. Translation: AAM09720.1.
AF491519 Genomic DNA. Translation: AAM09721.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1.
AF491509 Genomic DNA. Translation: AAM09711.1.
AF491510 Genomic DNA. Translation: AAM09712.1.
AF491511 Genomic DNA. Translation: AAM09713.1.
AF491512 Genomic DNA. Translation: AAM09714.1.
AF491513 Genomic DNA. Translation: AAM09715.1.
AF491514 Genomic DNA. Translation: AAM09716.1.
AF491515 Genomic DNA. Translation: AAM09717.1.
AF491516 Genomic DNA. Translation: AAM09718.1.
AF491517 Genomic DNA. Translation: AAM09719.1.
AF491518 Genomic DNA. Translation: AAM09720.1.
AF491519 Genomic DNA. Translation: AAM09721.1.

3D structure databases

ProteinModelPortaliQ8SEM9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_CAERE
AccessioniPrimary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: September 16, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.