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Q8SEM9 (COX2_CAERE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox-2
Synonyms:coII
Encoded onMitochondrion
OrganismCaenorhabditis remanei (Caenorhabditis vulgaris)
Taxonomic identifier31234 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length230 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. UniProtKB P24894

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A. UniProtKB P24894

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 230›230Cytochrome c oxidase subunit 2
PRO_0000183527

Regions

Topological domain‹1 – 29›29Mitochondrial intermembrane Potential
Transmembrane30 – 5021Helical; Potential
Topological domain51 – 6313Mitochondrial matrix Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 230146Mitochondrial intermembrane Potential

Sites

Metal binding1631Copper A Probable UniProtKB P24894
Metal binding1981Copper A Probable UniProtKB P24894
Metal binding2021Copper A Probable UniProtKB P24894
Metal binding2061Copper A Probable UniProtKB P24894

Natural variations

Natural variant791V → I in strain: SB146. Ref.1

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q8SEM9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4086C53A06107DEA

FASTA23026,459
        10         20         30         40         50         60 
NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF YFKSKKIEYQ 

        70         80         90        100        110        120 
FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK VTGHQWYWSY EYSDIPGLEF 

       130        140        150        160        170        180 
DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT NIRFCITSAD VIHAWALNSL SVKLDAMSGI 

       190        200        210        220        230 
LSTFSYSFPM VGVFYGQCSE ICGANHSFMP IALEVTLLDN FKSWCFGTME 

« Hide

References

[1]"Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-79.
Strain: CR1014, CR1415, CR2124, EM464, PB205, PB206, PB212, PB219, PB228, PB229, SB146 and VT733.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF491508 Genomic DNA. Translation: AAM09710.1.
AF491509 Genomic DNA. Translation: AAM09711.1.
AF491510 Genomic DNA. Translation: AAM09712.1.
AF491511 Genomic DNA. Translation: AAM09713.1.
AF491512 Genomic DNA. Translation: AAM09714.1.
AF491513 Genomic DNA. Translation: AAM09715.1.
AF491514 Genomic DNA. Translation: AAM09716.1.
AF491515 Genomic DNA. Translation: AAM09717.1.
AF491516 Genomic DNA. Translation: AAM09718.1.
AF491517 Genomic DNA. Translation: AAM09719.1.
AF491518 Genomic DNA. Translation: AAM09720.1.
AF491519 Genomic DNA. Translation: AAM09721.1.

3D structure databases

ProteinModelPortalQ8SEM9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CAERE
AccessionPrimary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families