SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8SEM9

- COX2_CAERE

UniProt

Q8SEM9 - COX2_CAERE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 2
Gene
cox-2, coII
Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi163 – 1631Copper A InferredBy similarity
Metal bindingi198 – 1981Copper A InferredBy similarity
Metal bindingi202 – 2021Copper A InferredBy similarity
Metal bindingi206 – 2061Copper A InferredBy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrion
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 29›29Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Reviewed prediction
Add
BLAST
Topological domaini51 – 6313Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 230146Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 230›230Cytochrome c oxidase subunit 2
PRO_0000183527Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8SEM9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8SEM9-1 [UniParc]FASTAAdd to Basket

« Hide

NNFFQGYNLL FQHSLFASYM DWFHAFNCSL LLGVLVFVTL LFGYLIFSTF    50
YFKSKKIEYQ FGELLCSIFP TIILLMQMVP SLSLLYYYGL MNLDSNLTVK 100
VTGHQWYWSY EYSDIPGLEF DSYMKSLDQL NLGEPRLLEV DNRCVIPCDT 150
NIRFCITSAD VIHAWALNSL SVKLDAMSGI LSTFSYSFPM VGVFYGQCSE 200
ICGANHSFMP IALEVTLLDN FKSWCFGTME 230
Length:230
Mass (Da):26,459
Last modified:June 1, 2002 - v1
Checksum:i4086C53A06107DEA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791V → I in strain: SB146. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1.
AF491509 Genomic DNA. Translation: AAM09711.1.
AF491510 Genomic DNA. Translation: AAM09712.1.
AF491511 Genomic DNA. Translation: AAM09713.1.
AF491512 Genomic DNA. Translation: AAM09714.1.
AF491513 Genomic DNA. Translation: AAM09715.1.
AF491514 Genomic DNA. Translation: AAM09716.1.
AF491515 Genomic DNA. Translation: AAM09717.1.
AF491516 Genomic DNA. Translation: AAM09718.1.
AF491517 Genomic DNA. Translation: AAM09719.1.
AF491518 Genomic DNA. Translation: AAM09720.1.
AF491519 Genomic DNA. Translation: AAM09721.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF491508 Genomic DNA. Translation: AAM09710.1 .
AF491509 Genomic DNA. Translation: AAM09711.1 .
AF491510 Genomic DNA. Translation: AAM09712.1 .
AF491511 Genomic DNA. Translation: AAM09713.1 .
AF491512 Genomic DNA. Translation: AAM09714.1 .
AF491513 Genomic DNA. Translation: AAM09715.1 .
AF491514 Genomic DNA. Translation: AAM09716.1 .
AF491515 Genomic DNA. Translation: AAM09717.1 .
AF491516 Genomic DNA. Translation: AAM09718.1 .
AF491517 Genomic DNA. Translation: AAM09719.1 .
AF491518 Genomic DNA. Translation: AAM09720.1 .
AF491519 Genomic DNA. Translation: AAM09721.1 .

3D structure databases

ProteinModelPortali Q8SEM9.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
    Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
    Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-79.
    Strain: CR1014, CR1415, CR2124, EM464, PB205, PB206, PB212, PB219, PB228, PB229, SB146 and VT733.

Entry informationi

Entry nameiCOX2_CAERE
AccessioniPrimary (citable) accession number: Q8SEM9
Secondary accession number(s): Q8SEN9, Q8SFX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi