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Protein

Ubiquitin-conjugating enzyme E2 5A

Gene

UBC5A

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • protein ubiquitination Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-OSA-5689896 Ovarian tumor domain proteases
R-OSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-OSA-9033241 Peroxisomal protein import
R-OSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 5A (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 5A
Ubiquitin carrier protein 5a
Short name:
OsUBC5a
Ubiquitin-protein ligase 5A
Gene namesi
Name:UBC5A
Ordered Locus Names:Os01g0658400, LOC_Os01g46926
ORF Names:OsJ_02884
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003976841 – 147Ubiquitin-conjugating enzyme E2 5AAdd BLAST147

Proteomic databases

PaxDbiQ8S920
PRIDEiQ8S920

Expressioni

Gene expression databases

ExpressionAtlasiQ8S920 differential
GenevisibleiQ8S920 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g46926.1

Structurei

3D structure databases

ProteinModelPortaliQ8S920
SMRiQ8S920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
InParanoidiQ8S920
KOiK06689
OMAiTDRQKYN
OrthoDBiEOG09360PU6

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8S920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRIQKEL KDLQKDPPTS CSAGPVGEDM FHWQATIMGP SDSPYAGGVF
60 70 80 90 100
LVTIHFPPDY PFKPPKVAFR TKVFHPNINS NGSICLDILK DQWSPALTIS
110 120 130 140
KVLLSICSLL TDPNPDDPLV PEIAHMYKTD RHKYENTART WTQRYAM
Length:147
Mass (Da):16,573
Last modified:June 1, 2002 - v1
Checksum:i9FAA726F5C506F09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074411 mRNA Translation: BAB89354.1
AP008207 Genomic DNA Translation: BAF05677.1
AP014957 Genomic DNA Translation: BAS73515.1
CM000138 Genomic DNA Translation: EEE55114.1
AK063826 mRNA Translation: BAG88879.1
AK099284 mRNA Translation: BAG94041.1
RefSeqiXP_015650522.1, XM_015795036.1
UniGeneiOs.8873

Genome annotation databases

EnsemblPlantsiOs01t0658400-01; Os01t0658400-01; Os01g0658400
GeneIDi4327162
GrameneiOs01t0658400-01; Os01t0658400-01; Os01g0658400
KEGGiosa:4327162

Similar proteinsi

Entry informationi

Entry nameiUBC5A_ORYSJ
AccessioniPrimary (citable) accession number: Q8S920
Secondary accession number(s): A0A0P0V661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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