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Q8S6N5

- ACC1_ORYSJ

UniProt

Q8S6N5 - ACC1_ORYSJ

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Protein
Acetyl-CoA carboxylase 1
Gene
ACC1, Os10g0363300, LOC_Os10g21910, OsJ_31236, OSJNBa0073L01.2
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation By similarity.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Biotin By similarity.
Binds 2 magnesium or manganese ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi339 – 3391Magnesium or manganese 1 By similarity
Metal bindingi353 – 3531Magnesium or manganese 1 By similarity
Metal bindingi353 – 3531Magnesium or manganese 2 By similarity
Metal bindingi355 – 3551Magnesium or manganese 2 By similarity
Active sitei357 – 3571 By similarity
Binding sitei1752 – 17521Coenzyme A By similarity
Binding sitei2053 – 20531Coenzyme A By similarity
Binding sitei2055 – 20551Coenzyme A By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi216 – 27358ATP Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA carboxylase 1 (EC:6.4.1.2)
Including the following 1 domains:
Biotin carboxylase (EC:6.3.4.14)
Gene namesi
Name:ACC1
Ordered Locus Names:Os10g0363300, LOC_Os10g21910
ORF Names:OsJ_31236, OSJNBa0073L01.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 10

Organism-specific databases

GrameneiQ8S6N5.

Subcellular locationi

Cytoplasmcytosol Inferred

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22672267Acetyl-CoA carboxylase 1
PRO_0000412213Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer Inferred.

Protein-protein interaction databases

STRINGi39947.LOC_Os10g21910.1.

Structurei

3D structure databases

ProteinModelPortaliQ8S6N5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 544507Biotin carboxylation
Add
BLAST
Domaini190 – 384195ATP-grasp
Add
BLAST
Domaini678 – 74467Biotinyl-binding
Add
BLAST
Domaini1628 – 2123496Carboxyltransferase
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0511.
HOGENOMiHOG000214115.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S6N5-1 [UniParc]FASTAAdd to Basket

« Hide

MEGSYQMNGI LNGMSNSRHP SSPSEVDEFC KALGGDSPIH SVLVANNGMA     50
AVKFMRSIRT WALETFGTEK AILLVAMATP EDLKINAEHI RIADQFVEVP 100
GGTNNNNYAN VQLIVEIAER THVSAVWPGW GHASENPELP DALKEKGIIF 150
LGPPSAAMAA LGDKIGSSLI AQAAGVPTLP WSGSHVKIPP ESCNSIPEEM 200
YRSACVSTTE EAVASCQVVG YPAMIKASWG GGGKGIRKVH NDDEVRALFK 250
QVQGEVPGSP IFIMKVASQS RHLEVQLLCD KHGNVAALHS RDCSVQRRHQ 300
KIIEEGPITV APSETVKELE QAARRLAKCV HYVGAATVEY LYSMETGEYY 350
FLELNPRLQV EHPVTEWIAE INLPAAQVVV GMGVPLYNIP EIRRFYGMEH 400
GGGYDAWRKI SAVATKFDLD NAQSVKPKGH CVAVRVTSED PDDGFKPTSG 450
RVEELNFKSK PNVWAYFSVK SGGAIHEFSD SQFGHVFAFG ESRSLAIANM 500
VLGLKEIQIR GEIRTNVDYT VDLLNAAEYR ENKIHTGWLD SRIAMRVRAE 550
RPPWYLSVVG GALYEASSRS SSVVTDYVGY LSKGQIPPKH ISLVNLTVTL 600
NIEGSKYTIE TVRRGPRSYT LRMNGSEIEA EIHSLRDGGL LMQLDGNSHV 650
IYAETEAAGT RLLINGRTCL LQKEHDPSKL LADTPCKLLR FLVADGSHVD 700
ADTPYAEVEV MKMCMPLLLP ASGVIHFVMP EGQAMQAADL IARLDLDDPS 750
SVRRAEPFHG TFPKLGPPTA VSGKVHQKFA ASVNSAHMIL AGYEHNINEV 800
VQDLLNCLDS PELPFLQWQE LMSVLATRLP KDLRNELDGK YKEYELNSDF 850
RKNKDFPAKL LRGIIEANLA YCSEKDRVTN ERLVEPLMSL VKSYEGGRES 900
HARVVVKSLF EEYLSVEELF SDNIQSDVIE RLRLQHAKDL EKVVYIVFSH 950
QGVRTKNKLI LRLMEALVYP NPSAYRDQLI RFSGLNNTVY SELALKASQL 1000
LEHTKLSELR TSIARSLSEL EMFTEEGERV STPRRKMAIN ERMEDLVGAP 1050
LAVEDALVAL FDHSDPTLQR RVVETYIRRL YQPYLVKGSV RMQWHRSGLI 1100
ALWEFSEEHI KQRNGQDAMS LKQQVEDPEE KRWGVMVVIK SLQYLSSAID 1150
AALKETSHYK AGAGNVSNGN SASSSHGNML HIALVGINNQ MSTLQDSGDE 1200
DQAQERINKI SKILKDSTVT SHLNGAGVRV VSCIIQRDEG RPPMRHSFQW 1250
SVDKIYYEED PMLRHVEPPL STFLELNKVN LDGYNEVKYT PSRDRQWHIY 1300
TLIKNKKDQR SNDQRLFLRT IVRQPGVTNG FLSGNVDNEV GRAQASSSYT 1350
SSSILRSLMA ALEEIELHAH NETVRSSYSH MYLCILRVQQ LFDLIPFSRT 1400
IDNVGQDEAT ACTLLKNMAL NIYEHVGVRM HRLSVCQWEV KLWLDCDGQA 1450
SGAWRVVVTN VTGHTCTVDI YREVEDSNTH KLFYHSVTPS LGPLHGIVLD 1500
EPYKPLDAID LKRYSARKNE TTYCYDFPLA FETALKRSWK STLSVVAEAN 1550
EHNKSYAKVT ELMFADSTGS WGTPLVPVER SPGINDIGIV AWIMKLSTPE 1600
FPSGREIIVV SNDVTFKAGS FGPREDAFFD AVTNLACERK LPLIYLSATA 1650
GARLGVAEEI KACFNVGWSD DESPERGFHY IYLTEQDYSR LSSSVIAHEL 1700
KLESGETRWV VDTIVGKEDG LGCENLHGSG AIASAYSKAY KETFTLTFVT 1750
GRAVGIGAYL ARLGMRCIQR LDQPIILTGF SALNKLLGRE VYSSHMQLGG 1800
PKIMATNGVV HLTVSDDLEG VSAILKWLSY VPPYVGGPLP IMKPLDPPDR 1850
PVTYFPENSC DARAAICGVQ DSQGKWMGGM FDRESFVETL EGWAKTVVTG 1900
RAKLGGIPVG VIAVETQTMM QVIPADPGQL DSAERVVPQA GQVWFPDSAT 1950
KTAQALLDFN REELPLFILA NWRGFSGGQR DLFEGILQAG SNIVENLRTY 2000
NQPAFVYIPM GGELRGGAWV VVDSKINPEH IEMYAERTAK GNVLEPEGLV 2050
EIKFRPKELE ECMLRLDPEL IKLSTRLREM KKENAGLSEM DTTRRSIIAR 2100
MKQLMPIYTQ VATRFAELHD TSARMAAKGV IGKVVDWEES RSFFYRRLRR 2150
RVTEDALAKE IREAAGEQLS QKSALDYIKK WYLSSNGSDG NSEKWNNDEA 2200
FFAWKDDPTN YENQLEELKA ERVSKWLSRL AESPDVKALP NGLSIVLNKM 2250
NPSKREQVID GLRQLLG 2267
Length:2,267
Mass (Da):252,809
Last modified:June 1, 2002 - v1
Checksum:i0B994DBBB3157FB1
GO

Sequence cautioni

The sequence AAP53321.2 differs from that shown. Reason: Erroneous gene model prediction.
The sequence BAF26353.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EEE50826.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000086 Genomic DNA. Translation: AAP53321.2. Sequence problems.
AC092548 Genomic DNA. Translation: AAM18728.1.
AP008216 Genomic DNA. Translation: BAF26353.1. Sequence problems.
CM000147 Genomic DNA. Translation: EEE50826.1. Sequence problems.
RefSeqiNP_001064439.1. NM_001070974.1.
UniGeneiOs.9680.

Genome annotation databases

GeneIDi4348450.
KEGGiosa:4348450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000086 Genomic DNA. Translation: AAP53321.2 . Sequence problems.
AC092548 Genomic DNA. Translation: AAM18728.1 .
AP008216 Genomic DNA. Translation: BAF26353.1 . Sequence problems.
CM000147 Genomic DNA. Translation: EEE50826.1 . Sequence problems.
RefSeqi NP_001064439.1. NM_001070974.1.
UniGenei Os.9680.

3D structure databases

ProteinModelPortali Q8S6N5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os10g21910.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4348450.
KEGGi osa:4348450.

Organism-specific databases

Gramenei Q8S6N5.

Phylogenomic databases

eggNOGi COG0511.
HOGENOMi HOG000214115.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProi IPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
    Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
    , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
    Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiACC1_ORYSJ
AccessioniPrimary (citable) accession number: Q8S6N5
Secondary accession number(s): B9G5C9, Q0IY62, Q7G3D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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