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Protein

Acetyl-CoA carboxylase 1

Gene

ACC1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.By similarity
ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.By similarity

Cofactori

Protein has several cofactor binding sites:
  • biotinBy similarity
  • Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-CoA carboxylase 1 (ACC1), Acetyl-CoA carboxylase 2 (ACC2)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi339Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi353Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi353Magnesium or manganese 2PROSITE-ProRule annotation1
Metal bindingi355Magnesium or manganese 2PROSITE-ProRule annotation1
Active sitei357By similarity1
Binding sitei1752Coenzyme ABy similarity1
Binding sitei2053Coenzyme ABy similarity1
Binding sitei2055Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 273ATPPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Ligase, Multifunctional enzyme
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-163765 ChREBP activates metabolic gene expression
R-OSA-196780 Biotin transport and metabolism
R-OSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-OSA-75105 Fatty acyl-CoA biosynthesis
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA carboxylase 1 (EC:6.4.1.2)
Including the following 1 domains:
Biotin carboxylase (EC:6.3.4.14)
Gene namesi
Name:ACC1
Ordered Locus Names:Os10g0363300, LOC_Os10g21910
ORF Names:OsJ_31236, OSJNBa0073L01.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122131 – 2267Acetyl-CoA carboxylase 1Add BLAST2267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei712N6-biotinyllysinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8S6N5
PRIDEiQ8S6N5

Expressioni

Gene expression databases

ExpressionAtlasiQ8S6N5 differential
GenevisibleiQ8S6N5 OS

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi39947.LOC_Os10g21910.1

Structurei

3D structure databases

ProteinModelPortaliQ8S6N5
SMRiQ8S6N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 544Biotin carboxylationAdd BLAST507
Domaini190 – 384ATP-graspPROSITE-ProRule annotationAdd BLAST195
Domaini671 – 745Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST75
Domaini1502 – 1843CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST342
Domaini1847 – 2163CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST317

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1502 – 2163CarboxyltransferasePROSITE-ProRule annotationAdd BLAST662

Phylogenomic databases

eggNOGiKOG0368 Eukaryota
COG0439 LUCA
COG0511 LUCA
COG4799 LUCA
HOGENOMiHOG000214115
InParanoidiQ8S6N5
KOiK11262
OrthoDBiEOG0936001E

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR013537 AcCoA_COase_cen
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
IPR011762 COA_CT_N
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF08326 ACC_central, 1 hit
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF01039 Carboxyl_trans, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52096 SSF52096, 2 hits
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS50989 COA_CT_CTER, 1 hit
PS50980 COA_CT_NTER, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8S6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSYQMNGI LNGMSNSRHP SSPSEVDEFC KALGGDSPIH SVLVANNGMA
60 70 80 90 100
AVKFMRSIRT WALETFGTEK AILLVAMATP EDLKINAEHI RIADQFVEVP
110 120 130 140 150
GGTNNNNYAN VQLIVEIAER THVSAVWPGW GHASENPELP DALKEKGIIF
160 170 180 190 200
LGPPSAAMAA LGDKIGSSLI AQAAGVPTLP WSGSHVKIPP ESCNSIPEEM
210 220 230 240 250
YRSACVSTTE EAVASCQVVG YPAMIKASWG GGGKGIRKVH NDDEVRALFK
260 270 280 290 300
QVQGEVPGSP IFIMKVASQS RHLEVQLLCD KHGNVAALHS RDCSVQRRHQ
310 320 330 340 350
KIIEEGPITV APSETVKELE QAARRLAKCV HYVGAATVEY LYSMETGEYY
360 370 380 390 400
FLELNPRLQV EHPVTEWIAE INLPAAQVVV GMGVPLYNIP EIRRFYGMEH
410 420 430 440 450
GGGYDAWRKI SAVATKFDLD NAQSVKPKGH CVAVRVTSED PDDGFKPTSG
460 470 480 490 500
RVEELNFKSK PNVWAYFSVK SGGAIHEFSD SQFGHVFAFG ESRSLAIANM
510 520 530 540 550
VLGLKEIQIR GEIRTNVDYT VDLLNAAEYR ENKIHTGWLD SRIAMRVRAE
560 570 580 590 600
RPPWYLSVVG GALYEASSRS SSVVTDYVGY LSKGQIPPKH ISLVNLTVTL
610 620 630 640 650
NIEGSKYTIE TVRRGPRSYT LRMNGSEIEA EIHSLRDGGL LMQLDGNSHV
660 670 680 690 700
IYAETEAAGT RLLINGRTCL LQKEHDPSKL LADTPCKLLR FLVADGSHVD
710 720 730 740 750
ADTPYAEVEV MKMCMPLLLP ASGVIHFVMP EGQAMQAADL IARLDLDDPS
760 770 780 790 800
SVRRAEPFHG TFPKLGPPTA VSGKVHQKFA ASVNSAHMIL AGYEHNINEV
810 820 830 840 850
VQDLLNCLDS PELPFLQWQE LMSVLATRLP KDLRNELDGK YKEYELNSDF
860 870 880 890 900
RKNKDFPAKL LRGIIEANLA YCSEKDRVTN ERLVEPLMSL VKSYEGGRES
910 920 930 940 950
HARVVVKSLF EEYLSVEELF SDNIQSDVIE RLRLQHAKDL EKVVYIVFSH
960 970 980 990 1000
QGVRTKNKLI LRLMEALVYP NPSAYRDQLI RFSGLNNTVY SELALKASQL
1010 1020 1030 1040 1050
LEHTKLSELR TSIARSLSEL EMFTEEGERV STPRRKMAIN ERMEDLVGAP
1060 1070 1080 1090 1100
LAVEDALVAL FDHSDPTLQR RVVETYIRRL YQPYLVKGSV RMQWHRSGLI
1110 1120 1130 1140 1150
ALWEFSEEHI KQRNGQDAMS LKQQVEDPEE KRWGVMVVIK SLQYLSSAID
1160 1170 1180 1190 1200
AALKETSHYK AGAGNVSNGN SASSSHGNML HIALVGINNQ MSTLQDSGDE
1210 1220 1230 1240 1250
DQAQERINKI SKILKDSTVT SHLNGAGVRV VSCIIQRDEG RPPMRHSFQW
1260 1270 1280 1290 1300
SVDKIYYEED PMLRHVEPPL STFLELNKVN LDGYNEVKYT PSRDRQWHIY
1310 1320 1330 1340 1350
TLIKNKKDQR SNDQRLFLRT IVRQPGVTNG FLSGNVDNEV GRAQASSSYT
1360 1370 1380 1390 1400
SSSILRSLMA ALEEIELHAH NETVRSSYSH MYLCILRVQQ LFDLIPFSRT
1410 1420 1430 1440 1450
IDNVGQDEAT ACTLLKNMAL NIYEHVGVRM HRLSVCQWEV KLWLDCDGQA
1460 1470 1480 1490 1500
SGAWRVVVTN VTGHTCTVDI YREVEDSNTH KLFYHSVTPS LGPLHGIVLD
1510 1520 1530 1540 1550
EPYKPLDAID LKRYSARKNE TTYCYDFPLA FETALKRSWK STLSVVAEAN
1560 1570 1580 1590 1600
EHNKSYAKVT ELMFADSTGS WGTPLVPVER SPGINDIGIV AWIMKLSTPE
1610 1620 1630 1640 1650
FPSGREIIVV SNDVTFKAGS FGPREDAFFD AVTNLACERK LPLIYLSATA
1660 1670 1680 1690 1700
GARLGVAEEI KACFNVGWSD DESPERGFHY IYLTEQDYSR LSSSVIAHEL
1710 1720 1730 1740 1750
KLESGETRWV VDTIVGKEDG LGCENLHGSG AIASAYSKAY KETFTLTFVT
1760 1770 1780 1790 1800
GRAVGIGAYL ARLGMRCIQR LDQPIILTGF SALNKLLGRE VYSSHMQLGG
1810 1820 1830 1840 1850
PKIMATNGVV HLTVSDDLEG VSAILKWLSY VPPYVGGPLP IMKPLDPPDR
1860 1870 1880 1890 1900
PVTYFPENSC DARAAICGVQ DSQGKWMGGM FDRESFVETL EGWAKTVVTG
1910 1920 1930 1940 1950
RAKLGGIPVG VIAVETQTMM QVIPADPGQL DSAERVVPQA GQVWFPDSAT
1960 1970 1980 1990 2000
KTAQALLDFN REELPLFILA NWRGFSGGQR DLFEGILQAG SNIVENLRTY
2010 2020 2030 2040 2050
NQPAFVYIPM GGELRGGAWV VVDSKINPEH IEMYAERTAK GNVLEPEGLV
2060 2070 2080 2090 2100
EIKFRPKELE ECMLRLDPEL IKLSTRLREM KKENAGLSEM DTTRRSIIAR
2110 2120 2130 2140 2150
MKQLMPIYTQ VATRFAELHD TSARMAAKGV IGKVVDWEES RSFFYRRLRR
2160 2170 2180 2190 2200
RVTEDALAKE IREAAGEQLS QKSALDYIKK WYLSSNGSDG NSEKWNNDEA
2210 2220 2230 2240 2250
FFAWKDDPTN YENQLEELKA ERVSKWLSRL AESPDVKALP NGLSIVLNKM
2260
NPSKREQVID GLRQLLG
Length:2,267
Mass (Da):252,809
Last modified:June 1, 2002 - v1
Checksum:i0B994DBBB3157FB1
GO

Sequence cautioni

The sequence AAP53321 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF26353 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EEE50826 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092548 Genomic DNA Translation: AAM18728.1
DP000086 Genomic DNA Translation: AAP53321.2 Sequence problems.
AP008216 Genomic DNA Translation: BAF26353.1 Sequence problems.
AP014966 Genomic DNA No translation available.
CM000147 Genomic DNA Translation: EEE50826.1 Sequence problems.
RefSeqiXP_015614129.1, XM_015758643.1
XP_015614130.1, XM_015758644.1
UniGeneiOs.9680

Genome annotation databases

EnsemblPlantsiOs10t0363300-01; Os10t0363300-01; Os10g0363300
GeneIDi4348450
GrameneiOs10t0363300-01; Os10t0363300-01; Os10g0363300
KEGGiosa:4348450

Similar proteinsi

Entry informationi

Entry nameiACC1_ORYSJ
AccessioniPrimary (citable) accession number: Q8S6N5
Secondary accession number(s): B9G5C9, Q0IY62, Q7G3D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations

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