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Q8S6N5 (ACC1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA carboxylase 1

EC=6.4.1.2

Including the following 1 domains:

  1. Biotin carboxylase
    EC=6.3.4.14
Gene names
Name:ACC1
Ordered Locus Names:Os10g0363300, LOC_Os10g21910
ORF Names:OsJ_31236, OSJNBa0073L01.2
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length2267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation By similarity.

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactor

Biotin By similarity.

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Subunit structure

Homodimer Probable.

Subcellular location

Cytoplasmcytosol Probable.

Sequence similarities

Contains 1 ATP-grasp domain.

Contains 1 biotin carboxylation domain.

Contains 1 biotinyl-binding domain.

Contains 1 carboxyltransferase domain.

Sequence caution

The sequence AAP53321.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAF26353.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence EEE50826.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22672267Acetyl-CoA carboxylase 1
PRO_0000412213

Regions

Domain38 – 544507Biotin carboxylation
Domain190 – 384195ATP-grasp
Domain678 – 74467Biotinyl-binding
Domain1628 – 2123496Carboxyltransferase
Nucleotide binding216 – 27358ATP Potential

Sites

Active site3571 By similarity
Metal binding3391Magnesium or manganese 1 By similarity
Metal binding3531Magnesium or manganese 1 By similarity
Metal binding3531Magnesium or manganese 2 By similarity
Metal binding3551Magnesium or manganese 2 By similarity
Binding site17521Coenzyme A By similarity
Binding site20531Coenzyme A By similarity
Binding site20551Coenzyme A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8S6N5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 0B994DBBB3157FB1

FASTA2,267252,809
        10         20         30         40         50         60 
MEGSYQMNGI LNGMSNSRHP SSPSEVDEFC KALGGDSPIH SVLVANNGMA AVKFMRSIRT 

        70         80         90        100        110        120 
WALETFGTEK AILLVAMATP EDLKINAEHI RIADQFVEVP GGTNNNNYAN VQLIVEIAER 

       130        140        150        160        170        180 
THVSAVWPGW GHASENPELP DALKEKGIIF LGPPSAAMAA LGDKIGSSLI AQAAGVPTLP 

       190        200        210        220        230        240 
WSGSHVKIPP ESCNSIPEEM YRSACVSTTE EAVASCQVVG YPAMIKASWG GGGKGIRKVH 

       250        260        270        280        290        300 
NDDEVRALFK QVQGEVPGSP IFIMKVASQS RHLEVQLLCD KHGNVAALHS RDCSVQRRHQ 

       310        320        330        340        350        360 
KIIEEGPITV APSETVKELE QAARRLAKCV HYVGAATVEY LYSMETGEYY FLELNPRLQV 

       370        380        390        400        410        420 
EHPVTEWIAE INLPAAQVVV GMGVPLYNIP EIRRFYGMEH GGGYDAWRKI SAVATKFDLD 

       430        440        450        460        470        480 
NAQSVKPKGH CVAVRVTSED PDDGFKPTSG RVEELNFKSK PNVWAYFSVK SGGAIHEFSD 

       490        500        510        520        530        540 
SQFGHVFAFG ESRSLAIANM VLGLKEIQIR GEIRTNVDYT VDLLNAAEYR ENKIHTGWLD 

       550        560        570        580        590        600 
SRIAMRVRAE RPPWYLSVVG GALYEASSRS SSVVTDYVGY LSKGQIPPKH ISLVNLTVTL 

       610        620        630        640        650        660 
NIEGSKYTIE TVRRGPRSYT LRMNGSEIEA EIHSLRDGGL LMQLDGNSHV IYAETEAAGT 

       670        680        690        700        710        720 
RLLINGRTCL LQKEHDPSKL LADTPCKLLR FLVADGSHVD ADTPYAEVEV MKMCMPLLLP 

       730        740        750        760        770        780 
ASGVIHFVMP EGQAMQAADL IARLDLDDPS SVRRAEPFHG TFPKLGPPTA VSGKVHQKFA 

       790        800        810        820        830        840 
ASVNSAHMIL AGYEHNINEV VQDLLNCLDS PELPFLQWQE LMSVLATRLP KDLRNELDGK 

       850        860        870        880        890        900 
YKEYELNSDF RKNKDFPAKL LRGIIEANLA YCSEKDRVTN ERLVEPLMSL VKSYEGGRES 

       910        920        930        940        950        960 
HARVVVKSLF EEYLSVEELF SDNIQSDVIE RLRLQHAKDL EKVVYIVFSH QGVRTKNKLI 

       970        980        990       1000       1010       1020 
LRLMEALVYP NPSAYRDQLI RFSGLNNTVY SELALKASQL LEHTKLSELR TSIARSLSEL 

      1030       1040       1050       1060       1070       1080 
EMFTEEGERV STPRRKMAIN ERMEDLVGAP LAVEDALVAL FDHSDPTLQR RVVETYIRRL 

      1090       1100       1110       1120       1130       1140 
YQPYLVKGSV RMQWHRSGLI ALWEFSEEHI KQRNGQDAMS LKQQVEDPEE KRWGVMVVIK 

      1150       1160       1170       1180       1190       1200 
SLQYLSSAID AALKETSHYK AGAGNVSNGN SASSSHGNML HIALVGINNQ MSTLQDSGDE 

      1210       1220       1230       1240       1250       1260 
DQAQERINKI SKILKDSTVT SHLNGAGVRV VSCIIQRDEG RPPMRHSFQW SVDKIYYEED 

      1270       1280       1290       1300       1310       1320 
PMLRHVEPPL STFLELNKVN LDGYNEVKYT PSRDRQWHIY TLIKNKKDQR SNDQRLFLRT 

      1330       1340       1350       1360       1370       1380 
IVRQPGVTNG FLSGNVDNEV GRAQASSSYT SSSILRSLMA ALEEIELHAH NETVRSSYSH 

      1390       1400       1410       1420       1430       1440 
MYLCILRVQQ LFDLIPFSRT IDNVGQDEAT ACTLLKNMAL NIYEHVGVRM HRLSVCQWEV 

      1450       1460       1470       1480       1490       1500 
KLWLDCDGQA SGAWRVVVTN VTGHTCTVDI YREVEDSNTH KLFYHSVTPS LGPLHGIVLD 

      1510       1520       1530       1540       1550       1560 
EPYKPLDAID LKRYSARKNE TTYCYDFPLA FETALKRSWK STLSVVAEAN EHNKSYAKVT 

      1570       1580       1590       1600       1610       1620 
ELMFADSTGS WGTPLVPVER SPGINDIGIV AWIMKLSTPE FPSGREIIVV SNDVTFKAGS 

      1630       1640       1650       1660       1670       1680 
FGPREDAFFD AVTNLACERK LPLIYLSATA GARLGVAEEI KACFNVGWSD DESPERGFHY 

      1690       1700       1710       1720       1730       1740 
IYLTEQDYSR LSSSVIAHEL KLESGETRWV VDTIVGKEDG LGCENLHGSG AIASAYSKAY 

      1750       1760       1770       1780       1790       1800 
KETFTLTFVT GRAVGIGAYL ARLGMRCIQR LDQPIILTGF SALNKLLGRE VYSSHMQLGG 

      1810       1820       1830       1840       1850       1860 
PKIMATNGVV HLTVSDDLEG VSAILKWLSY VPPYVGGPLP IMKPLDPPDR PVTYFPENSC 

      1870       1880       1890       1900       1910       1920 
DARAAICGVQ DSQGKWMGGM FDRESFVETL EGWAKTVVTG RAKLGGIPVG VIAVETQTMM 

      1930       1940       1950       1960       1970       1980 
QVIPADPGQL DSAERVVPQA GQVWFPDSAT KTAQALLDFN REELPLFILA NWRGFSGGQR 

      1990       2000       2010       2020       2030       2040 
DLFEGILQAG SNIVENLRTY NQPAFVYIPM GGELRGGAWV VVDSKINPEH IEMYAERTAK 

      2050       2060       2070       2080       2090       2100 
GNVLEPEGLV EIKFRPKELE ECMLRLDPEL IKLSTRLREM KKENAGLSEM DTTRRSIIAR 

      2110       2120       2130       2140       2150       2160 
MKQLMPIYTQ VATRFAELHD TSARMAAKGV IGKVVDWEES RSFFYRRLRR RVTEDALAKE 

      2170       2180       2190       2200       2210       2220 
IREAAGEQLS QKSALDYIKK WYLSSNGSDG NSEKWNNDEA FFAWKDDPTN YENQLEELKA 

      2230       2240       2250       2260 
ERVSKWLSRL AESPDVKALP NGLSIVLNKM NPSKREQVID GLRQLLG 

« Hide

References

« Hide 'large scale' references
[1]"In-depth view of structure, activity, and evolution of rice chromosome 10."
Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H. expand/collapse author list , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000086 Genomic DNA. Translation: AAP53321.2. Sequence problems.
AC092548 Genomic DNA. Translation: AAM18728.1.
AP008216 Genomic DNA. Translation: BAF26353.1. Sequence problems.
CM000147 Genomic DNA. Translation: EEE50826.1. Sequence problems.
RefSeqNP_001064439.1. NM_001070974.1.
UniGeneOs.9680.

3D structure databases

ProteinModelPortalQ8S6N5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os10g21910.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4348450.
KEGGosa:4348450.

Organism-specific databases

GrameneQ8S6N5.

Phylogenomic databases

eggNOGCOG0511.
HOGENOMHOG000214115.
ProtClustDBCLSN2695491.

Enzyme and pathway databases

UniPathwayUPA00655; UER00711.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACC1_ORYSJ
AccessionPrimary (citable) accession number: Q8S6N5
Secondary accession number(s): B9G5C9, Q0IY62, Q7G3D3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways