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Q8S6N5

- ACC1_ORYSJ

UniProt

Q8S6N5 - ACC1_ORYSJ

Protein

Acetyl-CoA carboxylase 1

Gene

ACC1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.By similarity

    Catalytic activityi

    ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
    ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

    Cofactori

    Biotin.By similarity
    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi339 – 3391Magnesium or manganese 1PROSITE-ProRule annotation
    Metal bindingi353 – 3531Magnesium or manganese 1PROSITE-ProRule annotation
    Metal bindingi353 – 3531Magnesium or manganese 2PROSITE-ProRule annotation
    Metal bindingi355 – 3551Magnesium or manganese 2PROSITE-ProRule annotation
    Active sitei357 – 3571By similarity
    Binding sitei1752 – 17521Coenzyme ABy similarity
    Binding sitei2053 – 20531Coenzyme ABy similarity
    Binding sitei2055 – 20551Coenzyme ABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi216 – 27358ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. biotin carboxylase activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00655; UER00711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA carboxylase 1 (EC:6.4.1.2)
    Including the following 1 domains:
    Biotin carboxylase (EC:6.3.4.14)
    Gene namesi
    Name:ACC1
    Ordered Locus Names:Os10g0363300, LOC_Os10g21910
    ORF Names:OsJ_31236, OSJNBa0073L01.2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 10

    Organism-specific databases

    GrameneiQ8S6N5.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22672267Acetyl-CoA carboxylase 1PRO_0000412213Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi39947.LOC_Os10g21910.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8S6N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 544507Biotin carboxylationAdd
    BLAST
    Domaini190 – 384195ATP-graspPROSITE-ProRule annotationAdd
    BLAST
    Domaini678 – 74467Biotinyl-bindingAdd
    BLAST
    Domaini1628 – 2123496CarboxyltransferaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
    Contains 1 biotin carboxylation domain.Curated
    Contains 1 biotinyl-binding domain.Curated
    Contains 1 carboxyltransferase domain.Curated

    Phylogenomic databases

    eggNOGiCOG0511.
    HOGENOMiHOG000214115.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProiIPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8S6N5-1 [UniParc]FASTAAdd to Basket

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    MEGSYQMNGI LNGMSNSRHP SSPSEVDEFC KALGGDSPIH SVLVANNGMA     50
    AVKFMRSIRT WALETFGTEK AILLVAMATP EDLKINAEHI RIADQFVEVP 100
    GGTNNNNYAN VQLIVEIAER THVSAVWPGW GHASENPELP DALKEKGIIF 150
    LGPPSAAMAA LGDKIGSSLI AQAAGVPTLP WSGSHVKIPP ESCNSIPEEM 200
    YRSACVSTTE EAVASCQVVG YPAMIKASWG GGGKGIRKVH NDDEVRALFK 250
    QVQGEVPGSP IFIMKVASQS RHLEVQLLCD KHGNVAALHS RDCSVQRRHQ 300
    KIIEEGPITV APSETVKELE QAARRLAKCV HYVGAATVEY LYSMETGEYY 350
    FLELNPRLQV EHPVTEWIAE INLPAAQVVV GMGVPLYNIP EIRRFYGMEH 400
    GGGYDAWRKI SAVATKFDLD NAQSVKPKGH CVAVRVTSED PDDGFKPTSG 450
    RVEELNFKSK PNVWAYFSVK SGGAIHEFSD SQFGHVFAFG ESRSLAIANM 500
    VLGLKEIQIR GEIRTNVDYT VDLLNAAEYR ENKIHTGWLD SRIAMRVRAE 550
    RPPWYLSVVG GALYEASSRS SSVVTDYVGY LSKGQIPPKH ISLVNLTVTL 600
    NIEGSKYTIE TVRRGPRSYT LRMNGSEIEA EIHSLRDGGL LMQLDGNSHV 650
    IYAETEAAGT RLLINGRTCL LQKEHDPSKL LADTPCKLLR FLVADGSHVD 700
    ADTPYAEVEV MKMCMPLLLP ASGVIHFVMP EGQAMQAADL IARLDLDDPS 750
    SVRRAEPFHG TFPKLGPPTA VSGKVHQKFA ASVNSAHMIL AGYEHNINEV 800
    VQDLLNCLDS PELPFLQWQE LMSVLATRLP KDLRNELDGK YKEYELNSDF 850
    RKNKDFPAKL LRGIIEANLA YCSEKDRVTN ERLVEPLMSL VKSYEGGRES 900
    HARVVVKSLF EEYLSVEELF SDNIQSDVIE RLRLQHAKDL EKVVYIVFSH 950
    QGVRTKNKLI LRLMEALVYP NPSAYRDQLI RFSGLNNTVY SELALKASQL 1000
    LEHTKLSELR TSIARSLSEL EMFTEEGERV STPRRKMAIN ERMEDLVGAP 1050
    LAVEDALVAL FDHSDPTLQR RVVETYIRRL YQPYLVKGSV RMQWHRSGLI 1100
    ALWEFSEEHI KQRNGQDAMS LKQQVEDPEE KRWGVMVVIK SLQYLSSAID 1150
    AALKETSHYK AGAGNVSNGN SASSSHGNML HIALVGINNQ MSTLQDSGDE 1200
    DQAQERINKI SKILKDSTVT SHLNGAGVRV VSCIIQRDEG RPPMRHSFQW 1250
    SVDKIYYEED PMLRHVEPPL STFLELNKVN LDGYNEVKYT PSRDRQWHIY 1300
    TLIKNKKDQR SNDQRLFLRT IVRQPGVTNG FLSGNVDNEV GRAQASSSYT 1350
    SSSILRSLMA ALEEIELHAH NETVRSSYSH MYLCILRVQQ LFDLIPFSRT 1400
    IDNVGQDEAT ACTLLKNMAL NIYEHVGVRM HRLSVCQWEV KLWLDCDGQA 1450
    SGAWRVVVTN VTGHTCTVDI YREVEDSNTH KLFYHSVTPS LGPLHGIVLD 1500
    EPYKPLDAID LKRYSARKNE TTYCYDFPLA FETALKRSWK STLSVVAEAN 1550
    EHNKSYAKVT ELMFADSTGS WGTPLVPVER SPGINDIGIV AWIMKLSTPE 1600
    FPSGREIIVV SNDVTFKAGS FGPREDAFFD AVTNLACERK LPLIYLSATA 1650
    GARLGVAEEI KACFNVGWSD DESPERGFHY IYLTEQDYSR LSSSVIAHEL 1700
    KLESGETRWV VDTIVGKEDG LGCENLHGSG AIASAYSKAY KETFTLTFVT 1750
    GRAVGIGAYL ARLGMRCIQR LDQPIILTGF SALNKLLGRE VYSSHMQLGG 1800
    PKIMATNGVV HLTVSDDLEG VSAILKWLSY VPPYVGGPLP IMKPLDPPDR 1850
    PVTYFPENSC DARAAICGVQ DSQGKWMGGM FDRESFVETL EGWAKTVVTG 1900
    RAKLGGIPVG VIAVETQTMM QVIPADPGQL DSAERVVPQA GQVWFPDSAT 1950
    KTAQALLDFN REELPLFILA NWRGFSGGQR DLFEGILQAG SNIVENLRTY 2000
    NQPAFVYIPM GGELRGGAWV VVDSKINPEH IEMYAERTAK GNVLEPEGLV 2050
    EIKFRPKELE ECMLRLDPEL IKLSTRLREM KKENAGLSEM DTTRRSIIAR 2100
    MKQLMPIYTQ VATRFAELHD TSARMAAKGV IGKVVDWEES RSFFYRRLRR 2150
    RVTEDALAKE IREAAGEQLS QKSALDYIKK WYLSSNGSDG NSEKWNNDEA 2200
    FFAWKDDPTN YENQLEELKA ERVSKWLSRL AESPDVKALP NGLSIVLNKM 2250
    NPSKREQVID GLRQLLG 2267
    Length:2,267
    Mass (Da):252,809
    Last modified:June 1, 2002 - v1
    Checksum:i0B994DBBB3157FB1
    GO

    Sequence cautioni

    The sequence AAP53321.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence BAF26353.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EEE50826.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000086 Genomic DNA. Translation: AAP53321.2. Sequence problems.
    AC092548 Genomic DNA. Translation: AAM18728.1.
    AP008216 Genomic DNA. Translation: BAF26353.1. Sequence problems.
    CM000147 Genomic DNA. Translation: EEE50826.1. Sequence problems.
    RefSeqiNP_001064439.1. NM_001070974.1.
    UniGeneiOs.9680.

    Genome annotation databases

    GeneIDi4348450.
    KEGGiosa:4348450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000086 Genomic DNA. Translation: AAP53321.2 . Sequence problems.
    AC092548 Genomic DNA. Translation: AAM18728.1 .
    AP008216 Genomic DNA. Translation: BAF26353.1 . Sequence problems.
    CM000147 Genomic DNA. Translation: EEE50826.1 . Sequence problems.
    RefSeqi NP_001064439.1. NM_001070974.1.
    UniGenei Os.9680.

    3D structure databases

    ProteinModelPortali Q8S6N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os10g21910.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4348450.
    KEGGi osa:4348450.

    Organism-specific databases

    Gramenei Q8S6N5.

    Phylogenomic databases

    eggNOGi COG0511.
    HOGENOMi HOG000214115.

    Enzyme and pathway databases

    UniPathwayi UPA00655 ; UER00711 .

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProi IPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
      Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
      , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
      Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiACC1_ORYSJ
    AccessioniPrimary (citable) accession number: Q8S6N5
    Secondary accession number(s): B9G5C9, Q0IY62, Q7G3D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3