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Q8S6N5

- ACC1_ORYSJ

UniProt

Q8S6N5 - ACC1_ORYSJ

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Protein

Acetyl-CoA carboxylase 1

Gene

ACC1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation.By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Protein has several cofactor binding sites:
  • biotinBy similarityNote: Biotin.By similarity
  • Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi339 – 3391Magnesium or manganese 1PROSITE-ProRule annotation
Metal bindingi353 – 3531Magnesium or manganese 1PROSITE-ProRule annotation
Metal bindingi353 – 3531Magnesium or manganese 2PROSITE-ProRule annotation
Metal bindingi355 – 3551Magnesium or manganese 2PROSITE-ProRule annotation
Active sitei357 – 3571By similarity
Binding sitei1752 – 17521Coenzyme ABy similarity
Binding sitei2053 – 20531Coenzyme ABy similarity
Binding sitei2055 – 20551Coenzyme ABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi216 – 27358ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. biotin carboxylase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA carboxylase 1 (EC:6.4.1.2)
Including the following 1 domains:
Biotin carboxylase (EC:6.3.4.14)
Gene namesi
Name:ACC1
Ordered Locus Names:Os10g0363300, LOC_Os10g21910
ORF Names:OsJ_31236, OSJNBa0073L01.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 10

Organism-specific databases

GrameneiQ8S6N5.

Subcellular locationi

Cytoplasmcytosol Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22672267Acetyl-CoA carboxylase 1PRO_0000412213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei712 – 7121N6-biotinyllysinePROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi39947.LOC_Os10g21910.1.

Structurei

3D structure databases

ProteinModelPortaliQ8S6N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 544507Biotin carboxylationAdd
BLAST
Domaini190 – 384195ATP-graspPROSITE-ProRule annotationAdd
BLAST
Domaini671 – 74575Biotinyl-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1628 – 2123496CarboxyltransferaseAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
Contains 1 biotin carboxylation domain.Curated
Contains 1 biotinyl-binding domain.CuratedPROSITE-ProRule annotation
Contains 1 carboxyltransferase domain.Curated

Phylogenomic databases

eggNOGiCOG0511.
HOGENOMiHOG000214115.
InParanoidiQ8S6N5.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S6N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGSYQMNGI LNGMSNSRHP SSPSEVDEFC KALGGDSPIH SVLVANNGMA
60 70 80 90 100
AVKFMRSIRT WALETFGTEK AILLVAMATP EDLKINAEHI RIADQFVEVP
110 120 130 140 150
GGTNNNNYAN VQLIVEIAER THVSAVWPGW GHASENPELP DALKEKGIIF
160 170 180 190 200
LGPPSAAMAA LGDKIGSSLI AQAAGVPTLP WSGSHVKIPP ESCNSIPEEM
210 220 230 240 250
YRSACVSTTE EAVASCQVVG YPAMIKASWG GGGKGIRKVH NDDEVRALFK
260 270 280 290 300
QVQGEVPGSP IFIMKVASQS RHLEVQLLCD KHGNVAALHS RDCSVQRRHQ
310 320 330 340 350
KIIEEGPITV APSETVKELE QAARRLAKCV HYVGAATVEY LYSMETGEYY
360 370 380 390 400
FLELNPRLQV EHPVTEWIAE INLPAAQVVV GMGVPLYNIP EIRRFYGMEH
410 420 430 440 450
GGGYDAWRKI SAVATKFDLD NAQSVKPKGH CVAVRVTSED PDDGFKPTSG
460 470 480 490 500
RVEELNFKSK PNVWAYFSVK SGGAIHEFSD SQFGHVFAFG ESRSLAIANM
510 520 530 540 550
VLGLKEIQIR GEIRTNVDYT VDLLNAAEYR ENKIHTGWLD SRIAMRVRAE
560 570 580 590 600
RPPWYLSVVG GALYEASSRS SSVVTDYVGY LSKGQIPPKH ISLVNLTVTL
610 620 630 640 650
NIEGSKYTIE TVRRGPRSYT LRMNGSEIEA EIHSLRDGGL LMQLDGNSHV
660 670 680 690 700
IYAETEAAGT RLLINGRTCL LQKEHDPSKL LADTPCKLLR FLVADGSHVD
710 720 730 740 750
ADTPYAEVEV MKMCMPLLLP ASGVIHFVMP EGQAMQAADL IARLDLDDPS
760 770 780 790 800
SVRRAEPFHG TFPKLGPPTA VSGKVHQKFA ASVNSAHMIL AGYEHNINEV
810 820 830 840 850
VQDLLNCLDS PELPFLQWQE LMSVLATRLP KDLRNELDGK YKEYELNSDF
860 870 880 890 900
RKNKDFPAKL LRGIIEANLA YCSEKDRVTN ERLVEPLMSL VKSYEGGRES
910 920 930 940 950
HARVVVKSLF EEYLSVEELF SDNIQSDVIE RLRLQHAKDL EKVVYIVFSH
960 970 980 990 1000
QGVRTKNKLI LRLMEALVYP NPSAYRDQLI RFSGLNNTVY SELALKASQL
1010 1020 1030 1040 1050
LEHTKLSELR TSIARSLSEL EMFTEEGERV STPRRKMAIN ERMEDLVGAP
1060 1070 1080 1090 1100
LAVEDALVAL FDHSDPTLQR RVVETYIRRL YQPYLVKGSV RMQWHRSGLI
1110 1120 1130 1140 1150
ALWEFSEEHI KQRNGQDAMS LKQQVEDPEE KRWGVMVVIK SLQYLSSAID
1160 1170 1180 1190 1200
AALKETSHYK AGAGNVSNGN SASSSHGNML HIALVGINNQ MSTLQDSGDE
1210 1220 1230 1240 1250
DQAQERINKI SKILKDSTVT SHLNGAGVRV VSCIIQRDEG RPPMRHSFQW
1260 1270 1280 1290 1300
SVDKIYYEED PMLRHVEPPL STFLELNKVN LDGYNEVKYT PSRDRQWHIY
1310 1320 1330 1340 1350
TLIKNKKDQR SNDQRLFLRT IVRQPGVTNG FLSGNVDNEV GRAQASSSYT
1360 1370 1380 1390 1400
SSSILRSLMA ALEEIELHAH NETVRSSYSH MYLCILRVQQ LFDLIPFSRT
1410 1420 1430 1440 1450
IDNVGQDEAT ACTLLKNMAL NIYEHVGVRM HRLSVCQWEV KLWLDCDGQA
1460 1470 1480 1490 1500
SGAWRVVVTN VTGHTCTVDI YREVEDSNTH KLFYHSVTPS LGPLHGIVLD
1510 1520 1530 1540 1550
EPYKPLDAID LKRYSARKNE TTYCYDFPLA FETALKRSWK STLSVVAEAN
1560 1570 1580 1590 1600
EHNKSYAKVT ELMFADSTGS WGTPLVPVER SPGINDIGIV AWIMKLSTPE
1610 1620 1630 1640 1650
FPSGREIIVV SNDVTFKAGS FGPREDAFFD AVTNLACERK LPLIYLSATA
1660 1670 1680 1690 1700
GARLGVAEEI KACFNVGWSD DESPERGFHY IYLTEQDYSR LSSSVIAHEL
1710 1720 1730 1740 1750
KLESGETRWV VDTIVGKEDG LGCENLHGSG AIASAYSKAY KETFTLTFVT
1760 1770 1780 1790 1800
GRAVGIGAYL ARLGMRCIQR LDQPIILTGF SALNKLLGRE VYSSHMQLGG
1810 1820 1830 1840 1850
PKIMATNGVV HLTVSDDLEG VSAILKWLSY VPPYVGGPLP IMKPLDPPDR
1860 1870 1880 1890 1900
PVTYFPENSC DARAAICGVQ DSQGKWMGGM FDRESFVETL EGWAKTVVTG
1910 1920 1930 1940 1950
RAKLGGIPVG VIAVETQTMM QVIPADPGQL DSAERVVPQA GQVWFPDSAT
1960 1970 1980 1990 2000
KTAQALLDFN REELPLFILA NWRGFSGGQR DLFEGILQAG SNIVENLRTY
2010 2020 2030 2040 2050
NQPAFVYIPM GGELRGGAWV VVDSKINPEH IEMYAERTAK GNVLEPEGLV
2060 2070 2080 2090 2100
EIKFRPKELE ECMLRLDPEL IKLSTRLREM KKENAGLSEM DTTRRSIIAR
2110 2120 2130 2140 2150
MKQLMPIYTQ VATRFAELHD TSARMAAKGV IGKVVDWEES RSFFYRRLRR
2160 2170 2180 2190 2200
RVTEDALAKE IREAAGEQLS QKSALDYIKK WYLSSNGSDG NSEKWNNDEA
2210 2220 2230 2240 2250
FFAWKDDPTN YENQLEELKA ERVSKWLSRL AESPDVKALP NGLSIVLNKM
2260
NPSKREQVID GLRQLLG
Length:2,267
Mass (Da):252,809
Last modified:June 1, 2002 - v1
Checksum:i0B994DBBB3157FB1
GO

Sequence cautioni

The sequence AAP53321.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAF26353.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EEE50826.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000086 Genomic DNA. Translation: AAP53321.2. Sequence problems.
AC092548 Genomic DNA. Translation: AAM18728.1.
AP008216 Genomic DNA. Translation: BAF26353.1. Sequence problems.
CM000147 Genomic DNA. Translation: EEE50826.1. Sequence problems.
RefSeqiNP_001064439.1. NM_001070974.1.
UniGeneiOs.9680.

Genome annotation databases

GeneIDi4348450.
KEGGiosa:4348450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000086 Genomic DNA. Translation: AAP53321.2 . Sequence problems.
AC092548 Genomic DNA. Translation: AAM18728.1 .
AP008216 Genomic DNA. Translation: BAF26353.1 . Sequence problems.
CM000147 Genomic DNA. Translation: EEE50826.1 . Sequence problems.
RefSeqi NP_001064439.1. NM_001070974.1.
UniGenei Os.9680.

3D structure databases

ProteinModelPortali Q8S6N5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os10g21910.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4348450.
KEGGi osa:4348450.

Organism-specific databases

Gramenei Q8S6N5.

Phylogenomic databases

eggNOGi COG0511.
HOGENOMi HOG000214115.
InParanoidi Q8S6N5.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.226.10. 3 hits.
InterProi IPR013537. AcCoA_COase_cen.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR000022. Carboxyl_trans.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF08326. ACC_central. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52096. SSF52096. 2 hits.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS50989. COA_CT_CTER. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
    Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
    , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
    Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiACC1_ORYSJ
AccessioniPrimary (citable) accession number: Q8S6N5
Secondary accession number(s): B9G5C9, Q0IY62, Q7G3D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3