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Q8S528

- AL2B7_ARATH

UniProt

Q8S528 - AL2B7_ARATH

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Protein
Aldehyde dehydrogenase family 2 member B7, mitochondrial
Gene
ALDH2B7, ALDH3, At1g23800, F5O8.33, F5O8.35
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei202 – 2021Transition state stabilizer By similarity
Active sitei301 – 3011Proton acceptor By similarity
Active sitei335 – 3351Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2836NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT1G23800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member B7, mitochondrial (EC:1.2.1.3)
Short name:
ALDH2b
Gene namesi
Name:ALDH2B7
Synonyms:ALDH3
Ordered Locus Names:At1g23800
ORF Names:F5O8.33, F5O8.35
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G23800.

Subcellular locationi

Mitochondrion matrix Reviewed prediction

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion Reviewed prediction
Add
BLAST
Chaini22 – 534513Aldehyde dehydrogenase family 2 member B7, mitochondrial
PRO_0000256057Add
BLAST

Proteomic databases

PaxDbiQ8S528.
PRIDEiQ8S528.

Expressioni

Gene expression databases

ArrayExpressiQ8S528.
GenevestigatoriQ8S528.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi3702.AT1G23800.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8S528.
SMRiQ8S528. Positions 55-518.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ8S528.
KOiK00128.
OMAiYINTGKQ.
PhylomeDBiQ8S528.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8S528-1 [UniParc]FASTAAdd to Basket

« Hide

MASRRVSSLL SRSFMSSSRS IFSLRGMNRG AQRYSNLAAA VENTITPPVK    50
VEHTQLLIGG RFVDAVSGKT FPTLDPRNGE VIAQVSEGDA EDVNRAVAAA 100
RKAFDEGPWP KMTAYERSKI LFRFADLIEK HNDEIAALET WDNGKPYEQS 150
AQIEVPMLAR VFRYYAGWAD KIHGMTMPGD GPHHVQTLHE PIGVAGQIIP 200
WNFPLLMLSW KLGPALACGN TVVLKTAEQT PLSALLVGKL LHEAGLPDGV 250
VNIVSGFGAT AGAAIASHMD VDKVAFTGST DVGKIILELA SKSNLKAVTL 300
ELGGKSPFIV CEDADVDQAV ELAHFALFFN QGQCCCAGSR TFVHERVYDE 350
FVEKAKARAL KRNVGDPFKS GIEQGPQVDS EQFNKILKYI KHGVEAGATL 400
QAGGDRLGSK GYYIQPTVFS DVKDDMLIAT DEIFGPVQTI LKFKDLDEVI 450
ARANNSRYGL AAGVFTQNLD TAHRLMRALR VGTVWINCFD VLDASIPFGG 500
YKMSGIGREK GIYSLNNYLQ VKAVVTSLKN PAWL 534
Length:534
Mass (Da):58,153
Last modified:October 31, 2006 - v2
Checksum:iC709B0E539E52C31
GO

Sequence cautioni

The sequence AAL99612.1 differs from that shown. Reason: Frameshift at positions 303 and 309.
The sequence AAC98035.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348416 mRNA. Translation: AAL99612.1. Frameshift.
AC005990 Genomic DNA. Translation: AAC98035.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30433.1.
AY035139 mRNA. Translation: AAK59643.1.
AY113912 mRNA. Translation: AAM44960.1.
PIRiC86372.
RefSeqiNP_564204.1. NM_102228.3.
UniGeneiAt.22317.

Genome annotation databases

EnsemblPlantsiAT1G23800.1; AT1G23800.1; AT1G23800.
GeneIDi838991.
KEGGiath:AT1G23800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348416 mRNA. Translation: AAL99612.1 . Frameshift.
AC005990 Genomic DNA. Translation: AAC98035.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE30433.1 .
AY035139 mRNA. Translation: AAK59643.1 .
AY113912 mRNA. Translation: AAM44960.1 .
PIRi C86372.
RefSeqi NP_564204.1. NM_102228.3.
UniGenei At.22317.

3D structure databases

ProteinModelPortali Q8S528.
SMRi Q8S528. Positions 55-518.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G23800.1-P.

Proteomic databases

PaxDbi Q8S528.
PRIDEi Q8S528.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G23800.1 ; AT1G23800.1 ; AT1G23800 .
GeneIDi 838991.
KEGGi ath:AT1G23800.

Organism-specific databases

GeneFarmi 4318.
TAIRi AT1G23800.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
InParanoidi Q8S528.
KOi K00128.
OMAi YINTGKQ.
PhylomeDBi Q8S528.

Enzyme and pathway databases

BioCyci ARA:AT1G23800-MONOMER.

Gene expression databases

ArrayExpressi Q8S528.
Genevestigatori Q8S528.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view ]
PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
    Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
    Plant Mol. Biol. 48:751-764(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiAL2B7_ARATH
AccessioniPrimary (citable) accession number: Q8S528
Secondary accession number(s): Q94C67, Q9ZUB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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