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Q8S528

- AL2B7_ARATH

UniProt

Q8S528 - AL2B7_ARATH

Protein

Aldehyde dehydrogenase family 2 member B7, mitochondrial

Gene

ALDH2B7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei202 – 2021Transition state stabilizerBy similarity
    Active sitei301 – 3011Proton acceptorPROSITE-ProRule annotation
    Active sitei335 – 3351NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi278 – 2836NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciARA:AT1G23800-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 2 member B7, mitochondrial (EC:1.2.1.3)
    Short name:
    ALDH2b
    Gene namesi
    Name:ALDH2B7
    Synonyms:ALDH3
    Ordered Locus Names:At1g23800
    ORF Names:F5O8.33, F5O8.35
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G23800.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionSequence AnalysisAdd
    BLAST
    Chaini22 – 534513Aldehyde dehydrogenase family 2 member B7, mitochondrialPRO_0000256057Add
    BLAST

    Proteomic databases

    PaxDbiQ8S528.
    PRIDEiQ8S528.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8S528.
    GenevestigatoriQ8S528.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi3702.AT1G23800.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8S528.
    SMRiQ8S528. Positions 55-518.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    InParanoidiQ8S528.
    KOiK00128.
    OMAiYINTGKQ.
    PhylomeDBiQ8S528.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8S528-1 [UniParc]FASTAAdd to Basket

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    MASRRVSSLL SRSFMSSSRS IFSLRGMNRG AQRYSNLAAA VENTITPPVK    50
    VEHTQLLIGG RFVDAVSGKT FPTLDPRNGE VIAQVSEGDA EDVNRAVAAA 100
    RKAFDEGPWP KMTAYERSKI LFRFADLIEK HNDEIAALET WDNGKPYEQS 150
    AQIEVPMLAR VFRYYAGWAD KIHGMTMPGD GPHHVQTLHE PIGVAGQIIP 200
    WNFPLLMLSW KLGPALACGN TVVLKTAEQT PLSALLVGKL LHEAGLPDGV 250
    VNIVSGFGAT AGAAIASHMD VDKVAFTGST DVGKIILELA SKSNLKAVTL 300
    ELGGKSPFIV CEDADVDQAV ELAHFALFFN QGQCCCAGSR TFVHERVYDE 350
    FVEKAKARAL KRNVGDPFKS GIEQGPQVDS EQFNKILKYI KHGVEAGATL 400
    QAGGDRLGSK GYYIQPTVFS DVKDDMLIAT DEIFGPVQTI LKFKDLDEVI 450
    ARANNSRYGL AAGVFTQNLD TAHRLMRALR VGTVWINCFD VLDASIPFGG 500
    YKMSGIGREK GIYSLNNYLQ VKAVVTSLKN PAWL 534
    Length:534
    Mass (Da):58,153
    Last modified:October 31, 2006 - v2
    Checksum:iC709B0E539E52C31
    GO

    Sequence cautioni

    The sequence AAL99612.1 differs from that shown. Reason: Frameshift at positions 303 and 309.
    The sequence AAC98035.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348416 mRNA. Translation: AAL99612.1. Frameshift.
    AC005990 Genomic DNA. Translation: AAC98035.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30433.1.
    AY035139 mRNA. Translation: AAK59643.1.
    AY113912 mRNA. Translation: AAM44960.1.
    PIRiC86372.
    RefSeqiNP_564204.1. NM_102228.3.
    UniGeneiAt.22317.

    Genome annotation databases

    EnsemblPlantsiAT1G23800.1; AT1G23800.1; AT1G23800.
    GeneIDi838991.
    KEGGiath:AT1G23800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348416 mRNA. Translation: AAL99612.1 . Frameshift.
    AC005990 Genomic DNA. Translation: AAC98035.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE30433.1 .
    AY035139 mRNA. Translation: AAK59643.1 .
    AY113912 mRNA. Translation: AAM44960.1 .
    PIRi C86372.
    RefSeqi NP_564204.1. NM_102228.3.
    UniGenei At.22317.

    3D structure databases

    ProteinModelPortali Q8S528.
    SMRi Q8S528. Positions 55-518.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G23800.1-P.

    Proteomic databases

    PaxDbi Q8S528.
    PRIDEi Q8S528.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G23800.1 ; AT1G23800.1 ; AT1G23800 .
    GeneIDi 838991.
    KEGGi ath:AT1G23800.

    Organism-specific databases

    GeneFarmi 4318.
    TAIRi AT1G23800.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    InParanoidi Q8S528.
    KOi K00128.
    OMAi YINTGKQ.
    PhylomeDBi Q8S528.

    Enzyme and pathway databases

    BioCyci ARA:AT1G23800-MONOMER.

    Gene expression databases

    ArrayExpressi Q8S528.
    Genevestigatori Q8S528.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
      Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
      Plant Mol. Biol. 48:751-764(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiAL2B7_ARATH
    AccessioniPrimary (citable) accession number: Q8S528
    Secondary accession number(s): Q94C67, Q9ZUB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3