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Protein

Aldehyde dehydrogenase family 2 member B7, mitochondrial

Gene

ALDH2B7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei202Transition state stabilizerBy similarity1
Active sitei301Proton acceptorPROSITE-ProRule annotation1
Active sitei335NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi278 – 283NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT1G23800-MONOMER.
ReactomeiR-ATH-196757. Metabolism of folate and pterines.
R-ATH-380612. Metabolism of serotonin.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-70350. Fructose catabolism.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member B7, mitochondrial (EC:1.2.1.3)
Short name:
ALDH2b
Gene namesi
Name:ALDH2B7
Synonyms:ALDH3
Ordered Locus Names:At1g23800
ORF Names:F5O8.33, F5O8.35
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G23800.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000025605722 – 534Aldehyde dehydrogenase family 2 member B7, mitochondrialAdd BLAST513

Proteomic databases

PaxDbiQ8S528.

Expressioni

Gene expression databases

GenevisibleiQ8S528. AT.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G23800.1.

Structurei

3D structure databases

ProteinModelPortaliQ8S528.
SMRiQ8S528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
InParanoidiQ8S528.
KOiK00128.
OMAiKTIWIAL.
OrthoDBiEOG0936062U.
PhylomeDBiQ8S528.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8S528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRVSSLL SRSFMSSSRS IFSLRGMNRG AQRYSNLAAA VENTITPPVK
60 70 80 90 100
VEHTQLLIGG RFVDAVSGKT FPTLDPRNGE VIAQVSEGDA EDVNRAVAAA
110 120 130 140 150
RKAFDEGPWP KMTAYERSKI LFRFADLIEK HNDEIAALET WDNGKPYEQS
160 170 180 190 200
AQIEVPMLAR VFRYYAGWAD KIHGMTMPGD GPHHVQTLHE PIGVAGQIIP
210 220 230 240 250
WNFPLLMLSW KLGPALACGN TVVLKTAEQT PLSALLVGKL LHEAGLPDGV
260 270 280 290 300
VNIVSGFGAT AGAAIASHMD VDKVAFTGST DVGKIILELA SKSNLKAVTL
310 320 330 340 350
ELGGKSPFIV CEDADVDQAV ELAHFALFFN QGQCCCAGSR TFVHERVYDE
360 370 380 390 400
FVEKAKARAL KRNVGDPFKS GIEQGPQVDS EQFNKILKYI KHGVEAGATL
410 420 430 440 450
QAGGDRLGSK GYYIQPTVFS DVKDDMLIAT DEIFGPVQTI LKFKDLDEVI
460 470 480 490 500
ARANNSRYGL AAGVFTQNLD TAHRLMRALR VGTVWINCFD VLDASIPFGG
510 520 530
YKMSGIGREK GIYSLNNYLQ VKAVVTSLKN PAWL
Length:534
Mass (Da):58,153
Last modified:October 31, 2006 - v2
Checksum:iC709B0E539E52C31
GO

Sequence cautioni

The sequence AAC98035 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL99612 differs from that shown. Reason: Frameshift at positions 303 and 309.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348416 mRNA. Translation: AAL99612.1. Frameshift.
AC005990 Genomic DNA. Translation: AAC98035.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30433.1.
AY035139 mRNA. Translation: AAK59643.1.
AY113912 mRNA. Translation: AAM44960.1.
PIRiC86372.
RefSeqiNP_564204.1. NM_102228.4.
UniGeneiAt.22317.

Genome annotation databases

EnsemblPlantsiAT1G23800.1; AT1G23800.1; AT1G23800.
GeneIDi838991.
GrameneiAT1G23800.1; AT1G23800.1; AT1G23800.
KEGGiath:AT1G23800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348416 mRNA. Translation: AAL99612.1. Frameshift.
AC005990 Genomic DNA. Translation: AAC98035.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30433.1.
AY035139 mRNA. Translation: AAK59643.1.
AY113912 mRNA. Translation: AAM44960.1.
PIRiC86372.
RefSeqiNP_564204.1. NM_102228.4.
UniGeneiAt.22317.

3D structure databases

ProteinModelPortaliQ8S528.
SMRiQ8S528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G23800.1.

Proteomic databases

PaxDbiQ8S528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G23800.1; AT1G23800.1; AT1G23800.
GeneIDi838991.
GrameneiAT1G23800.1; AT1G23800.1; AT1G23800.
KEGGiath:AT1G23800.

Organism-specific databases

TAIRiAT1G23800.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
InParanoidiQ8S528.
KOiK00128.
OMAiKTIWIAL.
OrthoDBiEOG0936062U.
PhylomeDBiQ8S528.

Enzyme and pathway databases

BioCyciARA:AT1G23800-MONOMER.
ReactomeiR-ATH-196757. Metabolism of folate and pterines.
R-ATH-380612. Metabolism of serotonin.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-70350. Fructose catabolism.
R-ATH-71384. Ethanol oxidation.

Miscellaneous databases

PROiQ8S528.

Gene expression databases

GenevisibleiQ8S528. AT.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL2B7_ARATH
AccessioniPrimary (citable) accession number: Q8S528
Secondary accession number(s): Q94C67, Q9ZUB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.