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Q8S4W7

- GAI1_VITVI

UniProt

Q8S4W7 - GAI1_VITVI

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Protein
DELLA protein GAI1
Gene
GAI1
Organism
Vitis vinifera (Grape)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway.

GO - Biological processi

  1. gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  2. hyperosmotic salinity response Source: EnsemblPlants/Gramene
  3. jasmonic acid mediated signaling pathway Source: EnsemblPlants/Gramene
  4. negative regulation of gibberellic acid mediated signaling pathway Source: EnsemblPlants/Gramene
  5. negative regulation of seed germination Source: EnsemblPlants/Gramene
  6. phloem transport Source: EnsemblPlants/Gramene
  7. regulation of nitrogen utilization Source: EnsemblPlants/Gramene
  8. regulation of protein catabolic process Source: EnsemblPlants/Gramene
  9. regulation of reactive oxygen species metabolic process Source: EnsemblPlants/Gramene
  10. regulation of seed dormancy process Source: EnsemblPlants/Gramene
  11. regulation of transcription, DNA-templated Source: UniProtKB-KW
  12. response to abscisic acid Source: EnsemblPlants/Gramene
  13. response to ethylene Source: EnsemblPlants/Gramene
  14. response to far red light Source: EnsemblPlants/Gramene
  15. salicylic acid mediated signaling pathway Source: EnsemblPlants/Gramene
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Gibberellin signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DELLA protein GAI1
Alternative name(s):
Gibberellic acid-insensitive mutant protein 1
VvGAI1
Gene namesi
Name:GAI1
OrganismiVitis vinifera (Grape)
Taxonomic identifieri29760 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590DELLA protein GAI1
PRO_0000132248Add
BLAST

Post-translational modificationi

Phosphorylated By similarity.
Ubiquitinated. Upon GA application it is ubiquitinated, leading to its subsequent degradation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 395DELLA motif
Motifi315 – 3195VHIID
Motifi413 – 4175LXXLL motif

Domaini

The DELLA motif is required for its GA-induced degradation By similarity.

Sequence similaritiesi

Belongs to the GRAS family. DELLA subfamily.

Phylogenomic databases

KOiK14494.

Family and domain databases

InterProiIPR021914. TF_DELLA_N.
IPR005202. TF_GRAS.
[Graphical view]
PfamiPF12041. DELLA. 1 hit.
PF03514. GRAS. 1 hit.
[Graphical view]
PROSITEiPS50985. GRAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S4W7-1 [UniParc]FASTAAdd to Basket

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MKREYHHPHH PTCSTSPTGK GKMWDADPQQ DAGMDELLAV LGYNVKASDM    50
AEVAQKLEQL EEVIVNAQED GLSHLASETV HYNPSDLSNW LGSMLSEFNP 100
TPNCALDNPF LPPISPLDYT NCSTQPKQEP SIFDSPSLDY DLKAIPGKAL 150
YSHIEQPPQQ PPAPPLYQRD NKRLKPTTSA TANSVSSVIG GWGVPTESAR 200
PVVLVDSQET GIRLVHTLMA CAEAVQQENL KLAEALVKQI GFLAVSQAGA 250
MRKVATYFAE GLARRIYRLY PDKPLDSSFS DILQMHFYET CPYLKFAHFT 300
ANQAILEAFE GKKRVHVIDF SMKQGMQWPA LMQALALRPG GPPSFRLTGI 350
GPPSTDNTDH LHEVGWKLAQ LAETIHVEFE YRGFVANSLA DLDASMLELR 400
DGESVAVNSV FELHSLLARP GGIERVLSAV KDMKPDIVTI VEQEANHNGP 450
VFLDRFTESL HYYSTLFDSL EGCGVSPVNT QDKLMSEVYL GQQICNVVAC 500
EGPERVERHE TLAQWRARLG SAGFDPVNLG SNAFKQASML LALFAGGDGY 550
RVEENNGCLM LGWHTRPLIA TSAWQLANKP ALPSSTPASN 590
Length:590
Mass (Da):64,866
Last modified:June 1, 2002 - v1
Checksum:i0D9CF844C81C0001
GO

Polymorphismi

In cv. Pinot Meunier, 1 of the 3 cultivars used for the sparkling wine Champagne, plants are genetically indistinguishable from Pinot noir in most cells, but their outer layer, the 'L1' epidermal cell layer, is different: cv. Pinot Meunier has a furry surface on its leaves whereas Pinot noir does not. This is due to the Ser-387 variant that is present only in cells of the L1 layer that causes this difference, demonstrating that GA inhibits flowering in grapewine.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381L → H in Pinot Meunier L1 layer; induces the formation of influorescence instead of grapewine tendrils. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871N → S in AAP20096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378125 Genomic DNA. Translation: AAM19210.1.
AY256862 mRNA. Translation: AAP20096.1.
RefSeqiXP_002284648.1. XM_002284612.2.
UniGeneiVvi.134.

Genome annotation databases

GeneIDi100232937.
KEGGivvi:100232937.

Cross-referencesi

Web resourcesi

Protein Spotlight

All things dwarfed and beautiful - Issue 70 of May 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378125 Genomic DNA. Translation: AAM19210.1 .
AY256862 mRNA. Translation: AAP20096.1 .
RefSeqi XP_002284648.1. XM_002284612.2.
UniGenei Vvi.134.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100232937.
KEGGi vvi:100232937.

Phylogenomic databases

KOi K14494.

Family and domain databases

InterProi IPR021914. TF_DELLA_N.
IPR005202. TF_GRAS.
[Graphical view ]
Pfami PF12041. DELLA. 1 hit.
PF03514. GRAS. 1 hit.
[Graphical view ]
PROSITEi PS50985. GRAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Association of dwarfism and floral induction with a grape 'green revolution' mutation."
    Boss P.K., Thomas M.R.
    Nature 416:847-850(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-38.
    Strain: cv. Pinot Meunier.
  2. Joly D., Perrin M., Gertz C., Masson J.E.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-440.
    Strain: cv. Riesling.

Entry informationi

Entry nameiGAI1_VITVI
AccessioniPrimary (citable) accession number: Q8S4W7
Secondary accession number(s): Q84MI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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