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Q8S4P6

- EZ1_MAIZE

UniProt

Q8S4P6 - EZ1_MAIZE

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Protein
Histone-lysine N-methyltransferase EZ1
Gene
EZ1, MEZ1
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. single-stranded RNA binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. DNA mediated transformation Source: EnsemblPlants/Gramene
  2. leaf morphogenesis Source: EnsemblPlants/Gramene
  3. negative regulation of molecular function, epigenetic Source: EnsemblPlants/Gramene
  4. regulation of gene expression by genetic imprinting Source: EnsemblPlants/Gramene
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
  7. vegetative to reproductive phase transition of meristem Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZ1 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste protein 1
Gene namesi
Name:EZ1
Synonyms:MEZ1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiQ8S4P6.
MaizeGDBi754841.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. PcG protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Histone-lysine N-methyltransferase EZ1
PRO_0000213998Add
BLAST

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8S4P6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 61551SANT
Add
BLAST
Domaini664 – 763100CXC
Add
BLAST
Domaini778 – 893116SET
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Ala
Compositional biasi675 – 75076Cys-rich
Add
BLAST

Sequence similaritiesi

Contains 1 CXC domain.
Contains 1 SANT domain.
Contains 1 SET domain.

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.
OMAiWKSAGYH.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S4P6-1 [UniParc]FASTAAdd to Basket

« Hide

MEAEAAAAVV ASSASASASA GRSRPSSSAA QVTSNSAVRA GEENAASLYV    50
LSVIDSLKKR ITADRLTYIK NRIGENKTNI SSYTQRTYNL SKNRQISTSK 100
GTDSASNLLT KRQDDALCTL HSLDIIPVDK DGGTFQDESP FSSSNVMFGG 150
NLGPKNAIIR PIKLPEVPKL PPYTTWIFLD RNQRMTEDQS VLGRRRIYYD 200
TSCGEALICS DSEDEAIEDE EEKKEFKHSE DHIIRMTVQE CGMSDAVLQT 250
LARHMERAAD DIKARYEILH GEKTKDSCKK GTEHNVKVED LYCDKDLDAA 300
LDSFDNLFCR RCLVFDCKLH GCSQDLVFPT EKQPAWSGVD DSVPCGIHCH 350
KLASEPDAAA GADHMLFDVE EPTHSSDNVM NQPGSNRKKN GSSGRKTKSQ 400
QSESSSTARV ISESSDSEVH PISNKSPQHS PSPSKVKIGP KGGIRKITNR 450
RIAERILMSV KKGQREMASS DSNFVSGYLL ARDMKLRSDT RNGNKELIVS 500
SQQSSPSTRS SKKKSTPQIG NSSAFAEAHN DSTEEANNRH SATDGYDSSR 550
KEEFVNENLC KQEVYLRSWK AIEQGLLVKG LEIFGRNSCL IARNLLGGMK 600
TCKDVFQYMN YIENNSASGA LSGVDSLVKG YIKGTELRTR SRYFRRRGKV 650
RRLKYTWKSA GYNFKRITER KDQPCRQYNP CGCQSTCGKQ CPCLSNGTCC 700
EKYCGCPKIC KNRFRGCHCA KSQCRSRQCP CFAADRECDP DVCRNCWVGC 750
GDGTLGVPNQ RGDNYECRNM KLLLKQQQRV LLGRSDVSGW GAFLKNSVSK 800
HEYLGEYTGE LISHKEADKR GKIYDRENSS FLFNLNNEYV LDAYRMGDKL 850
KFANHAPDPN CYAKVIMVTG DHRVGIFAKE RILAGEELFY DYRYEPDRAP 900
AWARKPEASG AKDDGQPFNG RAKKLAQNNR G 931
Length:931
Mass (Da):103,769
Last modified:June 1, 2002 - v1
Checksum:i4F3CD84B17783B6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF443596 mRNA. Translation: AAM13420.1.
RefSeqiNP_001105078.1. NM_001111608.1.
UniGeneiZm.10343.

Genome annotation databases

GeneIDi541954.
KEGGizma:541954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF443596 mRNA. Translation: AAM13420.1 .
RefSeqi NP_001105078.1. NM_001111608.1.
UniGenei Zm.10343.

3D structure databases

ProteinModelPortali Q8S4P6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 541954.
KEGGi zma:541954.

Organism-specific databases

Gramenei Q8S4P6.
MaizeGDBi 754841.

Phylogenomic databases

HOGENOMi HOG000083511.
KOi K11430.
OMAi WKSAGYH.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
    Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
    Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Seed.

Entry informationi

Entry nameiEZ1_MAIZE
AccessioniPrimary (citable) accession number: Q8S4P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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