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Q8S4P6 (EZ1_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase EZ1

EC=2.1.1.43
Alternative name(s):
Enhancer of zeste protein 1
Gene names
Name:EZ1
Synonyms:MEZ1
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length931 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus Probable.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.

Contains 1 CXC domain.

Contains 1 SANT domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 931931Histone-lysine N-methyltransferase EZ1
PRO_0000213998

Regions

Domain565 – 61551SANT
Domain664 – 763100CXC
Domain778 – 893116SET
Compositional bias3 – 86Poly-Ala
Compositional bias675 – 75076Cys-rich

Sequences

Sequence LengthMass (Da)Tools
Q8S4P6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4F3CD84B17783B6C

FASTA931103,769
        10         20         30         40         50         60 
MEAEAAAAVV ASSASASASA GRSRPSSSAA QVTSNSAVRA GEENAASLYV LSVIDSLKKR 

        70         80         90        100        110        120 
ITADRLTYIK NRIGENKTNI SSYTQRTYNL SKNRQISTSK GTDSASNLLT KRQDDALCTL 

       130        140        150        160        170        180 
HSLDIIPVDK DGGTFQDESP FSSSNVMFGG NLGPKNAIIR PIKLPEVPKL PPYTTWIFLD 

       190        200        210        220        230        240 
RNQRMTEDQS VLGRRRIYYD TSCGEALICS DSEDEAIEDE EEKKEFKHSE DHIIRMTVQE 

       250        260        270        280        290        300 
CGMSDAVLQT LARHMERAAD DIKARYEILH GEKTKDSCKK GTEHNVKVED LYCDKDLDAA 

       310        320        330        340        350        360 
LDSFDNLFCR RCLVFDCKLH GCSQDLVFPT EKQPAWSGVD DSVPCGIHCH KLASEPDAAA 

       370        380        390        400        410        420 
GADHMLFDVE EPTHSSDNVM NQPGSNRKKN GSSGRKTKSQ QSESSSTARV ISESSDSEVH 

       430        440        450        460        470        480 
PISNKSPQHS PSPSKVKIGP KGGIRKITNR RIAERILMSV KKGQREMASS DSNFVSGYLL 

       490        500        510        520        530        540 
ARDMKLRSDT RNGNKELIVS SQQSSPSTRS SKKKSTPQIG NSSAFAEAHN DSTEEANNRH 

       550        560        570        580        590        600 
SATDGYDSSR KEEFVNENLC KQEVYLRSWK AIEQGLLVKG LEIFGRNSCL IARNLLGGMK 

       610        620        630        640        650        660 
TCKDVFQYMN YIENNSASGA LSGVDSLVKG YIKGTELRTR SRYFRRRGKV RRLKYTWKSA 

       670        680        690        700        710        720 
GYNFKRITER KDQPCRQYNP CGCQSTCGKQ CPCLSNGTCC EKYCGCPKIC KNRFRGCHCA 

       730        740        750        760        770        780 
KSQCRSRQCP CFAADRECDP DVCRNCWVGC GDGTLGVPNQ RGDNYECRNM KLLLKQQQRV 

       790        800        810        820        830        840 
LLGRSDVSGW GAFLKNSVSK HEYLGEYTGE LISHKEADKR GKIYDRENSS FLFNLNNEYV 

       850        860        870        880        890        900 
LDAYRMGDKL KFANHAPDPN CYAKVIMVTG DHRVGIFAKE RILAGEELFY DYRYEPDRAP 

       910        920        930 
AWARKPEASG AKDDGQPFNG RAKKLAQNNR G 

« Hide

References

[1]"Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Seed.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF443596 mRNA. Translation: AAM13420.1.
RefSeqNP_001105078.1. NM_001111608.1.
UniGeneZm.10343.

3D structure databases

ProteinModelPortalQ8S4P6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID541954.
KEGGzma:541954.

Organism-specific databases

GrameneQ8S4P6.
MaizeGDB754841.

Phylogenomic databases

HOGENOMHOG000083511.
KOK11430.
OMAKVIMVAG.

Family and domain databases

InterProIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEZ1_MAIZE
AccessionPrimary (citable) accession number: Q8S4P6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families