Histone-lysine N-methyltransferase EZ1

Preferred order of sections

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase EZ1
EC=2.1.1.43

Alternative name(s):
Enhancer of zeste protein 1

Gene names

Name:	EZ1
Synonyms:	MEZ1

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus Probable.
Tissue specificity	Widely expressed. Ref.1
Sequence similarities	Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 CXC domain. Contains 1 SANT domain. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Repressor Transferase
Gene Ontology (GO)
Biological_process	DNA mediated transformation Inferred from electronic annotation. Source: EnsemblPlants/Gramene histone lysine methylation Inferred from electronic annotation. Source: GOC leaf morphogenesis Inferred from electronic annotation. Source: EnsemblPlants/Gramene negative regulation of molecular function, epigenetic Inferred from electronic annotation. Source: EnsemblPlants/Gramene regulation of gene expression by genetic imprinting Inferred from electronic annotation. Source: EnsemblPlants/Gramene regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW vegetative to reproductive phase transition of meristem Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Cellular_component	PcG protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	chromatin binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC single-stranded RNA binding Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 931

931

Histone-lysine N-methyltransferase EZ1

PRO_0000213998

Regions

Domain

565 – 615

51

SANT

Domain

664 – 763

100

CXC

Domain

777 – 897

121

SET

Compositional bias

3 – 8

6

Poly-Ala

Compositional bias

675 – 750

76

Cys-rich

Sequences

Sequence

Length

Mass (Da)

Tools

Q8S4P6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4F3CD84B17783B6C
Show »

FASTA

931

103,769

        10         20         30         40         50         60 
MEAEAAAAVV ASSASASASA GRSRPSSSAA QVTSNSAVRA GEENAASLYV LSVIDSLKKR 

        70         80         90        100        110        120 
ITADRLTYIK NRIGENKTNI SSYTQRTYNL SKNRQISTSK GTDSASNLLT KRQDDALCTL 

       130        140        150        160        170        180 
HSLDIIPVDK DGGTFQDESP FSSSNVMFGG NLGPKNAIIR PIKLPEVPKL PPYTTWIFLD 

       190        200        210        220        230        240 
RNQRMTEDQS VLGRRRIYYD TSCGEALICS DSEDEAIEDE EEKKEFKHSE DHIIRMTVQE 

       250        260        270        280        290        300 
CGMSDAVLQT LARHMERAAD DIKARYEILH GEKTKDSCKK GTEHNVKVED LYCDKDLDAA 

       310        320        330        340        350        360 
LDSFDNLFCR RCLVFDCKLH GCSQDLVFPT EKQPAWSGVD DSVPCGIHCH KLASEPDAAA 

       370        380        390        400        410        420 
GADHMLFDVE EPTHSSDNVM NQPGSNRKKN GSSGRKTKSQ QSESSSTARV ISESSDSEVH 

       430        440        450        460        470        480 
PISNKSPQHS PSPSKVKIGP KGGIRKITNR RIAERILMSV KKGQREMASS DSNFVSGYLL 

       490        500        510        520        530        540 
ARDMKLRSDT RNGNKELIVS SQQSSPSTRS SKKKSTPQIG NSSAFAEAHN DSTEEANNRH 

       550        560        570        580        590        600 
SATDGYDSSR KEEFVNENLC KQEVYLRSWK AIEQGLLVKG LEIFGRNSCL IARNLLGGMK 

       610        620        630        640        650        660 
TCKDVFQYMN YIENNSASGA LSGVDSLVKG YIKGTELRTR SRYFRRRGKV RRLKYTWKSA 

       670        680        690        700        710        720 
GYNFKRITER KDQPCRQYNP CGCQSTCGKQ CPCLSNGTCC EKYCGCPKIC KNRFRGCHCA 

       730        740        750        760        770        780 
KSQCRSRQCP CFAADRECDP DVCRNCWVGC GDGTLGVPNQ RGDNYECRNM KLLLKQQQRV 

       790        800        810        820        830        840 
LLGRSDVSGW GAFLKNSVSK HEYLGEYTGE LISHKEADKR GKIYDRENSS FLFNLNNEYV 

       850        860        870        880        890        900 
LDAYRMGDKL KFANHAPDPN CYAKVIMVTG DHRVGIFAKE RILAGEELFY DYRYEPDRAP 

       910        920        930 
AWARKPEASG AKDDGQPFNG RAKKLAQNNR G

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References

[1]

"Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Seed.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF443596 mRNA. Translation: AAM13420.1.
RefSeq	NP_001105078.1. NM_001111608.1.
UniGene	Zm.10343.
3D structure databases
ProteinModelPortal	Q8S4P6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	541954.
KEGG	zma:541954.
Organism-specific databases
Gramene	Q8S4P6.
MaizeGDB	754841.
Phylogenomic databases
HOGENOM	HOG000083511.
KO	K11430.
OMA	KVIMVAG.
Family and domain databases
InterPro	IPR026489. CXC_dom. IPR025778. Hist-Lys_N-MeTrfase_EZ. IPR001005. SANT/Myb. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00717. SANT. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51633. CXC. 1 hit. PS51293. SANT. False negative. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EZ1_MAIZE

Accession

Primary (citable) accession number: Q8S4P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents