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Q8S4P6

- EZ1_MAIZE

UniProt

Q8S4P6 - EZ1_MAIZE

Protein

Histone-lysine N-methyltransferase EZ1

Gene

EZ1

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    3. single-stranded RNA binding Source: EnsemblPlants/Gramene

    GO - Biological processi

    1. DNA mediated transformation Source: EnsemblPlants/Gramene
    2. leaf morphogenesis Source: EnsemblPlants/Gramene
    3. negative regulation of molecular function, epigenetic Source: EnsemblPlants/Gramene
    4. regulation of gene expression by genetic imprinting Source: EnsemblPlants/Gramene
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW
    7. vegetative to reproductive phase transition of meristem Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase EZ1 (EC:2.1.1.43)
    Alternative name(s):
    Enhancer of zeste protein 1
    Gene namesi
    Name:EZ1
    Synonyms:MEZ1
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiQ8S4P6.
    MaizeGDBi754841.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. PcG protein complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 931931Histone-lysine N-methyltransferase EZ1PRO_0000213998Add
    BLAST

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8S4P6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini565 – 61551SANTAdd
    BLAST
    Domaini664 – 763100CXCPROSITE-ProRule annotationAdd
    BLAST
    Domaini778 – 893116SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 86Poly-Ala
    Compositional biasi675 – 75076Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
    Contains 1 CXC domain.PROSITE-ProRule annotation
    Contains 1 SANT domain.Curated
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000083511.
    KOiK11430.
    OMAiWKSAGYH.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8S4P6-1 [UniParc]FASTAAdd to Basket

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    MEAEAAAAVV ASSASASASA GRSRPSSSAA QVTSNSAVRA GEENAASLYV    50
    LSVIDSLKKR ITADRLTYIK NRIGENKTNI SSYTQRTYNL SKNRQISTSK 100
    GTDSASNLLT KRQDDALCTL HSLDIIPVDK DGGTFQDESP FSSSNVMFGG 150
    NLGPKNAIIR PIKLPEVPKL PPYTTWIFLD RNQRMTEDQS VLGRRRIYYD 200
    TSCGEALICS DSEDEAIEDE EEKKEFKHSE DHIIRMTVQE CGMSDAVLQT 250
    LARHMERAAD DIKARYEILH GEKTKDSCKK GTEHNVKVED LYCDKDLDAA 300
    LDSFDNLFCR RCLVFDCKLH GCSQDLVFPT EKQPAWSGVD DSVPCGIHCH 350
    KLASEPDAAA GADHMLFDVE EPTHSSDNVM NQPGSNRKKN GSSGRKTKSQ 400
    QSESSSTARV ISESSDSEVH PISNKSPQHS PSPSKVKIGP KGGIRKITNR 450
    RIAERILMSV KKGQREMASS DSNFVSGYLL ARDMKLRSDT RNGNKELIVS 500
    SQQSSPSTRS SKKKSTPQIG NSSAFAEAHN DSTEEANNRH SATDGYDSSR 550
    KEEFVNENLC KQEVYLRSWK AIEQGLLVKG LEIFGRNSCL IARNLLGGMK 600
    TCKDVFQYMN YIENNSASGA LSGVDSLVKG YIKGTELRTR SRYFRRRGKV 650
    RRLKYTWKSA GYNFKRITER KDQPCRQYNP CGCQSTCGKQ CPCLSNGTCC 700
    EKYCGCPKIC KNRFRGCHCA KSQCRSRQCP CFAADRECDP DVCRNCWVGC 750
    GDGTLGVPNQ RGDNYECRNM KLLLKQQQRV LLGRSDVSGW GAFLKNSVSK 800
    HEYLGEYTGE LISHKEADKR GKIYDRENSS FLFNLNNEYV LDAYRMGDKL 850
    KFANHAPDPN CYAKVIMVTG DHRVGIFAKE RILAGEELFY DYRYEPDRAP 900
    AWARKPEASG AKDDGQPFNG RAKKLAQNNR G 931
    Length:931
    Mass (Da):103,769
    Last modified:June 1, 2002 - v1
    Checksum:i4F3CD84B17783B6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443596 mRNA. Translation: AAM13420.1.
    RefSeqiNP_001105078.1. NM_001111608.1.
    UniGeneiZm.10343.

    Genome annotation databases

    GeneIDi541954.
    KEGGizma:541954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443596 mRNA. Translation: AAM13420.1 .
    RefSeqi NP_001105078.1. NM_001111608.1.
    UniGenei Zm.10343.

    3D structure databases

    ProteinModelPortali Q8S4P6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 541954.
    KEGGi zma:541954.

    Organism-specific databases

    Gramenei Q8S4P6.
    MaizeGDBi 754841.

    Phylogenomic databases

    HOGENOMi HOG000083511.
    KOi K11430.
    OMAi WKSAGYH.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
      Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
      Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Seed.

    Entry informationi

    Entry nameiEZ1_MAIZE
    AccessioniPrimary (citable) accession number: Q8S4P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3