Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase EZ1

Gene

EZ1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. sequence-specific DNA binding transcription factor activity Source: EnsemblPlants/Gramene
  4. single-stranded RNA binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. cell differentiation Source: EnsemblPlants/Gramene
  2. DNA mediated transformation Source: EnsemblPlants/Gramene
  3. DNA methylation Source: EnsemblPlants/Gramene
  4. flower development Source: EnsemblPlants/Gramene
  5. gene silencing by RNA Source: EnsemblPlants/Gramene
  6. histone H3-K9 methylation Source: EnsemblPlants/Gramene
  7. leaf morphogenesis Source: EnsemblPlants/Gramene
  8. negative regulation of molecular function, epigenetic Source: EnsemblPlants/Gramene
  9. regulation of gene expression by genetic imprinting Source: EnsemblPlants/Gramene
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. vegetative to reproductive phase transition of meristem Source: EnsemblPlants/Gramene
  12. vernalization response Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZ1 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste protein 1
Gene namesi
Name:EZ1
Synonyms:MEZ1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305 Componenti: Chromosome 6

Organism-specific databases

GrameneiQ8S4P6.
MaizeGDBi754841.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. PcG protein complex Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Histone-lysine N-methyltransferase EZ1PRO_0000213998Add
BLAST

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ExpressionAtlasiQ8S4P6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8S4P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 61551SANTAdd
BLAST
Domaini664 – 763100CXCPROSITE-ProRule annotationAdd
BLAST
Domaini778 – 893116SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Ala
Compositional biasi675 – 75076Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
Contains 1 CXC domain.PROSITE-ProRule annotation
Contains 1 SANT domain.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.
OMAiNEYVLDA.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S4P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEAAAAVV ASSASASASA GRSRPSSSAA QVTSNSAVRA GEENAASLYV
60 70 80 90 100
LSVIDSLKKR ITADRLTYIK NRIGENKTNI SSYTQRTYNL SKNRQISTSK
110 120 130 140 150
GTDSASNLLT KRQDDALCTL HSLDIIPVDK DGGTFQDESP FSSSNVMFGG
160 170 180 190 200
NLGPKNAIIR PIKLPEVPKL PPYTTWIFLD RNQRMTEDQS VLGRRRIYYD
210 220 230 240 250
TSCGEALICS DSEDEAIEDE EEKKEFKHSE DHIIRMTVQE CGMSDAVLQT
260 270 280 290 300
LARHMERAAD DIKARYEILH GEKTKDSCKK GTEHNVKVED LYCDKDLDAA
310 320 330 340 350
LDSFDNLFCR RCLVFDCKLH GCSQDLVFPT EKQPAWSGVD DSVPCGIHCH
360 370 380 390 400
KLASEPDAAA GADHMLFDVE EPTHSSDNVM NQPGSNRKKN GSSGRKTKSQ
410 420 430 440 450
QSESSSTARV ISESSDSEVH PISNKSPQHS PSPSKVKIGP KGGIRKITNR
460 470 480 490 500
RIAERILMSV KKGQREMASS DSNFVSGYLL ARDMKLRSDT RNGNKELIVS
510 520 530 540 550
SQQSSPSTRS SKKKSTPQIG NSSAFAEAHN DSTEEANNRH SATDGYDSSR
560 570 580 590 600
KEEFVNENLC KQEVYLRSWK AIEQGLLVKG LEIFGRNSCL IARNLLGGMK
610 620 630 640 650
TCKDVFQYMN YIENNSASGA LSGVDSLVKG YIKGTELRTR SRYFRRRGKV
660 670 680 690 700
RRLKYTWKSA GYNFKRITER KDQPCRQYNP CGCQSTCGKQ CPCLSNGTCC
710 720 730 740 750
EKYCGCPKIC KNRFRGCHCA KSQCRSRQCP CFAADRECDP DVCRNCWVGC
760 770 780 790 800
GDGTLGVPNQ RGDNYECRNM KLLLKQQQRV LLGRSDVSGW GAFLKNSVSK
810 820 830 840 850
HEYLGEYTGE LISHKEADKR GKIYDRENSS FLFNLNNEYV LDAYRMGDKL
860 870 880 890 900
KFANHAPDPN CYAKVIMVTG DHRVGIFAKE RILAGEELFY DYRYEPDRAP
910 920 930
AWARKPEASG AKDDGQPFNG RAKKLAQNNR G
Length:931
Mass (Da):103,769
Last modified:June 1, 2002 - v1
Checksum:i4F3CD84B17783B6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443596 mRNA. Translation: AAM13420.1.
RefSeqiNP_001105078.1. NM_001111608.1.
UniGeneiZm.10343.

Genome annotation databases

EnsemblPlantsiGRMZM2G157820_T02; GRMZM2G157820_P02; GRMZM2G157820.
GeneIDi541954.
KEGGizma:541954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443596 mRNA. Translation: AAM13420.1.
RefSeqiNP_001105078.1. NM_001111608.1.
UniGeneiZm.10343.

3D structure databases

ProteinModelPortaliQ8S4P6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM2G157820_T02; GRMZM2G157820_P02; GRMZM2G157820.
GeneIDi541954.
KEGGizma:541954.

Organism-specific databases

GrameneiQ8S4P6.
MaizeGDBi754841.

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.
OMAiNEYVLDA.

Gene expression databases

ExpressionAtlasiQ8S4P6. baseline and differential.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
    Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
    Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Seed.

Entry informationi

Entry nameiEZ1_MAIZE
AccessioniPrimary (citable) accession number: Q8S4P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: March 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.