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Q8S4P5

- EZ2_MAIZE

UniProt

Q8S4P5 - EZ2_MAIZE

Protein

Histone-lysine N-methyltransferase EZ2

Gene

EZ2

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    3. single-stranded RNA binding Source: EnsemblPlants/Gramene

    GO - Biological processi

    1. endosperm development Source: EnsemblPlants/Gramene
    2. regulation of gene expression by genetic imprinting Source: EnsemblPlants/Gramene
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase EZ2 (EC:2.1.1.43)
    Alternative name(s):
    Enhancer of zeste protein 2
    Gene namesi
    Name:EZ2
    Synonyms:MEZ2
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiQ8S4P5.
    MaizeGDBi754843.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. chromatin silencing complex Source: EnsemblPlants/Gramene
    2. PcG protein complex Source: InterPro
    3. plasmodesma Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 894894Histone-lysine N-methyltransferase EZ2PRO_0000213999Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8S4P5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini527 – 57751SANTAdd
    BLAST
    Domaini627 – 731105CXCPROSITE-ProRule annotationAdd
    BLAST
    Domaini746 – 861116SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 284Poly-Ala
    Compositional biasi74 – 774Poly-Ala
    Compositional biasi642 – 71877Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
    Contains 1 CXC domain.PROSITE-ProRule annotation
    Contains 1 SANT domain.Curated
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000083511.
    KOiK11430.
    OMAiCIEVANY.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8S4P5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSSKASDS SQRSKRSDQG MGKDAAAASV VPIHANLTQL IRQVQSGRLA    50
    YIKEKLEVNR KTLQRHSCSL FDVAAAAEVA SRGTDGGNAL SQRAAERQCG 100
    SDLANGIGER DVVSVQEENL ATGTLALSSS GATAQRTIVR FVKLPLVEKI 150
    PPYTTWIFLD KNQRMADDQS VVGRRRIYYD TVGNEALICS DSDEEIPEPE 200
    EEKHFFTKGE DHLIWRATQD HGLNQEVVNV LCQFIGATPS EIEERSEVLF 250
    EKNEKHSGSS DKIESRLSLD KTMDAVLDSF DNLFCRRCLV FDCRLHGCSQ 300
    NLVFPCEKQP YSFDPDENKK PCGHLCYLRF PQWREGFKEM HDDGLAGGAT 350
    YTMESGTASQ RVDVNVMYES EDSNRQKGNI RSMTLVGTSG SKIISSVSAE 400
    ESTTTPSADI SETENVSSDL PPSSLRKHKI SKHGPRYREH SPGKRQKVFT 450
    SDISFEGNIM NKLSIPEIRD TRLESRESGG DKLRILDEST KKTSRKDMCG 500
    ESPATTMENV GRQSNKVSST KNFLESTLSC WSALERDLYL KGIEIFGKNS 550
    CLIARNLLSG LKTCIEVANY MYNNGAAMAK RPLLNKSISG DFAENEQDYM 600
    EQDMAARTRI YRRRGRNRKL KYTWKSAGHP TVRKRTDDGK QCYTQYSPCA 650
    CQQMCGKDCP CADKGTCCEK YCGCSKSCKN KFRGCHCAKS QCRSRQCPCF 700
    AASRECDPDV CRNCWVSCGD GSLGEPLARG DGYQCGNMKL LLKQQQRILL 750
    GRSDVAGWGA FIKNPVNKND YLGEYTGELI SHKEADKRGK IYDRANSSFL 800
    FDLNDQYVLD AYRKGDKLKF ANHSSNPNCY AKVMLVAGDH RVGIYAKEHI 850
    EASEELFYDY RYGPDQAPAW ARRPEGSKKD EASVSHRRAH KVAR 894
    Length:894
    Mass (Da):99,979
    Last modified:June 1, 2002 - v1
    Checksum:i9C2B04E6F80BA113
    GO
    Isoform 2 (identifier: Q8S4P5-2) [UniParc]FASTAAdd to Basket

    Also known as: as1

    The sequence of this isoform differs from the canonical sequence as follows:
         342-894: Missing.

    Show »
    Length:341
    Mass (Da):38,167
    Checksum:i0CFBD999C5BD4604
    GO
    Isoform 3 (identifier: Q8S4P5-3) [UniParc]FASTAAdd to Basket

    Also known as: as2

    The sequence of this isoform differs from the canonical sequence as follows:
         625-894: Missing.

    Show »
    Length:624
    Mass (Da):69,732
    Checksum:iD94D319FADF43A19
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei342 – 894553Missing in isoform 2. 1 PublicationVSP_007783Add
    BLAST
    Alternative sequencei625 – 894270Missing in isoform 3. 1 PublicationVSP_007784Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443597 mRNA. Translation: AAM13421.1.
    RefSeqiNP_001105650.1. NM_001112180.1. [Q8S4P5-1]
    UniGeneiZm.10342.

    Genome annotation databases

    GeneIDi542659.
    KEGGizma:542659.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443597 mRNA. Translation: AAM13421.1 .
    RefSeqi NP_001105650.1. NM_001112180.1. [Q8S4P5-1 ]
    UniGenei Zm.10342.

    3D structure databases

    ProteinModelPortali Q8S4P5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 542659.
    KEGGi zma:542659.

    Organism-specific databases

    Gramenei Q8S4P5.
    MaizeGDBi 754843.

    Phylogenomic databases

    HOGENOMi HOG000083511.
    KOi K11430.
    OMAi CIEVANY.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
      Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
      Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
      Tissue: Seed.

    Entry informationi

    Entry nameiEZ2_MAIZE
    AccessioniPrimary (citable) accession number: Q8S4P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3