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Q8S4P5 (EZ2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase EZ2

EC=2.1.1.43
Alternative name(s):
Enhancer of zeste protein 2
Gene names
Name:EZ2
Synonyms:MEZ2
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length894 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.

Contains 1 CXC domain.

Contains 1 SANT domain.

Contains 1 SET domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8S4P5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8S4P5-2)

Also known as: as1;

The sequence of this isoform differs from the canonical sequence as follows:
     342-894: Missing.
Isoform 3 (identifier: Q8S4P5-3)

Also known as: as2;

The sequence of this isoform differs from the canonical sequence as follows:
     625-894: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 894894Histone-lysine N-methyltransferase EZ2
PRO_0000213999

Regions

Domain527 – 57751SANT
Domain627 – 731105CXC
Domain746 – 861116SET
Compositional bias25 – 284Poly-Ala
Compositional bias74 – 774Poly-Ala
Compositional bias642 – 71877Cys-rich

Natural variations

Alternative sequence342 – 894553Missing in isoform 2.
VSP_007783
Alternative sequence625 – 894270Missing in isoform 3.
VSP_007784

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 9C2B04E6F80BA113

FASTA89499,979
        10         20         30         40         50         60 
MASSSKASDS SQRSKRSDQG MGKDAAAASV VPIHANLTQL IRQVQSGRLA YIKEKLEVNR 

        70         80         90        100        110        120 
KTLQRHSCSL FDVAAAAEVA SRGTDGGNAL SQRAAERQCG SDLANGIGER DVVSVQEENL 

       130        140        150        160        170        180 
ATGTLALSSS GATAQRTIVR FVKLPLVEKI PPYTTWIFLD KNQRMADDQS VVGRRRIYYD 

       190        200        210        220        230        240 
TVGNEALICS DSDEEIPEPE EEKHFFTKGE DHLIWRATQD HGLNQEVVNV LCQFIGATPS 

       250        260        270        280        290        300 
EIEERSEVLF EKNEKHSGSS DKIESRLSLD KTMDAVLDSF DNLFCRRCLV FDCRLHGCSQ 

       310        320        330        340        350        360 
NLVFPCEKQP YSFDPDENKK PCGHLCYLRF PQWREGFKEM HDDGLAGGAT YTMESGTASQ 

       370        380        390        400        410        420 
RVDVNVMYES EDSNRQKGNI RSMTLVGTSG SKIISSVSAE ESTTTPSADI SETENVSSDL 

       430        440        450        460        470        480 
PPSSLRKHKI SKHGPRYREH SPGKRQKVFT SDISFEGNIM NKLSIPEIRD TRLESRESGG 

       490        500        510        520        530        540 
DKLRILDEST KKTSRKDMCG ESPATTMENV GRQSNKVSST KNFLESTLSC WSALERDLYL 

       550        560        570        580        590        600 
KGIEIFGKNS CLIARNLLSG LKTCIEVANY MYNNGAAMAK RPLLNKSISG DFAENEQDYM 

       610        620        630        640        650        660 
EQDMAARTRI YRRRGRNRKL KYTWKSAGHP TVRKRTDDGK QCYTQYSPCA CQQMCGKDCP 

       670        680        690        700        710        720 
CADKGTCCEK YCGCSKSCKN KFRGCHCAKS QCRSRQCPCF AASRECDPDV CRNCWVSCGD 

       730        740        750        760        770        780 
GSLGEPLARG DGYQCGNMKL LLKQQQRILL GRSDVAGWGA FIKNPVNKND YLGEYTGELI 

       790        800        810        820        830        840 
SHKEADKRGK IYDRANSSFL FDLNDQYVLD AYRKGDKLKF ANHSSNPNCY AKVMLVAGDH 

       850        860        870        880        890 
RVGIYAKEHI EASEELFYDY RYGPDQAPAW ARRPEGSKKD EASVSHRRAH KVAR 

« Hide

Isoform 2 (as1) [UniParc].

Checksum: 0CFBD999C5BD4604
Show »

FASTA34138,167
Isoform 3 (as2) [UniParc].

Checksum: D94D319FADF43A19
Show »

FASTA62469,732

References

[1]"Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
Tissue: Seed.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF443597 mRNA. Translation: AAM13421.1.
RefSeqNP_001105650.1. NM_001112180.1. [Q8S4P5-1]
UniGeneZm.10342.

3D structure databases

ProteinModelPortalQ8S4P5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID542659.
KEGGzma:542659.

Organism-specific databases

GrameneQ8S4P5.
MaizeGDB754843.

Phylogenomic databases

HOGENOMHOG000083511.
OMACIEVANY.

Family and domain databases

InterProIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEZ2_MAIZE
AccessionPrimary (citable) accession number: Q8S4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families