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Protein

Histone-lysine N-methyltransferase EZ2

Gene

EZ2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZ2 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste protein 2
Gene namesi
Name:EZ2
Synonyms:MEZ2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi754843

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139991 – 894Histone-lysine N-methyltransferase EZ2Add BLAST894

Proteomic databases

PaxDbiQ8S4P5

Expressioni

Gene expression databases

ExpressionAtlasiQ8S4P5 baseline and differential
GenevisibleiQ8S4P5 ZM

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM5G875502_P02

Structurei

3D structure databases

ProteinModelPortaliQ8S4P5
SMRiQ8S4P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini527 – 577SANTAdd BLAST51
Domaini627 – 731CXCPROSITE-ProRule annotationAdd BLAST105
Domaini746 – 861SETPROSITE-ProRule annotationAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Ala4
Compositional biasi74 – 77Poly-Ala4
Compositional biasi642 – 718Cys-richAdd BLAST77

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1079 Eukaryota
COG2940 LUCA
HOGENOMiHOG000083511
KOiK11430
OMAiHRRPRKH
OrthoDBiEOG09360260

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR026489 CXC_dom
IPR025778 Hist-Lys_N-MeTrfase_EZ
IPR001005 SANT/Myb
IPR001214 SET_dom
IPR033467 Tesmin/TSO1-like_CXC
PANTHERiPTHR22884:SF237 PTHR22884:SF237, 1 hit
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM01114 CXC, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51633 CXC, 1 hit
PS51576 SAM_MT43_EZ, 1 hit
PS50280 SET, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8S4P5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSKASDS SQRSKRSDQG MGKDAAAASV VPIHANLTQL IRQVQSGRLA
60 70 80 90 100
YIKEKLEVNR KTLQRHSCSL FDVAAAAEVA SRGTDGGNAL SQRAAERQCG
110 120 130 140 150
SDLANGIGER DVVSVQEENL ATGTLALSSS GATAQRTIVR FVKLPLVEKI
160 170 180 190 200
PPYTTWIFLD KNQRMADDQS VVGRRRIYYD TVGNEALICS DSDEEIPEPE
210 220 230 240 250
EEKHFFTKGE DHLIWRATQD HGLNQEVVNV LCQFIGATPS EIEERSEVLF
260 270 280 290 300
EKNEKHSGSS DKIESRLSLD KTMDAVLDSF DNLFCRRCLV FDCRLHGCSQ
310 320 330 340 350
NLVFPCEKQP YSFDPDENKK PCGHLCYLRF PQWREGFKEM HDDGLAGGAT
360 370 380 390 400
YTMESGTASQ RVDVNVMYES EDSNRQKGNI RSMTLVGTSG SKIISSVSAE
410 420 430 440 450
ESTTTPSADI SETENVSSDL PPSSLRKHKI SKHGPRYREH SPGKRQKVFT
460 470 480 490 500
SDISFEGNIM NKLSIPEIRD TRLESRESGG DKLRILDEST KKTSRKDMCG
510 520 530 540 550
ESPATTMENV GRQSNKVSST KNFLESTLSC WSALERDLYL KGIEIFGKNS
560 570 580 590 600
CLIARNLLSG LKTCIEVANY MYNNGAAMAK RPLLNKSISG DFAENEQDYM
610 620 630 640 650
EQDMAARTRI YRRRGRNRKL KYTWKSAGHP TVRKRTDDGK QCYTQYSPCA
660 670 680 690 700
CQQMCGKDCP CADKGTCCEK YCGCSKSCKN KFRGCHCAKS QCRSRQCPCF
710 720 730 740 750
AASRECDPDV CRNCWVSCGD GSLGEPLARG DGYQCGNMKL LLKQQQRILL
760 770 780 790 800
GRSDVAGWGA FIKNPVNKND YLGEYTGELI SHKEADKRGK IYDRANSSFL
810 820 830 840 850
FDLNDQYVLD AYRKGDKLKF ANHSSNPNCY AKVMLVAGDH RVGIYAKEHI
860 870 880 890
EASEELFYDY RYGPDQAPAW ARRPEGSKKD EASVSHRRAH KVAR
Length:894
Mass (Da):99,979
Last modified:June 1, 2002 - v1
Checksum:i9C2B04E6F80BA113
GO
Isoform 2 (identifier: Q8S4P5-2) [UniParc]FASTAAdd to basket
Also known as: as1

The sequence of this isoform differs from the canonical sequence as follows:
     342-894: Missing.

Show »
Length:341
Mass (Da):38,167
Checksum:i0CFBD999C5BD4604
GO
Isoform 3 (identifier: Q8S4P5-3) [UniParc]FASTAAdd to basket
Also known as: as2

The sequence of this isoform differs from the canonical sequence as follows:
     625-894: Missing.

Show »
Length:624
Mass (Da):69,732
Checksum:iD94D319FADF43A19
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007783342 – 894Missing in isoform 2. 1 PublicationAdd BLAST553
Alternative sequenceiVSP_007784625 – 894Missing in isoform 3. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443597 mRNA Translation: AAM13421.1
RefSeqiNP_001105650.1, NM_001112180.1 [Q8S4P5-1]
UniGeneiZm.10342

Genome annotation databases

GeneIDi542659
KEGGizma:542659

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEZ2_MAIZE
AccessioniPrimary (citable) accession number: Q8S4P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health