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Q8S4P4

- EZ3_MAIZE

UniProt

Q8S4P4 - EZ3_MAIZE

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Protein

Histone-lysine N-methyltransferase EZ3

Gene
EZ3, MEZ3
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZ3 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste protein 3
Gene namesi
Name:EZ3
Synonyms:MEZ3
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiQ8S4P4.
MaizeGDBi754846.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. PcG protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 895895Histone-lysine N-methyltransferase EZ3PRO_0000214000Add
BLAST

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8S4P4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini528 – 57851SANTAdd
BLAST
Domaini628 – 732105CXCAdd
BLAST
Domaini747 – 862116SETAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 784Poly-Ala
Compositional biasi650 – 71970Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 CXC domain.
Contains 1 SANT domain.
Contains 1 SET domain.

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S4P4-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSKASDS SSQRSKRSDQ GTGREAAPAS VVPIHGNLTQ LIRQIKSRRL    50
LYIKEKLEAN RKTLQRHSCS LFDVAAAAEV ASRGSDGGNA LSQRAAEGQF 100
RLAGSDLAHG IGERDVVYMQ EENLASGTLV LSSSGAAAQR TVVRFVKLPL 150
VERIPPYTTW IFLDKNQRMA DDQSVVGRRR IYYDPVGNEA LICSDSDEEI 200
PEPEEEKHFF TEGEDQLIWR ATQEHGLNRE VVNVLCQFID STPSEIEERS 250
EVLFEKNEKN SGSSDKIERQ LSLDKTMDAV LDSFDNLFCR RCLVFDCRLH 300
GCSQNLVFPT EKQPYSFEPD ENKKPCGRQC YLRWRGGFQE IHDVGLSGCA 350
TYNMESGTVS HKVDVSIMSE SEDSNREKGN IRSMTLVGTS GSKIISSVSA 400
EESTTPPSAD TSETENASSD MPPSSLRKYK ISKRGPRYRE RSPGKRQKVF 450
TSDISFASNI LNKLSIPEIR DTRLESREPG GDKLQILDES TKKTSSKDIC 500
GESPITTTEN MGIESKKVSS TKNFLEHTLS CWSALERDLY LKGIEIFGKN 550
SCLIARNLLS GMKTCMEVAN YMYNNGAAMA KRPLLNKSIS GDFAETEQDY 600
MEQDMVARTR IYRRRGRNRK LKYTWKSAGH PTVRKRIGDG KQWYTQYNPC 650
VCQQMCGKDC PCVENGTCCE KYCGCSKSCK NKFRGCHCAK SQCRSRQCPC 700
FAASRECDPD VCRNCWVSCG DGSLGEPPAR GDGYQCGNMK LLLKQQQRIL 750
LGRSDVAGWG AFIKNPVNKN DYLGEYTGEL ISHKEADKRG KIYDRANSSF 800
LFDLNDQYVL DAYRKGDKLK FANHSSNPNC YAKVMLVAGD HRVGIYAKEH 850
IEASEELFYD YRYGPDQAPA WARRPEGSKK DEASVSHHRA HKVAR 895
Length:895
Mass (Da):100,393
Last modified:June 1, 2002 - v1
Checksum:i2659DCF992A08919
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF443598 mRNA. Translation: AAM13422.1.
RefSeqiNP_001105079.1. NM_001111609.1.
UniGeneiZm.10341.

Genome annotation databases

GeneIDi541955.
KEGGizma:541955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF443598 mRNA. Translation: AAM13422.1 .
RefSeqi NP_001105079.1. NM_001111609.1.
UniGenei Zm.10341.

3D structure databases

ProteinModelPortali Q8S4P4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 541955.
KEGGi zma:541955.

Organism-specific databases

Gramenei Q8S4P4.
MaizeGDBi 754846.

Phylogenomic databases

HOGENOMi HOG000083511.
KOi K11430.

Family and domain databases

InterProi IPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
    Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
    Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Seed.

Entry informationi

Entry nameiEZ3_MAIZE
AccessioniPrimary (citable) accession number: Q8S4P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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