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Q8S4P4

- EZ3_MAIZE

UniProt

Q8S4P4 - EZ3_MAIZE

Protein

Histone-lysine N-methyltransferase EZ3

Gene

EZ3

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase EZ3 (EC:2.1.1.43)
    Alternative name(s):
    Enhancer of zeste protein 3
    Gene namesi
    Name:EZ3
    Synonyms:MEZ3
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiQ8S4P4.
    MaizeGDBi754846.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. PcG protein complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 895895Histone-lysine N-methyltransferase EZ3PRO_0000214000Add
    BLAST

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8S4P4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini528 – 57851SANTAdd
    BLAST
    Domaini628 – 732105CXCPROSITE-ProRule annotationAdd
    BLAST
    Domaini747 – 862116SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi75 – 784Poly-Ala
    Compositional biasi650 – 71970Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
    Contains 1 CXC domain.PROSITE-ProRule annotation
    Contains 1 SANT domain.Curated
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000083511.
    KOiK11430.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8S4P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSSKASDS SSQRSKRSDQ GTGREAAPAS VVPIHGNLTQ LIRQIKSRRL    50
    LYIKEKLEAN RKTLQRHSCS LFDVAAAAEV ASRGSDGGNA LSQRAAEGQF 100
    RLAGSDLAHG IGERDVVYMQ EENLASGTLV LSSSGAAAQR TVVRFVKLPL 150
    VERIPPYTTW IFLDKNQRMA DDQSVVGRRR IYYDPVGNEA LICSDSDEEI 200
    PEPEEEKHFF TEGEDQLIWR ATQEHGLNRE VVNVLCQFID STPSEIEERS 250
    EVLFEKNEKN SGSSDKIERQ LSLDKTMDAV LDSFDNLFCR RCLVFDCRLH 300
    GCSQNLVFPT EKQPYSFEPD ENKKPCGRQC YLRWRGGFQE IHDVGLSGCA 350
    TYNMESGTVS HKVDVSIMSE SEDSNREKGN IRSMTLVGTS GSKIISSVSA 400
    EESTTPPSAD TSETENASSD MPPSSLRKYK ISKRGPRYRE RSPGKRQKVF 450
    TSDISFASNI LNKLSIPEIR DTRLESREPG GDKLQILDES TKKTSSKDIC 500
    GESPITTTEN MGIESKKVSS TKNFLEHTLS CWSALERDLY LKGIEIFGKN 550
    SCLIARNLLS GMKTCMEVAN YMYNNGAAMA KRPLLNKSIS GDFAETEQDY 600
    MEQDMVARTR IYRRRGRNRK LKYTWKSAGH PTVRKRIGDG KQWYTQYNPC 650
    VCQQMCGKDC PCVENGTCCE KYCGCSKSCK NKFRGCHCAK SQCRSRQCPC 700
    FAASRECDPD VCRNCWVSCG DGSLGEPPAR GDGYQCGNMK LLLKQQQRIL 750
    LGRSDVAGWG AFIKNPVNKN DYLGEYTGEL ISHKEADKRG KIYDRANSSF 800
    LFDLNDQYVL DAYRKGDKLK FANHSSNPNC YAKVMLVAGD HRVGIYAKEH 850
    IEASEELFYD YRYGPDQAPA WARRPEGSKK DEASVSHHRA HKVAR 895
    Length:895
    Mass (Da):100,393
    Last modified:June 1, 2002 - v1
    Checksum:i2659DCF992A08919
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443598 mRNA. Translation: AAM13422.1.
    RefSeqiNP_001105079.1. NM_001111609.1.
    UniGeneiZm.10341.

    Genome annotation databases

    GeneIDi541955.
    KEGGizma:541955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF443598 mRNA. Translation: AAM13422.1 .
    RefSeqi NP_001105079.1. NM_001111609.1.
    UniGenei Zm.10341.

    3D structure databases

    ProteinModelPortali Q8S4P4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 541955.
    KEGGi zma:541955.

    Organism-specific databases

    Gramenei Q8S4P4.
    MaizeGDBi 754846.

    Phylogenomic databases

    HOGENOMi HOG000083511.
    KOi K11430.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR025778. Hist-Lys_N-MeTrfase_EZ.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS51576. SAM_MT43_EZ. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
      Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
      Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Seed.

    Entry informationi

    Entry nameiEZ3_MAIZE
    AccessioniPrimary (citable) accession number: Q8S4P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3