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Protein

Histone-lysine N-methyltransferase EZ3

Gene

EZ3

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EZ3 (EC:2.1.1.43)
Alternative name(s):
Enhancer of zeste protein 3
Gene namesi
Name:EZ3
Synonyms:MEZ3
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305 Componenti: Unplaced

Organism-specific databases

GrameneiQ8S4P4.
MaizeGDBi754846.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 895895Histone-lysine N-methyltransferase EZ3PRO_0000214000Add
BLAST

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8S4P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini528 – 57851SANTAdd
BLAST
Domaini628 – 732105CXCPROSITE-ProRule annotationAdd
BLAST
Domaini747 – 862116SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 784Poly-Ala
Compositional biasi650 – 71970Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
Contains 1 CXC domain.PROSITE-ProRule annotation
Contains 1 SANT domain.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8S4P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSKASDS SSQRSKRSDQ GTGREAAPAS VVPIHGNLTQ LIRQIKSRRL
60 70 80 90 100
LYIKEKLEAN RKTLQRHSCS LFDVAAAAEV ASRGSDGGNA LSQRAAEGQF
110 120 130 140 150
RLAGSDLAHG IGERDVVYMQ EENLASGTLV LSSSGAAAQR TVVRFVKLPL
160 170 180 190 200
VERIPPYTTW IFLDKNQRMA DDQSVVGRRR IYYDPVGNEA LICSDSDEEI
210 220 230 240 250
PEPEEEKHFF TEGEDQLIWR ATQEHGLNRE VVNVLCQFID STPSEIEERS
260 270 280 290 300
EVLFEKNEKN SGSSDKIERQ LSLDKTMDAV LDSFDNLFCR RCLVFDCRLH
310 320 330 340 350
GCSQNLVFPT EKQPYSFEPD ENKKPCGRQC YLRWRGGFQE IHDVGLSGCA
360 370 380 390 400
TYNMESGTVS HKVDVSIMSE SEDSNREKGN IRSMTLVGTS GSKIISSVSA
410 420 430 440 450
EESTTPPSAD TSETENASSD MPPSSLRKYK ISKRGPRYRE RSPGKRQKVF
460 470 480 490 500
TSDISFASNI LNKLSIPEIR DTRLESREPG GDKLQILDES TKKTSSKDIC
510 520 530 540 550
GESPITTTEN MGIESKKVSS TKNFLEHTLS CWSALERDLY LKGIEIFGKN
560 570 580 590 600
SCLIARNLLS GMKTCMEVAN YMYNNGAAMA KRPLLNKSIS GDFAETEQDY
610 620 630 640 650
MEQDMVARTR IYRRRGRNRK LKYTWKSAGH PTVRKRIGDG KQWYTQYNPC
660 670 680 690 700
VCQQMCGKDC PCVENGTCCE KYCGCSKSCK NKFRGCHCAK SQCRSRQCPC
710 720 730 740 750
FAASRECDPD VCRNCWVSCG DGSLGEPPAR GDGYQCGNMK LLLKQQQRIL
760 770 780 790 800
LGRSDVAGWG AFIKNPVNKN DYLGEYTGEL ISHKEADKRG KIYDRANSSF
810 820 830 840 850
LFDLNDQYVL DAYRKGDKLK FANHSSNPNC YAKVMLVAGD HRVGIYAKEH
860 870 880 890
IEASEELFYD YRYGPDQAPA WARRPEGSKK DEASVSHHRA HKVAR
Length:895
Mass (Da):100,393
Last modified:June 1, 2002 - v1
Checksum:i2659DCF992A08919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443598 mRNA. Translation: AAM13422.1.
RefSeqiNP_001105079.1. NM_001111609.1.
UniGeneiZm.10341.

Genome annotation databases

GeneIDi541955.
KEGGizma:541955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443598 mRNA. Translation: AAM13422.1.
RefSeqiNP_001105079.1. NM_001111609.1.
UniGeneiZm.10341.

3D structure databases

ProteinModelPortaliQ8S4P4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi541955.
KEGGizma:541955.

Organism-specific databases

GrameneiQ8S4P4.
MaizeGDBi754846.

Phylogenomic databases

HOGENOMiHOG000083511.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR025778. Hist-Lys_N-MeTrfase_EZ.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS51576. SAM_MT43_EZ. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence relationships, conserved domains, and expression patterns for maize homologs of the Polycomb group genes E(z), esc, and E(Pc)."
    Springer N.M., Danilevskaya O.N., Hermon P., Helentjaris T.G., Phillips R.L., Kaeppler H.F., Kaeppler S.M.
    Plant Physiol. 128:1332-1345(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Seed.

Entry informationi

Entry nameiEZ3_MAIZE
AccessioniPrimary (citable) accession number: Q8S4P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2002
Last modified: May 27, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.