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Q8S341

- PPA7_ARATH

UniProt

Q8S341 - PPA7_ARATH

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Protein

Purple acid phosphatase 7

Gene

PAP7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481IronBy similarity
Metal bindingi81 – 811IronBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi84 – 841IronBy similarity
Metal bindingi119 – 1191ZincBy similarity
Metal bindingi213 – 2131ZincBy similarity
Active sitei222 – 2221Proton donorBy similarity
Metal bindingi248 – 2481ZincBy similarity
Metal bindingi250 – 2501IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT2G01880-MONOMER.
ReactomeiREACT_244898. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 7 (EC:3.1.3.2)
Gene namesi
Name:PAP7
Ordered Locus Names:At2g01880
ORF Names:T23K3.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G01880.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 328304Purple acid phosphatase 7PRO_0000372812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8S341.
PRIDEiQ8S341.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ8S341.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT2G01880.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8S341.
SMRiQ8S341. Positions 41-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2503Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000239892.
InParanoidiQ8S341.
OMAiVEKYFTE.
PhylomeDBiQ8S341.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8S341-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMHVCFSVI LMFLSIFFIN GALSKLERLK HPVKKKSDGS LSFLVIGDWG
60 70 80 90 100
RKGGFNQSLV AHQMGVVGEK LDIDFVISVG DNFYDDGLKG VNDPSFEASF
110 120 130 140 150
SHIYTHPSLQ KQWYSVLGNH DYRGNVEAQL SKVLTQKDWR WFCRRSFVLS
160 170 180 190 200
SGMVDFFFAD TNPFVEKYFT EPEDHTYDWR NVLPRNKYIS NLLHDLDLEI
210 220 230 240 250
KKSRATWKFV VGHHGIKTAG NHGVTQELVD QLLPILEENK VDLYINGHDH
260 270 280 290 300
CLQHIGSHGK TQFLTSGGGS KAWRGHVQPW DPKELKLYYD GQGFMSLHIT
310 320
HSKAKFIYYD VSGNVLHRSS LSKRSAHL
Length:328
Mass (Da):37,549
Last modified:June 1, 2002 - v1
Checksum:iF897E0A8D39CA052
GO

Sequence cautioni

The sequence AAD21780.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171H → L in BAC43423. (PubMed:11910074)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492659 mRNA. Translation: AAM15908.1.
AC007069 Genomic DNA. Translation: AAD21780.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC05511.1.
AK118834 mRNA. Translation: BAC43423.1.
BT026449 mRNA. Translation: ABH04556.1.
PIRiC84430.
RefSeqiNP_178297.2. NM_126249.4.
UniGeneiAt.42460.

Genome annotation databases

EnsemblPlantsiAT2G01880.1; AT2G01880.1; AT2G01880.
GeneIDi814719.
KEGGiath:AT2G01880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492659 mRNA. Translation: AAM15908.1 .
AC007069 Genomic DNA. Translation: AAD21780.1 . Sequence problems.
CP002685 Genomic DNA. Translation: AEC05511.1 .
AK118834 mRNA. Translation: BAC43423.1 .
BT026449 mRNA. Translation: ABH04556.1 .
PIRi C84430.
RefSeqi NP_178297.2. NM_126249.4.
UniGenei At.42460.

3D structure databases

ProteinModelPortali Q8S341.
SMRi Q8S341. Positions 41-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G01880.1-P.

Proteomic databases

PaxDbi Q8S341.
PRIDEi Q8S341.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G01880.1 ; AT2G01880.1 ; AT2G01880 .
GeneIDi 814719.
KEGGi ath:AT2G01880.

Organism-specific databases

TAIRi AT2G01880.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000239892.
InParanoidi Q8S341.
OMAi VEKYFTE.
PhylomeDBi Q8S341.

Enzyme and pathway databases

BioCyci ARA:AT2G01880-MONOMER.
Reactomei REACT_244898. Vitamin B2 (riboflavin) metabolism.

Gene expression databases

Genevestigatori Q8S341.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation."
    Li D., Zhu H., Liu K., Liu X., Leggewie G., Udvardi M., Wang D.
    J. Biol. Chem. 277:27772-27781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Col-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ORF Clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower."
    Zhu H., Qian W., Lu X., Li D., Liu X., Liu K., Wang D.
    Plant Mol. Biol. 59:581-594(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPPA7_ARATH
AccessioniPrimary (citable) accession number: Q8S341
Secondary accession number(s): Q8GWH8, Q9SIS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3