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Protein

Purple acid phosphatase 7

Gene

PAP7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48IronBy similarity1
Metal bindingi81IronBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi84IronBy similarity1
Metal bindingi119ZincBy similarity1
Metal bindingi213ZincBy similarity1
Active sitei222Proton donorBy similarity1
Metal bindingi248ZincBy similarity1
Metal bindingi250IronBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT2G01880-MONOMER.
ReactomeiR-ATH-196843. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Purple acid phosphatase 7 (EC:3.1.3.2)
Gene namesi
Name:PAP7
Ordered Locus Names:At2g01880
ORF Names:T23K3.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G01880.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000037281225 – 328Purple acid phosphatase 7Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8S341.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ8S341. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi122. 1 interactor.
STRINGi3702.AT2G01880.1.

Structurei

3D structure databases

ProteinModelPortaliQ8S341.
SMRiQ8S341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 250Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000239892.
InParanoidiQ8S341.
OMAiPRNKYIS.
OrthoDBiEOG09360IST.
PhylomeDBiQ8S341.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8S341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMHVCFSVI LMFLSIFFIN GALSKLERLK HPVKKKSDGS LSFLVIGDWG
60 70 80 90 100
RKGGFNQSLV AHQMGVVGEK LDIDFVISVG DNFYDDGLKG VNDPSFEASF
110 120 130 140 150
SHIYTHPSLQ KQWYSVLGNH DYRGNVEAQL SKVLTQKDWR WFCRRSFVLS
160 170 180 190 200
SGMVDFFFAD TNPFVEKYFT EPEDHTYDWR NVLPRNKYIS NLLHDLDLEI
210 220 230 240 250
KKSRATWKFV VGHHGIKTAG NHGVTQELVD QLLPILEENK VDLYINGHDH
260 270 280 290 300
CLQHIGSHGK TQFLTSGGGS KAWRGHVQPW DPKELKLYYD GQGFMSLHIT
310 320
HSKAKFIYYD VSGNVLHRSS LSKRSAHL
Length:328
Mass (Da):37,549
Last modified:June 1, 2002 - v1
Checksum:iF897E0A8D39CA052
GO

Sequence cautioni

The sequence AAD21780 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317H → L in BAC43423 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492659 mRNA. Translation: AAM15908.1.
AC007069 Genomic DNA. Translation: AAD21780.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC05511.1.
AK118834 mRNA. Translation: BAC43423.1.
BT026449 mRNA. Translation: ABH04556.1.
PIRiC84430.
RefSeqiNP_178297.2. NM_126249.5.
UniGeneiAt.42460.

Genome annotation databases

EnsemblPlantsiAT2G01880.1; AT2G01880.1; AT2G01880.
GeneIDi814719.
GrameneiAT2G01880.1; AT2G01880.1; AT2G01880.
KEGGiath:AT2G01880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492659 mRNA. Translation: AAM15908.1.
AC007069 Genomic DNA. Translation: AAD21780.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC05511.1.
AK118834 mRNA. Translation: BAC43423.1.
BT026449 mRNA. Translation: ABH04556.1.
PIRiC84430.
RefSeqiNP_178297.2. NM_126249.5.
UniGeneiAt.42460.

3D structure databases

ProteinModelPortaliQ8S341.
SMRiQ8S341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122. 1 interactor.
STRINGi3702.AT2G01880.1.

Proteomic databases

PaxDbiQ8S341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G01880.1; AT2G01880.1; AT2G01880.
GeneIDi814719.
GrameneiAT2G01880.1; AT2G01880.1; AT2G01880.
KEGGiath:AT2G01880.

Organism-specific databases

TAIRiAT2G01880.

Phylogenomic databases

eggNOGiKOG2679. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000239892.
InParanoidiQ8S341.
OMAiPRNKYIS.
OrthoDBiEOG09360IST.
PhylomeDBiQ8S341.

Enzyme and pathway databases

BioCyciARA:AT2G01880-MONOMER.
ReactomeiR-ATH-196843. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

PROiQ8S341.

Gene expression databases

GenevisibleiQ8S341. AT.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR024927. Acid_Pase_5.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000898. Acid_Ptase_5. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPA7_ARATH
AccessioniPrimary (citable) accession number: Q8S341
Secondary accession number(s): Q8GWH8, Q9SIS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.