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Q8RZA1

- UMPS2_ORYSJ

UniProt

Q8RZA1 - UMPS2_ORYSJ

Protein

Uridine 5'-monophosphate synthase

Gene

UMPS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
    Orotidine 5'-phosphate = UMP + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei305 – 3051By similarity

    GO - Molecular functioni

    1. orotate phosphoribosyltransferase activity Source: UniProtKB-EC
    2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Glycosyltransferase, Lyase, Transferase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00119.
    UPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Including the following 2 domains:
    Orotate phosphoribosyltransferase (EC:2.4.2.10)
    Short name:
    OPRTase
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMPdecase
    Gene namesi
    Name:UMPS2
    Ordered Locus Names:Os01g0951400, LOC_Os01g72250
    ORF Names:B1147A04.39
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ8RZA1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Uridine 5'-monophosphate synthasePRO_0000423082Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RZA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
    In the C-terminal section; belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    KOiK13421.
    OMAiFRITDWA.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPiMF_01208. PyrE.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RZA1-1 [UniParc]FASTAAdd to Basket

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    MDAAAMESLI LELHAIEAVK FGAFVLKSGI TSPIYLDLRM LVAHPRLLST    50
    VASLLGSLPA TRPYDLLCGV PYTALPIASV LSAAASVPML LRRYHVTPHA 100
    AAECLDGSFR AGDAVLIVED LVTTGSSVLE TVAPLREVGL VVADAVVVID 150
    REQGGRENLA ANGVALHSLM TLTEVLAVLV KRGKLGEEKA QEVKRFLDAN 200
    RKMAVPGLPV KPKVVRKAFS ERAGLATNPM GRKLFELMEA KQSNLCVAAD 250
    VGTATELLDL ADKIGPEICM LKTHVDILSD FTPDFGHKLR SIAERHSFLI 300
    FEDRKFADIG NTVTMQYEGG IFRILDWADI VNAHIVSGPG IVEGLKLKGL 350
    PKGRGLLLLS EMSSAGNLAH GDYTAAAVKI AEQHSDIVIG FISVNPASWS 400
    VTPSSPAFIH ATPGVQLVAG GDSLGQQYNT PYSVINDRGS DIIIVGRGII 450
    RANNPAETAR EYRIQGWHAY QSSLS 475
    Length:475
    Mass (Da):50,807
    Last modified:June 1, 2002 - v1
    Checksum:iF9A503E621AEC0A0
    GO

    Sequence cautioni

    The sequence BAF07327.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003735 Genomic DNA. Translation: BAB86208.1.
    AP008207 Genomic DNA. Translation: BAF07327.2. Sequence problems.
    AK102468 mRNA. Translation: BAG95570.1.
    RefSeqiNP_001045413.2. NM_001051948.2.
    UniGeneiOs.88441.

    Genome annotation databases

    EnsemblPlantsiOS01T0951400-01; OS01T0951400-01; OS01G0951400.
    GeneIDi4325740.
    KEGGiosa:4325740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003735 Genomic DNA. Translation: BAB86208.1 .
    AP008207 Genomic DNA. Translation: BAF07327.2 . Sequence problems.
    AK102468 mRNA. Translation: BAG95570.1 .
    RefSeqi NP_001045413.2. NM_001051948.2.
    UniGenei Os.88441.

    3D structure databases

    ProteinModelPortali Q8RZA1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0951400-01 ; OS01T0951400-01 ; OS01G0951400 .
    GeneIDi 4325740.
    KEGGi osa:4325740.

    Organism-specific databases

    Gramenei Q8RZA1.

    Phylogenomic databases

    KOi K13421.
    OMAi FRITDWA.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00119 .
    UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPi MF_01208. PyrE.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiUMPS2_ORYSJ
    AccessioniPrimary (citable) accession number: Q8RZA1
    Secondary accession number(s): Q0JG01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2013
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3