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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
  2. Orotidine 5'-phosphate decarboxylase (UMPS2), Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiR-OSA-500753. Pyrimidine biosynthesis.
UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:UMPS2
Ordered Locus Names:Os01g0951400, LOC_Os01g72250
ORF Names:B1147A04.39
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004230821 – 475Uridine 5'-monophosphate synthaseAdd BLAST475

Proteomic databases

PaxDbiQ8RZA1.

Expressioni

Gene expression databases

ExpressionAtlasiQ8RZA1. baseline and differential.
GenevisibleiQ8RZA1. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g72250.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RZA1.
SMRiQ8RZA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
COG0461. LUCA.
InParanoidiQ8RZA1.
KOiK13421.
OMAiYVYPSMI.
OrthoDBiEOG093602IE.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01208. PyrE. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
SMARTiView protein in SMART
SM00934. OMPdecase. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiView protein in PROSITE
PS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RZA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAAMESLI LELHAIEAVK FGAFVLKSGI TSPIYLDLRM LVAHPRLLST
60 70 80 90 100
VASLLGSLPA TRPYDLLCGV PYTALPIASV LSAAASVPML LRRYHVTPHA
110 120 130 140 150
AAECLDGSFR AGDAVLIVED LVTTGSSVLE TVAPLREVGL VVADAVVVID
160 170 180 190 200
REQGGRENLA ANGVALHSLM TLTEVLAVLV KRGKLGEEKA QEVKRFLDAN
210 220 230 240 250
RKMAVPGLPV KPKVVRKAFS ERAGLATNPM GRKLFELMEA KQSNLCVAAD
260 270 280 290 300
VGTATELLDL ADKIGPEICM LKTHVDILSD FTPDFGHKLR SIAERHSFLI
310 320 330 340 350
FEDRKFADIG NTVTMQYEGG IFRILDWADI VNAHIVSGPG IVEGLKLKGL
360 370 380 390 400
PKGRGLLLLS EMSSAGNLAH GDYTAAAVKI AEQHSDIVIG FISVNPASWS
410 420 430 440 450
VTPSSPAFIH ATPGVQLVAG GDSLGQQYNT PYSVINDRGS DIIIVGRGII
460 470
RANNPAETAR EYRIQGWHAY QSSLS
Length:475
Mass (Da):50,807
Last modified:June 1, 2002 - v1
Checksum:iF9A503E621AEC0A0
GO

Sequence cautioni

The sequence BAF07327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003735 Genomic DNA. Translation: BAB86208.1.
AP008207 Genomic DNA. Translation: BAF07327.2. Sequence problems.
AP014957 Genomic DNA. Translation: BAS76245.1.
AK102468 mRNA. Translation: BAG95570.1.
RefSeqiXP_015621270.1. XM_015765784.1.
UniGeneiOs.88441.

Genome annotation databases

EnsemblPlantsiOS01T0951400-01; OS01T0951400-01; OS01G0951400.
GeneIDi4325740.
GrameneiOS01T0951400-01; OS01T0951400-01; OS01G0951400.
KEGGiosa:4325740.

Similar proteinsi

Entry informationi

Entry nameiUMPS2_ORYSJ
AccessioniPrimary (citable) accession number: Q8RZA1
Secondary accession number(s): A0A0P0VCW6, Q0JG01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families