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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
  2. Orotidine 5'-phosphate decarboxylase (UMPS2), Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiR-OSA-500753 Pyrimidine biosynthesis
UniPathwayiUPA00070; UER00119
UPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:UMPS2
Ordered Locus Names:Os01g0951400, LOC_Os01g72250
ORF Names:B1147A04.39
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004230821 – 475Uridine 5'-monophosphate synthaseAdd BLAST475

Proteomic databases

PaxDbiQ8RZA1
PRIDEiQ8RZA1

Expressioni

Gene expression databases

ExpressionAtlasiQ8RZA1 differential
GenevisibleiQ8RZA1 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g72250.1

Structurei

3D structure databases

ProteinModelPortaliQ8RZA1
SMRiQ8RZA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
InParanoidiQ8RZA1
KOiK13421
OMAiGIKLHSM
OrthoDBiEOG093602IE

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RZA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAAMESLI LELHAIEAVK FGAFVLKSGI TSPIYLDLRM LVAHPRLLST
60 70 80 90 100
VASLLGSLPA TRPYDLLCGV PYTALPIASV LSAAASVPML LRRYHVTPHA
110 120 130 140 150
AAECLDGSFR AGDAVLIVED LVTTGSSVLE TVAPLREVGL VVADAVVVID
160 170 180 190 200
REQGGRENLA ANGVALHSLM TLTEVLAVLV KRGKLGEEKA QEVKRFLDAN
210 220 230 240 250
RKMAVPGLPV KPKVVRKAFS ERAGLATNPM GRKLFELMEA KQSNLCVAAD
260 270 280 290 300
VGTATELLDL ADKIGPEICM LKTHVDILSD FTPDFGHKLR SIAERHSFLI
310 320 330 340 350
FEDRKFADIG NTVTMQYEGG IFRILDWADI VNAHIVSGPG IVEGLKLKGL
360 370 380 390 400
PKGRGLLLLS EMSSAGNLAH GDYTAAAVKI AEQHSDIVIG FISVNPASWS
410 420 430 440 450
VTPSSPAFIH ATPGVQLVAG GDSLGQQYNT PYSVINDRGS DIIIVGRGII
460 470
RANNPAETAR EYRIQGWHAY QSSLS
Length:475
Mass (Da):50,807
Last modified:June 1, 2002 - v1
Checksum:iF9A503E621AEC0A0
GO

Sequence cautioni

The sequence BAF07327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003735 Genomic DNA Translation: BAB86208.1
AP008207 Genomic DNA Translation: BAF07327.2 Sequence problems.
AP014957 Genomic DNA Translation: BAS76245.1
AK102468 mRNA Translation: BAG95570.1
RefSeqiXP_015621270.1, XM_015765784.1
UniGeneiOs.88441

Genome annotation databases

EnsemblPlantsiOs01t0951400-01; Os01t0951400-01; Os01g0951400
GeneIDi4325740
GrameneiOs01t0951400-01; Os01t0951400-01; Os01g0951400
KEGGiosa:4325740

Similar proteinsi

Entry informationi

Entry nameiUMPS2_ORYSJ
AccessioniPrimary (citable) accession number: Q8RZA1
Secondary accession number(s): A0A0P0VCW6, Q0JG01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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