LAC2

Functionⁱ

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityⁱ

4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.

Cofactorⁱ

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature key	Position(s)	Length	Description
Metal bindingⁱ	84 – 84	1	Copper 1By similarity
Metal bindingⁱ	86 – 86	1	Copper 2By similarity
Metal bindingⁱ	129 – 129	1	Copper 2By similarity
Metal bindingⁱ	131 – 131	1	Copper 3By similarity
Metal bindingⁱ	463 – 463	1	Copper 4By similarity
Metal bindingⁱ	466 – 466	1	Copper 1By similarity
Metal bindingⁱ	468 – 468	1	Copper 3By similarity
Metal bindingⁱ	525 – 525	1	Copper 3By similarity
Metal bindingⁱ	526 – 526	1	Copper 4By similarity
Metal bindingⁱ	527 – 527	1	Copper 2By similarity
Metal bindingⁱ	531 – 531	1	Copper 4By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Laccase-2 (EC:1.10.3.2) Alternative name(s): Benzenediol:oxygen oxidoreductase 2 Diphenol oxidase 2 Urishiol oxidase 2
Gene namesⁱ	Name:LAC2 Ordered Locus Names:Os01g0634500, LOC_Os01g44330 ORF Names:OsJ_002637, P0663E10.27
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 1

Subcellular locationⁱ

Secreted › extracellular space › apoplast Curated

GO - Cellular componentⁱ

apoplast Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Apoplast, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Signal peptideⁱ	1 – 26	26	Sequence analysis			Add BLAST
Chainⁱ	27 – 562	536	Laccase-2		PRO_0000291887	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Glycosylationⁱ	39 – 39	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	53 – 53	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	72 – 72	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	80 – 80	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	118 – 118	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	189 – 189	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	244 – 244	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	300 – 300	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	328 – 328	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	376 – 376	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	386 – 386	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	421 – 421	1	N-linked (GlcNAc...)Sequence analysis
Glycosylationⁱ	445 – 445	1	N-linked (GlcNAc...)Sequence analysis

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8RYM9.

PaxDbⁱ

Q8RYM9.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q8RYM9. OS.

Genevisibleⁱ

Q8RYM9. OS.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os01g44330.1.

STRINGⁱ

39947.LOC_Os01g44330.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8RYM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Actions
Domainⁱ	34 – 150	117	Plastocyanin-like 1	Add BLAST
Domainⁱ	160 – 312	153	Plastocyanin-like 2	Add BLAST
Domainⁱ	411 – 546	136	Plastocyanin-like 3	Add BLAST

Sequence similaritiesⁱ

Belongs to the multicopper oxidase family.Curated

Contains 3 plastocyanin-like domains.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG1263. Eukaryota. COG2132. LUCA.
InParanoidⁱ	Q8RYM9.
OrthoDBⁱ	EOG09360579.

Family and domain databases

Gene3Dⁱ	2.60.40.420. 3 hits.
InterProⁱ	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR033138. Cu_oxidase_CS. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR017761. Laccase. [Graphical view]
Pfamⁱ	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
SUPFAMⁱ	SSF49503. SSF49503. 3 hits.
TIGRFAMsⁱ	TIGR03389. laccase. 1 hit.
PROSITEⁱ	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8RYM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASAASSLPL LVSSLLLALF ALGAHADVKR YQFDIVMSNV SRLCHEKAMV 
        60         70         80         90        100
TVNGSYPGPT IYAREGDRVI VNVTNHVKHN MTIHWHGLKQ RRNGWADGPA 
       110        120        130        140        150
YVTQCPIGSG GSYVYDFNVT RQRGTLWWHA HIAWMRATVH GAIVILPAAG 
       160        170        180        190        200
VPYPFPKPDD EAEIVLGEWW HADVETVERQ GSMLGMAPNM SDAHTINGKP 
       210        220        230        240        250
GPLVPFCSEK HTYALQVQSG KTYLLRIINA AVNDELFFSI AGHNMTVVEI 
       260        270        280        290        300
DATYTKPFAA STVQLSPGQT MNVLVSADQS PGRYFMVAKP FNDVPIPADN 
       310        320        330        340        350
KTATAILQYA GVPTSVVPAL PQTMPATNST GSVAAFHDKL RSLNSPRYPA 
       360        370        380        390        400
DVPLAVDRHL LYTIGLNIDP CETCLNRSRL AASLNNITFV MPRTALLQAH 
       410        420        430        440        450
YYGQKGVFAA DFPDRPPARF NYTGVPLTAG LGTSLGTRLS KIAYNATVEL 
       460        470        480        490        500
VLQDTNLLSV ESHPFHLHGY NFFVVGRGVG NFDPAKDPAK YNLVDPPERN 
       510        520        530        540        550
TVGVPAGGWT AIRFRADNPG VWFLHCHLEV HTSWGLKMAF LVEDGSGPDE 
       560 
SVLPPPKDLP KC

Length:562

Mass (Da):61,296

Last modified:June 1, 2002 - v1

Checksum:ⁱ0BF4F84B9E7996A9

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Sequence conflictⁱ	168 – 168	1	E → D in EAZ12812 (PubMed:15685292).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004317 Genomic DNA. Translation: BAB90733.1. AP014957 Genomic DNA. No translation available. CM000138 Genomic DNA. Translation: EAZ12812.1.
RefSeqⁱ	XP_015633503.1. XM_015778017.1.

Genome annotation databases

GeneIDⁱ	107276614.

GeneIDⁱ

107276614.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004317 Genomic DNA. Translation: BAB90733.1. AP014957 Genomic DNA. No translation available. CM000138 Genomic DNA. Translation: EAZ12812.1.
RefSeqⁱ	XP_015633503.1. XM_015778017.1.

3D structure databases

ProteinModelPortalⁱ	Q8RYM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os01g44330.1.

STRINGⁱ

39947.LOC_Os01g44330.1.

Proteomic databases

PaxDbⁱ	Q8RYM9.

PaxDbⁱ

Q8RYM9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	107276614.

GeneIDⁱ

107276614.

Phylogenomic databases

eggNOGⁱ	KOG1263. Eukaryota. COG2132. LUCA.
InParanoidⁱ	Q8RYM9.
OrthoDBⁱ	EOG09360579.

Gene expression databases

Genevisibleⁱ	Q8RYM9. OS.

Genevisibleⁱ

Q8RYM9. OS.

Family and domain databases

Gene3Dⁱ	2.60.40.420. 3 hits.
InterProⁱ	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR033138. Cu_oxidase_CS. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR017761. Laccase. [Graphical view]
Pfamⁱ	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
SUPFAMⁱ	SSF49503. SSF49503. 3 hits.
TIGRFAMsⁱ	TIGR03389. laccase. 1 hit.
PROSITEⁱ	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

LAC2_ORYSJ

Accessionⁱ

Primary (citable) accession number: Q8RYM9
Secondary accession number(s): A2ZVR5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 1, 2002
Last modified:	September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8RYM9 (LAC2_ORYSJ)

UniProt

Q8RYM9 - LAC2_ORYSJ

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Laccase-2

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ