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Protein

Laccase-2

Gene

LAC2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1By similarity1
Metal bindingi86Copper 2By similarity1
Metal bindingi129Copper 2By similarity1
Metal bindingi131Copper 3By similarity1
Metal bindingi463Copper 4By similarity1
Metal bindingi466Copper 1By similarity1
Metal bindingi468Copper 3By similarity1
Metal bindingi525Copper 3By similarity1
Metal bindingi526Copper 4By similarity1
Metal bindingi527Copper 2By similarity1
Metal bindingi531Copper 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Urishiol oxidase 2
Gene namesi
Name:LAC2
Ordered Locus Names:Os01g0634500, LOC_Os01g44330
ORF Names:OsJ_002637, P0663E10.27
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000029188727 – 562Laccase-2Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi376N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi445N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8RYM9.

Expressioni

Gene expression databases

GenevisibleiQ8RYM9. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g44330.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RYM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150Plastocyanin-like 1Add BLAST117
Domaini160 – 312Plastocyanin-like 2Add BLAST153
Domaini411 – 546Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ8RYM9.
KOiK05909.
OrthoDBiEOG09360579.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8RYM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAASSLPL LVSSLLLALF ALGAHADVKR YQFDIVMSNV SRLCHEKAMV
60 70 80 90 100
TVNGSYPGPT IYAREGDRVI VNVTNHVKHN MTIHWHGLKQ RRNGWADGPA
110 120 130 140 150
YVTQCPIGSG GSYVYDFNVT RQRGTLWWHA HIAWMRATVH GAIVILPAAG
160 170 180 190 200
VPYPFPKPDD EAEIVLGEWW HADVETVERQ GSMLGMAPNM SDAHTINGKP
210 220 230 240 250
GPLVPFCSEK HTYALQVQSG KTYLLRIINA AVNDELFFSI AGHNMTVVEI
260 270 280 290 300
DATYTKPFAA STVQLSPGQT MNVLVSADQS PGRYFMVAKP FNDVPIPADN
310 320 330 340 350
KTATAILQYA GVPTSVVPAL PQTMPATNST GSVAAFHDKL RSLNSPRYPA
360 370 380 390 400
DVPLAVDRHL LYTIGLNIDP CETCLNRSRL AASLNNITFV MPRTALLQAH
410 420 430 440 450
YYGQKGVFAA DFPDRPPARF NYTGVPLTAG LGTSLGTRLS KIAYNATVEL
460 470 480 490 500
VLQDTNLLSV ESHPFHLHGY NFFVVGRGVG NFDPAKDPAK YNLVDPPERN
510 520 530 540 550
TVGVPAGGWT AIRFRADNPG VWFLHCHLEV HTSWGLKMAF LVEDGSGPDE
560
SVLPPPKDLP KC
Length:562
Mass (Da):61,296
Last modified:June 1, 2002 - v1
Checksum:i0BF4F84B9E7996A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168E → D in EAZ12812 (PubMed:15685292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004317 Genomic DNA. Translation: BAB90733.1.
AP014957 Genomic DNA. No translation available.
CM000138 Genomic DNA. Translation: EAZ12812.1.
RefSeqiXP_015633503.1. XM_015778017.1.

Genome annotation databases

GeneIDi107276614.
KEGGiosa:107276614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004317 Genomic DNA. Translation: BAB90733.1.
AP014957 Genomic DNA. No translation available.
CM000138 Genomic DNA. Translation: EAZ12812.1.
RefSeqiXP_015633503.1. XM_015778017.1.

3D structure databases

ProteinModelPortaliQ8RYM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os01g44330.1.

Proteomic databases

PaxDbiQ8RYM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107276614.
KEGGiosa:107276614.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
InParanoidiQ8RYM9.
KOiK05909.
OrthoDBiEOG09360579.

Gene expression databases

GenevisibleiQ8RYM9. OS.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC2_ORYSJ
AccessioniPrimary (citable) accession number: Q8RYM9
Secondary accession number(s): A2ZVR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.