LAC2

Functionⁱ

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityⁱ

4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.

Cofactorⁱ

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	84	Copper 1By similarity	1
Metal bindingⁱ	86	Copper 2By similarity	1
Metal bindingⁱ	129	Copper 2By similarity	1
Metal bindingⁱ	131	Copper 3By similarity	1
Metal bindingⁱ	463	Copper 4By similarity	1
Metal bindingⁱ	466	Copper 1By similarity	1
Metal bindingⁱ	468	Copper 3By similarity	1
Metal bindingⁱ	525	Copper 3By similarity	1
Metal bindingⁱ	526	Copper 4By similarity	1
Metal bindingⁱ	527	Copper 2By similarity	1
Metal bindingⁱ	531	Copper 4By similarity	1

GO - Molecular functionⁱ

copper ion binding Source: InterPro
hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
oxidoreductase activity, oxidizing metal ions Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lignin catabolic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Lignin degradation
Ligand	Copper, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Laccase-2 (EC:1.10.3.2) Alternative name(s): Benzenediol:oxygen oxidoreductase 2 Diphenol oxidase 2 Urishiol oxidase 2
Gene namesⁱ	Name:LAC2 Ordered Locus Names:Os01g0634500, LOC_Os01g44330 ORF Names:OsJ_002637, P0663E10.27
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 1

Keywords - Cellular componentⁱ

Apoplast, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000291887	27 – 562	Laccase-2Add BLAST		536

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	189	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	244	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	328	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	376	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	386	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	421	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	445	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8RYM9.

PaxDbⁱ

Q8RYM9.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q8RYM9. baseline and differential.
Genevisibleⁱ	Q8RYM9. OS.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os01g44330.1.

STRINGⁱ

39947.LOC_Os01g44330.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8RYM9.
SMRⁱ	Q8RYM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	34 – 150	Plastocyanin-like 1Add BLAST	117
Domainⁱ	160 – 312	Plastocyanin-like 2Add BLAST	153
Domainⁱ	411 – 546	Plastocyanin-like 3Add BLAST	136

Sequence similaritiesⁱ

Belongs to the multicopper oxidase family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG1263. Eukaryota. COG2132. LUCA.
InParanoidⁱ	Q8RYM9.
KEGG Orthology (KO) More...KOⁱ	K05909.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360579.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13849. CuRO_1_LCC_plant. 1 hit. cd13875. CuRO_2_LCC_plant. 1 hit. cd13897. CuRO_3_LCC_plant. 1 hit.
Gene3Dⁱ	2.60.40.420. 3 hits.
InterProⁱ	View protein in InterPro IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR033138. Cu_oxidase_CS. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR034288. CuRO_1_LCC. IPR034285. CuRO_2_LCC. IPR034289. CuRO_3_LCC. IPR017761. Laccase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit.
SUPFAMⁱ	SSF49503. SSF49503. 3 hits.
TIGRFAMsⁱ	TIGR03389. laccase. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8RYM9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASAASSLPL LVSSLLLALF ALGAHADVKR YQFDIVMSNV SRLCHEKAMV 
        60         70         80         90        100
TVNGSYPGPT IYAREGDRVI VNVTNHVKHN MTIHWHGLKQ RRNGWADGPA 
       110        120        130        140        150
YVTQCPIGSG GSYVYDFNVT RQRGTLWWHA HIAWMRATVH GAIVILPAAG 
       160        170        180        190        200
VPYPFPKPDD EAEIVLGEWW HADVETVERQ GSMLGMAPNM SDAHTINGKP 
       210        220        230        240        250
GPLVPFCSEK HTYALQVQSG KTYLLRIINA AVNDELFFSI AGHNMTVVEI 
       260        270        280        290        300
DATYTKPFAA STVQLSPGQT MNVLVSADQS PGRYFMVAKP FNDVPIPADN 
       310        320        330        340        350
KTATAILQYA GVPTSVVPAL PQTMPATNST GSVAAFHDKL RSLNSPRYPA 
       360        370        380        390        400
DVPLAVDRHL LYTIGLNIDP CETCLNRSRL AASLNNITFV MPRTALLQAH 
       410        420        430        440        450
YYGQKGVFAA DFPDRPPARF NYTGVPLTAG LGTSLGTRLS KIAYNATVEL 
       460        470        480        490        500
VLQDTNLLSV ESHPFHLHGY NFFVVGRGVG NFDPAKDPAK YNLVDPPERN 
       510        520        530        540        550
TVGVPAGGWT AIRFRADNPG VWFLHCHLEV HTSWGLKMAF LVEDGSGPDE 
       560 
SVLPPPKDLP KC

Length:562

Mass (Da):61,296

Last modified:June 1, 2002 - v1

Checksum:ⁱ0BF4F84B9E7996A9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	168	E → D in EAZ12812 (PubMed:15685292).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004317 Genomic DNA. Translation: BAB90733.1. AP014957 Genomic DNA. No translation available. CM000138 Genomic DNA. Translation: EAZ12812.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015633503.1. XM_015778017.1.

Genome annotation databases

EnsemblPlantsⁱ	Os01t0634500-00; Os01t0634500-00; Os01g0634500.
GeneIDⁱ	107276614.
Grameneⁱ	Os01t0634500-00; Os01t0634500-00; Os01g0634500.
KEGGⁱ	osa:107276614.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8RYM9	A0A0P0V5L8	Oryza sativa subsp. japonica (Rice)	562	UniRef100_Q8RYM9	Cluster: Laccase-2	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8RYM9	A0A0P0V5L8 A0A0E0C541 A0A0E0JLI4 A0A0E0FPW8 A0A0D9V3A8 A0A0D9YC53 A0A0D3ERL4 A0A0E0MZP9	Oryza sativa subsp. japonica (Rice) Oryza meridionalis Oryza punctata (Red rice) Oryza nivara (Indian wild rice) Leersia perrieri Oryza glumipatula Oryza barthii Oryza rufipogon (Brownbeard rice) (Asian wild rice)	562	UniRef90_Q8RYM9	Cluster: Laccase-2	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8RYM9	O80434 A0A178VQR2 A0A1J3HK02 A0A1J3FT28 A0A1J3JKL9 A0A1J3D4C5 M4CLQ3 UPI0004F1A8BE A0A0D3C4X2 A0A087H3K4 +501	Arabidopsis thaliana (Mouse-ear cress) Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens) Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) Brassica campestris (Field mustard) Brassica oleracea var. oleracea Arabis alpina (Alpine rock-cress) Brassica napus (Rape) Camelina sativa (False flax) (Myagrum sativum) Capsella rubella Raphanus sativus (Radish) And more	558	UniRef50_O80434	Cluster: Laccase-4	512

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP004317 Genomic DNA. Translation: BAB90733.1. AP014957 Genomic DNA. No translation available. CM000138 Genomic DNA. Translation: EAZ12812.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015633503.1. XM_015778017.1.

3D structure databases

ProteinModelPortalⁱ	Q8RYM9.
SMRⁱ	Q8RYM9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	39947.LOC_Os01g44330.1.

STRINGⁱ

39947.LOC_Os01g44330.1.

Proteomic databases

PaxDbⁱ	Q8RYM9.

PaxDbⁱ

Q8RYM9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	Os01t0634500-00; Os01t0634500-00; Os01g0634500.
GeneIDⁱ	107276614.
Grameneⁱ	Os01t0634500-00; Os01t0634500-00; Os01g0634500.
KEGGⁱ	osa:107276614.

Phylogenomic databases

eggNOGⁱ	KOG1263. Eukaryota. COG2132. LUCA.
InParanoidⁱ	Q8RYM9.
KEGG Orthology (KO) More...KOⁱ	K05909.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360579.

Gene expression databases

ExpressionAtlasⁱ	Q8RYM9. baseline and differential.
Genevisibleⁱ	Q8RYM9. OS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13849. CuRO_1_LCC_plant. 1 hit. cd13875. CuRO_2_LCC_plant. 1 hit. cd13897. CuRO_3_LCC_plant. 1 hit.
Gene3Dⁱ	2.60.40.420. 3 hits.
InterProⁱ	View protein in InterPro IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR033138. Cu_oxidase_CS. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. IPR034288. CuRO_1_LCC. IPR034285. CuRO_2_LCC. IPR034289. CuRO_3_LCC. IPR017761. Laccase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit.
SUPFAMⁱ	SSF49503. SSF49503. 3 hits.
TIGRFAMsⁱ	TIGR03389. laccase. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAC2_ORYSJ
Accessionⁱ	Q8RYM9Primary (citable) accession number: Q8RYM9 Secondary accession number(s): A2ZVR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	June 1, 2002
	Last modified:	February 28, 2018
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8RYM9 (LAC2_ORYSJ)

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Laccase-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ