Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 4-phosphate 5-kinase 8

Gene

PIP5K8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G60890-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 8 (EC:2.7.1.68)
Short name:
AtPIP5K8
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 8
Diphosphoinositide kinase 8
PtdIns(4)P-5-kinase 8
Gene namesi
Name:PIP5K8
Ordered Locus Names:At1g60890
ORF Names:T7P1.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G60890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854801 – 769Phosphatidylinositol 4-phosphate 5-kinase 8Add BLAST769

Proteomic databases

PaxDbiQ8RY89.
PRIDEiQ8RY89.

PTM databases

iPTMnetiQ8RY89.

Expressioni

Gene expression databases

ExpressionAtlasiQ8RY89. baseline and differential.
GenevisibleiQ8RY89. AT.

Interactioni

Protein-protein interaction databases

BioGridi27605. 1 interactor.
STRINGi3702.AT1G60890.2.

Structurei

3D structure databases

ProteinModelPortaliQ8RY89.
SMRiQ8RY89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 61MORN 2Add BLAST23
Repeati62 – 84MORN 3Add BLAST23
Repeati85 – 107MORN 4Add BLAST23
Repeati108 – 130MORN 5Add BLAST23
Repeati131 – 153MORN 6Add BLAST23
Repeati154 – 176MORN 7Add BLAST23
Repeati177 – 198MORN 8Add BLAST22
Domaini344 – 765PIPKPROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni725 – 746Activation loopBy similarityAdd BLAST22

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ8RY89.
KOiK00889.
PhylomeDBiQ8RY89.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8RY89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METRPAERVF SNGDVYSGQL KGTLPHGKGK YAWPDGIIYE GDWEEGKISG
60 70 80 90 100
RGKLMWSSGA KYEGDFSGGY LHGFGTLTSP DGSVYAGAWR MNVRHGLGRK
110 120 130 140 150
EYCNSDVYDG SWREGLQDGS GSYSWYNGNR FIGNWKKGKM SGRGVMSWAN
160 170 180 190 200
GDLFNGFWLN GLRHGSGVYK YADGGFYFGT WSRGLKDGSG VFYPAGSKHP
210 220 230 240 250
SLKKWHRHFG YDDTGNFLLS HNSTINIDDL RTSKAVSRSL SELTTTSGLT
260 270 280 290 300
RTSERYPDDY WSTSDPPRDF MHHGPSSKSA RSVDSGQSEI RDKNPIVFER
310 320 330 340 350
EYMQGVLIKE RIMSSIDMSH RARPLNLTKE VTVSACVSFL GGKWNHYLML
360 370 380 390 400
NLQLGIRYTV GKITPVPPRE VRASDFSERA RIMMFFPRNG SQYTPPHKSI
410 420 430 440 450
DFDWKDYCPM VFRNLREMFK LDAADYMMSI CGDDGLREIS SPGKSGSIFY
460 470 480 490 500
LSHDDRFVIK TLKRSELKVL LRMLPRYYEH VGDYENTLIT KFFGVHRIKL
510 520 530 540 550
KWGKKVRFVV MGNMFCTELK IHRRYDLKGS TQGRYTEKNK IGEKTTLKDL
560 570 580 590 600
DLAYEFHMDK LLREALFKQI ILDCSFLESL QILDYSLLLG LHFRAPDPLT
610 620 630 640 650
DILEPPNEMS DQESDSVGSV DVNLPREPSI PPKGLLMVTH EPNSVNTAPG
660 670 680 690 700
PHIRGSTLRA FSVGEKEVDL ILPGTARLRV QLGVNMPAQA HHKLGQDNEE
710 720 730 740 750
SGTVELFEVY DVVVYMGIID ILQEYNMKKK VEHTCKSMKY DPMTISAIEP
760
TLYSKRFIDF LLKVFPEKA
Length:769
Mass (Da):87,403
Last modified:June 1, 2002 - v1
Checksum:i2E8A045211FB39A3
GO

Sequence cautioni

The sequence AAG51639 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018908 Genomic DNA. Translation: AAG51639.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33744.1.
AY074507 mRNA. Translation: AAL69491.1.
AY133824 mRNA. Translation: AAM91758.1.
PIRiD96634.
RefSeqiNP_176286.2. NM_104770.5. [Q8RY89-1]
UniGeneiAt.28792.

Genome annotation databases

EnsemblPlantsiAT1G60890.1; AT1G60890.1; AT1G60890. [Q8RY89-1]
GeneIDi842381.
GrameneiAT1G60890.1; AT1G60890.1; AT1G60890.
KEGGiath:AT1G60890.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018908 Genomic DNA. Translation: AAG51639.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33744.1.
AY074507 mRNA. Translation: AAL69491.1.
AY133824 mRNA. Translation: AAM91758.1.
PIRiD96634.
RefSeqiNP_176286.2. NM_104770.5. [Q8RY89-1]
UniGeneiAt.28792.

3D structure databases

ProteinModelPortaliQ8RY89.
SMRiQ8RY89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27605. 1 interactor.
STRINGi3702.AT1G60890.2.

PTM databases

iPTMnetiQ8RY89.

Proteomic databases

PaxDbiQ8RY89.
PRIDEiQ8RY89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G60890.1; AT1G60890.1; AT1G60890. [Q8RY89-1]
GeneIDi842381.
GrameneiAT1G60890.1; AT1G60890.1; AT1G60890.
KEGGiath:AT1G60890.

Organism-specific databases

TAIRiAT1G60890.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ8RY89.
KOiK00889.
PhylomeDBiQ8RY89.

Enzyme and pathway databases

BioCyciARA:AT1G60890-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ8RY89.

Gene expression databases

ExpressionAtlasiQ8RY89. baseline and differential.
GenevisibleiQ8RY89. AT.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K8_ARATH
AccessioniPrimary (citable) accession number: Q8RY89
Secondary accession number(s): Q9C962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.