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Q8RY89

- PI5K8_ARATH

UniProt

Q8RY89 - PI5K8_ARATH

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Protein

Phosphatidylinositol 4-phosphate 5-kinase 8

Gene
PIP5K8, At1g60890, T7P1.4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G60890-MONOMER.
ARA:GQT-2287-MONOMER.
ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 8 (EC:2.7.1.68)
Short name:
AtPIP5K8
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 8
Diphosphoinositide kinase 8
PtdIns(4)P-5-kinase 8
Gene namesi
Name:PIP5K8
Ordered Locus Names:At1g60890
ORF Names:T7P1.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G60890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769Phosphatidylinositol 4-phosphate 5-kinase 8PRO_0000185480Add
BLAST

Proteomic databases

PaxDbiQ8RY89.
PRIDEiQ8RY89.

Expressioni

Gene expression databases

ArrayExpressiQ8RY89.
GenevestigatoriQ8RY89.

Interactioni

Protein-protein interaction databases

BioGridi27605. 1 interaction.
STRINGi3702.AT1G60890.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8RY89.
SMRiQ8RY89. Positions 352-592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati16 – 3823MORN 1Add
BLAST
Repeati39 – 6123MORN 2Add
BLAST
Repeati62 – 8423MORN 3Add
BLAST
Repeati85 – 10723MORN 4Add
BLAST
Repeati108 – 13023MORN 5Add
BLAST
Repeati131 – 15323MORN 6Add
BLAST
Repeati154 – 17623MORN 7Add
BLAST
Repeati177 – 19822MORN 8Add
BLAST
Domaini344 – 765422PIPKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni725 – 74622Activation loop By similarityAdd
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.
Contains 1 PIPK domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ8RY89.
KOiK00889.
PhylomeDBiQ8RY89.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q8RY89-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

METRPAERVF SNGDVYSGQL KGTLPHGKGK YAWPDGIIYE GDWEEGKISG    50
RGKLMWSSGA KYEGDFSGGY LHGFGTLTSP DGSVYAGAWR MNVRHGLGRK 100
EYCNSDVYDG SWREGLQDGS GSYSWYNGNR FIGNWKKGKM SGRGVMSWAN 150
GDLFNGFWLN GLRHGSGVYK YADGGFYFGT WSRGLKDGSG VFYPAGSKHP 200
SLKKWHRHFG YDDTGNFLLS HNSTINIDDL RTSKAVSRSL SELTTTSGLT 250
RTSERYPDDY WSTSDPPRDF MHHGPSSKSA RSVDSGQSEI RDKNPIVFER 300
EYMQGVLIKE RIMSSIDMSH RARPLNLTKE VTVSACVSFL GGKWNHYLML 350
NLQLGIRYTV GKITPVPPRE VRASDFSERA RIMMFFPRNG SQYTPPHKSI 400
DFDWKDYCPM VFRNLREMFK LDAADYMMSI CGDDGLREIS SPGKSGSIFY 450
LSHDDRFVIK TLKRSELKVL LRMLPRYYEH VGDYENTLIT KFFGVHRIKL 500
KWGKKVRFVV MGNMFCTELK IHRRYDLKGS TQGRYTEKNK IGEKTTLKDL 550
DLAYEFHMDK LLREALFKQI ILDCSFLESL QILDYSLLLG LHFRAPDPLT 600
DILEPPNEMS DQESDSVGSV DVNLPREPSI PPKGLLMVTH EPNSVNTAPG 650
PHIRGSTLRA FSVGEKEVDL ILPGTARLRV QLGVNMPAQA HHKLGQDNEE 700
SGTVELFEVY DVVVYMGIID ILQEYNMKKK VEHTCKSMKY DPMTISAIEP 750
TLYSKRFIDF LLKVFPEKA 769
Length:769
Mass (Da):87,403
Last modified:June 1, 2002 - v1
Checksum:i2E8A045211FB39A3
GO

Sequence cautioni

The sequence AAG51639.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018908 Genomic DNA. Translation: AAG51639.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33744.1.
AY074507 mRNA. Translation: AAL69491.1.
AY133824 mRNA. Translation: AAM91758.1.
PIRiD96634.
RefSeqiNP_176286.2. NM_104770.4. [Q8RY89-1]
UniGeneiAt.28792.

Genome annotation databases

EnsemblPlantsiAT1G60890.1; AT1G60890.1; AT1G60890. [Q8RY89-1]
GeneIDi842381.
KEGGiath:AT1G60890.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018908 Genomic DNA. Translation: AAG51639.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE33744.1 .
AY074507 mRNA. Translation: AAL69491.1 .
AY133824 mRNA. Translation: AAM91758.1 .
PIRi D96634.
RefSeqi NP_176286.2. NM_104770.4. [Q8RY89-1 ]
UniGenei At.28792.

3D structure databases

ProteinModelPortali Q8RY89.
SMRi Q8RY89. Positions 352-592.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 27605. 1 interaction.
STRINGi 3702.AT1G60890.1-P.

Proteomic databases

PaxDbi Q8RY89.
PRIDEi Q8RY89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G60890.1 ; AT1G60890.1 ; AT1G60890 . [Q8RY89-1 ]
GeneIDi 842381.
KEGGi ath:AT1G60890.

Organism-specific databases

TAIRi AT1G60890.

Phylogenomic databases

eggNOGi COG4642.
HOGENOMi HOG000193875.
InParanoidi Q8RY89.
KOi K00889.
PhylomeDBi Q8RY89.

Enzyme and pathway databases

BioCyci ARA:AT1G60890-MONOMER.
ARA:GQT-2287-MONOMER.
Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

Gene expression databases

ArrayExpressi Q8RY89.
Genevestigatori Q8RY89.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProi IPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view ]
PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTi SM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPI5K8_ARATH
AccessioniPrimary (citable) accession number: Q8RY89
Secondary accession number(s): Q9C962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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