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Protein

Mitochondrial thiamine diphosphate carrier 1

Gene

At3g21390

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria.1 Publication

GO - Molecular functioni

  • thiamine pyrophosphate transmembrane transporter activity Source: TAIR
  • thiamine transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • mitochondrial transport Source: GO_Central
  • thiamine pyrophosphate transmembrane transport Source: TAIR

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-ATH-196819 Vitamin B1 (thiamin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine diphosphate carrier 1Curated
Gene namesi
Ordered Locus Names:At3g21390Imported
ORF Names:MHC9.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G21390
TAIRilocus:2089453 AT3G21390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 29Helical; Name=1CuratedAdd BLAST17
Transmembranei88 – 105Helical; Name=2Sequence analysisAdd BLAST18
Transmembranei127 – 150Helical; Name=3Sequence analysisAdd BLAST24
Transmembranei182 – 199Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei231 – 247Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei304 – 323Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004398931 – 335Mitochondrial thiamine diphosphate carrier 1Add BLAST335

Proteomic databases

PaxDbiQ8RXZ9

Expressioni

Gene expression databases

ExpressionAtlasiQ8RXZ9 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G21390.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 111Solcar 1PROSITE-ProRule annotationAdd BLAST99
Repeati124 – 210Solcar 2PROSITE-ProRule annotationAdd BLAST87
Repeati232 – 329Solcar 3PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 234Ser-richPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]1 Publication

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
HOGENOMiHOG000165726
KOiK15108
OMAiYELASDW
OrthoDBiEOG09360IG8

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q8RXZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTELDEPG KLKRAVIDAS AGGVAGAISR MVTSPLDVIK IRFQVQLEPT
60 70 80 90 100
ATWALKDSQL KPKYNGLFRT TKDIFREEGL SGFWRGNVPA LLMVVPYTSI
110 120 130 140 150
QFAVLHKVKS FAAGSSKAEN HAQLSPYLSY ISGALAGCAA TVGSYPFDLL
160 170 180 190 200
RTVLASQGEP KVYPNMRSAF LSIVQTRGIK GLYAGLSPTL IEIIPYAGLQ
210 220 230 240 250
FGTYDTFKRW SMVYNKRYRS SSSSSTNPSD SLSSFQLFLC GLASGTVSKL
260 270 280 290 300
VCHPLDVVKK RFQVEGLQRH PKYGARVELN AYKNMFDGLG QILRSEGWHG
310 320 330
LYKGIVPSTI KAAPAGAVTF VAYELASDWF EANLT
Length:335
Mass (Da):36,560
Last modified:June 1, 2002 - v1
Checksum:iD7691C32FCA2E445
GO

Sequence cautioni

The sequence BAB03052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001305 Genomic DNA Translation: BAB03052.1 Different initiation.
CP002686 Genomic DNA Translation: AEE76504.1
AY122945 mRNA Translation: AAM67478.1
AY080592 mRNA Translation: AAL85968.1
AY087894 mRNA Translation: AAM65445.1
RefSeqiNP_566683.1, NM_113034.4
UniGeneiAt.43250

Genome annotation databases

EnsemblPlantsiAT3G21390.1; AT3G21390.1; AT3G21390
AT3G21390.2; AT3G21390.2; AT3G21390
GeneIDi821693
GrameneiAT3G21390.1; AT3G21390.1; AT3G21390
AT3G21390.2; AT3G21390.2; AT3G21390
KEGGiath:AT3G21390

Similar proteinsi

Entry informationi

Entry nameiTDPC1_ARATH
AccessioniPrimary (citable) accession number: Q8RXZ9
Secondary accession number(s): Q9LIF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health