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Q8RXZ4 (P2C18_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 18

Short name=AtPP2C18
EC=3.1.3.16
Gene names
Ordered Locus Names:At1g79630
ORF Names:F20B17.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence AAF68125.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BX814900 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8RXZ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8RXZ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.
Note: Derived from EST data. No experimental confirmation available.
Isoform 3 (identifier: Q8RXZ4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Probable protein phosphatase 2C 18
PRO_0000367948

Regions

Domain195 – 379185PP2C-like

Sites

Metal binding1031Manganese 1 By similarity
Metal binding1031Manganese 2 By similarity
Metal binding1041Manganese 1; via carbonyl oxygen By similarity
Metal binding3441Manganese 2 By similarity
Metal binding3901Manganese 2 By similarity

Natural variations

Alternative sequence1 – 110110Missing in isoform 3.
VSP_036761
Alternative sequence1 – 8383Missing in isoform 2.
VSP_036762

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 71B511B182D7B86E

FASTA50455,604
        10         20         30         40         50         60 
MGLCYSVDRT TGKEPGEASS TATTAETVEE RSGSGRWRRP RDLKGGGDIE GIPQVLGRLV 

        70         80         90        100        110        120 
SNGSSKIACL YTQQGKKGTN QDAMLVFENF CSRDDTVFCG VFDGHGPFGH MVAKKVRDTL 

       130        140        150        160        170        180 
PFTLLTQLKM TSESDQSSLV GANGFQIKCT EEEEVQTTES EQVQKTESVT TMDEQWCELN 

       190        200        210        220        230        240 
PNVNNDELPE MYLPLKHAML KSCQQIDKEL KMHPTIDCFC SGTTSVTLIK QGEDLVVGNI 

       250        260        270        280        290        300 
GDSRAVLATR DEDNALLAVQ LTIDLKPDLP GESARIQKCK GRVFALQDEP EVARVWLPNS 

       310        320        330        340        350        360 
DSPGLAMARA FGDFCLKDYG LISVPDINYR RLTERDQFII LASDGVWDVL SNKEAVDIVA 

       370        380        390        400        410        420 
SAPSRSTAAR ALVDTAVRSW RIKYPTSKND DCTVVCLFLQ DSSVAMEVST NVKKDSPKEE 

       430        440        450        460        470        480 
SIESVTNSTS KEEDEIVPVK DEKIPESCGI ESKMMTMTLA ECISVAQDDE EWSALEGLTR 

       490        500 
VNSLLSIPRF LSGELRSTSW RKWL 

« Hide

Isoform 2 [UniParc].

Checksum: E4AFFC657B47DFBE
Show »

FASTA42146,848
Isoform 3 [UniParc].

Checksum: 69D9FD75D3E43E46
Show »

FASTA39443,832

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: cv. Columbia.
[4]"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: cv. Columbia.
[5]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010793 Genomic DNA. Translation: AAF68125.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36274.1.
CP002684 Genomic DNA. Translation: AEE36275.1.
CP002684 Genomic DNA. Translation: AEE36276.1.
AY080600 mRNA. Translation: AAL85011.1.
AY114037 mRNA. Translation: AAM45085.1.
BX814900 mRNA. No translation available.
PIRE96827.
RefSeqNP_001031302.1. NM_001036225.1. [Q8RXZ4-2]
NP_178081.2. NM_106612.3. [Q8RXZ4-1]
NP_974180.1. NM_202451.1. [Q8RXZ4-3]
UniGeneAt.44013.

3D structure databases

ProteinModelPortalQ8RXZ4.
SMRQ8RXZ4. Positions 68-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid29520. 1 interaction.
IntActQ8RXZ4. 1 interaction.
MINTMINT-8390527.

Proteomic databases

PaxDbQ8RXZ4.
PRIDEQ8RXZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G79630.1; AT1G79630.1; AT1G79630. [Q8RXZ4-1]
GeneID844302.
KEGGath:AT1G79630.

Organism-specific databases

TAIRAT1G79630.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233897.
InParanoidQ8RXZ4.
OMAKMHPTID.
PhylomeDBQ8RXZ4.

Enzyme and pathway databases

BioCycARA:AT1G79630-MONOMER.
ARA:GQT-2197-MONOMER.
ARA:GQT-2198-MONOMER.

Gene expression databases

GenevestigatorQ8RXZ4.

Family and domain databases

Gene3D3.60.40.10. 2 hits.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
ProtoNetSearch...

Entry information

Entry nameP2C18_ARATH
AccessionPrimary (citable) accession number: Q8RXZ4
Secondary accession number(s): Q2V4C0, Q3ECA6, Q9MA12
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names