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Q8RXZ4

- P2C18_ARATH

UniProt

Q8RXZ4 - P2C18_ARATH

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Protein

Probable protein phosphatase 2C 18

Gene
At1g79630, F20B17.6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Manganese 1 By similarity
Metal bindingi103 – 1031Manganese 2 By similarity
Metal bindingi104 – 1041Manganese 1; via carbonyl oxygen By similarity
Metal bindingi344 – 3441Manganese 2 By similarity
Metal bindingi390 – 3901Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G79630-MONOMER.
ARA:GQT-2197-MONOMER.
ARA:GQT-2198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 18 (EC:3.1.3.16)
Short name:
AtPP2C18
Gene namesi
Ordered Locus Names:At1g79630
ORF Names:F20B17.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G79630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Probable protein phosphatase 2C 18PRO_0000367948Add
BLAST

Proteomic databases

PaxDbiQ8RXZ4.
PRIDEiQ8RXZ4.

Expressioni

Gene expression databases

GenevestigatoriQ8RXZ4.

Interactioni

Protein-protein interaction databases

BioGridi29520. 1 interaction.
IntActiQ8RXZ4. 1 interaction.
MINTiMINT-8390527.

Structurei

3D structure databases

ProteinModelPortaliQ8RXZ4.
SMRiQ8RXZ4. Positions 68-445.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 379185PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233897.
InParanoidiQ8RXZ4.
OMAiKMHPTID.
PhylomeDBiQ8RXZ4.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8RXZ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLCYSVDRT TGKEPGEASS TATTAETVEE RSGSGRWRRP RDLKGGGDIE    50
GIPQVLGRLV SNGSSKIACL YTQQGKKGTN QDAMLVFENF CSRDDTVFCG 100
VFDGHGPFGH MVAKKVRDTL PFTLLTQLKM TSESDQSSLV GANGFQIKCT 150
EEEEVQTTES EQVQKTESVT TMDEQWCELN PNVNNDELPE MYLPLKHAML 200
KSCQQIDKEL KMHPTIDCFC SGTTSVTLIK QGEDLVVGNI GDSRAVLATR 250
DEDNALLAVQ LTIDLKPDLP GESARIQKCK GRVFALQDEP EVARVWLPNS 300
DSPGLAMARA FGDFCLKDYG LISVPDINYR RLTERDQFII LASDGVWDVL 350
SNKEAVDIVA SAPSRSTAAR ALVDTAVRSW RIKYPTSKND DCTVVCLFLQ 400
DSSVAMEVST NVKKDSPKEE SIESVTNSTS KEEDEIVPVK DEKIPESCGI 450
ESKMMTMTLA ECISVAQDDE EWSALEGLTR VNSLLSIPRF LSGELRSTSW 500
RKWL 504
Length:504
Mass (Da):55,604
Last modified:June 1, 2002 - v1
Checksum:i71B511B182D7B86E
GO
Isoform 2 (identifier: Q8RXZ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:421
Mass (Da):46,848
Checksum:iE4AFFC657B47DFBE
GO
Isoform 3 (identifier: Q8RXZ4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.

Show »
Length:394
Mass (Da):43,832
Checksum:i69D9FD75D3E43E46
GO

Sequence cautioni

The sequence BX814900 differs from that shown. Reason: Sequencing errors.
The sequence AAF68125.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 110110Missing in isoform 3. VSP_036761Add
BLAST
Alternative sequencei1 – 8383Missing in isoform 2. VSP_036762Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010793 Genomic DNA. Translation: AAF68125.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36274.1.
CP002684 Genomic DNA. Translation: AEE36275.1.
CP002684 Genomic DNA. Translation: AEE36276.1.
AY080600 mRNA. Translation: AAL85011.1.
AY114037 mRNA. Translation: AAM45085.1.
BX814900 mRNA. No translation available.
PIRiE96827.
RefSeqiNP_001031302.1. NM_001036225.1. [Q8RXZ4-2]
NP_178081.2. NM_106612.3. [Q8RXZ4-1]
NP_974180.1. NM_202451.1. [Q8RXZ4-3]
UniGeneiAt.44013.

Genome annotation databases

EnsemblPlantsiAT1G79630.1; AT1G79630.1; AT1G79630. [Q8RXZ4-1]
GeneIDi844302.
KEGGiath:AT1G79630.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010793 Genomic DNA. Translation: AAF68125.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE36274.1 .
CP002684 Genomic DNA. Translation: AEE36275.1 .
CP002684 Genomic DNA. Translation: AEE36276.1 .
AY080600 mRNA. Translation: AAL85011.1 .
AY114037 mRNA. Translation: AAM45085.1 .
BX814900 mRNA. No translation available.
PIRi E96827.
RefSeqi NP_001031302.1. NM_001036225.1. [Q8RXZ4-2 ]
NP_178081.2. NM_106612.3. [Q8RXZ4-1 ]
NP_974180.1. NM_202451.1. [Q8RXZ4-3 ]
UniGenei At.44013.

3D structure databases

ProteinModelPortali Q8RXZ4.
SMRi Q8RXZ4. Positions 68-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 29520. 1 interaction.
IntActi Q8RXZ4. 1 interaction.
MINTi MINT-8390527.

Proteomic databases

PaxDbi Q8RXZ4.
PRIDEi Q8RXZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G79630.1 ; AT1G79630.1 ; AT1G79630 . [Q8RXZ4-1 ]
GeneIDi 844302.
KEGGi ath:AT1G79630.

Organism-specific databases

TAIRi AT1G79630.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233897.
InParanoidi Q8RXZ4.
OMAi KMHPTID.
PhylomeDBi Q8RXZ4.

Enzyme and pathway databases

BioCyci ARA:AT1G79630-MONOMER.
ARA:GQT-2197-MONOMER.
ARA:GQT-2198-MONOMER.

Gene expression databases

Genevestigatori Q8RXZ4.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C18_ARATH
AccessioniPrimary (citable) accession number: Q8RXZ4
Secondary accession number(s): Q2V4C0, Q3ECA6, Q9MA12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi