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Protein

Probable protein phosphatase 2C 18

Gene

At1g79630

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103Manganese 1By similarity1
Metal bindingi103Manganese 2By similarity1
Metal bindingi104Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi344Manganese 2By similarity1
Metal bindingi390Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 18 (EC:3.1.3.16)
Short name:
AtPP2C18
Gene namesi
Ordered Locus Names:At1g79630
ORF Names:F20B17.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G79630.
TAIRilocus:2019868. AT1G79630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679481 – 504Probable protein phosphatase 2C 18Add BLAST504

Proteomic databases

PaxDbiQ8RXZ4.

Expressioni

Gene expression databases

ExpressionAtlasiQ8RXZ4. baseline and differential.
GenevisibleiQ8RXZ4. AT.

Interactioni

Protein-protein interaction databases

BioGridi29520. 2 interactors.
IntActiQ8RXZ4. 1 interactor.
MINTiMINT-8390527.
STRINGi3702.AT1G79630.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RXZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 399PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST333

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233897.
InParanoidiQ8RXZ4.
OMAiHIPGRIL.
OrthoDBiEOG09360CO1.
PhylomeDBiQ8RXZ4.

Family and domain databases

CDDicd00143. PP2Cc. 1 hit.
Gene3Di3.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR036457. PPM-type_dom_sf.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiView protein in PROSITE
PS51746. PPM_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8RXZ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLCYSVDRT TGKEPGEASS TATTAETVEE RSGSGRWRRP RDLKGGGDIE
60 70 80 90 100
GIPQVLGRLV SNGSSKIACL YTQQGKKGTN QDAMLVFENF CSRDDTVFCG
110 120 130 140 150
VFDGHGPFGH MVAKKVRDTL PFTLLTQLKM TSESDQSSLV GANGFQIKCT
160 170 180 190 200
EEEEVQTTES EQVQKTESVT TMDEQWCELN PNVNNDELPE MYLPLKHAML
210 220 230 240 250
KSCQQIDKEL KMHPTIDCFC SGTTSVTLIK QGEDLVVGNI GDSRAVLATR
260 270 280 290 300
DEDNALLAVQ LTIDLKPDLP GESARIQKCK GRVFALQDEP EVARVWLPNS
310 320 330 340 350
DSPGLAMARA FGDFCLKDYG LISVPDINYR RLTERDQFII LASDGVWDVL
360 370 380 390 400
SNKEAVDIVA SAPSRSTAAR ALVDTAVRSW RIKYPTSKND DCTVVCLFLQ
410 420 430 440 450
DSSVAMEVST NVKKDSPKEE SIESVTNSTS KEEDEIVPVK DEKIPESCGI
460 470 480 490 500
ESKMMTMTLA ECISVAQDDE EWSALEGLTR VNSLLSIPRF LSGELRSTSW

RKWL
Length:504
Mass (Da):55,604
Last modified:June 1, 2002 - v1
Checksum:i71B511B182D7B86E
GO
Isoform 2 (identifier: Q8RXZ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):43,832
Checksum:i69D9FD75D3E43E46
GO

Sequence cautioni

The sequence AAF68125 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BX814900 differs from that shown. Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367611 – 110Missing in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010793 Genomic DNA. Translation: AAF68125.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36274.1.
CP002684 Genomic DNA. Translation: AEE36275.1.
CP002684 Genomic DNA. Translation: AEE36276.2.
CP002684 Genomic DNA. Translation: ANM57733.1.
CP002684 Genomic DNA. Translation: ANM57736.1.
CP002684 Genomic DNA. Translation: ANM57737.1.
AY080600 mRNA. Translation: AAL85011.1.
AY114037 mRNA. Translation: AAM45085.1.
BX814900 mRNA. No translation available.
PIRiE96827.
RefSeqiNP_001319417.1. NM_001334900.1.
NP_001319418.1. NM_001334901.1. [Q8RXZ4-3]
NP_001320218.1. NM_001334903.1. [Q8RXZ4-3]
NP_001320220.1. NM_001334905.1.
NP_001320221.1. NM_001334902.1. [Q8RXZ4-3]
NP_001320222.1. NM_001334904.1. [Q8RXZ4-3]
NP_178081.2. NM_106612.4. [Q8RXZ4-1]
UniGeneiAt.44013.

Genome annotation databases

EnsemblPlantsiAT1G79630.1; AT1G79630.1; AT1G79630. [Q8RXZ4-1]
AT1G79630.3; AT1G79630.3; AT1G79630. [Q8RXZ4-3]
AT1G79630.4; AT1G79630.4; AT1G79630. [Q8RXZ4-3]
AT1G79630.5; AT1G79630.5; AT1G79630. [Q8RXZ4-3]
AT1G79630.6; AT1G79630.6; AT1G79630. [Q8RXZ4-3]
GeneIDi844302.
GrameneiAT1G79630.1; AT1G79630.1; AT1G79630.
AT1G79630.3; AT1G79630.3; AT1G79630.
AT1G79630.4; AT1G79630.4; AT1G79630.
AT1G79630.5; AT1G79630.5; AT1G79630.
AT1G79630.6; AT1G79630.6; AT1G79630.
KEGGiath:AT1G79630.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2C18_ARATH
AccessioniPrimary (citable) accession number: Q8RXZ4
Secondary accession number(s): Q2V4C0, Q3ECA6, Q9MA12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families