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Q8RXZ4

- P2C18_ARATH

UniProt

Q8RXZ4 - P2C18_ARATH

Protein

Probable protein phosphatase 2C 18

Gene

At1g79630

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi103 – 1031Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 2By similarity
    Metal bindingi104 – 1041Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi344 – 3441Manganese 2By similarity
    Metal bindingi390 – 3901Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G79630-MONOMER.
    ARA:GQT-2197-MONOMER.
    ARA:GQT-2198-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 18 (EC:3.1.3.16)
    Short name:
    AtPP2C18
    Gene namesi
    Ordered Locus Names:At1g79630
    ORF Names:F20B17.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G79630.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Probable protein phosphatase 2C 18PRO_0000367948Add
    BLAST

    Proteomic databases

    PaxDbiQ8RXZ4.
    PRIDEiQ8RXZ4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8RXZ4.

    Interactioni

    Protein-protein interaction databases

    BioGridi29520. 1 interaction.
    IntActiQ8RXZ4. 1 interaction.
    MINTiMINT-8390527.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RXZ4.
    SMRiQ8RXZ4. Positions 68-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 379185PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    InParanoidiQ8RXZ4.
    OMAiKMHPTID.
    PhylomeDBiQ8RXZ4.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8RXZ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLCYSVDRT TGKEPGEASS TATTAETVEE RSGSGRWRRP RDLKGGGDIE    50
    GIPQVLGRLV SNGSSKIACL YTQQGKKGTN QDAMLVFENF CSRDDTVFCG 100
    VFDGHGPFGH MVAKKVRDTL PFTLLTQLKM TSESDQSSLV GANGFQIKCT 150
    EEEEVQTTES EQVQKTESVT TMDEQWCELN PNVNNDELPE MYLPLKHAML 200
    KSCQQIDKEL KMHPTIDCFC SGTTSVTLIK QGEDLVVGNI GDSRAVLATR 250
    DEDNALLAVQ LTIDLKPDLP GESARIQKCK GRVFALQDEP EVARVWLPNS 300
    DSPGLAMARA FGDFCLKDYG LISVPDINYR RLTERDQFII LASDGVWDVL 350
    SNKEAVDIVA SAPSRSTAAR ALVDTAVRSW RIKYPTSKND DCTVVCLFLQ 400
    DSSVAMEVST NVKKDSPKEE SIESVTNSTS KEEDEIVPVK DEKIPESCGI 450
    ESKMMTMTLA ECISVAQDDE EWSALEGLTR VNSLLSIPRF LSGELRSTSW 500
    RKWL 504
    Length:504
    Mass (Da):55,604
    Last modified:June 1, 2002 - v1
    Checksum:i71B511B182D7B86E
    GO
    Isoform 2 (identifier: Q8RXZ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:421
    Mass (Da):46,848
    Checksum:iE4AFFC657B47DFBE
    GO
    Isoform 3 (identifier: Q8RXZ4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:394
    Mass (Da):43,832
    Checksum:i69D9FD75D3E43E46
    GO

    Sequence cautioni

    The sequence BX814900 differs from that shown. Reason: Sequencing errors.
    The sequence AAF68125.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 110110Missing in isoform 3. 1 PublicationVSP_036761Add
    BLAST
    Alternative sequencei1 – 8383Missing in isoform 2. CuratedVSP_036762Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010793 Genomic DNA. Translation: AAF68125.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36274.1.
    CP002684 Genomic DNA. Translation: AEE36275.1.
    CP002684 Genomic DNA. Translation: AEE36276.1.
    AY080600 mRNA. Translation: AAL85011.1.
    AY114037 mRNA. Translation: AAM45085.1.
    BX814900 mRNA. No translation available.
    PIRiE96827.
    RefSeqiNP_001031302.1. NM_001036225.1. [Q8RXZ4-2]
    NP_178081.2. NM_106612.3. [Q8RXZ4-1]
    NP_974180.1. NM_202451.1. [Q8RXZ4-3]
    UniGeneiAt.44013.

    Genome annotation databases

    EnsemblPlantsiAT1G79630.1; AT1G79630.1; AT1G79630. [Q8RXZ4-1]
    GeneIDi844302.
    KEGGiath:AT1G79630.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010793 Genomic DNA. Translation: AAF68125.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36274.1 .
    CP002684 Genomic DNA. Translation: AEE36275.1 .
    CP002684 Genomic DNA. Translation: AEE36276.1 .
    AY080600 mRNA. Translation: AAL85011.1 .
    AY114037 mRNA. Translation: AAM45085.1 .
    BX814900 mRNA. No translation available.
    PIRi E96827.
    RefSeqi NP_001031302.1. NM_001036225.1. [Q8RXZ4-2 ]
    NP_178081.2. NM_106612.3. [Q8RXZ4-1 ]
    NP_974180.1. NM_202451.1. [Q8RXZ4-3 ]
    UniGenei At.44013.

    3D structure databases

    ProteinModelPortali Q8RXZ4.
    SMRi Q8RXZ4. Positions 68-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 29520. 1 interaction.
    IntActi Q8RXZ4. 1 interaction.
    MINTi MINT-8390527.

    Proteomic databases

    PaxDbi Q8RXZ4.
    PRIDEi Q8RXZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G79630.1 ; AT1G79630.1 ; AT1G79630 . [Q8RXZ4-1 ]
    GeneIDi 844302.
    KEGGi ath:AT1G79630.

    Organism-specific databases

    TAIRi AT1G79630.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    InParanoidi Q8RXZ4.
    OMAi KMHPTID.
    PhylomeDBi Q8RXZ4.

    Enzyme and pathway databases

    BioCyci ARA:AT1G79630-MONOMER.
    ARA:GQT-2197-MONOMER.
    ARA:GQT-2198-MONOMER.

    Gene expression databases

    Genevestigatori Q8RXZ4.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
      Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
      Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C18_ARATH
    AccessioniPrimary (citable) accession number: Q8RXZ4
    Secondary accession number(s): Q2V4C0, Q3ECA6, Q9MA12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3