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Protein

Probable protein phosphatase 2C 59

Gene

WIN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase that modulates defense response to pathogenic bacteria, conferring resistance and promoting salicylic acid (SA) accumulation.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Enzyme regulationi

Inhibited by sodium fluoride (NaF).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Manganese 1By similarity1
Metal bindingi69Manganese 2By similarity1
Metal bindingi70Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi231Manganese 2By similarity1
Metal bindingi270Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • interspecies interaction between organisms Source: UniProtKB
  • protein dephosphorylation Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processPlant defense
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 59 (EC:3.1.3.16)
Short name:
AtPP2C59
Alternative name(s):
HopW1-1-interacting protein 2
Protein phosphatase 2C WIN2
Short name:
PP2C WIN2
Gene namesi
Name:WIN2
Ordered Locus Names:At4g31750
ORF Names:F28M20.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G31750
TAIRilocus:2124784 AT4G31750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679811 – 311Probable protein phosphatase 2C 59Add BLAST311

Proteomic databases

PaxDbiQ8RXV3
PRIDEiQ8RXV3

PTM databases

iPTMnetiQ8RXV3

Expressioni

Gene expression databases

ExpressionAtlasiQ8RXV3 baseline and differential
GenevisibleiQ8RXV3 AT

Interactioni

Subunit structurei

Interacts with the Pseudomonas syringae pv. maculicola effector HopW1-1 (via C-terminus).1 Publication

Protein-protein interaction databases

STRINGi3702.AT4G31750.1

Structurei

3D structure databases

ProteinModelPortaliQ8RXV3
SMRiQ8RXV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 279PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000233896
InParanoidiQ8RXV3
KOiK17506
OMAiMMQNERF
OrthoDBiEOG09360FJK
PhylomeDBiQ8RXV3

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RXV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYLNSVLSS SSQVHSDDGP VSGGGLSQNG KFSYGYASSP GKRSSMEDFY
60 70 80 90 100
ETRIDGVEGE IVGLFGVFDG HGGARAAEYV KQNLFSNLIR HPKFISDTTA
110 120 130 140 150
AIADAYNQTD SEFLKSENSQ NRDAGSTAST AILVGDRLLV ANVGDSRAVI
160 170 180 190 200
CRGGNAIAVS RDHKPDQSDE RQRIEDAGGF VMWAGTWRVG GVLAVSRAFG
210 220 230 240 250
DRLLKQYVVA DPEIQEEKVD SSLEFLILAS DGLWDVVSNE EAVGMIKAIE
260 270 280 290 300
DPEEGAKRLM MEAYQRGSAD NITCVVVRFF SDQAGGIGSS STNIPIDHGI
310
VPDRISGDSS T
Length:311
Mass (Da):33,248
Last modified:June 1, 2002 - v1
Checksum:i5E3098E91F116BFD
GO

Sequence cautioni

The sequence CAA19748 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79893 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU214909 mRNA Translation: ABW84225.1
AL031004 Genomic DNA Translation: CAA19748.1 Sequence problems.
AL161579 Genomic DNA Translation: CAB79893.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85953.1
CP002687 Genomic DNA Translation: ANM66655.1
AY080658 mRNA Translation: AAL86334.1
AY133761 mRNA Translation: AAM91695.1
PIRiT05095
RefSeqiNP_001328538.1, NM_001342111.1
NP_194903.2, NM_119324.4
UniGeneiAt.31716
At.51039

Genome annotation databases

EnsemblPlantsiAT4G31750.1; AT4G31750.1; AT4G31750
AT4G31750.3; AT4G31750.3; AT4G31750
GeneIDi829303
GrameneiAT4G31750.1; AT4G31750.1; AT4G31750
AT4G31750.3; AT4G31750.3; AT4G31750
KEGGiath:AT4G31750

Similar proteinsi

Entry informationi

Entry nameiP2C59_ARATH
AccessioniPrimary (citable) accession number: Q8RXV3
Secondary accession number(s): O81773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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