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Q8RXV3

- P2C59_ARATH

UniProt

Q8RXV3 - P2C59_ARATH

Protein

Probable protein phosphatase 2C 59

Gene

WIN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Protein phosphatase that modulates defense response to pathogenic bacteria, conferring resistance and promoting salicylic acid (SA) accumulation.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Enzyme regulationi

    Inhibited by sodium fluoride (NaF).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi69 – 691Manganese 1By similarity
    Metal bindingi69 – 691Manganese 2By similarity
    Metal bindingi70 – 701Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi231 – 2311Manganese 2By similarity
    Metal bindingi270 – 2701Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: TAIR

    GO - Biological processi

    1. defense response to bacterium Source: TAIR
    2. interspecies interaction between organisms Source: UniProtKB
    3. protein dephosphorylation Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Plant defense

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G31750-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 59 (EC:3.1.3.16)
    Short name:
    AtPP2C59
    Alternative name(s):
    HopW1-1-interacting protein 2
    Protein phosphatase 2C WIN2
    Short name:
    PP2C WIN2
    Gene namesi
    Name:WIN2
    Ordered Locus Names:At4g31750
    ORF Names:F28M20.60
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G31750.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Probable protein phosphatase 2C 59PRO_0000367981Add
    BLAST

    Proteomic databases

    PaxDbiQ8RXV3.
    PRIDEiQ8RXV3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8RXV3.

    Interactioni

    Subunit structurei

    Interacts with the Pseudomonas syringae pv. maculicola effector HopW1-1 (via C-terminus).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RXV3.
    SMRiQ8RXV3. Positions 34-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 272213PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ8RXV3.
    KOiK17506.
    OMAiNHDEAGT.
    PhylomeDBiQ8RXV3.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RXV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYLNSVLSS SSQVHSDDGP VSGGGLSQNG KFSYGYASSP GKRSSMEDFY    50
    ETRIDGVEGE IVGLFGVFDG HGGARAAEYV KQNLFSNLIR HPKFISDTTA 100
    AIADAYNQTD SEFLKSENSQ NRDAGSTAST AILVGDRLLV ANVGDSRAVI 150
    CRGGNAIAVS RDHKPDQSDE RQRIEDAGGF VMWAGTWRVG GVLAVSRAFG 200
    DRLLKQYVVA DPEIQEEKVD SSLEFLILAS DGLWDVVSNE EAVGMIKAIE 250
    DPEEGAKRLM MEAYQRGSAD NITCVVVRFF SDQAGGIGSS STNIPIDHGI 300
    VPDRISGDSS T 311
    Length:311
    Mass (Da):33,248
    Last modified:June 1, 2002 - v1
    Checksum:i5E3098E91F116BFD
    GO

    Sequence cautioni

    The sequence CAA19748.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB79893.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU214909 mRNA. Translation: ABW84225.1.
    AL031004 Genomic DNA. Translation: CAA19748.1. Sequence problems.
    AL161579 Genomic DNA. Translation: CAB79893.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85953.1.
    AY080658 mRNA. Translation: AAL86334.1.
    AY133761 mRNA. Translation: AAM91695.1.
    PIRiT05095.
    RefSeqiNP_194903.2. NM_119324.3.
    UniGeneiAt.31716.
    At.51039.

    Genome annotation databases

    EnsemblPlantsiAT4G31750.1; AT4G31750.1; AT4G31750.
    GeneIDi829303.
    KEGGiath:AT4G31750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU214909 mRNA. Translation: ABW84225.1 .
    AL031004 Genomic DNA. Translation: CAA19748.1 . Sequence problems.
    AL161579 Genomic DNA. Translation: CAB79893.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE85953.1 .
    AY080658 mRNA. Translation: AAL86334.1 .
    AY133761 mRNA. Translation: AAM91695.1 .
    PIRi T05095.
    RefSeqi NP_194903.2. NM_119324.3.
    UniGenei At.31716.
    At.51039.

    3D structure databases

    ProteinModelPortali Q8RXV3.
    SMRi Q8RXV3. Positions 34-277.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8RXV3.
    PRIDEi Q8RXV3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G31750.1 ; AT4G31750.1 ; AT4G31750 .
    GeneIDi 829303.
    KEGGi ath:AT4G31750.

    Organism-specific databases

    TAIRi AT4G31750.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q8RXV3.
    KOi K17506.
    OMAi NHDEAGT.
    PhylomeDBi Q8RXV3.

    Enzyme and pathway databases

    BioCyci ARA:AT4G31750-MONOMER.

    Gene expression databases

    Genevestigatori Q8RXV3.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1."
      Lee M.W., Jelenska J., Greenberg J.T.
      Plant J. 54:452-465(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, INTERACTION WITH PSEUDOMONAS SYRINGAE MACULICOLA HOPW1-1.
      Strain: cv. Wassilewskija.
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C59_ARATH
    AccessioniPrimary (citable) accession number: Q8RXV3
    Secondary accession number(s): O81773
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3