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Protein

ABC transporter G family member 11

Gene

ABCG11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the cuticle and pollen coat development by controlling cutin and maybe wax transport to the extracellular matrix. Involved in developmental plasticity and stress responses.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 948ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • fatty acid transporter activity Source: TAIR
  • protein homodimerization activity Source: TAIR

GO - Biological processi

  • cotyledon vascular tissue pattern formation Source: TAIR
  • cutin transport Source: TAIR
  • fatty acid transport Source: TAIR
  • response to abscisic acid Source: UniProtKB
  • response to salt stress Source: UniProtKB
  • response to wounding Source: UniProtKB
  • stem vascular tissue pattern formation Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-1369062. ABC transporters in lipid homeostasis.
R-ATH-265473. Trafficking of dietary sterols.

Protein family/group databases

TCDBi3.A.1.204.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter G family member 11
Short name:
ABC transporter ABCG.11
Short name:
AtABCG11
Alternative name(s):
Protein CUTICULAR DEFECT AND ORGAN FUSION 1
Protein DESPERADO
Protein PERMEABLE LEAVES 1
White-brown complex homolog protein 11
Short name:
AtWBC11
Gene namesi
Name:ABCG11
Synonyms:COF1, DSO, PEL1, WBC11
Ordered Locus Names:At1g17840
ORF Names:F2H15.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17840.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Transmembranei513 – 53321HelicalSequence analysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence analysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: TAIR
  • integral component of membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Bushy phenotype. Abnormal cuticle and pollen grain shapes, reduced levels of wax and cutin monomers, unusual lipidic cytoplasmatic inclusions in epidermal cells, inter-organ postgenital fusions, and altered morphology of trichomes and pavement cells. Highly susceptibility to salt and reduced root branching.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703ABC transporter G family member 11PRO_0000240683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei688 – 6881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8RXN0.
PRIDEiQ8RXN0.

PTM databases

iPTMnetiQ8RXN0.

Expressioni

Tissue specificityi

Expressed in seedlings, roots, stems, leaves, flowers, and siliques, mostly in epidermis, trichomes, vasculatures and developing tissues.4 Publications

Developmental stagei

First observed in seed coat and the endosperm. During embryo development, expressed in the radical tip. In seedlings, localized in the cotyledons, root tip, and young leaves. As secondary root tips emerge, expressed in the pericycle during the initial cell divisions. In leaves, mostly detected in the expanding basal portion, trichomes and stomatal cells. In roots of mature plants, mainly expressed in lateral root primordia and developing lateral roots. In the inflorescence, found in all floral organs, predominantly in the anthers, styles, and young siliques. Upon anthesis and later, progressively restricted to the carpel.2 Publications

Inductioni

By light, NaCl, abscisic acid (ABA), wounding, and glucose stresses. Repressed by H2O2 and cytokinin.3 Publications

Gene expression databases

GenevisibleiQ8RXN0. AT.

Interactioni

Subunit structurei

Homodimer.Curated

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi23602. 18 interactions.
STRINGi3702.AT1G17840.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RXN0.
SMRiQ8RXN0. Positions 16-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 293244ABC transporterPROSITE-ProRule annotationAdd
BLAST
Domaini382 – 594213ABC transmembrane type-2Add
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000166547.
InParanoidiQ8RXN0.
OMAiKMPMEEK.
PhylomeDBiQ8RXN0.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RXN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIEASRQQT TVPVSVGGGN FPVGGLSPLS EAIWREKAPT EFVGDVSARL
60 70 80 90 100
TWQDLTVMVT MGDGETQNVL EGLTGYAEPG SLTALMGPSG SGKSTMLDAL
110 120 130 140 150
ASRLAANAFL SGTVLLNGRK TKLSFGTAAY VTQDDNLIGT LTVRETIWYS
160 170 180 190 200
ARVRLPDKML RSEKRALVER TIIEMGLQDC ADTVIGNWHL RGISGGEKRR
210 220 230 240 250
VSIALEILMR PRLLFLDEPT SGLDSASAFF VTQTLRALSR DGRTVIASIH
260 270 280 290 300
QPSSEVFELF DRLYLLSGGK TVYFGQASDA YEFFAQAGFP CPALRNPSDH
310 320 330 340 350
FLRCINSDFD KVRATLKGSM KLRFEASDDP LEKITTAEAI RLLVDYYHTS
360 370 380 390 400
DYYYTAKAKV EEISQFKGTI LDSGGSQASF LLQTYTLTKR SFINMSRDFG
410 420 430 440 450
YYWLRLLIYI LVTVCIGTIY LNVGTSYSAI LARGSCASFV FGFVTFMSIG
460 470 480 490 500
GFPSFVEDMK VFQRERLNGH YGVAAFVIAN TLSATPFLIM ITFISGTICY
510 520 530 540 550
FMVGLHPGFT HYLFFVLCLY ASVTVVESLM MAIASIVPNF LMGIIIGAGI
560 570 580 590 600
QGIFMLVSGF FRLPNDIPKP FWRYPMSYIS FHFWALQGQY QNDLRGLTFD
610 620 630 640 650
SQGSAFKIPG EYVLENVFQI DLHRSKWINL SVILSMIIIY RIIFFIMIKT
660 670 680 690 700
NEDVTPWVRG YIARRRMKQK NGTQNTTVAP DGLTQSPSLR NYIATRTDGA

RRW
Length:703
Mass (Da):78,413
Last modified:June 1, 2002 - v1
Checksum:i8D85EE940AC39003
GO

Sequence cautioni

The sequence AAF97264.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034106 Genomic DNA. Translation: AAF97264.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29642.1.
AY080792 mRNA. Translation: AAL87274.1.
AY150457 mRNA. Translation: AAN12898.1.
PIRiE86313.
RefSeqiNP_173226.2. NM_101647.4.
UniGeneiAt.41813.
At.70679.
At.74421.
At.75384.

Genome annotation databases

EnsemblPlantsiAT1G17840.1; AT1G17840.1; AT1G17840.
GeneIDi838363.
GrameneiAT1G17840.1; AT1G17840.1; AT1G17840.
KEGGiath:AT1G17840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034106 Genomic DNA. Translation: AAF97264.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29642.1.
AY080792 mRNA. Translation: AAL87274.1.
AY150457 mRNA. Translation: AAN12898.1.
PIRiE86313.
RefSeqiNP_173226.2. NM_101647.4.
UniGeneiAt.41813.
At.70679.
At.74421.
At.75384.

3D structure databases

ProteinModelPortaliQ8RXN0.
SMRiQ8RXN0. Positions 16-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23602. 18 interactions.
STRINGi3702.AT1G17840.1.

Protein family/group databases

TCDBi3.A.1.204.8. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ8RXN0.

Proteomic databases

PaxDbiQ8RXN0.
PRIDEiQ8RXN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17840.1; AT1G17840.1; AT1G17840.
GeneIDi838363.
GrameneiAT1G17840.1; AT1G17840.1; AT1G17840.
KEGGiath:AT1G17840.

Organism-specific databases

TAIRiAT1G17840.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000166547.
InParanoidiQ8RXN0.
OMAiKMPMEEK.
PhylomeDBiQ8RXN0.

Enzyme and pathway databases

ReactomeiR-ATH-1369062. ABC transporters in lipid homeostasis.
R-ATH-265473. Trafficking of dietary sterols.

Miscellaneous databases

PROiQ8RXN0.

Gene expression databases

GenevisibleiQ8RXN0. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
    Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
    J. Biol. Chem. 276:30231-30244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Gene trapping with firefly luciferase in Arabidopsis. Tagging of stress-responsive genes."
    Alvarado M.C., Zsigmond L.M., Kovacs I., Cseploe A., Koncz C., Szabados L.M.
    Plant Physiol. 134:18-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  6. "A new method for rapid visualization of defects in leaf cuticle reveals five intrinsic patterns of surface defects in Arabidopsis."
    Tanaka T., Tanaka H., Machida C., Watanabe M., Machida Y.
    Plant J. 37:139-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Cytological and biochemical analysis of COF1, an Arabidopsis mutant of an ABC transporter gene."
    Ukitsu H., Kuromori T., Toyooka K., Goto Y., Matsuoka K., Sakuradani E., Shimizu S., Kamiya A., Imura Y., Yuguchi M., Wada T., Hirayama T., Shinozaki K.
    Plant Cell Physiol. 48:1524-1533(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  8. "An ABC transporter gene of Arabidopsis thaliana, AtWBC11, is involved in cuticle development and prevention of organ fusion."
    Luo B., Xue X.-Y., Hu W.-L., Wang L.-J., Chen X.-Y.
    Plant Cell Physiol. 48:1790-1802(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY LIGHT AND ABA, REPRESSION BY CYTOKININ, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Characterization of Arabidopsis ABCG11/WBC11, an ATP binding cassette (ABC) transporter that is required for cuticular lipid secretion."
    Bird D., Beisson F., Brigham A., Shin J., Greer S., Jetter R., Kunst L., Wu X., Yephremov A., Samuels L.
    Plant J. 52:485-498(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  10. "The Arabidopsis DESPERADO/AtWBC11 transporter is required for cutin and wax secretion."
    Panikashvili D., Savaldi-Goldstein S., Mandel T., Yifhar T., Franke R.B., Hoefer R., Schreiber L., Chory J., Aharoni A.
    Plant Physiol. 145:1345-1360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY SALT; ABSCISIC ACID AND WOUNDING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  11. Cited for: GENE FAMILY, NOMENCLATURE.
  12. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAB11G_ARATH
AccessioniPrimary (citable) accession number: Q8RXN0
Secondary accession number(s): Q9LMU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.