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Protein

Kunitz trypsin inhibitor 1

Gene

KTI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits Kunitz trypsin protease inhibitor activity. Involved in modulating programmed cell death (PCD) in plant-pathogen interactions.1 Publication

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • programmed cell death Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to insect Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • response to molecule of fungal origin Source: UniProtKB
  • response to nematode Source: UniProtKB
  • response to salicylic acid Source: TAIR
  • response to salt stress Source: TAIR
  • response to wounding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Keywords - Biological processi

Apoptosis, Plant defense

Protein family/group databases

MEROPSiI03.031.

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz trypsin inhibitor 11 Publication
Short name:
AtKTI11 Publication
Alternative name(s):
Trypsin protease inhibitor1 Publication
Gene namesi
Name:KTI11 Publication
Synonyms:TPI1 Publication
Ordered Locus Names:At1g73260Imported
ORF Names:T18K17.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G73260.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: TAIR
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Enhanced lesion development after infiltration of leaf tissue with the programmed cell death (PCD)-eliciting fungal toxin fumonisin B1 (FB1) or the avirulent bacterial pathogen P.syringae pv. tomato DC3000 carrying avrB (Pst avrB). Enhanced resistance to the virulent pathogen E.carotovora subsp. carotovora SCC1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500771437129 – 215Kunitz trypsin inhibitor 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi165 ↔ 176By similarity
Glycosylationi206N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Inductioni

Down-regulated after root-knot nematode infection (PubMed:16236154). Accumulates locally within 72 hours after P.brassicae butterflies oviposition (PubMed:17142483). Induced late in response to bacterial and fungal elicitors (e.g. Pst DC3000 and Ecc culture filtrates), and upon wounding, salicylic acid (SA) and hydrogen peroxide H2O2 treatments (PubMed:19825555).3 Publications

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G73260.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RXD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWBP. Eukaryota.
ENOG410YHN1. LUCA.
HOGENOMiHOG000006442.
OMAiDHERKQY.
OrthoDBiEOG09360O64.
PhylomeDBiQ8RXD5.

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8RXD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKTTKTMNP KFYLVLALTA VLASNAYGAV VDIDGNAMFH ESYYVLPVIR
60 70 80 90 100
GRGGGLTLAG RGGQPCPYDI VQESSEVDEG IPVKFSNWRL KVAFVPESQN
110 120 130 140 150
LNIETDVGAT ICIQSTYWRV GEFDHERKQY FVVAGPKPEG FGQDSLKSFF
160 170 180 190 200
KIEKSGEDAY KFVFCPRTCD SGNPKCSDVG IFIDELGVRR LALSDKPFLV
210
MFKKANVTEV SSKTM
Length:215
Mass (Da):23,793
Last modified:June 1, 2002 - v1
Checksum:iA3799CCA9B25322A
GO
Isoform 2 (identifier: Q8RXD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-215: VMFKKANVTEVSSKTM → GYVQKS

Note: No experimental confirmation available.Imported
Show »
Length:205
Mass (Da):22,674
Checksum:i4D94A96CB8BB4BCD
GO

Sequence cautioni

The sequence AAG52121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128K → R in AAN15685 (PubMed:14593172).Curated1
Sequence conflicti128K → R in AAK96757 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058577200 – 215VMFKK…SSKTM → GYVQKS in isoform 2. Add BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA. Translation: AAG52121.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35435.1.
AY054566 mRNA. Translation: AAK96757.1.
AY081323 mRNA. Translation: AAL91212.1.
BT000366 mRNA. Translation: AAN15685.1.
BT002548 mRNA. Translation: AAO00908.1.
AK230302 mRNA. Translation: BAF02103.1.
PIRiG96758.
RefSeqiNP_565061.1. NM_105985.3.
UniGeneiAt.21000.

Genome annotation databases

EnsemblPlantsiAT1G73260.1; AT1G73260.1; AT1G73260. [Q8RXD5-1]
GeneIDi843660.
GrameneiAT1G73260.1; AT1G73260.1; AT1G73260.
KEGGiath:AT1G73260.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA. Translation: AAG52121.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35435.1.
AY054566 mRNA. Translation: AAK96757.1.
AY081323 mRNA. Translation: AAL91212.1.
BT000366 mRNA. Translation: AAN15685.1.
BT002548 mRNA. Translation: AAO00908.1.
AK230302 mRNA. Translation: BAF02103.1.
PIRiG96758.
RefSeqiNP_565061.1. NM_105985.3.
UniGeneiAt.21000.

3D structure databases

ProteinModelPortaliQ8RXD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G73260.1.

Protein family/group databases

MEROPSiI03.031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G73260.1; AT1G73260.1; AT1G73260. [Q8RXD5-1]
GeneIDi843660.
GrameneiAT1G73260.1; AT1G73260.1; AT1G73260.
KEGGiath:AT1G73260.

Organism-specific databases

TAIRiAT1G73260.

Phylogenomic databases

eggNOGiENOG410IWBP. Eukaryota.
ENOG410YHN1. LUCA.
HOGENOMiHOG000006442.
OMAiDHERKQY.
OrthoDBiEOG09360O64.
PhylomeDBiQ8RXD5.

Family and domain databases

CDDicd00178. STI. 1 hit.
InterProiIPR011065. Kunitz_inhibitor_ST1-like.
IPR002160. Prot_inh_Kunz-lg.
[Graphical view]
PfamiPF00197. Kunitz_legume. 1 hit.
[Graphical view]
PRINTSiPR00291. KUNITZINHBTR.
SMARTiSM00452. STI. 1 hit.
[Graphical view]
SUPFAMiSSF50386. SSF50386. 1 hit.
PROSITEiPS00283. SOYBEAN_KUNITZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTI1_ARATH
AccessioniPrimary (citable) accession number: Q8RXD5
Secondary accession number(s): Q8H190, Q93Y29, Q9CAT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.