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Protein

Kunitz trypsin inhibitor 1

Gene

KTI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits Kunitz trypsin protease inhibitor activity. Involved in modulating programmed cell death (PCD) in plant-pathogen interactions.1 Publication

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • programmed cell death Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to insect Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • response to molecule of fungal origin Source: UniProtKB
  • response to nematode Source: UniProtKB
  • response to salicylic acid Source: TAIR
  • response to salt stress Source: TAIR
  • response to wounding Source: UniProtKB

Keywordsi

Molecular functionProtease inhibitor
Biological processApoptosis, Plant defense

Protein family/group databases

MEROPSiI03.031

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz trypsin inhibitor 11 Publication
Short name:
AtKTI11 Publication
Alternative name(s):
Trypsin protease inhibitor1 Publication
Gene namesi
Name:KTI11 Publication
Synonyms:TPI1 Publication
Ordered Locus Names:At1g73260Imported
ORF Names:T18K17.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G73260
TAIRilocus:2197249 AT1G73260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Enhanced lesion development after infiltration of leaf tissue with the programmed cell death (PCD)-eliciting fungal toxin fumonisin B1 (FB1) or the avirulent bacterial pathogen P.syringae pv. tomato DC3000 carrying avrB (Pst avrB). Enhanced resistance to the virulent pathogen E.carotovora subsp. carotovora SCC1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500771437129 – 215Kunitz trypsin inhibitor 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi165 ↔ 176By similarity
Glycosylationi206N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8RXD5
PRIDEiQ8RXD5

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Inductioni

Down-regulated after root-knot nematode infection (PubMed:16236154). Accumulates locally within 72 hours after P.brassicae butterflies oviposition (PubMed:17142483). Induced late in response to bacterial and fungal elicitors (e.g. Pst DC3000 and Ecc culture filtrates), and upon wounding, salicylic acid (SA) and hydrogen peroxide H2O2 treatments (PubMed:19825555).3 Publications

Gene expression databases

ExpressionAtlasiQ8RXD5 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ8RXD5, 1 interactor
STRINGi3702.AT1G73260.1

Structurei

3D structure databases

ProteinModelPortaliQ8RXD5
SMRiQ8RXD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWBP Eukaryota
ENOG410YHN1 LUCA
HOGENOMiHOG000006442
OMAiPCPYDIV
OrthoDBiEOG09360O64
PhylomeDBiQ8RXD5

Family and domain databases

CDDicd00178 STI, 1 hit
InterProiView protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg
PANTHERiPTHR33107 PTHR33107, 1 hit
PfamiView protein in Pfam
PF00197 Kunitz_legume, 1 hit
PRINTSiPR00291 KUNITZINHBTR
SMARTiView protein in SMART
SM00452 STI, 1 hit
SUPFAMiSSF50386 SSF50386, 1 hit
PROSITEiView protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8RXD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKTTKTMNP KFYLVLALTA VLASNAYGAV VDIDGNAMFH ESYYVLPVIR
60 70 80 90 100
GRGGGLTLAG RGGQPCPYDI VQESSEVDEG IPVKFSNWRL KVAFVPESQN
110 120 130 140 150
LNIETDVGAT ICIQSTYWRV GEFDHERKQY FVVAGPKPEG FGQDSLKSFF
160 170 180 190 200
KIEKSGEDAY KFVFCPRTCD SGNPKCSDVG IFIDELGVRR LALSDKPFLV
210
MFKKANVTEV SSKTM
Length:215
Mass (Da):23,793
Last modified:June 1, 2002 - v1
Checksum:iA3799CCA9B25322A
GO
Isoform 2 (identifier: Q8RXD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-215: VMFKKANVTEVSSKTM → GYVQKS

Note: No experimental confirmation available.Imported
Show »
Length:205
Mass (Da):22,674
Checksum:i4D94A96CB8BB4BCD
GO

Sequence cautioni

The sequence AAG52121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128K → R in AAN15685 (PubMed:14593172).Curated1
Sequence conflicti128K → R in AAK96757 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058577200 – 215VMFKK…SSKTM → GYVQKS in isoform 2. Add BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA Translation: AAG52121.1 Different initiation.
CP002684 Genomic DNA Translation: AEE35435.1
AY054566 mRNA Translation: AAK96757.1
AY081323 mRNA Translation: AAL91212.1
BT000366 mRNA Translation: AAN15685.1
BT002548 mRNA Translation: AAO00908.1
AK230302 mRNA Translation: BAF02103.1
PIRiG96758
RefSeqiNP_565061.1, NM_105985.3 [Q8RXD5-1]
UniGeneiAt.21000

Genome annotation databases

EnsemblPlantsiAT1G73260.1; AT1G73260.1; AT1G73260 [Q8RXD5-1]
GeneIDi843660
GrameneiAT1G73260.1; AT1G73260.1; AT1G73260 [Q8RXD5-1]
KEGGiath:AT1G73260

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKTI1_ARATH
AccessioniPrimary (citable) accession number: Q8RXD5
Secondary accession number(s): Q8H190, Q93Y29, Q9CAT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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