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Q8RX97 (FRI1_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-1, chloroplastic

EC=1.16.3.1
Alternative name(s):
NtFer1
Gene names
Name:FER1
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Subcellular location

Plastidchloroplast By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4545Chloroplast Potential
Chain46 – 251206Ferritin-1, chloroplastic
PRO_0000008868

Regions

Domain79 – 232154Ferritin-like diiron
Region46 – 7833Extension peptide (EP)

Sites

Metal binding961Iron 1 By similarity
Metal binding1311Iron 1 By similarity
Metal binding1311Iron 2 By similarity
Metal binding1341Iron 1 By similarity
Metal binding1801Iron 2 By similarity
Metal binding2141Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RX97 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2FBC3C5CCAEEA5D8

FASTA25128,197
        10         20         30         40         50         60 
MLLKAAPAFA LLNTQGENLS PLFSSSKSFS PKNGNRFVVS ASKATNHKPL TGVVFEPFEE 

        70         80         90        100        110        120 
LKKELMLVPA VPDTSLCRQK YSDDCEAAIN EQINVEYNNS YVYHAMFAYF DRDNVALKGL 

       130        140        150        160        170        180 
AKFFKESSLE EREHAEKLME FQNKRGGRVK LLSICAPPTE FDHCEKGDAL YAMELALCLE 

       190        200        210        220        230        240 
KLTNQRLLNL HAVASRSNDV HLADFLESEF LVEQVDAIKK ISEYVAQLRR VGQGHGVWQF 

       250 
DQMLLNEGAA A 

« Hide

References

[1]"cDNA cloning and gene expression of ferritin in tobacco."
Jiang T., Yoshihara T., Goto F., Masuda T.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY083924 mRNA. Translation: AAM11429.1.

3D structure databases

ProteinModelPortalQ8RX97.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

ProMEXQ8RX97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI1_TOBAC
AccessionPrimary (citable) accession number: Q8RX97
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families