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Protein

Ferritin-1, chloroplastic

Gene

FER1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron 1PROSITE-ProRule annotation1
Metal bindingi131Iron 1PROSITE-ProRule annotation1
Metal bindingi131Iron 2PROSITE-ProRule annotation1
Metal bindingi134Iron 1PROSITE-ProRule annotation1
Metal bindingi180Iron 2PROSITE-ProRule annotation1
Metal bindingi214Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1, chloroplastic (EC:1.16.3.1)
Alternative name(s):
NtFer1
Gene namesi
Name:FER1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45ChloroplastSequence analysisAdd BLAST45
ChainiPRO_000000886846 – 251Ferritin-1, chloroplasticAdd BLAST206

Proteomic databases

ProMEXiQ8RX97

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8RX97
SMRiQ8RX97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 232Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 78Extension peptide (EP)Add BLAST33

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK00522

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8RX97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKAAPAFA LLNTQGENLS PLFSSSKSFS PKNGNRFVVS ASKATNHKPL
60 70 80 90 100
TGVVFEPFEE LKKELMLVPA VPDTSLCRQK YSDDCEAAIN EQINVEYNNS
110 120 130 140 150
YVYHAMFAYF DRDNVALKGL AKFFKESSLE EREHAEKLME FQNKRGGRVK
160 170 180 190 200
LLSICAPPTE FDHCEKGDAL YAMELALCLE KLTNQRLLNL HAVASRSNDV
210 220 230 240 250
HLADFLESEF LVEQVDAIKK ISEYVAQLRR VGQGHGVWQF DQMLLNEGAA

A
Length:251
Mass (Da):28,197
Last modified:June 1, 2002 - v1
Checksum:i2FBC3C5CCAEEA5D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083924 mRNA Translation: AAM11429.1
RefSeqiNP_001312408.1, NM_001325479.1
UniGeneiNta.798

Genome annotation databases

GeneIDi107789800
KEGGinta:107789800

Similar proteinsi

Entry informationi

Entry nameiFRI1_TOBAC
AccessioniPrimary (citable) accession number: Q8RX97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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