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Q8RX37

- P2C02_ARATH

UniProt

Q8RX37 - P2C02_ARATH

Protein

Probable protein phosphatase 2C 2

Gene

At1g07160

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi158 – 1581Manganese 1By similarity
    Metal bindingi158 – 1581Manganese 2By similarity
    Metal bindingi159 – 1591Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi321 – 3211Manganese 2By similarity
    Metal bindingi367 – 3671Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G07160-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 2 (EC:3.1.3.16)
    Short name:
    AtPP2C02
    Alternative name(s):
    Protein phosphatase AP2C2
    Gene namesi
    Ordered Locus Names:At1g07160
    ORF Names:F10K1.13
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G07160.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Probable protein phosphatase 2C 2PRO_0000367936Add
    BLAST

    Proteomic databases

    PRIDEiQ8RX37.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8RX37.

    Interactioni

    Protein-protein interaction databases

    BioGridi22468. 1 interaction.
    IntActiQ8RX37. 1 interaction.
    STRINGi3702.AT1G07160.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RX37.
    SMRiQ8RX37. Positions 122-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 369249PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ8RX37.
    OMAiRINPQHE.
    PhylomeDBiQ8RX37.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RX37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSVAVCNS PVFSPSSSLF CNKPLNTSPA HETLTLSLSH LNPPVSSTSP    50
    SAASPTSPFC LRLLKPPAKL GFGSDSGPGS ILKRKRPTTL DIPVAPVGIA 100
    APISNADTPR EESRAVEREG DGYSVYCKRG KREAMEDRFS AITNLQGDPK 150
    QAIFGVYDGH GGPTAAEFAA KNLCSNILGE IVGGRNESKI EEAVKRGYLA 200
    TDSEFLKEKN VKGGSCCVTA LISDGNLVVA NAGDCRAVLS VGGFAEALTS 250
    DHRPSRDDER NRIESSGGYV DTFNSVWRIQ GSLAVSRGIG DAHLKQWIIS 300
    EPEINILRIN PQHEFLILAS DGLWDKVSNQ EAVDIARPFC KGTDQKRKPL 350
    LACKKLVDLS VSRGSLDDIS VMLIQLCHLF 380
    Length:380
    Mass (Da):40,709
    Last modified:June 1, 2002 - v1
    Checksum:i7EA1D8B991F0E88D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067971 Genomic DNA. Translation: AAF82204.1.
    CP002684 Genomic DNA. Translation: AEE28084.1.
    AY090917 mRNA. Translation: AAM13912.1.
    PIRiF86206.
    RefSeqiNP_172196.1. NM_100590.3.
    UniGeneiAt.42311.

    Genome annotation databases

    EnsemblPlantsiAT1G07160.1; AT1G07160.1; AT1G07160.
    GeneIDi837227.
    KEGGiath:AT1G07160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067971 Genomic DNA. Translation: AAF82204.1 .
    CP002684 Genomic DNA. Translation: AEE28084.1 .
    AY090917 mRNA. Translation: AAM13912.1 .
    PIRi F86206.
    RefSeqi NP_172196.1. NM_100590.3.
    UniGenei At.42311.

    3D structure databases

    ProteinModelPortali Q8RX37.
    SMRi Q8RX37. Positions 122-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 22468. 1 interaction.
    IntActi Q8RX37. 1 interaction.
    STRINGi 3702.AT1G07160.1-P.

    Proteomic databases

    PRIDEi Q8RX37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G07160.1 ; AT1G07160.1 ; AT1G07160 .
    GeneIDi 837227.
    KEGGi ath:AT1G07160.

    Organism-specific databases

    GeneFarmi 3527. 320.
    TAIRi AT1G07160.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q8RX37.
    OMAi RINPQHE.
    PhylomeDBi Q8RX37.

    Enzyme and pathway databases

    BioCyci ARA:AT1G07160-MONOMER.

    Gene expression databases

    Genevestigatori Q8RX37.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C02_ARATH
    AccessioniPrimary (citable) accession number: Q8RX37
    Secondary accession number(s): Q9LMK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3