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Protein

Histone deacetylase 5

Gene

HDA5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity1 Publication

Miscellaneous

Unlike its tandem duplication HDA18, HDA5 is not required for the cellular patterning in the root epidermis.

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-5617833 Cilium Assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 5 (EC:3.5.1.98)
Gene namesi
Name:HDA5
Ordered Locus Names:At5g61060
ORF Names:MAF19.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G61060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002800842 – 660Histone deacetylase 5Add BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8RX28
PRIDEiQ8RX28

PTM databases

iPTMnetiQ8RX28

Expressioni

Gene expression databases

ExpressionAtlasiQ8RX28 baseline and differential
GenevisibleiQ8RX28 AT

Interactioni

Protein-protein interaction databases

BioGridi21471, 6 interactors
STRINGi3702.AT5G61060.2

Structurei

3D structure databases

ProteinModelPortaliQ8RX28
SMRiQ8RX28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 349Histone deacetylaseAdd BLAST324

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225183
InParanoidiQ8RX28
KOiK11407
PhylomeDBiQ8RX28

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8RX28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMAGESSGK KIGDCDGKVA GNRQRKVGLI YDETMCKHDT PDGEDHPECP
60 70 80 90 100
DRIRVIWEKL QLAGVSQRCV VLGSSKAEDK HLQLVHTKDH VNLVKSISTK
110 120 130 140 150
QKDYRRNRIA SQLNSIYLNG GSSEAAYLAA GSVVKLAEKV AEGELDCGFA
160 170 180 190 200
IVRPPGHHAE ADEAMGFCLF NNVAVAASFL LNERPDLGVK KILIVDWDVH
210 220 230 240 250
HGNGTQKMFW KDPRVLFFSV HRHEYGGFYP AGDDGDYNMV GEGPGEGFNI
260 270 280 290 300
NVPWDQGRCG DADYLAAWDH ILIPVAREFN PDVIFLSAGF DAAINDPLGG
310 320 330 340 350
CCVTPYGYSV MLKKLMEFAQ GKIVLALEGG YNLDSIAKSS LACVQVLLED
360 370 380 390 400
KQIQGPPEAY PFESTWRVIQ AVRKRLCTYW PSLADELSWK LINQKTPTPI
410 420 430 440 450
ILISSSDSET EDNAQGLLDQ MSKLSIENPQ GTLLENHQVE PASTSWRADL
460 470 480 490 500
AKVDVWYASF GSNMWKPRFL CYIQGGQVDG LKKVCVGSMD KSPPKETVWE
510 520 530 540 550
TFPHRLFFGR ESSVGWGVGG VAFTNPLANL IDQTHMCLYR ITLEQFNDVL
560 570 580 590 600
SQENGLNVDS DSPVFDLAAL QLVDNKGSIL EAPLNSWYGN VVCLGKERDI
610 620 630 640 650
PILTMTCTLS AVEKFKSGEI PIRPPAKAYA NTLIRGLVEG GRLSKEEAEA
660
YIDKAVSKPL
Length:660
Mass (Da):72,723
Last modified:June 1, 2002 - v1
Checksum:iA40906BF82B397DE
GO

Sequence cautioni

The sequence BAB10369 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB10370 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006696 Genomic DNA Translation: BAB10369.1 Sequence problems.
AB006696 Genomic DNA Translation: BAB10370.1 Sequence problems.
CP002688 Genomic DNA Translation: AED97417.1
AY090936 mRNA Translation: AAM13986.1
AY120784 mRNA Translation: AAM53342.1
BT000073 mRNA Translation: AAN15392.1
RefSeqiNP_200914.2, NM_125499.5 [Q8RX28-1]
UniGeneiAt.44759
At.75645

Genome annotation databases

EnsemblPlantsiAT5G61060.1; AT5G61060.1; AT5G61060 [Q8RX28-1]
GeneIDi836227
GrameneiAT5G61060.1; AT5G61060.1; AT5G61060 [Q8RX28-1]
KEGGiath:AT5G61060

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHDA5_ARATH
AccessioniPrimary (citable) accession number: Q8RX28
Secondary accession number(s): Q9FNQ7, Q9FNQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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