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Protein

G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5

Gene

SD25

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei521ATPPROSITE-ProRule annotation1
Active sitei618Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 507ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB
  • carbohydrate binding Source: UniProtKB-KW
  • protein kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • protein autophosphorylation Source: TAIR

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Lectin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 (EC:2.7.11.1)
Alternative name(s):
S-domain-2 (SD2) receptor kinase 5
Short name:
SD2-5
Gene namesi
Name:SD25
Ordered Locus Names:At4g32300
ORF Names:F10M6.60, F8B4.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G32300.
TAIRilocus:2116525. AT4G32300.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 429ExtracellularSequence analysisAdd BLAST408
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 821CytoplasmicSequence analysisAdd BLAST371

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000040130322 – 821G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5Add BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 296PROSITE-ProRule annotation
Disulfide bondi290 ↔ 302PROSITE-ProRule annotation
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi363 ↔ 385PROSITE-ProRule annotation
Disulfide bondi367 ↔ 373PROSITE-ProRule annotation
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei635PhosphoserineBy similarity1
Modified residuei652PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8RWZ5.

PTM databases

iPTMnetiQ8RWZ5.
SwissPalmiQ8RWZ5.

Expressioni

Gene expression databases

ExpressionAtlasiQ8RWZ5. baseline and differential.
GenevisibleiQ8RWZ5. AT.

Interactioni

Subunit structurei

Interacts with PUB9, PUB13, PUB14 and PUB29.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi14651. 1 interactor.
STRINGi3702.AT4G32300.1.

Structurei

3D structure databases

ProteinModelPortaliQ8RWZ5.
SMRiQ8RWZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 148Bulb-type lectinPROSITE-ProRule annotationAdd BLAST116
Domaini280 – 314EGF-like; atypicalAdd BLAST35
Domaini323 – 411PANAdd BLAST89
Domaini493 – 768Protein kinasePROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni581 – 599CaM-bindingBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNU. Eukaryota.
ENOG410Y0GQ. LUCA.
HOGENOMiHOG000116559.
InParanoidiQ8RWZ5.
OMAiYIGFWIY.
OrthoDBiEOG0936021O.
PhylomeDBiQ8RWZ5.

Family and domain databases

Gene3Di2.90.10.10. 2 hits.
InterProiView protein in InterPro
IPR001480. Bulb-type_lectin_dom.
IPR036426. Bulb-type_lectin_dom_sf.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR024171. SRK-like_kinase.
PfamiView protein in Pfam
PF01453. B_lectin. 1 hit.
PF00069. Pkinase. 1 hit.
PIRSFiPIRSF000641. SRK. 1 hit.
SMARTiView protein in SMART
SM00108. B_lectin. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF51110. SSF51110. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50927. BULB_LECTIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8RWZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGVFIVIVT CLVFLPDPLR AGVASIGSIT PGFGGSQMNY INNDGIFLES
60 70 80 90 100
NNSAFGFGFV TTQDSVTLFT LSIIHKSSTK LIWSANRASP VSNSDKFVFD
110 120 130 140 150
DNGNVVMEGT EVWRLDNSGK NASRIELRDS GNLVVVSVDG TSIWESFDHP
160 170 180 190 200
TDTLITNQAF KEGMKLTSSP SSSNMTYALE IKSGDMVLSV NSLTPQVYWS
210 220 230 240 250
MANARERIIN KDGGVVTSSS LLGNSWRFFD QKQVLLWQFV FSDNKDDNTT
260 270 280 290 300
WIAVLGNNGV ISFSNLGSGA SAADSSTKIP SDLCGTPEPC GPYYVCSGSK
310 320 330 340 350
VCGCVSGLSR ARSDCKTGIT SPCKKTKDNA TLPLQLVSAG DGVDYFALGY
360 370 380 390 400
APPFSKKTDL DSCKEFCHNN CSCLGLFFQN SSGNCFLFDY IGSFKTSGNG
410 420 430 440 450
GSGFVSYIKI ASTGSGGGDN GEDDGKHFPY VVIIVVVTVF IIAVLIFVAF
460 470 480 490 500
RIHKRKKMIL EAPQESSEED NFLENLSGMP IRFAYKDLQS ATNNFSVKLG
510 520 530 540 550
QGGFGSVYEG TLPDGSRLAV KKLEGIGQGK KEFRAEVSII GSIHHLHLVR
560 570 580 590 600
LRGFCAEGAH RLLAYEFLSK GSLERWIFRK KDGDVLLDWD TRFNIALGTA
610 620 630 640 650
KGLAYLHEDC DARIVHCDIK PENILLDDNF NAKVSDFGLA KLMTREQSHV
660 670 680 690 700
FTTMRGTRGY LAPEWITNYA ISEKSDVYSY GMVLLELIGG RKNYDPSETS
710 720 730 740 750
EKCHFPSFAF KKMEEGKLMD IVDGKMKNVD VTDERVQRAM KTALWCIQED
760 770 780 790 800
MQTRPSMSKV VQMLEGVFPV VQPPSSSTMG SRLYSSFFKS ISEDGGATTS
810 820
SGPSDCNSEN YLSAVRLSGP R
Length:821
Mass (Da):89,740
Last modified:June 1, 2002 - v1
Checksum:iBE1BD7656E3D3811
GO

Sequence cautioni

The sequence CAA16960 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA22558 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79948 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021811 Genomic DNA. Translation: CAA16960.1. Sequence problems.
AL034567 Genomic DNA. Translation: CAA22558.1. Sequence problems.
AL161581 Genomic DNA. Translation: CAB79948.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86038.1.
AY091010 mRNA. Translation: AAM14032.1.
AY117229 mRNA. Translation: AAM51304.1.
PIRiT05341.
RefSeqiNP_194957.2. NM_119383.4.
UniGeneiAt.27667.

Genome annotation databases

EnsemblPlantsiAT4G32300.1; AT4G32300.1; AT4G32300.
GeneIDi829365.
GrameneiAT4G32300.1; AT4G32300.1; AT4G32300.
KEGGiath:AT4G32300.

Similar proteinsi

Entry informationi

Entry nameiSD25_ARATH
AccessioniPrimary (citable) accession number: Q8RWZ5
Secondary accession number(s): O49361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families