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Protein

Thiol protease aleurain-like

Gene

At3g45310

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165By similarity1
Active sitei305By similarity1
Active sitei325By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-ATH-2132295 MHC class II antigen presentation
R-ATH-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.162

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol protease aleurain-like (EC:3.4.22.16)
Gene namesi
Ordered Locus Names:At3g45310
ORF Names:F18N11.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G45310
TAIRilocus:2078312 AT3G45310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002641822 – 140Activation peptideBy similarityAdd BLAST119
ChainiPRO_0000026419141 – 358Thiol protease aleurain-likeAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 205By similarity
Disulfide bondi196 ↔ 238By similarity
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi296 ↔ 346By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ8RWQ9
PRIDEiQ8RWQ9

PTM databases

iPTMnetiQ8RWQ9

Expressioni

Gene expression databases

ExpressionAtlasiQ8RWQ9 baseline and differential
GenevisibleiQ8RWQ9 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G45310.1

Structurei

3D structure databases

ProteinModelPortaliQ8RWQ9
SMRiQ8RWQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
HOGENOMiHOG000230774
InParanoidiQ8RWQ9
KOiK01366
OMAiHEFRFYK
OrthoDBiEOG09360DEX
PhylomeDBiQ8RWQ9

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8RWQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVKLNLSSS ILLILFAAAA SKEIGFDESN PIKMVSDNLH ELEDTVVQIL
60 70 80 90 100
GQSRHVLSFS RFTHRYGKKY QSVEEMKLRF SVFKENLDLI RSTNKKGLSY
110 120 130 140 150
KLSLNQFADL TWQEFQRYKL GAAQNCSATL KGSHKITEAT VPDTKDWRED
160 170 180 190 200
GIVSPVKEQG HCGSCWTFST TGALEAAYHQ AFGKGISLSE QQLVDCAGTF
210 220 230 240 250
NNFGCHGGLP SQAFEYIKYN GGLDTEEAYP YTGKDGGCKF SAKNIGVQVR
260 270 280 290 300
DSVNITLGAE DELKHAVGLV RPVSVAFEVV HEFRFYKKGV FTSNTCGNTP
310 320 330 340 350
MDVNHAVLAV GYGVEDDVPY WLIKNSWGGE WGDNGYFKME MGKNMCGVAT

CSSYPVVA
Length:358
Mass (Da):39,542
Last modified:June 1, 2002 - v1
Checksum:i0EE54FAADBADCDFD
GO

Sequence cautioni

The sequence CAB72480 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132953 Genomic DNA Translation: CAB72480.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE78021.1
AY091771 mRNA Translation: AAM10319.1
PIRiT47471
RefSeqiNP_566880.1, NM_114400.4 [Q8RWQ9-1]
UniGeneiAt.25239

Genome annotation databases

EnsemblPlantsiAT3G45310.1; AT3G45310.1; AT3G45310 [Q8RWQ9-1]
GeneIDi823669
GrameneiAT3G45310.1; AT3G45310.1; AT3G45310 [Q8RWQ9-1]
KEGGiath:AT3G45310

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALEUL_ARATH
AccessioniPrimary (citable) accession number: Q8RWQ9
Secondary accession number(s): Q9M3E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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