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Protein

Acyl-CoA-binding domain-containing protein 5

Gene

ACBP5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with oleoyl-CoA, barely with palmitoyl-CoA, but not with arachidonyl-CoA. May function as an intracellular carrier of acyl-CoA esters (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34Acyl-CoABy similarity1
Binding sitei75Acyl-CoABy similarity1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: TAIR
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • lipid transport Source: TAIR
  • response to hypoxia Source: TAIR
  • response to light stimulus Source: UniProtKB

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
Short name:
Acyl-CoA binding protein 5
Gene namesi
Name:ACBP5
Ordered Locus Names:At5g27630
ORF Names:F15A18.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G27630
TAIRilocus:2143676 AT5G27630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25G → T: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi26L → T: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi29S → A: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi46L → Q: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi49Y → A: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi53Q → A: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi75K → A: Reduction of oleoyl-CoA-binding activity. 1 Publication1
Mutagenesisi94F → A: Reduction of oleoyl-CoA-binding activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003799041 – 648Acyl-CoA-binding domain-containing protein 5Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei517PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8RWD9
PRIDEiQ8RWD9

PTM databases

iPTMnetiQ8RWD9

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Inductioni

Up-regulated in the light and down-regulated in constant darkness.

Gene expression databases

ExpressionAtlasiQ8RWD9 baseline and differential
GenevisibleiQ8RWD9 AT

Interactioni

Protein-protein interaction databases

BioGridi18099, 2 interactors
IntActiQ8RWD9, 2 interactors
STRINGi3702.AT5G27630.1

Structurei

3D structure databases

ProteinModelPortaliQ8RWD9
SMRiQ8RWD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 107ACBPROSITE-ProRule annotationAdd BLAST95
Repeati196 – 244Kelch 1Add BLAST49
Repeati256 – 306Kelch 2Add BLAST51
Repeati307 – 357Kelch 3Add BLAST51
Repeati359 – 408Kelch 4Add BLAST50
Repeati409 – 457Kelch 5Add BLAST49
Repeati464 – 509Kelch 6Add BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 53Acyl-CoA bindingCurated5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili520 – 632Sequence analysisAdd BLAST113

Sequence similaritiesi

Belongs to the ACBP family.Curated

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
KOG0817 Eukaryota
ENOG410Y5WM LUCA
HOGENOMiHOG000239625
InParanoidiQ8RWD9
OMAiNQWTAPL
OrthoDBiEOG093607PP
PhylomeDBiQ8RWD9

Family and domain databases

Gene3Di1.20.80.10, 1 hit
2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
SMARTiView protein in SMART
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RWD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHMVRASSG LSYPERFYAA ASYVGLDGSQ SSVKQLSSKF SNDTSLLLYT
60 70 80 90 100
LHQQATLGPC SIPKPSAWNP VEQSKWKSWQ GLGTMPSIEA MRLFVKILEE
110 120 130 140 150
ADPGWYPRTS NSVLDPAVHV QINSTKAEPS FESGASFGET KTITSEDGRL
160 170 180 190 200
TETQDKDVVL EDPDTVSVYN QWTAPRTSGQ PPKARYQHGA AVIQDKMYMY
210 220 230 240 250
GGNHNGRYLG DLHVLDLKNW TWSRVETKVV TGSQETSSPA KLTHCAGHSL
260 270 280 290 300
IPWDNQLLSI GGHTKDPSES MPVMVFDLHC CSWSILKTYG KPPISRGGQS
310 320 330 340 350
VTLVGKSLVI FGGQDAKRSL LNDLHILDLD TMTWEEIDAV GSPPTPRSDH
360 370 380 390 400
AAAVHAERYL LIFGGGSHAT CFDDLHVLDL QTMEWSRHTQ QGDAPTPRAG
410 420 430 440 450
HAGVTIGENW YIVGGGDNKS GASKTVVLNM STLAWSVVTS VQEHVPLASE
460 470 480 490 500
GLSLVVSSYN GEDIVVAFGG YNGHYNNEVN VLKPSHKSSL KSKIMGASAV
510 520 530 540 550
PDSFSAVNNA TTRDIESEIK VEGKADRIIT TLKSEKEEVE ASLNKEKIQT
560 570 580 590 600
LQLKEELAEI DTRNTELYKE LQSVRNQLAA EQSRCFKLEV EVAELRQKLQ
610 620 630 640
TMETLQKELE LLQRQRAVAS EQAATMNAKR QSSGGVWGWL AGTPPPKT
Length:648
Mass (Da):71,009
Last modified:June 1, 2002 - v1
Checksum:iFD0800C090E17C85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007478 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED93708.1
AY093156 mRNA Translation: AAM13155.1
BT008399 mRNA Translation: AAP37758.1
RefSeqiNP_198115.2, NM_122645.5
UniGeneiAt.49071
At.69930

Genome annotation databases

EnsemblPlantsiAT5G27630.1; AT5G27630.1; AT5G27630
GeneIDi832825
GrameneiAT5G27630.1; AT5G27630.1; AT5G27630
KEGGiath:AT5G27630

Similar proteinsi

Entry informationi

Entry nameiACBP5_ARATH
AccessioniPrimary (citable) accession number: Q8RWD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health