Reviewed,
UniProtKB/Swiss-Prot Q8RUN1 (ACA3_ORYSJ)
Last modified
June 16, 2009.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Calcium-transporting ATPase 3, plasma membrane-type EC=3.6.3.8 Alternative name(s): Ca(2+)-ATPase isoform 3 | ||||
| Gene names |
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| Organism | Oryza sativa subsp. japonica (Rice) | ||||
| Taxonomic identifier | 39947 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza |
Protein attributes
| Sequence length | 1043 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles By similarity. |
| Catalytic activity | ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans). |
| Enzyme regulation | Activated by calmodulin By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein By similarity. |
| Domain | The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity. |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Calcium transport Ion transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Ligand | ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion bindingInferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activityInferred from electronic annotation. Source: EC calmodulin bindingInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1043 | 1043 | Calcium-transporting ATPase 3, plasma membrane-type | PRO_0000247302 | |||||
Regions | |||||||||
| Topological domain | 1 – 178 | 178 | Cytoplasmic Potential | ||||||
| Transmembrane | 179 – 199 | 21 | Potential | ||||||
| Transmembrane | 202 – 222 | 21 | Potential | ||||||
| Topological domain | 223 – 258 | 36 | Cytoplasmic Potential | ||||||
| Transmembrane | 259 – 279 | 21 | Potential | ||||||
| Transmembrane | 356 – 376 | 21 | Potential | ||||||
| Topological domain | 377 – 395 | 19 | Cytoplasmic Potential | ||||||
| Transmembrane | 396 – 416 | 21 | Potential | ||||||
| Transmembrane | 824 – 844 | 21 | Potential | ||||||
| Topological domain | 845 | 1 | Cytoplasmic Potential | ||||||
| Transmembrane | 846 – 866 | 21 | Potential | ||||||
| Transmembrane | 891 – 911 | 21 | Potential | ||||||
| Topological domain | 912 – 955 | 44 | Cytoplasmic Potential | ||||||
| Transmembrane | 956 – 976 | 21 | Potential | ||||||
| Transmembrane | 998 – 1018 | 21 | Potential | ||||||
| Topological domain | 1019 – 1043 | 25 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Active site | 460 | 1 | 4-aspartylphosphate intermediate By similarity | ||||||
| Metal binding | 761 | 1 | Magnesium By similarity | ||||||
| Metal binding | 765 | 1 | Magnesium By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. Gojobori T.Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare. |
| [2] | "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare. |
Cross-references
Sequence databases | |
|---|---|
| AP003269 Genomic DNA. Translation: BAB89725.1. AP003412 Genomic DNA. Translation: BAB90248.1. AK070064 mRNA. No translation available. | |
| RefSeq | NP_001045345.1. |
| UniGene | Os.34808 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1SU4 based on UniProtKB P04191. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4326507. |
| KEGG | osa:4326507. |
| NMPDR | fig|39947.1.peg.7045. |
Organism-specific databases | |
| Gramene | Q8RUN1. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. [Graphical view] |
| PANTHER | PTHR11939. ATPase_P. 1 hit. |
| Pfam | PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. PR00120. HATPASE. |
| TIGRFAMs | TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACA3_ORYSJ | ||||||||
| Accession | Primary (citable) accession number: Q8RUN1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Oryza sativa (rice) Index of Oryza sativa entries and their corresponding gene designations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


