Calcium-transporting ATPase 3, plasma membrane-type - Oryza sativa subsp. japonica (Rice)

Names and origin

Protein names

Recommended name:
    Calcium-transporting ATPase 3, plasma membrane-type
    EC=3.6.3.8
Alternative name(s):
    Ca(2+)-ATPase isoform 3

Gene names

Ordered Locus Names:	Os01g0939100, LOC_Os01g71240
ORF Names:	B1150F11.11, P0504E02.35

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length	1043 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Enzyme regulation	Activated by calmodulin By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Domain	The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

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Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1043

1043

Calcium-transporting ATPase 3, plasma membrane-type

PRO_0000247302

Regions

Topological domain

1 – 178

178

Cytoplasmic Potential

Transmembrane

179 – 199

21

Potential

Transmembrane

202 – 222

21

Potential

Topological domain

223 – 258

36

Cytoplasmic Potential

Transmembrane

259 – 279

21

Potential

Transmembrane

356 – 376

21

Potential

Topological domain

377 – 395

19

Cytoplasmic Potential

Transmembrane

396 – 416

21

Potential

Transmembrane

824 – 844

21

Potential

Topological domain

845

1

Cytoplasmic Potential

Transmembrane

846 – 866

21

Potential

Transmembrane

891 – 911

21

Potential

Topological domain

912 – 955

44

Cytoplasmic Potential

Transmembrane

956 – 976

21

Potential

Transmembrane

998 – 1018

21

Potential

Topological domain

1019 – 1043

25

Cytoplasmic Potential

Sites

Active site

460

1

4-aspartylphosphate intermediate By similarity

Metal binding

761

1

Magnesium By similarity

Metal binding

765

1

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q8RUN1-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A16B82561803AF56
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FASTA

1,043

112,842

        10         20         30         40         50         60 
MSFIRKKSME FLKSFEVPAK NPSEEAQRRW RDAVGTLVKN RRRRFRMVPD LDKRSQAETQ 

        70         80         90        100        110        120 
RRKIQEKLRV ALFVQKAALQ FIDAVRKTEH PLPELARQCG FSVSAEELAS IVRGHDTKSL 

       130        140        150        160        170        180 
RFHNGVDGIA RKVAVSLADG VKSDDAGLRA EVYGANQYTE KPPRTFWMFL WDASQDMTLL 

       190        200        210        220        230        240 
LLAFCAAVSV AIGLATEGWP SGMYDGVGIM LTILLVVMIT AASDYKQSLQ FRDLDKEKKK 

       250        260        270        280        290        300 
IDVQVTRDGY RQKVSIYDIV VGDIVHLSIG DQVPADGLFI DGYSFVVDES NLSGESEPVH 

       310        320        330        340        350        360 
VSTANRFLLG GTKVQDGSAR MLVTAVGMRT EWGNLMETLS QGGEDETPLQ VKLNGVATII 

       370        380        390        400        410        420 
GKIGLAFAVL TFTVLMARFL LGKAGAPGGL LRWRMVDALA VLNFFAVAVT IIVVAVPEGL 

       430        440        450        460        470        480 
PLAVTLSLAF AMKKLMQERA LVRHLSACET MGSASCICTD KTGTLTTNHM VVEKIWASGA 

       490        500        510        520        530        540 
AQTMSNAKGF DQLTSSMSET FAKVLLEGVF HCSGSEVVRG KDGRHTIMGT PTETAILEFG 

       550        560        570        580        590        600 
LAVEKRARIE HTGAGKLKVE PFNSVKKTMA VVIASPSAGG RPRAFLKGAS EVVLSRCSLV 

       610        620        630        640        650        660 
LDGTGNVEKL TDAKAKRVAS AIDAFACEAL RTLCLAYQDV DGGGGDIPGE GYTLIAVFGI 

       670        680        690        700        710        720 
KDPLRPGVRE AVATCHAAGI NVRMVTGDNI NTAKAIAREC GILTDDGIAI EGPEFRNKDP 

       730        740        750        760        770        780 
DQMREIIPKI QVMARSLPLD KHTLVTNLRG MFNEVVAVTG DGTNDAPALH EADIGLAMGI 

       790        800        810        820        830        840 
AGTEVAKENA DVIIMDDNFS TIINVAKWGR SVYINIQKFV QFQLTVNVVA LMVNFISASF 

       850        860        870        880        890        900 
TGSAPLTIVQ LLWVNLIMDT LGALALATEP PNDAMMKRPP VGRGDNFITK VMWRNIVGQS 

       910        920        930        940        950        960 
IYQLVVLGVL LLRGKSLLQI NGPQADSLLN TFVFNTFVFC QVFNEVNSRE MEKINVFSGI 

       970        980        990       1000       1010       1020 
FSSWIFSAVV GVTAGFQVIM VELLGTFANT VHLSGKLWLT SVLIGSVGLV IGAILKCIPV 

      1030       1040 
ESGSDASDRH DGYRPIPTGP SAV

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References

[1]

"The genome sequence and structure of rice chromosome 1."
Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.

Gojobori T.
Nature 420:312-316(2002) [PubMed: 12447438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

[2]

"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed: 12869764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

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Cross-references

Sequence databases
	AP003269 Genomic DNA. Translation: BAB89725.1. AP003412 Genomic DNA. Translation: BAB90248.1. AK070064 mRNA. No translation available.
RefSeq	NP_001045345.1.
UniGene	Os.34808
3D structure databases
HSSP	HSSP built from PDB template 1SU4 based on UniProtKB P04191.
ModBase	Search...
Genome annotation databases
GeneID	4326507.
KEGG	osa:4326507.
NMPDR	fig\|39947.1.peg.7045.
Organism-specific databases
Gramene	Q8RUN1.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ACA3_ORYSJ

Accession

Primary (citable) accession number: Q8RUN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry information

Relevant documents