Reviewed, UniProtKB/Swiss-Prot Q8RT67 (COAD_BARBK)

Names and origin

Protein names

Recommended name:
    Phosphopantetheine adenylyltransferase
    EC=2.7.7.3
Alternative name(s):
    Pantetheine-phosphate adenylyltransferase
      Short name=PPAT
    Dephospho-CoA pyrophosphorylase

Gene names

Name:	coaD
Ordered Locus Names:	BARBAKC583_0738

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity.
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial coaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_0000156171

Sequences

	Sequence		Length	Mass (Da)
	Q8RT67-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 908CDE3A48A891B2	FASTA	164	17,912
	10 20 30 40 50 60 MTIAFYAGSF DPITNGHLDV LRGSLLLADK VVVAIGVQAQ KQSLFSFEER VDLITQVGRD 70 80 90 100 110 120 LLNVGPDRLQ VISFNNLLID TAREIGASFL VRGLRDGTDF DYEMQMAGMN GIMAPELQTV 130 140 150 160 FLPASISGRV ITSTLVHQIA AMGGDVTHFV PQNVAQALRL KFKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bartonella bacilliformis gyrA mutations conferring resistance to ciprofloxacin." Minnick M.F., Smitherman L.S., Wilson Z.R., Samuels D.S. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF469609 Genomic DNA. Translation: AAL82404.1. CP000524 Genomic DNA. Translation: ABM44487.1. Different initiation.
RefSeq	YP_989036.1.
3D structure databases
HSSP	HSSP built from PDB template 1QJC based on UniProtKB P23875.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8RT67.
Genome annotation databases
GeneID	4685071.
GenomeReviews	Gene locus BARBAKC583_0738 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0738.
NMPDR	fig|360095.3.peg.760.
TIGR	BARBAKC583_0738.
Phylogenomic databases
OMA	AMSDFEY.
Family and domain databases
HAMAP	MF_00151. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. coaD_prev_kdtB. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BARBK

Accession

Primary (citable) accession number: Q8RT67
Secondary accession number(s): A1UST3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)