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Protein
Submitted name:

RalF

Gene

ralF

Organism
Legionella pneumophila
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
RalFImported
Gene namesi
Name:ralFImported
OrganismiLegionella pneumophilaImported
Taxonomic identifieri446 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

PTM / Processingi

Proteomic databases

PaxDbiQ8RT31.

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg1950.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XSZX-ray1.41A/B2-353[»]
1XT0X-ray2.16B2-201[»]
4C7PX-ray3.10A2-374[»]
4D7RX-ray1.80A91-117[»]
A153-187[»]
A225-225[»]
A269-269[»]
A329-374[»]
ProteinModelPortaliQ8RT31.
SMRiQ8RT31. Positions 2-353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8RT31.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 190178SEC7InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4106MJN. Bacteria.
COG5307. LUCA.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
PROSITEiPS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RT31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPEIEKAQR EIIEAFNAKP KNGINKIKEI CEQYKISPNE EIAEFFHQQR
60 70 80 90 100
KNLDLEAVGD YLSSPEAENQ QVLKAFTSQM NFNGQSFVEG LRTFLKTFKL
110 120 130 140 150
PGEAQKIDRL VQSFSGAYFQ QNPDVVSNAD AAYLLAFQTI MLNTDLHNPS
160 170 180 190 200
IPEKNKMTVD GLKRNLRGGN NGGDFDAKFL EELYSEIKAK PFELNFVKTS
210 220 230 240 250
PGYELTSTTL NKDSTFKKLD SFLHSTDVNI NTVFPGIGDN VKTTVDQPKS
260 270 280 290 300
WLSFFTGYKG TITLTDNKTS AQATIQVYTP NIFSKWLFGE QPRVIIQPGQ
310 320 330 340 350
TKESIDLAAK AAADFSSPVK NFKATYDYEV GDLIKAYDNQ KKLITIERNL
360 370
ALKEGVPKDP DAEMQKEKGR QLKF
Length:374
Mass (Da):42,173
Last modified:June 1, 2002 - v1
Checksum:i192AF1200A3A7A2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY056455 Genomic DNA. Translation: AAL23711.1.
RefSeqiWP_010947666.1. NZ_LOLY01000059.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY056455 Genomic DNA. Translation: AAL23711.1.
RefSeqiWP_010947666.1. NZ_LOLY01000059.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XSZX-ray1.41A/B2-353[»]
1XT0X-ray2.16B2-201[»]
4C7PX-ray3.10A2-374[»]
4D7RX-ray1.80A91-117[»]
A153-187[»]
A225-225[»]
A269-269[»]
A329-374[»]
ProteinModelPortaliQ8RT31.
SMRiQ8RT31. Positions 2-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg1950.

Proteomic databases

PaxDbiQ8RT31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4106MJN. Bacteria.
COG5307. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ8RT31.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
PROSITEiPS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes."
    Nagai H., Kagan J.C., Zhu X., Kahn R.A., Roy C.R.
    Science 295:679-682(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LP01Imported.
  2. "The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site."
    Amor J.C., Swails J., Zhu X., Roy C.R., Nagai H., Ingmundson A., Cheng X., Kahn R.A.
    J. Biol. Chem. 280:1392-1400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) OF 2-353.
  3. "A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF."
    Folly-Klan M., Alix E., Stalder D., Ray P., Duarte L.V., Delprato A., Zeghouf M., Antonny B., Campanacci V., Roy C.R., Cherfils J.
    PLoS Pathog. 9:e1003747-e1003747(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 2-374.
  4. "On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF."
    Folly-Klan M., Sancerne B., Alix E., Roy C.R., Cherfils J., Campanacci V.
    J. Struct. Biol. 189:98-104(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 91-117; 153-187; 225-225; 269-269 AND 329-374.

Entry informationi

Entry nameiQ8RT31_LEGPN
AccessioniPrimary (citable) accession number: Q8RT31
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.